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Gene: ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase) Homo sapiens
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Symbol: ATIC
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Description: Exhibits protein homodimerization activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Localizes to the cytosol and plasma membrane. Implicated in purine-pyrimidine metabolic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/imp; 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICARFT; AICARFT/IMPCHASE; bifunctional purine biosynthesis protein PURH; epididymis secretory sperm binding protein Li 70p; FLJ93545; HEL-S-70p; IMPCHASE; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PURH
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2215,311,956 - 215,349,773 (+)Ensembl
GRCh382215,311,974 - 215,359,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372216,176,679 - 216,214,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,885,081 - 215,922,724 (+)NCBINCBI36hg18NCBI36
Build 342216,002,341 - 216,039,983NCBI
Celera2209,946,316 - 209,984,125 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2208,033,447 - 208,071,522 (+)NCBIHuRef
CHM1_12216,182,580 - 216,220,395 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ATIC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731594
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.