Spa17 (sperm autoantigenic protein 17) - Rat Genome Database
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Gene: Spa17 (sperm autoantigenic protein 17) Mus musculus
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Symbol: Spa17
Name: sperm autoantigenic protein 17
RGD ID: 731295
MGI Page MGI
Description: Predicted to have calmodulin binding activity. Predicted to be involved in binding activity of sperm to zona pellucida. Localizes to cytoplasm; external side of plasma membrane; and sperm flagellum. Is expressed in several structures, including brain; gonad; heart; hemolymphoid system gland; and lung. Orthologous to human SPA17 (sperm autoantigenic protein 17); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: band 34; Sp; Sp17; sperm protein 17; sperm surface protein Sp17
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,514,590 - 37,525,196 (-)NCBIGRCm39mm39
GRCm38937,603,294 - 37,613,916 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,603,290 - 37,613,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv37937,410,883 - 37,421,207 (-)NCBIGRCm37mm9NCBIm37
MGSCv36937,352,969 - 37,363,285 (-)NCBImm8
Celera934,820,392 - 34,830,716 (-)NCBICelera
Cytogenetic Map9A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (IDA,ISO)
cytoplasm  (IBA,IDA,ISO)
external side of plasma membrane  (IDA)
membrane  (IEA)
motile cilium  (ISO)
sperm fibrous sheath  (IBA,IDA,ISO)
sperm principal piece  (IBA,IDA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:7525387   PMID:7578682   PMID:9589353   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11415432   PMID:12477932   PMID:12530914   PMID:14610273   PMID:15257753   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:16311122   PMID:16458478   PMID:16602821   PMID:17971504   PMID:18492746   PMID:18689890   PMID:18799693   PMID:18973680   PMID:21267068   PMID:21677750  
PMID:21873635  


Genomics

Comparative Map Data
Spa17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,514,590 - 37,525,196 (-)NCBIGRCm39mm39
GRCm38937,603,294 - 37,613,916 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,603,290 - 37,613,722 (-)EnsemblGRCm38mm10GRCm38
MGSCv37937,410,883 - 37,421,207 (-)NCBIGRCm37mm9NCBIm37
MGSCv36937,352,969 - 37,363,285 (-)NCBImm8
Celera934,820,392 - 34,830,716 (-)NCBICelera
Cytogenetic Map9A4NCBI
SPA17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11124,673,798 - 124,697,518 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl11124,673,844 - 124,697,518 (+)EnsemblGRCh38hg38GRCh38
GRCh3811124,673,904 - 124,697,518 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711124,543,740 - 124,564,690 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3711124,543,800 - 124,567,414 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611124,048,950 - 124,069,900 (+)NCBINCBI36hg18NCBI36
Build 3411124,048,949 - 124,069,895NCBI
Celera11121,703,917 - 121,724,867 (+)NCBI
Cytogenetic Map11q24.2NCBI
HuRef11120,486,154 - 120,507,105 (+)NCBIHuRef
CHM1_111124,429,875 - 124,450,825 (+)NCBICHM1_1
Spa17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2837,307,432 - 37,318,645 (-)NCBI
Rnor_6.0 Ensembl840,067,076 - 40,078,165 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0840,066,954 - 40,078,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0840,067,778 - 40,078,956 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,843,007 - 38,852,080 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1838,851,772 - 38,860,846 (-)NCBI
Celera837,138,678 - 37,147,723 (+)NCBICelera
Cytogenetic Map8q21NCBI
Spa17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541225,741,228 - 25,753,903 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541225,741,369 - 25,753,681 (+)NCBIChiLan1.0ChiLan1.0
SPA17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111123,416,864 - 123,437,823 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11123,416,725 - 123,437,818 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011119,501,604 - 119,526,103 (+)NCBIMhudiblu_PPA_v0panPan3
SPA17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl59,719,241 - 9,730,913 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.159,719,222 - 9,731,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
SPA17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl951,918,916 - 51,931,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1951,918,916 - 51,931,459 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2957,436,391 - 57,448,928 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103215961
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1955,994,382 - 55,996,655 (+)NCBI
Spa17
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624927678,390 - 691,963 (+)NCBI

Position Markers
D9Mit326  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38937,611,630 - 37,611,878UniSTSGRCm38
MGSCv37937,419,215 - 37,419,463UniSTSGRCm37
Celera934,828,724 - 34,828,972UniSTS
Cytogenetic Map9BUniSTS
cM Map917.0UniSTS
Whitehead Genetic913.1UniSTS
RH139440  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38937,603,242 - 37,603,417UniSTSGRCm38
MGSCv37937,410,827 - 37,411,002UniSTSGRCm37
Celera934,820,336 - 34,820,511UniSTS
Cytogenetic Map9BUniSTS
mSpa17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9BUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13504833Bglu19_mblood glucose level 19 (mouse)9999947243999472Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91550045549500594Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91550045549500594Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91550045549500594Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91550045549500594Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91583833149838331Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91583833149838331Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91583833149838331Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91610000050100000Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91610000050100000Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91679834550798345Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91706754451067647Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined92003211054032229Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92024206654242196Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92039490154395074Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92039490154395074Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92039490154395074Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92039490154395074Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92094144454941444Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92859203741888030Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1558949Igan3_mIgA nephropathy 3 (mouse)Not determined93050339840654618Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93419332342853570Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93682494749509211Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93703211050199840Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93724206644340026Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:74
Interacting mature miRNAs:79
Transcripts:ENSMUST00000002013
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000002013   ⟹   ENSMUSP00000002013
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl937,603,290 - 37,613,722 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214786   ⟹   ENSMUSP00000150651
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl937,603,400 - 37,613,570 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215336
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl937,611,767 - 37,613,722 (-)Ensembl
RefSeq Acc Id: NM_001324545   ⟹   NP_001311474
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39937,514,590 - 37,525,017 (-)NCBI
GRCm38937,603,294 - 37,613,721 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011449   ⟹   NP_035579
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39937,514,590 - 37,525,016 (-)NCBI
GRCm38937,603,294 - 37,613,720 (-)NCBI
MGSCv37937,410,883 - 37,421,207 (-)RGD
Celera934,820,388 - 34,830,815 (-)ENTREZGENE
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242439   ⟹   XP_011240741
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39937,514,590 - 37,525,196 (-)NCBI
GRCm38937,603,294 - 37,613,916 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035579   ⟸   NM_011449
- UniProtKB: Q62252 (UniProtKB/Swiss-Prot),   Q545M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240741   ⟸   XM_011242439
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001311474   ⟸   NM_001324545
- UniProtKB: Q62252 (UniProtKB/Swiss-Prot),   Q545M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000002013   ⟸   ENSMUST00000002013
RefSeq Acc Id: ENSMUSP00000150651   ⟸   ENSMUST00000214786
Protein Domains
IQ   RIIa

Promoters
RGD ID:6845214
Promoter ID:MM_KWN:56852
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000002007,   ENSMUST00000002013,   UC009OVE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36937,421,039 - 37,421,539 (-)MPROMDB
RGD ID:8669240
Promoter ID:EPDNEW_M12651
Type:initiation region
Name:Spa17_2
Description:Mus musculus sperm autoantigenic protein 17 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12652  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38937,613,588 - 37,613,648EPDNEW
RGD ID:8669242
Promoter ID:EPDNEW_M12652
Type:multiple initiation site
Name:Spa17_1
Description:Mus musculus sperm autoantigenic protein 17 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M12651  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38937,613,722 - 37,613,782EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333778 AgrOrtholog
Ensembl Genes ENSMUSG00000001948 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000002013 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000150651 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000002013 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000214786 ENTREZGENE, UniProtKB/TrEMBL
InterPro cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sp17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1333778 ENTREZGENE
NCBI Gene 20686 ENTREZGENE
Pfam PF00612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spa17 PhenoGen
PIRSF Sp17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RIIa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SU87_MOUSE UniProtKB/TrEMBL
  C3VDI7_MOUSE UniProtKB/TrEMBL
  C3VDI8_MOUSE UniProtKB/TrEMBL
  Q545M2 ENTREZGENE, UniProtKB/TrEMBL
  Q62252 ENTREZGENE, UniProtKB/Swiss-Prot