Alox8 (arachidonate 8-lipoxygenase) - Rat Genome Database
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Gene: Alox8 (arachidonate 8-lipoxygenase) Mus musculus
Analyze
Symbol: Alox8
Name: arachidonate 8-lipoxygenase
RGD ID: 731630
MGI Page MGI
Description: Orthologous to human ALOX15B (arachidonate 15-lipoxygenase type B).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 15-lipoxygenase 2; 15-LOX-2; 15-LOX-B; 8-L; 8-LOX; 8S-; 8S-lipoxygenase; 8S-LOX; Alox; Alox15b; arachidonate 15-lipoxygenase B; arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; arachidonate 8S-lipoxygenase; linoleate 9S-lipoxygenase ALOX8; polyunsaturated fatty acid lipoxygenase ALOX8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,074,711 - 69,088,669 (-)NCBIGRCm39mm39
GRCm39 Ensembl1169,074,758 - 69,088,669 (-)Ensembl
GRCm381169,183,885 - 69,197,843 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,183,932 - 69,197,843 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,997,387 - 69,011,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,000,080 - 69,014,034 (-)NCBImm8
Celera1176,136,086 - 76,151,253 (-)NCBICelera
Cytogenetic Map11B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:1874732   PMID:3335028   PMID:9305900   PMID:9518531   PMID:10064896   PMID:10078938   PMID:10086180   PMID:10216287   PMID:10349636   PMID:10625675   PMID:10965849   PMID:11042159  
PMID:11076861   PMID:11217851   PMID:11368335   PMID:12432921   PMID:12477932   PMID:12727848   PMID:14681479   PMID:14711820   PMID:15086555   PMID:15489334   PMID:15558016   PMID:16112079  
PMID:16129665   PMID:16141072   PMID:16141073   PMID:16143298   PMID:19481615   PMID:19661680   PMID:20514017   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22912809   PMID:25313597  
PMID:26438362   PMID:27435673   PMID:30936179   PMID:31013822   PMID:31362020   PMID:31505254  


Genomics

Comparative Map Data
Alox8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,074,711 - 69,088,669 (-)NCBIGRCm39mm39
GRCm39 Ensembl1169,074,758 - 69,088,669 (-)Ensembl
GRCm381169,183,885 - 69,197,843 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,183,932 - 69,197,843 (-)EnsemblGRCm38mm10GRCm38
MGSCv371168,997,387 - 69,011,341 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,000,080 - 69,014,034 (-)NCBImm8
Celera1176,136,086 - 76,151,253 (-)NCBICelera
Cytogenetic Map11B3NCBI
ALOX15B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl178,039,034 - 8,049,134 (+)EnsemblGRCh38hg38GRCh38
GRCh38178,039,059 - 8,049,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,942,377 - 7,952,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,883,083 - 7,893,177 (+)NCBINCBI36hg18NCBI36
Build 34177,883,126 - 7,893,174NCBI
Celera177,969,928 - 7,980,051 (+)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,837,153 - 7,847,282 (+)NCBIHuRef
CHM1_1177,951,127 - 7,961,240 (+)NCBICHM1_1
Alox15b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21053,892,496 - 53,901,812 (-)NCBI
Rnor_6.0 Ensembl1055,774,006 - 55,783,489 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01055,773,748 - 55,783,489 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01055,517,096 - 55,526,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41055,951,005 - 55,960,265 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11055,964,626 - 55,973,888 (-)NCBI
Celera1053,057,844 - 53,067,039 (-)NCBICelera
Cytogenetic Map10q24NCBI
Alox15b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,895,095 - 8,906,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554678,896,740 - 8,906,032 (-)NCBIChiLan1.0ChiLan1.0
ALOX15B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11748,340,759 - 48,350,808 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,340,777 - 48,350,808 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01743,609,146 - 43,619,713 (-)NCBIMhudiblu_PPA_v0panPan3
ALOX15B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl532,878,338 - 32,888,316 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1532,878,348 - 32,888,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Alox15b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365951,279,944 - 1,288,321 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX15B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,259,940 - 53,281,520 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11253,259,867 - 53,281,127 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,734,620 - 55,757,204 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX15B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,425,533 - 7,435,896 (+)NCBI
ChlSab1.1 Ensembl167,425,990 - 7,435,327 (+)Ensembl

Position Markers
Alox8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B4UniSTS
cM Map1142.38UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111231863769794121Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113568778969794161Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115936579169591873Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116910000072600000Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116910000072600000Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116910000072600000Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116910000072600000Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116910000072600000Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116910000072600000Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116910000072600000Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116910000072600000Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116910000072600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:929
Count of miRNA genes:523
Interacting mature miRNAs:614
Transcripts:ENSMUST00000021262, ENSMUST00000094078, ENSMUST00000144787, ENSMUST00000156157
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021262   ⟹   ENSMUSP00000021262
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,183,932 - 69,197,843 (-)Ensembl
RefSeq Acc Id: ENSMUST00000094078   ⟹   ENSMUSP00000091621
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,185,090 - 69,197,809 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144787
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,189,872 - 69,197,811 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156157
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,191,537 - 69,197,384 (-)Ensembl
RefSeq Acc Id: NM_009661   ⟹   NP_033791
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,074,711 - 69,088,669 (-)NCBI
GRCm381169,183,885 - 69,197,843 (-)NCBI
MGSCv371168,997,387 - 69,011,341 (-)RGD
Celera1176,136,086 - 76,151,257 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033791   ⟸   NM_009661
- UniProtKB: O35936 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000091621   ⟸   ENSMUST00000094078
RefSeq Acc Id: ENSMUSP00000021262   ⟸   ENSMUST00000021262
Protein Domains
Lipoxygenase   PLAT

Promoters
RGD ID:8675154
Promoter ID:EPDNEW_M15608
Type:single initiation site
Name:Alox8_1
Description:Mus musculus arachidonate 8-lipoxygenase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,197,837 - 69,197,897EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1098228 AgrOrtholog
Ensembl Genes ENSMUSG00000020891 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000021262 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000091621 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021262 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000094078 UniProtKB/TrEMBL
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11688 UniProtKB/Swiss-Prot
MGD MGI:1098228 ENTREZGENE
NCBI Gene 11688 ENTREZGENE
PANTHER PTHR11771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alox8 PhenoGen
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ALOX8_MOUSE UniProtKB/Swiss-Prot
  B1ASX6_MOUSE UniProtKB/TrEMBL
  O35936 ENTREZGENE
  Q3TYK7_MOUSE UniProtKB/TrEMBL
UniProt Secondary B1ASX5 UniProtKB/Swiss-Prot