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Gene: NPR3 (natriuretic peptide receptor 3) Homo sapiens
Symbol: NPR3
Name: natriuretic peptide receptor 3
Description: Exhibits several functions, including chloride ion binding activity; natriuretic peptide receptor activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of cold-induced thermogenesis; osteoclast proliferation; and positive regulation of nitric-oxide synthase activity. Localizes to protein-containing complex. Implicated in hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ANP-C; ANPR-C; ANPRC; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide receptor 3; atrial natriuretic peptide receptor type C; atrionatriuretic peptide receptor C; atrionatriuretic peptide receptor type C; C5orf23; chromosome 5 open reading frame 23; FLJ14054; guanylate cyclase C; GUCY2B; hypothetical protein LOC79614; MGC22189; natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C); NPR-C; NPRC
Mus musculus (house mouse) : Npr3 (natriuretic peptide receptor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Npr3 (natriuretic peptide receptor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr3 (natriuretic peptide receptor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR3 (natriuretic peptide receptor 3)
Canis lupus familiaris (dog) : NPR3 (natriuretic peptide receptor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr3 (natriuretic peptide receptor 3)
Sus scrofa (pig) : NPR3 (natriuretic peptide receptor 3)
Chlorocebus sabaeus (African green monkey) : NPR3 (natriuretic peptide receptor 3)
Heterocephalus glaber (naked mole-rat) : Npr3 (natriuretic peptide receptor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl532,689,070 - 32,791,724 (+)EnsemblGRCh38hg38GRCh38
GRCh38532,689,076 - 32,791,724 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37532,710,284 - 32,791,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36532,747,422 - 32,823,013 (+)NCBINCBI36hg18NCBI36
Build 34532,747,421 - 32,823,009NCBI
Celera532,593,318 - 32,668,888 (+)NCBI
Cytogenetic Map5p13.3NCBI
HuRef532,678,571 - 32,759,879 (+)NCBIHuRef
CHM1_1532,712,833 - 32,793,931 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NPR3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731641
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.