EMP3 (epithelial membrane protein 3 (MAM blood group)) - Rat Genome Database

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Gene: EMP3 (epithelial membrane protein 3 (MAM blood group)) Homo sapiens
Analyze
Symbol: EMP3
Name: epithelial membrane protein 3 (MAM blood group) (Ensembl:epithelial membrane protein 3)
RGD ID: 731841
HGNC Page HGNC:3335
Description: Involved in apoptotic process and bleb assembly. Located in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EMP-3; epithelial membrane protein 3; hematopoietic neural membrane protein 1; HNMP-1; YMP
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,325,552 - 48,330,553 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,321,509 - 48,330,553 (+)EnsemblGRCh38hg38GRCh38
GRCh371948,828,809 - 48,833,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,520,454 - 53,525,622 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,520,453 - 53,525,622NCBI
Celera1945,693,863 - 45,699,044 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,209,377 - 45,214,558 (+)NCBIHuRef
CHM1_11948,830,732 - 48,835,916 (+)NCBICHM1_1
T2T-CHM13v2.01951,319,698 - 51,324,699 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
aristolochic acids  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
avobenzone  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP)
endosulfan  (ISO)
epoxiconazole  (ISO)
etoposide  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
gentamycin  (ISO)
hydralazine  (EXP)
indole-3-methanol  (ISO)
iron dichloride  (EXP)
ivermectin  (EXP)
L-ascorbic acid  (EXP)
lidocaine  (ISO)
methyl methanesulfonate  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (EXP)
ochratoxin A  (ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (EXP)
quercetin  (EXP)
quinolin-8-ol  (EXP)
Salinomycin  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP)
Soman  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetradecane  (ISO)
thioacetamide  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8884260   PMID:8917086   PMID:8996089   PMID:9204931   PMID:10331954   PMID:12107182   PMID:12477932   PMID:15489334   PMID:15583422   PMID:16015083   PMID:17187361   PMID:17610521  
PMID:18823699   PMID:19270820   PMID:20388442   PMID:21873635   PMID:21988832   PMID:22992787   PMID:23920144   PMID:24083241   PMID:25416956   PMID:26398721   PMID:26472188   PMID:27279240  
PMID:27527869   PMID:27801851   PMID:28718375   PMID:29676528   PMID:29794476   PMID:30614533   PMID:31515488   PMID:32296183   PMID:32678083   PMID:32687490   PMID:32780723   PMID:33961781  
PMID:33964937   PMID:34067658   PMID:34268874   PMID:34476496   PMID:34511602   PMID:34617578   PMID:34856762   PMID:36789459   PMID:37936247   PMID:38229014  


Genomics

Comparative Map Data
EMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,325,552 - 48,330,553 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,321,509 - 48,330,553 (+)EnsemblGRCh38hg38GRCh38
GRCh371948,828,809 - 48,833,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,520,454 - 53,525,622 (+)NCBINCBI36Build 36hg18NCBI36
Build 341953,520,453 - 53,525,622NCBI
Celera1945,693,863 - 45,699,044 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,209,377 - 45,214,558 (+)NCBIHuRef
CHM1_11948,830,732 - 48,835,916 (+)NCBICHM1_1
T2T-CHM13v2.01951,319,698 - 51,324,699 (+)NCBIT2T-CHM13v2.0
Emp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,567,447 - 45,570,850 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,567,447 - 45,570,828 (-)EnsemblGRCm39 Ensembl
GRCm38745,918,023 - 45,921,426 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,918,023 - 45,921,404 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,173,393 - 53,176,796 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,786,106 - 45,789,446 (-)NCBIMGSCv36mm8
Celera741,383,035 - 41,386,440 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.6NCBI
Emp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,525,086 - 105,528,370 (-)NCBIGRCr8
mRatBN7.2196,388,651 - 96,391,946 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,388,652 - 96,391,988 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,774,797 - 101,777,974 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,246,785 - 110,249,962 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,537,150 - 103,540,327 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,900,731 - 101,903,948 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,900,733 - 101,903,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,979,695 - 102,982,874 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,389,783 - 96,392,960 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,467,893 - 96,471,071 (-)NCBI
Celera190,641,302 - 90,644,479 (-)NCBICelera
Cytogenetic Map1q22NCBI
Emp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555592,117,200 - 2,121,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555592,117,200 - 2,121,366 (-)NCBIChiLan1.0ChiLan1.0
EMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,429,929 - 54,435,117 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,356,040 - 56,361,407 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,326,302 - 45,331,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11953,919,933 - 53,925,147 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1953,919,986 - 53,925,147 (+)Ensemblpanpan1.1panPan2
EMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,901,778 - 107,905,912 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,901,781 - 107,905,619 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,423,282 - 107,427,399 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,426,213 - 108,430,346 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,426,216 - 108,430,232 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,092,642 - 108,096,761 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,739,405 - 107,743,526 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,575,501 - 108,579,626 (-)NCBIUU_Cfam_GSD_1.0
Emp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934920,850,007 - 20,853,482 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,468,269 - 2,471,675 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,467,240 - 2,471,672 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,757,776 - 53,761,833 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1653,757,513 - 53,761,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,394,027 - 49,398,349 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,591,145 - 41,596,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl641,591,020 - 41,596,951 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607321,368,887 - 21,374,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Emp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,432,166 - 5,436,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,432,204 - 5,437,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EMP3
7 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 copy number gain See cases [RCV000052913] Chr19:46658791..49050450 [GRCh38]
Chr19:47162048..49553707 [GRCh37]
Chr19:51853888..54245519 [NCBI36]
Chr19:19q13.32-13.33		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.33(chr19:48807201-48846153)x3 copy number gain See cases [RCV000446679] Chr19:48807201..48846153 [GRCh37]
Chr19:19q13.33		 benign
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_001425.3(EMP3):c.50T>C (p.Ile17Thr) single nucleotide variant Inborn genetic diseases [RCV003286692] Chr19:48326894 [GRCh38]
Chr19:48830151 [GRCh37]
Chr19:19q13.33		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.33(chr19:48119589-49595956)x3 copy number gain not provided [RCV000848800] Chr19:48119589..49595956 [GRCh37]
Chr19:19q13.33		 uncertain significance
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42		 not provided
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NC_000019.9:g.(?_48618906)_(50921204_?)dup duplication Developmental and epileptic encephalopathy, 12 [RCV001939968]|not provided [RCV001916178] Chr19:48618906..50921204 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_001425.3(EMP3):c.208A>T (p.Met70Leu) single nucleotide variant Inborn genetic diseases [RCV002839756] Chr19:48329378 [GRCh38]
Chr19:48832635 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_001425.3(EMP3):c.22G>A (p.Val8Ile) single nucleotide variant Inborn genetic diseases [RCV002992714] Chr19:48326866 [GRCh38]
Chr19:48830123 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_001425.3(EMP3):c.359T>C (p.Ile120Thr) single nucleotide variant Inborn genetic diseases [RCV002782510] Chr19:48330337 [GRCh38]
Chr19:48833594 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_001425.3(EMP3):c.320C>T (p.Thr107Ile) single nucleotide variant Inborn genetic diseases [RCV002788201] Chr19:48329490 [GRCh38]
Chr19:48832747 [GRCh37]
Chr19:19q13.33		 uncertain significance
NM_001425.3(EMP3):c.301G>A (p.Gly101Ser) single nucleotide variant Inborn genetic diseases [RCV003174174] Chr19:48329471 [GRCh38]
Chr19:48832728 [GRCh37]
Chr19:19q13.33		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3078
Count of miRNA genes:792
Interacting mature miRNAs:946
Transcripts:ENST00000270221, ENST00000593437, ENST00000594198, ENST00000596315, ENST00000597057, ENST00000597279, ENST00000597529, ENST00000599255, ENST00000599704
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH79835  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371948,833,580 - 48,833,829UniSTSGRCh37
Build 361953,525,392 - 53,525,641RGDNCBI36
Celera1945,698,814 - 45,699,063RGD
Cytogenetic Map19q13.3UniSTS
HuRef1945,214,328 - 45,214,577UniSTS
RH71237  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371948,833,560 - 48,833,727UniSTSGRCh37
Build 361953,525,372 - 53,525,539RGDNCBI36
Celera1945,698,794 - 45,698,961RGD
Cytogenetic Map19q13.3UniSTS
HuRef1945,214,308 - 45,214,475UniSTS
RH44868  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371948,833,602 - 48,833,706UniSTSGRCh37
Build 361953,525,414 - 53,525,518RGDNCBI36
Celera1945,698,836 - 45,698,940RGD
Cytogenetic Map19q13.3UniSTS
HuRef1945,214,350 - 45,214,454UniSTS
GeneMap99-GB4 RH Map19266.31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 2 2
Medium 2312 2948 1394 345 1916 187 3696 1505 2350 373 1406 1521 168 1204 2143 1
Low 126 43 330 277 33 278 660 692 1371 44 45 88 6 1 645 4
Below cutoff 1 2 8 2 7 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL541088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN121937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN164486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN164487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U87947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X94771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000270221   ⟹   ENSP00000270221
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,325,552 - 48,330,553 (+)Ensembl
RefSeq Acc Id: ENST00000593437   ⟹   ENSP00000469275
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,325,608 - 48,330,524 (+)Ensembl
RefSeq Acc Id: ENST00000594198   ⟹   ENSP00000471964
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,325,544 - 48,330,355 (+)Ensembl
RefSeq Acc Id: ENST00000596315   ⟹   ENSP00000469341
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,325,347 - 48,330,553 (+)Ensembl
RefSeq Acc Id: ENST00000597057
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,329,270 - 48,330,483 (+)Ensembl
RefSeq Acc Id: ENST00000597279   ⟹   ENSP00000469194
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,325,581 - 48,330,553 (+)Ensembl
RefSeq Acc Id: ENST00000597529
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,325,547 - 48,327,800 (+)Ensembl
RefSeq Acc Id: ENST00000599255   ⟹   ENSP00000471592
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,325,561 - 48,330,539 (+)Ensembl
RefSeq Acc Id: ENST00000599704   ⟹   ENSP00000470331
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,321,509 - 48,329,439 (+)Ensembl
RefSeq Acc Id: NM_001313905   ⟹   NP_001300834
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,325,999 - 48,330,553 (+)NCBI
CHM1_11948,831,359 - 48,835,916 (+)NCBI
T2T-CHM13v2.01951,320,145 - 51,324,699 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001425   ⟹   NP_001416
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,325,552 - 48,330,553 (+)NCBI
GRCh371948,828,629 - 48,833,810 (+)ENTREZGENE
Build 361953,520,454 - 53,525,622 (+)NCBI Archive
HuRef1945,209,377 - 45,214,558 (+)ENTREZGENE
CHM1_11948,830,732 - 48,835,916 (+)NCBI
T2T-CHM13v2.01951,319,698 - 51,324,699 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526605   ⟹   XP_011524907
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,325,552 - 48,330,553 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054320174   ⟹   XP_054176149
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01951,319,698 - 51,324,699 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001416   ⟸   NM_001425
- UniProtKB: Q6FH01 (UniProtKB/Swiss-Prot),   P54852 (UniProtKB/Swiss-Prot),   Q6IBD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011524907   ⟸   XM_011526605
- Peptide Label: isoform X1
- UniProtKB: Q6FH01 (UniProtKB/Swiss-Prot),   P54852 (UniProtKB/Swiss-Prot),   Q6IBD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300834   ⟸   NM_001313905
- UniProtKB: Q6FH01 (UniProtKB/Swiss-Prot),   P54852 (UniProtKB/Swiss-Prot),   Q6IBD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000469341   ⟸   ENST00000596315
RefSeq Acc Id: ENSP00000469194   ⟸   ENST00000597279
RefSeq Acc Id: ENSP00000471592   ⟸   ENST00000599255
RefSeq Acc Id: ENSP00000470331   ⟸   ENST00000599704
RefSeq Acc Id: ENSP00000270221   ⟸   ENST00000270221
RefSeq Acc Id: ENSP00000469275   ⟸   ENST00000593437
RefSeq Acc Id: ENSP00000471964   ⟸   ENST00000594198
RefSeq Acc Id: XP_054176149   ⟸   XM_054320174
- Peptide Label: isoform X1
- UniProtKB: P54852 (UniProtKB/Swiss-Prot),   Q6FH01 (UniProtKB/Swiss-Prot),   Q6IBD3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54852-F1-model_v2 AlphaFold P54852 1-163 view protein structure

Promoters
RGD ID:13204929
Promoter ID:EPDNEW_H26049
Type:initiation region
Name:EMP3_3
Description:epithelial membrane protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26051  EPDNEW_H26052  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,321,480 - 48,321,540EPDNEW
RGD ID:13204937
Promoter ID:EPDNEW_H26051
Type:initiation region
Name:EMP3_2
Description:epithelial membrane protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26049  EPDNEW_H26052  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,325,358 - 48,325,418EPDNEW
RGD ID:13204939
Promoter ID:EPDNEW_H26052
Type:initiation region
Name:EMP3_1
Description:epithelial membrane protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H26049  EPDNEW_H26051  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,325,560 - 48,325,620EPDNEW
RGD ID:6795376
Promoter ID:HG_KWN:30439
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001425
Position:
Human AssemblyChrPosition (strand)Source
Build 361953,520,311 - 53,520,811 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3335 AgrOrtholog
COSMIC EMP3 COSMIC
Ensembl Genes ENSG00000142227 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000270221 ENTREZGENE
  ENST00000270221.11 UniProtKB/Swiss-Prot
  ENST00000593437.1 UniProtKB/TrEMBL
  ENST00000594198.1 UniProtKB/TrEMBL
  ENST00000596315.5 UniProtKB/TrEMBL
  ENST00000597279 ENTREZGENE
  ENST00000597279.5 UniProtKB/Swiss-Prot
  ENST00000599255.5 UniProtKB/TrEMBL
  ENST00000599704.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000142227 GTEx
HGNC ID HGNC:3335 ENTREZGENE
Human Proteome Map EMP3 Human Proteome Map
InterPro EMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22_EMP_MP20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2014 UniProtKB/Swiss-Prot
NCBI Gene 2014 ENTREZGENE
OMIM 602335 OMIM
PANTHER EPITHELIAL MEMBRANE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10671:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27772 PharmGKB
PRINTS EPMEMFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPMEMPROT3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PMP22_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EMP3_HUMAN UniProtKB/Swiss-Prot
  M0QXN1_HUMAN UniProtKB/TrEMBL
  M0QXS0_HUMAN UniProtKB/TrEMBL
  M0QZ66_HUMAN UniProtKB/TrEMBL
  M0R122_HUMAN UniProtKB/TrEMBL
  M0R1L9_HUMAN UniProtKB/TrEMBL
  P54852 ENTREZGENE
  Q6FH01 ENTREZGENE
  Q6IBD3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6FH01 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-12-18 EMP3  epithelial membrane protein 3 (MAM blood group)  EMP3  epithelial membrane protein 3  Symbol and/or name change 19259463 PROVISIONAL