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Gene: VPS33A (VPS33A core subunit of CORVET and HOPS complexes) Homo sapiens
Symbol: VPS33A
Name: VPS33A core subunit of CORVET and HOPS complexes
Description: This gene encodes a tethering protein and a core subunit of the homotypic fusion and protein sorting (HOPS) complex. The HOPS complex and a second endosomal tethering complex called the class C core vacuole/endosome tethering (CORVET) complex, perform diverse functions in endocytosis including membrane tethering, RabGTPase interaction, activation and proofreading of synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) assembly to drive membrane fusion, and endosome-to-cytoskeleton attachment. The HOPS complex controls endosome maturation as well as endosome traffic to the lysosome. This complex is essential for vacuolar fusion and is required for adaptor protein complex 3-dependent transport from the golgi to the vacuole. The encoded protein belongs to the Sec1/Munc18 (SM) family of SNARE-mediated membrane fusion regulators. Naturally occurring mutations in this gene are associated with a novel mucopolysaccharidosis-like disease. [provided by RefSeq, Apr 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ22395; FLJ23187; hVPS33A; MPSPS; vacuolar protein sorting 33 homolog A; vacuolar protein sorting 33A; vacuolar protein sorting protein 33a; vacuolar protein sorting-associated protein 33A; VPS33A CORVET/HOPS core subunit; VPS33A, CORVET/HOPS core subunit
Mus musculus (house mouse) : Vps33a (VPS33A CORVET/HOPS core subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vps33a (VPS33A core subunit of CORVET and HOPS complexes)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vps33a (VPS33A core subunit of CORVET and HOPS complexes)
Pan paniscus (bonobo/pygmy chimpanzee) : VPS33A (VPS33A core subunit of CORVET and HOPS complexes)
Canis lupus familiaris (dog) : VPS33A (VPS33A core subunit of CORVET and HOPS complexes)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vps33a (VPS33A core subunit of CORVET and HOPS complexes)
Sus scrofa (pig) : VPS33A (VPS33A core subunit of CORVET and HOPS complexes)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812122,229,561 - 122,266,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712122,714,111 - 122,751,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612121,282,047 - 121,317,021 (-)NCBINCBI36hg18NCBI36
Build 3412121,240,974 - 121,275,897NCBI
Celera12122,305,460 - 122,340,912 (-)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12119,676,859 - 119,711,913 (-)NCBIHuRef
CHM1_112122,684,386 - 122,719,360 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on VPS33A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731826
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.