Kcnd1 (potassium voltage-gated channel, Shal-related family, member 1) - Rat Genome Database

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Gene: Kcnd1 (potassium voltage-gated channel, Shal-related family, member 1) Mus musculus
Analyze
Symbol: Kcnd1
Name: potassium voltage-gated channel, Shal-related family, member 1
RGD ID: 731639
MGI Page MGI
Description: Enables A-type (transient outward) potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Part of voltage-gated potassium channel complex. Is expressed in brain; heart; and hindlimb muscle. Orthologous to human KCND1 (potassium voltage-gated channel subfamily D member 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 1110037K09Rik; A-type voltage-gated potassium channel KCND1; Kca2-; Kca2-1; Kv4.; Kv4.1; mSh; mShal; mShal1; potassium voltage gated channel, Shal-related family, member 1; potassium voltage-gated channel subfamily D member 1; S; Shal; Shal1; voltage-gated potassium channel subunit Kv4.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,686,907 - 7,704,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,688,528 - 7,704,519 (+)EnsemblGRCm39 Ensembl
GRCm38X7,823,759 - 7,838,278 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,822,289 - 7,838,280 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,400,969 - 7,413,629 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,980,802 - 6,993,462 (+)NCBIMGSCv36mm8
CeleraX3,633,556 - 3,646,421 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Brunkow ME, etal., Nat Genet 2001 Jan;27(1):68-73.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones. Kim J, etal., J Physiol. 2005 Nov 15;569(Pt 1):41-57. Epub 2005 Sep 1.
4. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, etal., Genomics 2000 May 1;65(3):213-23.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1383027   PMID:2034678   PMID:7903683   PMID:8034307   PMID:8524851   PMID:8889548   PMID:10050014   PMID:10228180   PMID:10349636   PMID:10479680   PMID:10700246   PMID:10962171  
PMID:11042159   PMID:11076861   PMID:11423117   PMID:11463631   PMID:12381814   PMID:12477932   PMID:15673604   PMID:15955876   PMID:16141072   PMID:16141073   PMID:16426762   PMID:16533897  
PMID:16985003   PMID:17610570   PMID:18371079   PMID:18799693   PMID:19713751   PMID:19939959   PMID:21267068   PMID:21540294   PMID:21873635   PMID:24194600   PMID:25590133   PMID:28560311  
PMID:32047055   PMID:33785038   PMID:34234278   PMID:34474245   PMID:38355793  


Genomics

Comparative Map Data
Kcnd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,686,907 - 7,704,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,688,528 - 7,704,519 (+)EnsemblGRCm39 Ensembl
GRCm38X7,823,759 - 7,838,278 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,822,289 - 7,838,280 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,400,969 - 7,413,629 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,980,802 - 6,993,462 (+)NCBIMGSCv36mm8
CeleraX3,633,556 - 3,646,421 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.53NCBI
KCND1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,961,380 - 48,971,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,960,982 - 48,971,844 (-)EnsemblGRCh38hg38GRCh38
GRCh37X48,818,641 - 48,828,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,703,583 - 48,713,195 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X48,574,886 - 48,584,499NCBI
CeleraX52,835,266 - 52,844,878 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,474,963 - 46,485,532 (-)NCBIHuRef
CHM1_1X48,849,929 - 48,859,553 (-)NCBICHM1_1
T2T-CHM13v2.0X48,371,842 - 48,382,307 (-)NCBIT2T-CHM13v2.0
Kcnd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,333,612 - 17,349,255 (-)NCBIGRCr8
mRatBN7.2X14,661,688 - 14,678,745 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,662,357 - 14,677,233 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,475,242 - 19,489,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,593,884 - 20,607,869 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,859,053 - 16,873,038 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,506,724 - 15,520,712 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,506,724 - 15,520,712 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,287,959 - 16,301,947 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,696,234 - 26,710,222 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X26,750,502 - 26,763,223 (-)NCBI
CeleraX14,746,408 - 14,760,394 (-)NCBICelera
Cytogenetic MapXq12NCBI
Kcnd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543487,312 - 498,626 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543487,312 - 500,232 (-)NCBIChiLan1.0ChiLan1.0
KCND1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,450,474 - 50,462,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,453,846 - 50,465,168 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,258,803 - 41,270,036 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X49,115,933 - 49,127,030 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,115,933 - 49,127,030 (-)Ensemblpanpan1.1panPan2
KCND1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,111,817 - 42,119,939 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,111,837 - 42,118,375 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,487,092 - 16,495,610 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,247,518 - 42,256,331 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,245,861 - 42,254,782 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,234,071 - 42,242,589 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,221,985 - 42,230,798 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,316,221 - 42,325,034 (-)NCBIUU_Cfam_GSD_1.0
Kcnd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,640,399 - 34,650,768 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721880,774 - 889,874 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721881,162 - 890,939 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCND1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,032,358 - 43,041,760 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,032,355 - 43,043,310 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,770,985 - 47,780,563 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCND1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,080,116 - 46,092,125 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX46,081,711 - 46,089,762 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,565,823 - 11,577,277 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893739,977 - 751,415 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893739,980 - 752,924 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnd1
502 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1294
Count of miRNA genes:652
Interacting mature miRNAs:803
Transcripts:ENSMUST00000009875, ENSMUST00000125440
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse

Markers in Region
DXImx3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,828,029 - 7,828,179UniSTSGRCm38
MGSCv37X7,405,155 - 7,405,305UniSTSGRCm37
CeleraX3,642,081 - 3,642,235UniSTS
Cytogenetic MapXA1.1UniSTS
cM MapX2.0UniSTS
PMC125678P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X7,831,220 - 7,831,468UniSTSGRCm38
MGSCv37X7,408,346 - 7,408,594UniSTSGRCm37
CeleraX3,638,816 - 3,639,064UniSTS
Cytogenetic MapXA1.1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000009875   ⟹   ENSMUSP00000009875
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX7,688,528 - 7,704,519 (+)Ensembl
GRCm38.p6 EnsemblX7,822,289 - 7,838,280 (+)Ensembl
Ensembl Acc Id: ENSMUST00000125440
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX7,688,546 - 7,689,506 (+)Ensembl
GRCm38.p6 EnsemblX7,822,307 - 7,823,267 (+)Ensembl
RefSeq Acc Id: NM_008423   ⟹   NP_032449
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X7,689,998 - 7,704,517 (+)NCBI
GRCm38X7,823,759 - 7,838,278 (+)NCBI
MGSCv37X7,400,969 - 7,413,629 (+)RGD
CeleraX3,633,556 - 3,646,421 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036161827   ⟹   XP_036017720
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X7,686,907 - 7,703,937 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032449   ⟸   NM_008423
- UniProtKB: Q03719 (UniProtKB/Swiss-Prot),   Q8CC68 (UniProtKB/Swiss-Prot),   A2AEX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000009875   ⟸   ENSMUST00000009875
RefSeq Acc Id: XP_036017720   ⟸   XM_036161827
- Peptide Label: isoform X1
- UniProtKB: Q03719 (UniProtKB/Swiss-Prot),   Q8CC68 (UniProtKB/Swiss-Prot),   A2AEX0 (UniProtKB/TrEMBL)
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03719-F1-model_v2 AlphaFold Q03719 1-651 view protein structure

Promoters
RGD ID:6845872
Promoter ID:MM_KWN:59445
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000043332,   OTTMUST00000043333
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X7,398,576 - 7,400,417 (+)MPROMDB
RGD ID:13680000
Promoter ID:EPDNEW_M24149
Type:single initiation site
Name:Kcnd1_1
Description:Mus musculus potassium voltage-gated channel, Shal-related family,member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X7,823,833 - 7,823,893EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96671 AgrOrtholog
Ensembl Genes ENSMUSG00000009731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000009875 ENTREZGENE
  ENSMUST00000009875.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Shal-type_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16506 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96671 ENTREZGENE
NCBI Gene 16506 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3399 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Shal-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnd1 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV41CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHALCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AEX0 ENTREZGENE, UniProtKB/TrEMBL
  KCND1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V4C3_MOUSE UniProtKB/TrEMBL
  Q8CC68 ENTREZGENE
UniProt Secondary Q8CC68 UniProtKB/Swiss-Prot