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Gene: CDS2 (CDP-diacylglycerol synthase 2) Homo sapiens
Symbol: CDS2
Name: CDP-diacylglycerol synthase 2
Description: Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDP-DAG synthase 2; CDP-DG synthase 2; CDP-DG synthetase 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; CDP-diglyceride diphosphorylase 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CDP-diglyceride synthetase 2; CDS 2; CTP:phosphatidate cytidylyltransferase 2; FLJ12936; FLJ38111; FLJ41837; phosphatidate cytidylyltransferase 2
Mus musculus (house mouse) : Cds2 (CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cds2 (CDP-diacylglycerol synthase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cds2 (CDP-diacylglycerol synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CDS2 (CDP-diacylglycerol synthase 2)
Canis lupus familiaris (dog) : CDS2 (CDP-diacylglycerol synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cds2 (CDP-diacylglycerol synthase 2)
Sus scrofa (pig) : CDS2 (CDP-diacylglycerol synthase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38205,126,844 - 5,197,887 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37205,107,407 - 5,178,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36205,055,482 - 5,119,989 (+)NCBINCBI36hg18NCBI36
Build 34205,055,481 - 5,119,987NCBI
Celera205,177,503 - 5,242,010 (+)NCBI
Cytogenetic Map20p12.3NCBI
HuRef205,061,336 - 5,132,462 (+)NCBIHuRef
CHM1_1205,108,785 - 5,179,904 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CDS2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731362
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.