Xylt2 (xylosyltransferase II) - Rat Genome Database

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Gene: Xylt2 (xylosyltransferase II) Mus musculus
Analyze
Symbol: Xylt2
Name: xylosyltransferase II
RGD ID: 731565
MGI Page MGI
Description: Predicted to have magnesium ion binding activity; manganese ion binding activity; and protein xylosyltransferase activity. Involved in heparin biosynthetic process and proteoglycan biosynthetic process. Predicted to localize to extracellular space. Is expressed in alimentary system; cardiovascular system; integumental system; and nervous system. Used to study polycystic kidney disease. Human ortholog(s) of this gene implicated in pseudoxanthoma elasticum. Orthologous to human XYLT2 (xylosyltransferase 2); PARTICIPATES IN chondroitin sulfate biosynthetic pathway; heparan sulfate biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; folic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E030002B02Rik; peptide O-xylosyltransferase 2; XT-II; XT2; xylosyltransferase 2; xylT-II
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,554,671 - 94,568,341 (-)NCBIGRCm39mm39
GRCm39 Ensembl1194,554,677 - 94,568,341 (-)Ensembl
GRCm381194,663,845 - 94,677,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,663,851 - 94,677,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,525,161 - 94,538,807 (-)NCBIGRCm37mm9NCBIm37
MGSCv361194,479,941 - 94,486,630 (-)NCBImm8
Celera11104,282,927 - 104,296,600 (-)NCBICelera
Cytogenetic Map11DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11099377   PMID:11217851   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:17189266   PMID:17363568   PMID:17517600   PMID:19389916   PMID:21267068   PMID:21677750   PMID:21873635   PMID:26027496   PMID:30778123   PMID:31138677   PMID:32325033   PMID:32675240  


Genomics

Comparative Map Data
Xylt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,554,671 - 94,568,341 (-)NCBIGRCm39mm39
GRCm39 Ensembl1194,554,677 - 94,568,341 (-)Ensembl
GRCm381194,663,845 - 94,677,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,663,851 - 94,677,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,525,161 - 94,538,807 (-)NCBIGRCm37mm9NCBIm37
MGSCv361194,479,941 - 94,486,630 (-)NCBImm8
Celera11104,282,927 - 104,296,600 (-)NCBICelera
Cytogenetic Map11DNCBI
XYLT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1750,346,126 - 50,363,138 (+)EnsemblGRCh38hg38GRCh38
GRCh381750,346,126 - 50,361,185 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371748,423,487 - 48,438,546 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,778,392 - 45,793,511 (+)NCBINCBI36hg18NCBI36
Build 341745,778,391 - 45,793,511NCBI
Celera1744,884,666 - 44,899,786 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1743,791,832 - 43,806,359 (+)NCBIHuRef
CHM1_11748,487,619 - 48,502,357 (+)NCBICHM1_1
Xylt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21079,605,910 - 79,619,482 (-)NCBI
Rnor_6.0 Ensembl1082,386,005 - 82,399,485 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01082,386,003 - 82,399,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01082,204,620 - 82,218,102 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41083,297,806 - 83,311,288 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11083,312,272 - 83,325,657 (-)NCBI
Celera1078,393,292 - 78,406,774 (-)NCBICelera
Cytogenetic Map10q26NCBI
Xylt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,344,780 - 11,354,489 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,347,254 - 11,354,489 (-)NCBIChiLan1.0ChiLan1.0
XYLT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11749,314,397 - 49,329,729 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,315,250 - 49,331,654 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01744,440,428 - 44,455,530 (+)NCBIMhudiblu_PPA_v0panPan3
XYLT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,316,812 - 26,329,333 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,316,774 - 26,329,511 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,709,840 - 25,722,329 (+)NCBI
ROS_Cfam_1.0927,111,261 - 27,123,755 (+)NCBI
UMICH_Zoey_3.1925,879,022 - 25,891,537 (+)NCBI
UNSW_CanFamBas_1.0926,137,674 - 26,150,182 (+)NCBI
UU_Cfam_GSD_1.0926,267,695 - 26,280,219 (+)NCBI
Xylt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,734,721 - 25,747,482 (+)NCBI
SpeTri2.0NW_00493649011,327,654 - 11,340,417 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XYLT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,640,899 - 26,663,520 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,640,802 - 26,656,809 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,625,115 - 26,633,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XYLT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,969,198 - 42,984,542 (-)NCBI
ChlSab1.1 Ensembl1642,970,041 - 42,984,438 (-)Ensembl
Vero_WHO_p1.0NW_02366607713,684,941 - 13,700,289 (-)NCBI
Xylt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247956,285,939 - 6,297,874 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170800372104800540Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170800372104800540Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170800372104800540Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170800372104800540Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172128823106128908Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117768304799486994Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179265183107725646Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179922933104611872Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1181000000102000000Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187800372103383289Mouse
1301491Abbp4_mA/J and C57BL/6 blood pressure 4 (mouse)Not determined118880876299190771Mouse
1301313Pas5a_mpulmonary adenoma susceptibility 5a (mouse)Not determined118907597898974942Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
1300847Par1_mpulmonary adenoma resistance 1 (mouse)Not determined119417295396276595Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2309
Count of miRNA genes:801
Interacting mature miRNAs:1050
Transcripts:ENSMUST00000116349, ENSMUST00000146693, ENSMUST00000150377, ENSMUST00000153485, ENSMUST00000154830, ENSMUST00000174178
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000116349   ⟹   ENSMUSP00000112052
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1194,663,851 - 94,677,515 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146693   ⟹   ENSMUSP00000122728
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1194,668,527 - 94,677,407 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150377   ⟹   ENSMUSP00000134495
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1194,666,227 - 94,668,192 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153485   ⟹   ENSMUSP00000122581
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1194,664,587 - 94,677,515 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154830
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1194,666,871 - 94,667,802 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174178
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1194,675,963 - 94,677,413 (-)Ensembl
RefSeq Acc Id: NM_145828   ⟹   NP_665827
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,554,673 - 94,568,319 (-)NCBI
GRCm381194,663,847 - 94,677,493 (-)NCBI
MGSCv371194,525,161 - 94,538,807 (-)RGD
Celera11104,282,927 - 104,296,600 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003949393
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,554,671 - 94,568,341 (-)NCBI
GRCm381194,663,845 - 94,677,516 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949394
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,554,671 - 94,568,341 (-)NCBI
GRCm381194,663,845 - 94,677,516 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003949395
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,554,671 - 94,568,341 (-)NCBI
GRCm381194,663,845 - 94,677,516 (-)NCBI
Sequence:
RefSeq Acc Id: XR_388412
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391194,554,671 - 94,568,341 (-)NCBI
GRCm381194,663,845 - 94,677,516 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_665827   ⟸   NM_145828
- UniProtKB: Q9EPL0 (UniProtKB/Swiss-Prot),   Q3TZ69 (UniProtKB/TrEMBL),   Q3UCI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000134495   ⟸   ENSMUST00000150377
RefSeq Acc Id: ENSMUSP00000122728   ⟸   ENSMUST00000146693
RefSeq Acc Id: ENSMUSP00000122581   ⟸   ENSMUST00000153485
RefSeq Acc Id: ENSMUSP00000112052   ⟸   ENSMUST00000116349
Protein Domains
Xylo_C

Promoters
RGD ID:6822478
Promoter ID:MM_KWN:9281
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000004131,   OTTMUST00000004133
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,529,201 - 94,529,872 (-)MPROMDB
RGD ID:6822479
Promoter ID:MM_KWN:9282
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:UC007KZH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,531,609 - 94,532,109 (-)MPROMDB
RGD ID:6821861
Promoter ID:MM_KWN:9283
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000004063,   OTTMUST00000004130,   OTTMUST00000004132,   OTTMUST00000004138
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361194,537,646 - 94,539,752 (+)MPROMDB
RGD ID:8676228
Promoter ID:EPDNEW_M16145
Type:initiation region
Name:Xylt2_1
Description:Mus musculus xylosyltransferase II , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381194,677,422 - 94,677,482EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444797 AgrOrtholog
Ensembl Genes ENSMUSG00000020868 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000112052 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000122581 UniProtKB/TrEMBL
  ENSMUSP00000122728 UniProtKB/TrEMBL
  ENSMUSP00000134495 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000116349 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000146693 UniProtKB/TrEMBL
  ENSMUST00000150377 UniProtKB/TrEMBL
  ENSMUST00000153485 UniProtKB/TrEMBL
InterPro Glyco_trans_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XylT UniProtKB/Swiss-Prot
  XYLT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  XylT_C UniProtKB/TrEMBL
KEGG Report mmu:217119 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2444797 ENTREZGENE
NCBI Gene 217119 ENTREZGENE
PANTHER PTHR46025 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Branch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xylo_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Xylt2 PhenoGen
UniProt F2Z434_MOUSE UniProtKB/TrEMBL
  F2Z436_MOUSE UniProtKB/TrEMBL
  G3UZH1_MOUSE UniProtKB/TrEMBL
  Q3TZ69 ENTREZGENE, UniProtKB/TrEMBL
  Q3U614_MOUSE UniProtKB/TrEMBL
  Q3UCI0 ENTREZGENE, UniProtKB/TrEMBL
  Q9EPL0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5SUY1 UniProtKB/Swiss-Prot
  Q8K060 UniProtKB/Swiss-Prot