Arf2 (ADP-ribosylation factor 2) - Rat Genome Database

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Gene: Arf2 (ADP-ribosylation factor 2) Mus musculus
Analyze
Symbol: Arf2
Name: ADP-ribosylation factor 2
RGD ID: 731334
MGI Page MGI
Description: Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including central nervous system; cranium; endocrine gland; genitourinary system; and nasal septum. Orthologous to human ARF2P (ADP ribosylation factor 2, pseudogene).
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Rat
Pig
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm13733  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,857,551 - 103,876,176 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,857,565 - 103,876,163 (+)EnsemblGRCm39 Ensembl
GRCm3811103,966,725 - 103,985,350 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,966,739 - 103,985,337 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711103,828,185 - 103,846,650 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611103,782,961 - 103,801,426 (+)NCBIMGSCv36mm8
Celera11115,682,724 - 115,701,306 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schurmann A, etal., J Biol Chem 1994 Jun 3;269(22):15683-8.
Additional References at PubMed
PMID:8947846   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12679809   PMID:14610273   PMID:15329828   PMID:15489334   PMID:15690355   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600   PMID:27626380   PMID:30352954   PMID:32325033   PMID:34474245  


Genomics

Comparative Map Data
Arf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911103,857,551 - 103,876,176 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11103,857,565 - 103,876,163 (+)EnsemblGRCm39 Ensembl
GRCm3811103,966,725 - 103,985,350 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11103,966,739 - 103,985,337 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711103,828,185 - 103,846,650 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611103,782,961 - 103,801,426 (+)NCBIMGSCv36mm8
Celera11115,682,724 - 115,701,306 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.64NCBI
ARL17B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381746,274,184 - 46,361,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1746,274,784 - 46,361,766 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1746,499,780 - 46,579,695 (-)EnsemblGRCh38hg38GRCh38
GRCh371744,351,550 - 44,439,153 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361741,784,502 - 41,794,826 (-)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map17q21.31NCBI
HuRef1739,312,323 - 39,312,702 (+)NCBIHuRef
HuRef1740,477,082 - 40,477,202 (-)NCBIHuRef
CHM1_11743,815,492 - 43,870,139 (+)NCBICHM1_1
T2T-CHM13v2.01747,136,194 - 47,223,769 (-)NCBIT2T-CHM13v2.0
Arf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81089,367,843 - 89,389,644 (+)NCBIGRCr8
mRatBN7.21088,867,836 - 88,889,654 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1088,867,836 - 88,889,659 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1093,906,655 - 93,928,391 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01093,370,144 - 93,391,815 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01088,765,181 - 88,786,917 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01092,018,562 - 92,040,335 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,018,562 - 92,040,333 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01091,783,781 - 91,805,591 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41093,114,540 - 93,136,313 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11093,128,909 - 93,150,681 (+)NCBI
Celera1087,565,485 - 87,587,254 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
ARF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11217,432,594 - 17,447,976 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21217,474,691 - 17,479,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12p13NCBI

Variants

.
Variants in Arf2
710 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1447
Count of miRNA genes:500
Interacting mature miRNAs:596
Transcripts:ENSMUST00000057921, ENSMUST00000063347, ENSMUST00000153092, ENSMUST00000154089
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102344123112384123Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103273992115021444Mouse

Markers in Region
Arf2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11E1UniSTS
cM Map1162.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001304574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK018235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL603829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY129623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY683617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D87899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000057921   ⟹   ENSMUSP00000051814
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11103,857,565 - 103,876,163 (+)Ensembl
GRCm38.p6 Ensembl11103,966,739 - 103,985,337 (+)Ensembl
RefSeq Acc Id: ENSMUST00000063347   ⟹   ENSMUSP00000102622
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11103,857,697 - 103,876,163 (+)Ensembl
GRCm38.p6 Ensembl11103,966,871 - 103,985,337 (+)Ensembl
RefSeq Acc Id: ENSMUST00000153092
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11103,863,779 - 103,872,724 (+)Ensembl
GRCm38.p6 Ensembl11103,972,953 - 103,981,898 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154089   ⟹   ENSMUSP00000120473
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11103,870,415 - 103,874,453 (+)Ensembl
GRCm38.p6 Ensembl11103,979,589 - 103,983,627 (+)Ensembl
RefSeq Acc Id: NM_001304574   ⟹   NP_001291503
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911103,857,551 - 103,876,176 (+)NCBI
GRCm3811103,966,725 - 103,985,350 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007477   ⟹   NP_031503
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911103,857,697 - 103,876,176 (+)NCBI
GRCm3811103,966,871 - 103,985,350 (+)NCBI
MGSCv3711103,828,185 - 103,846,650 (+)RGD
Celera11115,682,724 - 115,701,306 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_031503   ⟸   NM_007477
- UniProtKB: Q3TJ37 (UniProtKB/Swiss-Prot),   Q91VR9 (UniProtKB/Swiss-Prot),   Q8BSL7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001291503   ⟸   NM_001304574
- UniProtKB: Q3TJ37 (UniProtKB/Swiss-Prot),   Q91VR9 (UniProtKB/Swiss-Prot),   Q8BSL7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000120473   ⟸   ENSMUST00000154089
RefSeq Acc Id: ENSMUSP00000102622   ⟸   ENSMUST00000063347
RefSeq Acc Id: ENSMUSP00000051814   ⟸   ENSMUST00000057921

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BSL7-F1-model_v2 AlphaFold Q8BSL7 1-181 view protein structure

Promoters
RGD ID:6820400
Promoter ID:MM_KWN:10114
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000063347,   OTTMUST00000006492
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611103,827,556 - 103,828,502 (+)MPROMDB
RGD ID:6820402
Promoter ID:MM_KWN:10116
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:OTTMUST00000006494
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611103,840,651 - 103,841,151 (+)MPROMDB
RGD ID:8676994
Promoter ID:EPDNEW_M16527
Type:initiation region
Name:Arf2_1
Description:Mus musculus ADP-ribosylation factor 2 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811103,966,765 - 103,966,825EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99595 AgrOrtholog
Ensembl Genes ENSMUSG00000062421 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057921 ENTREZGENE
  ENSMUST00000057921.10 UniProtKB/Swiss-Prot
  ENSMUST00000063347 ENTREZGENE
  ENSMUST00000063347.12 UniProtKB/Swiss-Prot
  ENSMUST00000154089.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arf1_5_like UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11841 UniProtKB/Swiss-Prot
MGD MGI:99595 ENTREZGENE
NCBI Gene 11841 ENTREZGENE
PANTHER ADP-RIBOSYLATION FACTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arf2 PhenoGen
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot
PROSITE ARF UniProtKB/Swiss-Prot
SMART ARF UniProtKB/Swiss-Prot
  RAB UniProtKB/Swiss-Prot
  SAR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2A6T9_MOUSE UniProtKB/TrEMBL
  ARF2_MOUSE UniProtKB/Swiss-Prot
  Q3TJ37 ENTREZGENE
  Q8BSL7 ENTREZGENE
  Q91VR9 ENTREZGENE
UniProt Secondary P10947 UniProtKB/Swiss-Prot
  P16500 UniProtKB/Swiss-Prot
  Q3TJ37 UniProtKB/Swiss-Prot
  Q91VR9 UniProtKB/Swiss-Prot