GTF2B (general transcription factor IIB)

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Gene: GTF2B (general transcription factor IIB) Homo sapiens

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Symbol:

GTF2B

Name:

general transcription factor IIB

RGD ID:

731364

HGNC Page

HGNC:4648

Description:

Enables several functions, including RNA polymerase II core promoter sequence-specific DNA binding activity; RNA polymerase II general transcription initiation factor activity; and TBP-class protein binding activity. Involved in several processes, including RNA polymerase II core complex assembly; protein acetylation; and transcription initiation at RNA polymerase II promoter. Located in chromosome and nuclear body. Part of protein-DNA complex and transcription factor TFIID complex.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

general transcription factor TFIIB; RNA polymerase II transcription factor IIB; S300-II; TF2B; TFIIB; transcription initiation factor IIB

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Gtf2b (general transcription factor IIB)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Gtf2b (general transcription factor IIB)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Gtf2b (general transcription factor IIB)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	GTF2B (general transcription factor IIB)	NCBI	Ortholog
Canis lupus familiaris (dog):	GTF2B (general transcription factor IIB)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gtf2b (general transcription factor IIB)	NCBI	Ortholog
Sus scrofa (pig):	GTF2B (general transcription factor IIB)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	GTF2B (general transcription factor IIB)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Gtf2b (general transcription factor IIB)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Gtf2b (general transcription factor IIB)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gtf2b (general transcription factor IIB)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gtf2b (general transcription factor IIB)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	SUA7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	TfIIB	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ttb-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gtf2b	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	gtf2b.L	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	gtf2b.S	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	88,852,633 - 88,891,567 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	88,852,633 - 88,891,944 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	89,318,316 - 89,357,250 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	89,090,909 - 89,129,889 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	89,030,635 - 89,069,275	NCBI
Celera	1	87,564,104 - 87,603,098 (-)	NCBI		Celera
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	87,435,703 - 87,474,719 (-)	NCBI		HuRef
CHM1_1	1	89,433,373 - 89,472,373 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	88,696,014 - 88,734,967 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (EXP)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (ISO)

2-hydroxypropanoic acid (EXP)

4-(ethoxymethylene)-2-phenyloxazol-5-one (EXP)

4-hydroxynon-2-enal (EXP)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (ISO)

amitrole (ISO)

ammonium chloride (ISO)

arsenite(3-) (EXP)

atrazine (EXP)

benzo[a]pyrene (EXP)

benzo[b]fluoranthene (ISO)

Benzo[ghi]perylene (EXP)

bisphenol A (EXP,ISO)

butanal (EXP)

caffeine (EXP)

chromium(6+) (EXP)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (EXP)

CU-O LINKAGE (EXP)

cyclophosphamide (ISO)

dicrotophos (EXP)

disulfiram (EXP)

diuron (ISO)

doxorubicin (EXP)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (EXP)

finasteride (ISO)

folic acid (ISO)

formaldehyde (EXP)

genistein (ISO)

gentamycin (ISO)

geraniol (EXP)

hydrogen peroxide (EXP)

isobutanol (EXP)

ivermectin (EXP)

methimazole (ISO)

methyl methanesulfonate (EXP)

monosodium L-glutamate (ISO)

nefazodone (ISO)

nickel sulfate (EXP)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

rac-lactic acid (EXP)

resveratrol (EXP,ISO)

sodium arsenite (EXP)

sulfadimethoxine (ISO)

sulindac (EXP,ISO)

temozolomide (EXP)

tetrachloromethane (ISO)

thimerosal (EXP)

thiram (EXP)

trichloroethene (ISO)

triphenyl phosphate (EXP)

urethane (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA)

chromosome organization (IEA)

DNA-templated transcription initiation (IEA)

gene expression (IEA)

meiotic sister chromatid cohesion (IEA)

protein acetylation (IDA)

RNA polymerase II core complex assembly (IBA,IMP)

RNA polymerase II preinitiation complex assembly (IBA,IDA,IMP)

spindle assembly (IEA)

transcription by RNA polymerase II (IDA,IMP,TAS)

transcription initiation at RNA polymerase II promoter (IBA,IDA,IMP)

transcription preinitiation complex assembly (IEA)

transcriptional start site selection at RNA polymerase II promoter (IBA,IMP)

viral transcription (IDA,IMP)

Cellular Component

cell division site (IEA,ISO)

chromosome (IDA,IEA)

condensed chromosome (IEA,ISO)

germinal vesicle (IEA,ISO)

kinetochore (IEA,ISO)

nuclear body (IDA)

nucleoplasm (IDA,TAS)

nucleus (IBA,IDA,IEA)

protein-DNA complex (IDA)

RNA polymerase II transcription regulator complex (IDA,IMP)

transcription factor TFIID complex (IDA)

transcription preinitiation complex (IBA)

Molecular Function

acetyltransferase activity (IBA,IDA)

acyltransferase activity (IEA)

DNA binding (IEA)

DNA-binding transcription factor binding (IPI)

histone acetyltransferase activity (IEA)

metal ion binding (IEA)

nuclear thyroid hormone receptor binding (IPI)

peptide-lysine-N-acetyltransferase activity (IEA)

promoter-specific chromatin binding (IDA,IEA)

protein binding (IPI)

RNA polymerase II complex binding (IDA)

RNA polymerase II core promoter sequence-specific DNA binding (IBA,IDA)

RNA polymerase II general transcription initiation factor activity (IBA,IDA)

TBP-class protein binding (IBA,IEA,IPI)

zinc ion binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription initiation pathway (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	Structural insights into transcription initiation by RNA polymerase II.	Grunberg S and Hahn S, Trends Biochem Sci. 2013 Dec;38(12):603-11. doi: 10.1016/j.tibs.2013.09.002. Epub 2013 Oct 11.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1517211	PMID:1876184	PMID:1939271	PMID:1946368	PMID:2449431	PMID:3029109	PMID:7597030	PMID:7601352	PMID:7608968	PMID:7609079	PMID:7641693	PMID:7651839
PMID:7666533	PMID:7671313	PMID:7675079	PMID:7706261	PMID:7707527	PMID:7707528	PMID:7757816	PMID:7848298	PMID:7913207	PMID:8006019	PMID:8162052	PMID:8413225
PMID:8413269	PMID:8415761	PMID:8504927	PMID:8515820	PMID:8516312	PMID:8524305	PMID:8551580	PMID:8566795	PMID:8598193	PMID:8621548	PMID:8662660	PMID:8754792
PMID:8800208	PMID:8849451	PMID:8870495	PMID:8889549	PMID:8946909	PMID:9054408	PMID:9058380	PMID:9089417	PMID:9121429	PMID:9159119	PMID:9177216	PMID:9259327
PMID:9267036	PMID:9292011	PMID:9295363	PMID:9305922	PMID:9311902	PMID:9315662	PMID:9405375	PMID:9420329	PMID:9611234	PMID:9722567	PMID:9765201	PMID:9765293
PMID:9792714	PMID:9812988	PMID:9841876	PMID:9874563	PMID:9892017	PMID:10220372	PMID:10318856	PMID:10330164	PMID:10359081	PMID:10409729	PMID:10449590	PMID:10454562
PMID:10478848	PMID:10619841	PMID:10704334	PMID:10756192	PMID:11005381	PMID:11029584	PMID:11045620	PMID:11080476	PMID:11113176	PMID:11118327	PMID:11149922	PMID:11416169
PMID:11782371	PMID:11864601	PMID:11959865	PMID:12167624	PMID:12392551	PMID:12477932	PMID:12529369	PMID:12535529	PMID:12552007	PMID:12578358	PMID:12665589	PMID:12791683
PMID:12931194	PMID:12972613	PMID:14585974	PMID:14612417	PMID:14641108	PMID:14644612	PMID:14963322	PMID:15013781	PMID:15024075	PMID:15037660	PMID:15081896	PMID:15142377
PMID:15197246	PMID:15207618	PMID:15207693	PMID:15249124	PMID:15265780	PMID:15282305	PMID:15342556	PMID:15353294	PMID:15489334	PMID:15604728	PMID:15635413	PMID:15710329
PMID:15989968	PMID:16230532	PMID:16449650	PMID:16595664	PMID:16710414	PMID:16878124	PMID:17643375	PMID:17994014	PMID:18391015	PMID:18562274	PMID:18768974	PMID:19193635
PMID:19235719	PMID:19275580	PMID:19590095	PMID:20226668	PMID:20347598	PMID:20398657	PMID:20880846	PMID:21489275	PMID:21873635	PMID:21896726	PMID:21988832	PMID:22079093
PMID:22761572	PMID:22939629	PMID:23055019	PMID:23115335	PMID:23184937	PMID:23251661	PMID:23827503	PMID:23940030	PMID:24441171	PMID:25281560	PMID:25416956	PMID:25492609
PMID:26016528	PMID:26186194	PMID:26284261	PMID:26344197	PMID:26496610	PMID:27193682	PMID:27432908	PMID:28298427	PMID:28514442	PMID:28515276	PMID:29158257	PMID:29540532
PMID:31048545	PMID:31091453	PMID:31515488	PMID:31540324	PMID:31980649	PMID:32296183	PMID:32416067	PMID:32417370	PMID:32814053	PMID:33082525	PMID:33226137	PMID:33961781
PMID:34079125	PMID:34373451	PMID:34461288	PMID:34597346	PMID:34795231	PMID:34932801	PMID:35271311	PMID:35831314	PMID:35944360	PMID:35947745	PMID:36575184	PMID:37108203
PMID:37827155	PMID:38113892

Genomics

Comparative Map Data

GTF2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	88,852,633 - 88,891,567 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	88,852,633 - 88,891,944 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	89,318,316 - 89,357,250 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	89,090,909 - 89,129,889 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	89,030,635 - 89,069,275	NCBI
Celera	1	87,564,104 - 87,603,098 (-)	NCBI		Celera
Cytogenetic Map	1	p22.2	NCBI
HuRef	1	87,435,703 - 87,474,719 (-)	NCBI		HuRef
CHM1_1	1	89,433,373 - 89,472,373 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	88,696,014 - 88,734,967 (-)	NCBI		T2T-CHM13v2.0

Gtf2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	142,471,008 - 142,489,367 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	142,470,806 - 142,489,367 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	142,765,247 - 142,783,606 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	142,765,045 - 142,783,606 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	142,428,211 - 142,446,570 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	142,702,633 - 142,720,992 (+)	NCBI		MGSCv36	mm8
Celera	3	149,197,374 - 149,215,676 (+)	NCBI		Celera
Cytogenetic Map	3	H1	NCBI
cM Map	3	66.69	NCBI

Gtf2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	234,427,734 - 234,446,043 (+)	NCBI		GRCr8
mRatBN7.2	2	231,767,317 - 231,785,626 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	231,767,238 - 231,785,651 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	239,546,251 - 239,564,580 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	237,440,531 - 237,458,860 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	232,303,904 - 232,322,233 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	248,709,433 - 248,727,741 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	248,715,281 - 248,727,741 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	267,239,559 - 267,257,867 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	240,877,342 - 240,895,650 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	240,864,081 - 240,882,390 (+)	NCBI
Celera	2	223,777,527 - 223,795,808 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

Gtf2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955423	5,420,584 - 5,447,148 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955423	5,420,795 - 5,447,148 (+)	NCBI	ChiLan1.0	ChiLan1.0

GTF2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	138,078,278 - 138,117,617 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	137,234,167 - 137,273,418 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	91,568,296 - 91,607,467 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	90,319,637 - 90,359,134 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	90,319,637 - 90,359,134 (-)	Ensembl	panpan1.1		panPan2

GTF2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	59,491,986 - 59,527,142 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	59,492,055 - 59,527,054 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	62,200,289 - 62,235,125 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	60,003,234 - 60,038,110 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	60,003,305 - 60,081,246 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	59,568,745 - 59,603,586 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	59,524,029 - 59,558,856 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	60,009,800 - 60,044,657 (+)	NCBI		UU_Cfam_GSD_1.0

Gtf2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	99,258,716 - 99,290,490 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936732	148,369 - 183,067 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936732	148,702 - 178,992 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GTF2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	127,522,870 - 127,561,135 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	127,522,802 - 127,559,605 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	139,747,986 - 139,784,762 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GTF2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	44,527,150 - 44,566,398 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	44,527,599 - 44,566,424 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	73,339,911 - 73,378,634 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gtf2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624742	8,686,537 - 8,723,399 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624742	8,687,002 - 8,721,505 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GTF2B
10 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 1p31.1-13.3(chr1:72661709-107456880)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]\|See cases [RCV000051825]	Chr1:72661709..107456880 [GRCh38] Chr1:73127392..107999502 [GRCh37] Chr1:72899980..107801025 [NCBI36] Chr1:1p31.1-13.3	pathogenic
GRCh38/hg38 1p31.1-21.1(chr1:83457325-104273917)x3	copy number gain	See cases [RCV000135654]	Chr1:83457325..104273917 [GRCh38] Chr1:83923008..104816539 [GRCh37] Chr1:83695596..104618062 [NCBI36] Chr1:1p31.1-21.1	pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3	copy number loss	not provided [RCV000762767]	Chr1:20608823..120546301 [GRCh37] Chr1:1p36.12-12	likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3	copy number gain	See cases [RCV000510383]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p31.1-22.1(chr1:72044544-92505091)x1	copy number loss	See cases [RCV000510161]	Chr1:72044544..92505091 [GRCh37] Chr1:1p31.1-22.1	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)	copy number gain	See cases [RCV000510926]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p22.2(chr1:88840026-89512154)x3	copy number gain	not provided [RCV000684595]	Chr1:88840026..89512154 [GRCh37] Chr1:1p22.2	uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3	copy number gain	not provided [RCV000736295]	Chr1:47851..249228449 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3	copy number gain	not provided [RCV000736305]	Chr1:82154..249218992 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p22.2(chr1:89123443-89399431)x3	copy number gain	not provided [RCV000736565]	Chr1:89123443..89399431 [GRCh37] Chr1:1p22.2	benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3	copy number gain	Global developmental delay [RCV000787285]	Chr1:103343285..103455144 [GRCh37] Chr1:1p36.22-21.1	uncertain significance
GRCh37/hg19 1p22.2(chr1:89239549-89733747)x3	copy number gain	not provided [RCV000846500]	Chr1:89239549..89733747 [GRCh37] Chr1:1p22.2	uncertain significance
GRCh37/hg19 1p22.2(chr1:89018909-89483015)x3	copy number gain	not provided [RCV001005118]	Chr1:89018909..89483015 [GRCh37] Chr1:1p22.2	uncertain significance
GRCh37/hg19 1p31.1-22.2(chr1:80804502-89490384)x3	copy number gain	not provided [RCV001259073]	Chr1:80804502..89490384 [GRCh37] Chr1:1p31.1-22.2	likely pathogenic
GRCh37/hg19 1p31.3-22.1(chr1:68180293-92731957)	copy number loss	not specified [RCV002053392]	Chr1:68180293..92731957 [GRCh37] Chr1:1p31.3-22.1	pathogenic
NM_001514.6(GTF2B):c.293A>G (p.Asn98Ser)	single nucleotide variant	not specified [RCV004288253]	Chr1:88860252 [GRCh38] Chr1:89325935 [GRCh37] Chr1:1p22.2	uncertain significance
NM_001514.6(GTF2B):c.88G>A (p.Gly30Ser)	single nucleotide variant	not specified [RCV004184378]	Chr1:88887297 [GRCh38] Chr1:89352980 [GRCh37] Chr1:1p22.2	uncertain significance
NM_001514.6(GTF2B):c.547G>A (p.Val183Ile)	single nucleotide variant	not specified [RCV004186260]	Chr1:88857476 [GRCh38] Chr1:89323159 [GRCh37] Chr1:1p22.2	uncertain significance
GRCh37/hg19 1p22.2(chr1:88895486-91863052)x3	copy number gain	not provided [RCV003484021]	Chr1:88895486..91863052 [GRCh37] Chr1:1p22.2	uncertain significance
GRCh37/hg19 1p22.3-22.2(chr1:87511398-90730302)x1	copy number loss	not provided [RCV003483216]	Chr1:87511398..90730302 [GRCh37] Chr1:1p22.3-22.2	uncertain significance
NM_001514.6(GTF2B):c.94A>G (p.Met32Val)	single nucleotide variant	not specified [RCV004388423]	Chr1:88887291 [GRCh38] Chr1:89352974 [GRCh37] Chr1:1p22.2	uncertain significance
NM_001514.6(GTF2B):c.923C>T (p.Thr308Ile)	single nucleotide variant	not specified [RCV004635048]	Chr1:88853241 [GRCh38] Chr1:89318924 [GRCh37] Chr1:1p22.2	uncertain significance
NM_001514.6(GTF2B):c.220C>T (p.Leu74Phe)	single nucleotide variant	not specified [RCV004635047]	Chr1:88864019 [GRCh38] Chr1:89329702 [GRCh37] Chr1:1p22.2	uncertain significance

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
MIR122	hsa-miR-122-5p	Mirtarbase	external_info	qRT-PCR	Functional MTI (Weak)	18073344

Predicted Target Of

	Summary Value
Count of predictions:	802
Count of miRNA genes:	497
Interacting mature miRNAs:	536
Transcripts:	ENST00000370500, ENST00000418217, ENST00000448623, ENST00000471296, ENST00000471471, ENST00000486078, ENST00000494819
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
406984676	GWAS633652_H	systolic blood pressure QTL GWAS633652 (human)		9e-22	systolic blood pressure	systolic blood pressure (CMO:0000004)	1	88866416	88866417	Human
407418817	GWAS1067793_H	pulse pressure measurement QTL GWAS1067793 (human)		5e-19	pulse pressure measurement	pulse pressure (CMO:0000292)	1	88866416	88866417	Human
1559226	SLEP4_H	Serum leptin concentration QTL 4 (human)	3.4		Hormone level	leptin	1	81532913	107532913	Human
407017996	GWAS666972_H	body height QTL GWAS666972 (human)		2e-18	body height (VT:0001253)	body height (CMO:0000106)	1	88860019	88860020	Human
407005842	GWAS654818_H	intraocular pressure measurement QTL GWAS654818 (human)		9e-10	intraocular pressure measurement		1	88878573	88878574	Human
406980881	GWAS629857_H	hematocrit QTL GWAS629857 (human)		9e-16	hematocrit	hematocrit (CMO:0000037)	1	88878966	88878967	Human
406953810	GWAS602786_H	serum gamma-glutamyl transferase measurement QTL GWAS602786 (human)		3e-10	serum gamma-glutamyl transferase measurement	serum gamma-glutamyltransferase activity level (CMO:0002241)	1	88886815	88886816	Human
407418911	GWAS1067887_H	diastolic blood pressure QTL GWAS1067887 (human)		9e-11	diastolic blood pressure	diastolic blood pressure (CMO:0000005)	1	88866416	88866417	Human
407308095	GWAS957071_H	insomnia QTL GWAS957071 (human)		7e-09	insomnia		1	88857300	88857301	Human
407201373	GWAS850349_H	central corneal thickness QTL GWAS850349 (human)		4e-10	central corneal thickness		1	88858044	88858045	Human
2316890	GLUCO302_H	Glucose level QTL 302 (human)		0.005	Glucose level		1	68532992	94532992	Human
2289499	BW445_H	Body weight QTL 445 (human)	2.26		Body morphometry	waist to hip ratio	1	68532992	94532992	Human
407085817	GWAS734793_H	systolic blood pressure QTL GWAS734793 (human)		3e-09	systolic blood pressure	systolic blood pressure (CMO:0000004)	1	88866416	88866417	Human
407028536	GWAS677512_H	ICAM-1 measurement QTL GWAS677512 (human)		0.000004	ICAM-1 measurement		1	88875725	88875726	Human
1581539	BP75_H	Blood pressure QTL 75 (human)	2.4	0.001	Blood pressure	pulse pressure	1	68532992	94532992	Human
2292793	PRSTS24_H	Prostate tumor susceptibility QTL 24 (human)			Prostate tumor susceptibility	late onset	1	68532992	94532992	Human
407325404	GWAS974380_H	serum gamma-glutamyl transferase measurement QTL GWAS974380 (human)		3e-11	serum gamma-glutamyl transferase measurement	serum gamma-glutamyltransferase activity level (CMO:0002241)	1	88881629	88881630	Human
407398358	GWAS1047334_H	systolic blood pressure QTL GWAS1047334 (human)		7e-23	systolic blood pressure	systolic blood pressure (CMO:0000004)	1	88866416	88866417	Human
407111962	GWAS760938_H	waist-hip ratio QTL GWAS760938 (human)		9e-08	waist-hip ratio	waist to hip ratio (WHR) (CMO:0000020)	1	88886929	88886930	Human

Markers in Region

RH12661

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	89,318,759 - 89,318,894	UniSTS	GRCh37
Build 36	1	89,091,347 - 89,091,482	RGD	NCBI36
Celera	1	87,564,542 - 87,564,677	RGD
Cytogenetic Map	1	p22-p21	UniSTS
HuRef	1	87,436,141 - 87,436,276	UniSTS
GeneMap99-GB4 RH Map	1	247.44	UniSTS
NCBI RH Map	1	575.5	UniSTS

RH70846

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	89,318,763 - 89,318,896	UniSTS	GRCh37
Build 36	1	89,091,351 - 89,091,484	RGD	NCBI36
Celera	1	87,564,546 - 87,564,679	RGD
Cytogenetic Map	1	p22-p21	UniSTS
HuRef	1	87,436,145 - 87,436,278	UniSTS
GeneMap99-GB4 RH Map	1	247.54	UniSTS
NCBI RH Map	1	579.4	UniSTS

A002M34

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	89,318,893 - 89,318,999	UniSTS	GRCh37
Build 36	1	89,091,481 - 89,091,587	RGD	NCBI36
Celera	1	87,564,676 - 87,564,782	RGD
Cytogenetic Map	1	p22-p21	UniSTS
HuRef	1	87,436,275 - 87,436,381	UniSTS
GeneMap99-GB4 RH Map	1	244.07	UniSTS
Whitehead-RH Map	1	261.0	UniSTS

D1S3261

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	89,318,665 - 89,318,839	UniSTS	GRCh37
Build 36	1	89,091,253 - 89,091,427	RGD	NCBI36
Celera	1	87,564,448 - 87,564,622	RGD
Cytogenetic Map	1	p22-p21	UniSTS
HuRef	1	87,436,047 - 87,436,221	UniSTS
Stanford-G3 RH Map	1	4380.0	UniSTS
NCBI RH Map	1	611.9	UniSTS
GeneMap99-G3 RH Map	1	4336.0	UniSTS

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011541299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001737129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_007059241	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_008486013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA031701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB451296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI457606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK289822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL445991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC020597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP379342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	F07886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M76766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	S44184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000370500 ⟹ ENSP00000359531

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	88,852,633 - 88,891,567 (-)	Ensembl

Ensembl Acc Id:

ENST00000418217 ⟹ ENSP00000402345

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	88,857,315 - 88,891,589 (-)	Ensembl

Ensembl Acc Id:

ENST00000448623 ⟹ ENSP00000415741

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	88,853,224 - 88,891,496 (-)	Ensembl

Ensembl Acc Id:

ENST00000471296

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	88,863,986 - 88,888,048 (-)	Ensembl

Ensembl Acc Id:

ENST00000471471

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	88,864,044 - 88,891,944 (-)	Ensembl

Ensembl Acc Id:

ENST00000486078

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	88,860,056 - 88,891,645 (-)	Ensembl

Ensembl Acc Id:

ENST00000494819

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	88,857,265 - 88,891,527 (-)	Ensembl

RefSeq Acc Id:

NM_001514 ⟹ NP_001505

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	88,852,633 - 88,891,567 (-)	NCBI
GRCh37	1	89,318,321 - 89,357,301 (-)	ENTREZGENE
Build 36	1	89,090,909 - 89,129,889 (-)	NCBI Archive
HuRef	1	87,435,703 - 87,474,719 (-)	ENTREZGENE
CHM1_1	1	89,433,373 - 89,472,373 (-)	NCBI
T2T-CHM13v2.0	1	88,696,014 - 88,734,967 (-)	NCBI

Sequence:

show sequence

GCCACATTCGCTTCCTGCTTTCGGTGTGTCTGTTGTGTCTTGTTGCGGGCACCGCAGTCGCCGT
GAAGATGGCGTCTACCAGCCGTTTGGATGCTCTTCCAAGAGTCACATGTCCAAACCATCCAGAT
GCGATTTTAGTGGAGGACTACAGAGCCGGTGATATGATCTGTCCTGAATGTGGCTTGGTTGTAG
GTGACCGGGTTATTGATGTGGGATCTGAATGGCGAACTTTCAGCAATGACAAAGCAACAAAAGA
TCCATCTCGAGTTGGAGATTCTCAGAATCCTCTTCTGAGTGATGGAGATTTGTCTACCATGATT
GGCAAGGGCACAGGAGCTGCAAGTTTTGACGAATTTGGCAATTCTAAGTACCAGAATCGGAGAA
CAATGAGCAGTTCTGATCGGGCAATGATGAATGCATTCAAAGAAATCACTACCATGGCAGACAG
AATCAATCTACCTCGAAATATAGTTGATCGAACAAATAATTTATTCAAGCAAGTATATGAACAG
AAGAGCCTGAAGGGAAGAGCTAATGATGCTATAGCTTCTGCTTGTCTCTATATTGCCTGTAGAC
AAGAAGGGGTTCCTAGGACATTTAAAGAAATATGTGCCGTATCACGAATTTCTAAGAAAGAAAT
TGGTCGGTGTTTTAAACTTATTTTGAAAGCGCTAGAAACCAGTGTGGATTTGATTACAACTGGG
GACTTCATGTCCAGGTTCTGTTCCAACCTTTGTCTTCCTAAACAAGTACAGATGGCAGCTACAC
ATATAGCCCGTAAAGCTGTGGAACTGGACTTGGTTCCTGGGAGGAGCCCCATCTCTGTGGCAGC
GGCAGCTATTTACATGGCCTCACAGGCATCAGCTGAAAAGAGGACCCAAAAAGAAATTGGAGAT
ATTGCTGGTGTTGCTGATGTTACAATCAGACAGTCCTATAGACTGATCTATCCTCGAGCCCCAG
ATCTGTTTCCTACAGACTTCAAATTTGACACCCCAGTGGACAAACTACCACAGCTATAAATTGA
GGCAGCTAACGTCAAATTCTTGAATACAAAACTTTGCCTGTTGTACATAGCCTATACAAAATGC
TGGGTTGAGCCTTTCATGAGGAAAAACAAAAGACATGGTACGCATTCCAGGGCTGAATACTATT
GCTTGGCATTCTGTATGTATATACTAGTGAAACATATTTAATGATTTAAATTTCTTATCAAATT
TCTTTTGTAGCAATCTAGGAAACTGTATTTTGGAAGATATTTGAAATTATGTAATTCTTGAATA
AAACATTTTTCAAAACTCAAGTTTTTGTTATATGTTACATGTAACTTATGATACATAATTACAA
ATAATGCAAATCATTGCAGCTAATAAAGCTGATAGACTTTATTTCCATTACTTATATATACATA
GTTTTTTATTTTAATAAATTTATGGAAAGAGCAAAAGCTTTTGAGAACCATTGTTAACATCAAC
ATCATAGTTTCCAGTTTGAAAGGATGTGTATGTGAGATTTATTATGTATATTATTAAACAAGAA
GTGATGAGCTTGGGCCTTGAAAGGCACCAGCTTGAGAGACATTAAAATGTTCTAAGTATGTGA

hide sequence

RefSeq Acc Id:

XR_007059241

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	88,857,416 - 88,891,567 (-)	NCBI

RefSeq Acc Id:

XR_008486013

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	1	88,700,800 - 88,734,967 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001505	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA61149	(Get FASTA)	NCBI Sequence Viewer
	AAB23144	(Get FASTA)	NCBI Sequence Viewer
	AAH20597	(Get FASTA)	NCBI Sequence Viewer
	BAF82511	(Get FASTA)	NCBI Sequence Viewer
	BAG70110	(Get FASTA)	NCBI Sequence Viewer
	EAW73159	(Get FASTA)	NCBI Sequence Viewer
	EAW73160	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000359531
	ENSP00000359531.5
	ENSP00000402345.1
	ENSP00000415741.1
GenBank Protein	Q00403	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001505 ⟸ NM_001514

- UniProtKB:

A8K1A7 (UniProtKB/Swiss-Prot), Q5JS30 (UniProtKB/Swiss-Prot), Q00403 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDP
SRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRI
NLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIG
RCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAA
AIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL

hide sequence

Ensembl Acc Id:

ENSP00000359531 ⟸ ENST00000370500

Ensembl Acc Id:

ENSP00000402345 ⟸ ENST00000418217

Ensembl Acc Id:

ENSP00000415741 ⟸ ENST00000448623

Protein Domains

TFIIB-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q00403-F1-model_v2	AlphaFold	Q00403	1-316	view protein structure

Promoters

RGD ID:

6856122

Promoter ID:

EPDNEW_H1226

Type:

initiation region

Name:

GTF2B_1

Description:

general transcription factor IIB

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H1227

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	88,891,567 - 88,891,627	EPDNEW

RGD ID:

6856124

Promoter ID:

EPDNEW_H1227

Type:

single initiation site

Name:

GTF2B_2

Description:

general transcription factor IIB

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H1226

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	88,892,532 - 88,892,592	EPDNEW

RGD ID:

6785687

Promoter ID:

HG_KWN:3536

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

NM_001514, OTTHUMT00000029280, OTTHUMT00000029281, OTTHUMT00000029282, OTTHUMT00000029283, OTTHUMT00000029285, UC009WCW.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	1	89,129,801 - 89,130,937 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:4648	AgrOrtholog
COSMIC	GTF2B	COSMIC
Ensembl Genes	ENSG00000137947	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000370500	ENTREZGENE
	ENST00000370500.10	UniProtKB/Swiss-Prot
	ENST00000418217.1	UniProtKB/TrEMBL
	ENST00000448623.5	UniProtKB/TrEMBL
Gene3D-CATH	2.20.25.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyclin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000137947	GTEx
HGNC ID	HGNC:4648	ENTREZGENE
Human Proteome Map	GTF2B	Human Proteome Map
InterPro	Cyclin-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cyclin-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TFIIB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TFIIB_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TFIIB_cyclin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Znf_TFIIB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:2959	UniProtKB/Swiss-Prot
NCBI Gene	2959	ENTREZGENE
OMIM	189963	OMIM
PANTHER	PTHR11618	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRANSCRIPTION INITIATION FACTOR IIB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	TF_Zn_Ribbon	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TFIIB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA29035	PharmGKB
PRINTS	TIFACTORIIB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	TFIIB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_TFIIB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	CYCLIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47954	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Zinc beta-ribbon	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A8K1A7	ENTREZGENE
	B1APE1_HUMAN	UniProtKB/TrEMBL
	B1APE2_HUMAN	UniProtKB/TrEMBL
	Q00403	ENTREZGENE
	Q5JS30	ENTREZGENE
	TF2B_HUMAN	UniProtKB/Swiss-Prot
UniProt Secondary	A8K1A7	UniProtKB/Swiss-Prot
	Q5JS30	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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RGD Manual Annotations