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Gene: VPS33A (VPS33A core subunit of CORVET and HOPS complexes) Homo sapiens
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Symbol: VPS33A
Name: VPS33A core subunit of CORVET and HOPS complexes
Description: This gene encodes a tethering protein and a core subunit of the homotypic fusion and protein sorting (HOPS) complex. The HOPS complex and a second endosomal tethering complex called the class C core vacuole/endosome tethering (CORVET) complex, perform diverse functions in endocytosis including membrane tethering, RabGTPase interaction, activation and proofreading of synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) assembly to drive membrane fusion, and endosome-to-cytoskeleton attachment. The HOPS complex controls endosome maturation as well as endosome traffic to the lysosome. This complex is essential for vacuolar fusion and is required for adaptor protein complex 3-dependent transport from the golgi to the vacuole. The encoded protein belongs to the Sec1/Munc18 (SM) family of SNARE-mediated membrane fusion regulators. Naturally occurring mutations in this gene are associated with a novel mucopolysaccharidosis-like disease. [provided by RefSeq, Apr 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ22395; FLJ23187; hVPS33A; MPSPS; vacuolar protein sorting 33 homolog A; vacuolar protein sorting 33A; vacuolar protein sorting protein 33a; vacuolar protein sorting-associated protein 33A; VPS33A CORVET/HOPS core subunit; VPS33A, CORVET/HOPS core subunit
Orthologs:
Mus musculus (house mouse) : Vps33a (VPS33A CORVET/HOPS core subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vps33a (VPS33A core subunit of CORVET and HOPS complexes)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vps33a (VPS33A core subunit of CORVET and HOPS complexes)
Pan paniscus (bonobo/pygmy chimpanzee) : VPS33A (VPS33A core subunit of CORVET and HOPS complexes)
Canis lupus familiaris (dog) : VPS33A (VPS33A core subunit of CORVET and HOPS complexes)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vps33a (VPS33A core subunit of CORVET and HOPS complexes)
Sus scrofa (pig) : VPS33A (VPS33A core subunit of CORVET and HOPS complexes)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812122,229,561 - 122,266,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712122,714,111 - 122,751,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612121,282,047 - 121,317,021 (-)NCBINCBI36hg18NCBI36
Build 3412121,240,974 - 121,275,897NCBI
Celera12122,305,460 - 122,340,912 (-)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12119,676,859 - 119,711,913 (-)NCBIHuRef
CHM1_112122,684,386 - 122,719,360 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Comparative Map Data
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Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on VPS33A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731826
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.