Bsnd (barttin CLCNK type accessory beta subunit) - Rat Genome Database

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Gene: Bsnd (barttin CLCNK type accessory beta subunit) Mus musculus
Analyze
Symbol: Bsnd
Name: barttin CLCNK type accessory beta subunit
RGD ID: 731636
MGI Page MGI
Description: Contributes to chloride channel activity. Predicted to be involved in cellular ion homeostasis and chloride transport. Localizes to basolateral plasma membrane; integral component of plasma membrane; and protein-containing complex. Is expressed in central nervous system; inner ear; and metanephros. Used to study Bartter disease type 4a. Human ortholog(s) of this gene implicated in Bartter disease; Bartter disease type 4a; and sensorineural hearing loss. Orthologous to human BSND (barttin CLCNK type accessory subunit beta); INTERACTS WITH 1,2-dimethylhydrazine; bisphenol A; vancomycin.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Bartter syndrome, infantile, with sensorineural deafness (Barttin); barttin; MGC47291
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,340,653 - 106,349,440 (-)NCBIGRCm39mm39
GRCm39 Ensembl4106,340,653 - 106,349,480 (-)Ensembl
GRCm384106,483,456 - 106,492,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,483,456 - 106,492,283 (-)EnsemblGRCm38mm10GRCm38
MGSCv374106,156,061 - 106,164,848 (-)NCBIGRCm37mm9NCBIm37
MGSCv364105,981,388 - 105,990,172 (-)NCBImm8
Celera4104,844,413 - 104,853,119 (-)NCBICelera
Cytogenetic Map4C7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11734858   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18353863  
PMID:18485340   PMID:18614997   PMID:18833191   PMID:19521566   PMID:20346939   PMID:20944551   PMID:21267068   PMID:21593186   PMID:21677750   PMID:21873635   PMID:21925491   PMID:23684652  
PMID:24727668   PMID:24952082   PMID:28994389   PMID:29107558   PMID:29326302   PMID:31362893   PMID:31879347  


Genomics

Comparative Map Data
Bsnd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,340,653 - 106,349,440 (-)NCBIGRCm39mm39
GRCm39 Ensembl4106,340,653 - 106,349,480 (-)Ensembl
GRCm384106,483,456 - 106,492,243 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,483,456 - 106,492,283 (-)EnsemblGRCm38mm10GRCm38
MGSCv374106,156,061 - 106,164,848 (-)NCBIGRCm37mm9NCBIm37
MGSCv364105,981,388 - 105,990,172 (-)NCBImm8
Celera4104,844,413 - 104,853,119 (-)NCBICelera
Cytogenetic Map4C7NCBI
BSND
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl154,998,933 - 55,017,172 (+)EnsemblGRCh38hg38GRCh38
GRCh38154,998,933 - 55,017,172 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37155,464,606 - 55,482,845 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,237,205 - 55,247,053 (+)NCBINCBI36hg18NCBI36
Build 34155,176,637 - 55,186,485NCBI
Celera153,752,220 - 53,762,073 (+)NCBI
Cytogenetic Map1p32.3NCBI
HuRef153,578,679 - 53,587,911 (+)NCBIHuRef
CHM1_1155,580,238 - 55,590,632 (+)NCBICHM1_1
Bsnd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25121,251,774 - 121,260,571 (-)NCBI
Rnor_6.0 Ensembl5126,071,846 - 126,080,698 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05126,071,849 - 126,080,647 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05129,918,748 - 129,927,546 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,542,219 - 127,551,017 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15127,547,444 - 127,556,243 (-)NCBI
Celera5120,001,260 - 120,010,060 (-)NCBICelera
Cytogenetic Map5q34NCBI
Bsnd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554644,459,628 - 4,468,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554644,459,686 - 4,468,749 (-)NCBIChiLan1.0ChiLan1.0
BSND
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1155,869,495 - 55,879,674 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl155,869,495 - 55,879,674 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0154,281,736 - 54,292,159 (+)NCBIMhudiblu_PPA_v0panPan3
BSND
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,225,393 - 54,239,305 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl554,225,389 - 54,237,110 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha554,294,651 - 54,310,910 (-)NCBI
ROS_Cfam_1.0554,413,340 - 54,426,512 (-)NCBI
UMICH_Zoey_3.1554,410,446 - 54,426,677 (-)NCBI
UNSW_CanFamBas_1.0554,300,457 - 54,315,533 (-)NCBI
UU_Cfam_GSD_1.0554,688,907 - 54,702,075 (-)NCBI
Bsnd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505869,077,490 - 69,086,314 (+)NCBI
SpeTri2.0NW_0049365226,329,981 - 6,338,825 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BSND
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,425,878 - 157,432,577 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16157,424,389 - 157,432,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,489,124 - 145,496,137 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BSND
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12077,943,853 - 77,960,883 (-)NCBI
ChlSab1.1 Ensembl2077,940,881 - 77,955,094 (-)Ensembl
Bsnd
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248624,917,196 - 4,927,139 (-)NCBI

Position Markers
Bsnd  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4C7UniSTS
cM Map449.67UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117215009Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000129100000Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108500000Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138615442Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123233418Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124161387Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000129100000Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465400000119000000Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465800000146500000Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468100000107300000Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468100000130500000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469200000131000000Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474145650108145792Mouse
1301597Anxty_manxiety (mouse)Not determined474219337128115487Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474556462108556746Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474556462108556746Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474556462108556746Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474556462108556746Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474556462108556746Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474556462108556746Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474556462108556746Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474556462108556746Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474556462108556746Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474556462108556746Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474800000108500000Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476874870110875068Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined478069342112069538Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479477514113477630Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479477514113477630Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479477514113477630Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479477514113477630Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481325754115325754Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482356158116356345Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483200000108500000Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483747673117747809Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)485000000107300000Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485571641119571840Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485571641119571840Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485923970119924082Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485923970119924082Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487600000107300000Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487600000108500000Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488200000108500000Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488200000118700000Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488600000108500000Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488600000108600000Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)489063832116413923Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined89063832140740892Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined89063832140740892Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined89063832140740892Mouse
1357529Lvrq8_mliver weight QTL 8 (mouse)Not determined489063832140740892Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)489063832140740892Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)490000000119000000Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined490112430124112550Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490733471124733584Mouse
27226760Feml19_mfemur length 19, 16 week (mouse)491000000108600000Mouse
27226782Tibl2_mtibia length 2, 5 week (mouse)491000000111400000Mouse
13208562Wght7_mweight 7 (mouse)491000000148000000Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)491025583125025583Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)493118593127118593Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494875058128875257Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined495069342128115487Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
14696687Gdq1_mgrooming duration QTL 1, males (mouse)497000000112000000Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498657302128115487Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100214774134215009Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100214774134215009Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4101000000125000000Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101300000135300000Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101717404123233418Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105812001139812001Mouse
15039378Adip30_madiposity 30 (mouse)4105812001139812001Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105812001139812001Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105978113141706527Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105978113141706527Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105978113141706527Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105978113141706527Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:768
Count of miRNA genes:473
Interacting mature miRNAs:552
Transcripts:ENSMUST00000054472
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000054472   ⟹   ENSMUSP00000049563
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4106,483,456 - 106,492,283 (-)Ensembl
RefSeq Acc Id: NM_080458   ⟹   NP_536706
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394106,340,653 - 106,349,440 (-)NCBI
GRCm384106,483,456 - 106,492,243 (-)ENTREZGENE
MGSCv374106,156,061 - 106,164,848 (-)RGD
Celera4104,844,413 - 104,853,119 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_536706   ⟸   NM_080458
- UniProtKB: Q8VIM4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000049563   ⟸   ENSMUST00000054472

Promoters
RGD ID:6834961
Promoter ID:MM_KWN:38775
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Spleen
Transcripts:OTTMUST00000018616
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364106,164,539 - 106,165,039 (-)MPROMDB
RGD ID:6884042
Promoter ID:EPDNEW_M5472
Type:initiation region
Name:Bsnd_1
Description:Mus musculus barttin CLCNK type accessory beta subunit , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384106,492,243 - 106,492,303EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2153465 AgrOrtholog
Ensembl Genes ENSMUSG00000025418 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000049563 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000054472 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Barttin UniProtKB/Swiss-Prot
KEGG Report mmu:140475 UniProtKB/Swiss-Prot
MGD MGI:2153465 ENTREZGENE
NCBI Gene 140475 ENTREZGENE
PANTHER PTHR28399 UniProtKB/Swiss-Prot
Pfam Barttin UniProtKB/Swiss-Prot
PhenoGen Bsnd PhenoGen
UniProt BSND_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B1AZI5 UniProtKB/Swiss-Prot
  Q8C740 UniProtKB/Swiss-Prot
  Q8CHY0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Bsnd  barttin CLCNK type accessory beta subunit    Bartter syndrome, infantile, with sensorineural deafness (Barttin)  Symbol and/or name change 5135510 APPROVED