Vax2 (ventral anterior homeobox 2) - Rat Genome Database
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Gene: Vax2 (ventral anterior homeobox 2) Mus musculus
Analyze
Symbol: Vax2
Name: ventral anterior homeobox 2
RGD ID: 731658
MGI Page MGI
Description: Is expressed in central nervous system; eye; and limb. Orthologous to human VAX2 (ventral anterior homeobox 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; choline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Dres93; MGC144411; MGC144412; ventral anterior homeobox containing gene 2; ventral retina homeodomain protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,688,221 - 83,715,295 (+)NCBIGRCm39mm39
GRCm39 Ensembl683,688,246 - 83,715,295 (+)Ensembl
GRCm38683,711,239 - 83,738,313 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,711,264 - 83,738,313 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,661,258 - 83,688,298 (+)NCBIGRCm37mm9NCBIm37
MGSCv36683,676,922 - 83,703,962 (+)NCBImm8
Celera685,693,897 - 85,720,932 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9817915   PMID:10421837   PMID:10595508   PMID:11456441   PMID:11830578   PMID:11830579   PMID:12223410   PMID:12477932   PMID:12654290   PMID:12756179   PMID:15531370   PMID:15618518  
PMID:15703187   PMID:15905411   PMID:15976303   PMID:16207763   PMID:16342201   PMID:16611695   PMID:16854970   PMID:17043310   PMID:17173667   PMID:18489003   PMID:18539269   PMID:18985738  
PMID:19576202   PMID:19596317   PMID:19754878   PMID:19854269   PMID:19906857   PMID:20059953   PMID:20122913   PMID:20147377   PMID:20211142   PMID:20386732   PMID:20798045   PMID:20890044  
PMID:21148184   PMID:21267068   PMID:21273545   PMID:21539829   PMID:21677750   PMID:21743013   PMID:21856776   PMID:21873635   PMID:22522080   PMID:22792072   PMID:23426374   PMID:23555005  
PMID:23720040   PMID:24324671   PMID:24952961   PMID:25451153   PMID:26253404   PMID:26449264   PMID:26839344   PMID:27633992   PMID:28778798   PMID:30692221   PMID:30953627   PMID:32169553  
PMID:32571845  


Genomics

Comparative Map Data
Vax2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,688,221 - 83,715,295 (+)NCBIGRCm39mm39
GRCm39 Ensembl683,688,246 - 83,715,295 (+)Ensembl
GRCm38683,711,239 - 83,738,313 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,711,264 - 83,738,313 (+)EnsemblGRCm38mm10GRCm38
MGSCv37683,661,258 - 83,688,298 (+)NCBIGRCm37mm9NCBIm37
MGSCv36683,676,922 - 83,703,962 (+)NCBImm8
Celera685,693,897 - 85,720,932 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
VAX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl270,900,576 - 70,965,373 (+)EnsemblGRCh38hg38GRCh38
GRCh38270,900,551 - 70,933,917 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37271,127,706 - 71,160,576 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36270,981,228 - 71,014,084 (+)NCBINCBI36hg18NCBI36
Build 34271,039,374 - 71,072,228NCBI
Celera270,978,415 - 71,011,262 (+)NCBI
Cytogenetic Map2p13.3NCBI
HuRef270,864,230 - 70,897,075 (+)NCBIHuRef
CHM1_1271,057,048 - 71,089,924 (+)NCBICHM1_1
Vax2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24116,195,576 - 116,219,597 (+)NCBI
Rnor_6.0 Ensembl4115,388,839 - 115,412,515 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04115,388,839 - 115,412,515 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04179,975,806 - 180,001,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,903,748 - 117,927,411 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14118,148,228 - 118,171,892 (+)NCBI
Celera4105,188,167 - 105,211,754 (+)NCBICelera
Cytogenetic Map4q34NCBI
Vax2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542414,283,327 - 14,309,809 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542414,283,336 - 14,309,809 (-)NCBIChiLan1.0ChiLan1.0
VAX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A72,078,829 - 72,111,463 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A72,078,829 - 72,111,463 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A70,964,829 - 70,997,702 (+)NCBIMhudiblu_PPA_v0panPan3
VAX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11069,252,926 - 69,262,225 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Vax2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649115,079,446 - 15,110,238 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl371,593,807 - 71,622,444 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1371,593,807 - 71,622,487 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2374,973,886 - 74,974,570 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAX2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11436,180,084 - 36,213,534 (-)NCBI
ChlSab1.1 Ensembl1436,180,324 - 36,213,439 (-)Ensembl
Vax2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247622,480,474 - 2,508,367 (-)NCBI

Position Markers
AW742418  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,728,819 - 83,729,080UniSTSGRCm38
MGSCv37683,678,813 - 83,679,074UniSTSGRCm37
Celera685,711,450 - 85,711,711UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.5UniSTS
Whitehead/MRC_RH6858.35UniSTS
Y17792  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,738,044 - 83,738,191UniSTSGRCm38
MGSCv37683,688,038 - 83,688,185UniSTSGRCm37
Celera685,720,672 - 85,720,819UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.5UniSTS
Whitehead/MRC_RH6855.51UniSTS
D6Mit8.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,714,026 - 83,714,250UniSTSGRCm38
MGSCv37683,664,020 - 83,664,244UniSTSGRCm37
Celera685,696,659 - 85,696,883UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.2UniSTS
cM Map6 UniSTS
Whitehead Genetic625.1UniSTS
D6Mit8.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,713,824 - 83,713,940UniSTSGRCm38
MGSCv37683,663,818 - 83,663,934UniSTSGRCm37
Celera685,696,457 - 85,696,573UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.2UniSTS
cM Map6 UniSTS
Whitehead Genetic625.1UniSTS
Vax2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
cM Map635.5UniSTS
D6Mit8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38683,713,869 - 83,714,031UniSTSGRCm38
MGSCv37683,663,863 - 83,664,025UniSTSGRCm37
Celera685,696,502 - 85,696,664UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.2UniSTS
Whitehead Genetic625.1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:211
Count of miRNA genes:173
Interacting mature miRNAs:197
Transcripts:ENSMUST00000037807
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037807   ⟹   ENSMUSP00000035976
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl683,711,264 - 83,738,313 (+)Ensembl
RefSeq Acc Id: NM_011912   ⟹   NP_036042
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39683,688,221 - 83,715,295 (+)NCBI
GRCm38683,711,239 - 83,738,313 (+)NCBI
MGSCv37683,661,258 - 83,688,298 (+)RGD
Celera685,693,897 - 85,720,932 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036042   ⟸   NM_011912
- UniProtKB: Q9WTP9 (UniProtKB/Swiss-Prot),   Q14B19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035976   ⟸   ENSMUST00000037807
Protein Domains
Homeobox

Promoters
RGD ID:6838875
Promoter ID:MM_KWN:46625
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_011912,   NR_002873,   NR_002873_VAX2OS1,   UC009CNZ.1,   UC009COA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36683,661,721 - 83,662,221 (-)MPROMDB
RGD ID:6890182
Promoter ID:EPDNEW_M8542
Type:initiation region
Name:Vax2_1
Description:Mus musculus ventral anterior homeobox 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38683,711,249 - 83,711,309EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346018 AgrOrtholog
Ensembl Genes ENSMUSG00000034777 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000035976 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000037807 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HTH_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vax2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:24113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1346018 ENTREZGENE
NCBI Gene 24113 ENTREZGENE
PANTHER PTHR24339:SF34 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vax2 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HTHREPRESSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q14B19 ENTREZGENE, UniProtKB/TrEMBL
  Q9WTP9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Vax2  ventral anterior homeobox 2    ventral anterior homeobox containing gene 2  Symbol and/or name change 5135510 APPROVED