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Gene: AFDN (afadin, adherens junction formation factor) Homo sapiens
Symbol: AFDN
Name: afadin, adherens junction formation factor
Description: Exhibits Ras GTPase binding activity and actin filament binding activity. Involved in several processes, including bicellular tight junction assembly; establishment of endothelial intestinal barrier; and positive regulation of cell-cell adhesion mediated by cadherin. Localizes to several cellular components, including the cell-cell contact zone; nuclear speck; and pore complex. Biomarker of Parkinson's disease and breast carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AF-6; AF6; afadin; ALL1-fused gene from chromosome 6 protein; FLJ34371; l-afadin; MLL-AF6; MLLT4; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); RP3-431P23.3; translocated to, 4
Mus musculus (house mouse) : Afdn (afadin, adherens junction formation factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Afdn (afadin, adherens junction formation factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afdn (afadin, adherens junction formation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : AFDN (afadin, adherens junction formation factor)
Canis lupus familiaris (dog) : AFDN (afadin, adherens junction formation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afdn (afadin, adherens junction formation factor)
Sus scrofa (pig) : AFDN (afadin, adherens junction formation factor)
Chlorocebus sabaeus (green monkey) : AFDN (afadin, adherens junction formation factor)
Heterocephalus glaber (naked mole-rat) : Afdn (afadin, adherens junction formation factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl6167,826,922 - 167,972,023 (+)Ensembl
GRCh386167,826,564 - 167,972,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376168,227,602 - 168,372,703 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366167,970,520 - 168,115,552 (+)NCBINCBI36hg18NCBI36
Build 346168,046,368 - 168,171,498NCBI
Celera6168,944,733 - 169,081,690 (+)NCBI
Cytogenetic Map6q27NCBI
HuRef6165,693,043 - 165,800,385 (+)NCBIHuRef
CHM1_16168,490,726 - 168,635,428 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AFDN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731514
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.