Rnf103 (ring finger protein 103) - Rat Genome Database

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Gene: Rnf103 (ring finger protein 103) Mus musculus
Analyze
Symbol: Rnf103
Name: ring finger protein 103
RGD ID: 731597
MGI Page MGI
Description: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent ERAD pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Is expressed in early conceptus and genitourinary system. Orthologous to human RNF103 (ring finger protein 103).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AW146237; AW212918; E3 ubiquitin-protein ligase RNF103; kf-1; mKF-1; RING-type E3 ubiquitin transferase RNF103; zfp-103; Zfp10; Zfp103; zinc finger protein 103
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39671,470,828 - 71,487,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl671,470,878 - 71,487,865 (+)Ensembl
GRCm38671,493,844 - 71,510,880 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl671,493,894 - 71,510,881 (+)EnsemblGRCm38mm10GRCm38
MGSCv37671,443,888 - 71,460,875 (+)NCBIGRCm37mm9NCBIm37
MGSCv36671,423,403 - 71,440,390 (+)NCBImm8
Celera673,573,253 - 73,590,240 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:9070305   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15282163   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:18287559   PMID:18958194   PMID:19753093   PMID:21267068   PMID:21455683   PMID:21677750   PMID:21873635   PMID:22988430   PMID:32325033  


Genomics

Comparative Map Data
Rnf103
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39671,470,828 - 71,487,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl671,470,878 - 71,487,865 (+)Ensembl
GRCm38671,493,844 - 71,510,880 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl671,493,894 - 71,510,881 (+)EnsemblGRCm38mm10GRCm38
MGSCv37671,443,888 - 71,460,875 (+)NCBIGRCm37mm9NCBIm37
MGSCv36671,423,403 - 71,440,390 (+)NCBImm8
Celera673,573,253 - 73,590,240 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.16NCBI
RNF103
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl286,603,398 - 86,623,866 (-)EnsemblGRCh38hg38GRCh38
GRCh38286,603,393 - 86,623,877 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37286,830,516 - 86,851,000 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36286,684,027 - 86,704,489 (-)NCBINCBI36hg18NCBI36
Build 34286,742,174 - 86,762,636NCBI
Celera286,658,407 - 86,678,870 (-)NCBI
Cytogenetic Map2p11.2NCBI
HuRef286,728,170 - 86,748,085 (-)NCBIHuRef
CHM1_1286,760,437 - 86,780,923 (-)NCBICHM1_1
Rnf103
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24103,526,456 - 103,542,529 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4103,526,502 - 103,555,919 (+)Ensembl
Rnor_6.0499,398,479 - 99,415,193 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl499,398,494 - 99,421,164 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04164,178,074 - 164,194,496 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44104,762,184 - 104,778,157 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14105,005,938 - 105,022,637 (+)NCBI
Celera492,685,410 - 92,701,383 (+)NCBICelera
Cytogenetic Map4q31NCBI
Rnf103
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,097,981 - 1,117,844 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,097,981 - 1,161,267 (+)NCBIChiLan1.0ChiLan1.0
RNF103
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v02A86,659,672 - 86,680,154 (-)NCBIMhudiblu_PPA_v0panPan3
RNF103
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11738,549,838 - 38,566,613 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1738,549,828 - 38,566,149 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1738,235,604 - 38,252,356 (+)NCBI
ROS_Cfam_1.01739,282,716 - 39,299,449 (+)NCBI
ROS_Cfam_1.0 Ensembl1739,282,705 - 39,299,839 (+)Ensembl
UMICH_Zoey_3.11738,449,002 - 38,465,752 (+)NCBI
UNSW_CanFamBas_1.01738,485,209 - 38,502,055 (+)NCBI
UU_Cfam_GSD_1.01738,833,202 - 38,849,951 (+)NCBI
Rnf103
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629279,860,350 - 79,880,798 (-)NCBI
SpeTri2.0NW_004936712977,650 - 997,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF103
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl358,161,304 - 58,186,858 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1358,161,087 - 58,183,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2360,919,064 - 60,941,736 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF103
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604591,947,140 - 91,967,856 (-)NCBIVero_WHO_p1.0
Rnf103
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474916,689,010 - 16,712,673 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AW146237  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38671,510,734 - 71,510,813UniSTSGRCm38
MGSCv37671,460,728 - 71,460,807UniSTSGRCm37
Celera673,590,093 - 73,590,172UniSTS
Cytogenetic Map6C1UniSTS
cM Map630.5UniSTS
Whitehead/MRC_RH6715.43UniSTS
Whitehead/MRC_RH6717.5UniSTS
UniSTS:235467  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38671,496,242 - 71,496,455UniSTSGRCm38
MGSCv37671,446,236 - 71,446,449UniSTSGRCm37
Celera673,575,601 - 73,575,814UniSTS
Cytogenetic Map6C1UniSTS
cM Map630.5UniSTS
MARC_24177-24178:1033563974:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38671,509,750 - 71,510,408UniSTSGRCm38
MGSCv37671,459,744 - 71,460,402UniSTSGRCm37
Celera673,589,109 - 73,589,767UniSTS
Cytogenetic Map6C1UniSTS
cM Map630.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64382681377811523Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64382681377811523Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64382681377811523Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64382681377811523Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64382681377811523Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64382681377811523Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4872655675447710Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:918
Count of miRNA genes:432
Interacting mature miRNAs:531
Transcripts:ENSMUST00000064637, ENSMUST00000114178, ENSMUST00000114179, ENSMUST00000150069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000064637   ⟹   ENSMUSP00000066324
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl671,470,878 - 71,487,865 (+)Ensembl
GRCm38.p6 Ensembl671,493,894 - 71,510,881 (+)Ensembl
RefSeq Acc Id: ENSMUST00000114178   ⟹   ENSMUSP00000109816
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl671,470,894 - 71,487,865 (+)Ensembl
GRCm38.p6 Ensembl671,493,910 - 71,510,881 (+)Ensembl
RefSeq Acc Id: ENSMUST00000114179   ⟹   ENSMUSP00000109817
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl671,470,987 - 71,487,747 (+)Ensembl
GRCm38.p6 Ensembl671,494,003 - 71,510,763 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150069
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl671,480,870 - 71,484,140 (+)Ensembl
GRCm38.p6 Ensembl671,503,886 - 71,507,156 (+)Ensembl
RefSeq Acc Id: NM_001308303   ⟹   NP_001295232
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39671,470,861 - 71,487,864 (+)NCBI
GRCm38671,493,877 - 71,510,880 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009543   ⟹   NP_033569
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39671,470,861 - 71,487,864 (+)NCBI
GRCm38671,493,877 - 71,510,880 (+)NCBI
MGSCv37671,443,888 - 71,460,875 (+)RGD
Celera673,573,253 - 73,590,240 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036166028   ⟹   XP_036021921
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39671,470,828 - 71,485,164 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036166029   ⟹   XP_036021922
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39671,470,828 - 71,487,864 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033569   ⟸   NM_009543
- Peptide Label: isoform 1
- UniProtKB: Q9R1W3 (UniProtKB/Swiss-Prot),   Q3UYK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295232   ⟸   NM_001308303
- Peptide Label: isoform 2
- UniProtKB: Q3TGP6 (UniProtKB/TrEMBL),   Q3UYK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000109817   ⟸   ENSMUST00000114179
RefSeq Acc Id: ENSMUSP00000109816   ⟸   ENSMUST00000114178
RefSeq Acc Id: ENSMUSP00000066324   ⟸   ENSMUST00000064637
RefSeq Acc Id: XP_036021922   ⟸   XM_036166029
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036021921   ⟸   XM_036166028
- Peptide Label: isoform X1
Protein Domains
RING-type

Promoters
RGD ID:6839862
Promoter ID:MM_KWN:46425
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000114178,   ENSMUST00000114179,   NM_009543,   OTTMUST00000058652
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36671,443,676 - 71,444,707 (+)MPROMDB
RGD ID:6889972
Promoter ID:EPDNEW_M8437
Type:initiation region
Name:Rnf103_1
Description:Mus musculus ring finger protein 103 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8438  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38671,493,910 - 71,493,970EPDNEW
RGD ID:6889974
Promoter ID:EPDNEW_M8438
Type:single initiation site
Name:Rnf103_2
Description:Mus musculus ring finger protein 103 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8437  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38671,504,297 - 71,504,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109483 AgrOrtholog
Ensembl Genes ENSMUSG00000052656 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000066324 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000109816 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000109817 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064637 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000114178 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000114179 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RNF103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22644 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109483 ENTREZGENE
NCBI Gene 22644 ENTREZGENE
PANTHER PTHR15302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnf103 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z0Y5_MOUSE UniProtKB/TrEMBL
  Q3TGP6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UYK9 ENTREZGENE, UniProtKB/TrEMBL
  Q9R1W3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B9EHC2 UniProtKB/Swiss-Prot
  O08670 UniProtKB/Swiss-Prot
  O08883 UniProtKB/Swiss-Prot