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Gene: TFF2 (trefoil factor 2) Homo sapiens
Symbol: TFF2
Name: trefoil factor 2
Description: Predicted to have CXCR4 chemokine receptor binding activity. Predicted to be involved in several processes, including negative regulation of gastric acid secretion; negative regulation of macrophage activation; and positive regulation of ERK1 and ERK2 cascade. Predicted to localize to extracellular space. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: SML1; SP; spasmolysin; spasmolytic polypeptide; spasmolytic protein 1; trefoil factor 2 (spasmolytic protein 1)
Mus musculus (house mouse) : Tff2 (trefoil factor 2 (spasmolytic protein 1))  MGI  Alliance
Rattus norvegicus (Norway rat) : Tff2 (trefoil factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tff2 (trefoil factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TFF2 (trefoil factor 2)
Canis lupus familiaris (dog) : TFF2 (trefoil factor 2)
Sus scrofa (pig) : TFF2 (trefoil factor 2)
Chlorocebus sabaeus (African green monkey) : TFF2 (trefoil factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2142,346,357 - 42,350,997 (-)EnsemblGRCh38hg38GRCh38
GRCh382142,346,357 - 42,350,994 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372143,766,466 - 43,771,208 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,639,535 - 42,644,176 (-)NCBINCBI36hg18NCBI36
Build 342142,639,537 - 42,644,176NCBI
Celera2128,915,432 - 28,920,174 (-)NCBI
Cytogenetic Map21q22.3NCBI
HuRef2129,183,694 - 29,188,435 (-)NCBIHuRef
CHM1_12143,326,640 - 43,331,381 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TFF2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731368
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.