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Gene: STX4 (syntaxin 4) Homo sapiens
Symbol: STX4
Name: syntaxin 4
Description: Exhibits sphingomyelin phosphodiesterase activator activity. Involved in several processes, including long-term synaptic potentiation; positive regulation of cellular protein localization; and positive regulation of secretion by cell. Localizes to several cellular components, including the basolateral plasma membrane; cytoplasmic vesicle; and glutamatergic synapse; PARTICIPATES IN E-cadherin signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: p35-2; renal carcinoma antigen NY-REN-31; STX4A; syntaxin 4A (placental); syntaxin-4
Mus musculus (house mouse) : Stx4a (syntaxin 4A (placental))  MGI  Alliance
Rattus norvegicus (Norway rat) : Stx4 (syntaxin 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : STX4 (syntaxin 4)
Canis lupus familiaris (dog) : STX4 (syntaxin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Stx4 (syntaxin 4)
Sus scrofa (pig) : STX4 (syntaxin 4)
Chlorocebus sabaeus (green monkey) : STX4 (syntaxin 4)
Heterocephalus glaber (naked mole-rat) : Stx4 (syntaxin 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1631,032,889 - 31,042,975 (+)Ensembl
GRCh381631,033,095 - 31,040,168 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371631,044,416 - 31,051,489 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361630,952,404 - 30,958,986 (+)NCBINCBI36hg18NCBI36
Build 341630,952,403 - 30,958,985NCBI
Celera1629,246,015 - 29,253,171 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,606,302 - 28,613,331 (+)NCBIHuRef
CHM1_11632,361,656 - 32,368,735 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on STX4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731468
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.