Prl8a9 (prolactin family8, subfamily a, member 9) - Rat Genome Database

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Gene: Prl8a9 (prolactin family8, subfamily a, member 9) Mus musculus
Analyze
No known orthologs.
Symbol: Prl8a9
Name: prolactin family8, subfamily a, member 9
RGD ID: 731280
MGI Page MGI
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including extraembryonic component and placenta.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1600019F10Rik; Ghd15; growth hormone d15; placental prolactin-like protein C2; PLP C-beta; PLP-C; PLP-C2; PLP-Cbeta; Pr; PRL-like protein C2; Prlpc2; prolactin-8A9; prolactin-like protein C 2; prolactin-like protein C-beta
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391327,741,978 - 27,748,589 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1327,741,978 - 27,748,589 (-)EnsemblGRCm39 Ensembl
GRCm381327,557,995 - 27,564,606 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1327,557,995 - 27,564,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv371327,649,870 - 27,656,473 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361327,565,466 - 27,572,069 (-)NCBIMGSCv36mm8
Celera1327,785,834 - 27,792,432 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1312.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10965907   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:17476555   PMID:18662396   PMID:21267068   PMID:21873635  
PMID:22193412   PMID:26476147   PMID:26697363   PMID:26862561   PMID:27542691   PMID:32798765  


Genomics

Variants

.
Variants in Prl8a9
228 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:36
Interacting mature miRNAs:36
Transcripts:ENSMUST00000006662
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse
4142489Ath25_matherosclerosis 25 (mouse)Not determined2583652959836529Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000006662   ⟹   ENSMUSP00000006662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1327,741,978 - 27,748,589 (-)Ensembl
GRCm38.p6 Ensembl1327,557,995 - 27,564,606 (-)Ensembl
RefSeq Acc Id: NM_001316721   ⟹   NP_001303650
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391327,741,978 - 27,748,589 (-)NCBI
GRCm381327,557,995 - 27,564,606 (-)NCBI
Sequence:
RefSeq Acc Id: NM_023332   ⟹   NP_075821
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391327,741,978 - 27,748,589 (-)NCBI
GRCm381327,557,995 - 27,564,606 (-)NCBI
MGSCv371327,649,870 - 27,656,473 (-)RGD
Celera1327,785,834 - 27,792,432 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_075821   ⟸   NM_023332
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9CQ58 (UniProtKB/Swiss-Prot),   A0A0M6L0N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303650   ⟸   NM_001316721
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9CQ58 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000006662   ⟸   ENSMUST00000006662

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQ58-F1-model_v2 AlphaFold Q9CQ58 1-241 view protein structure

Promoters
RGD ID:8679944
Promoter ID:EPDNEW_M18003
Type:multiple initiation site
Name:Prl8a9_1
Description:Mus musculus prolactin family8, subfamily a, member 9 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381327,564,604 - 27,564,664EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914560 AgrOrtholog
Ensembl Genes ENSMUSG00000006490 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000006662 ENTREZGENE
  ENSMUST00000006662.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Somatotropin/Prolactin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67310 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1914560 ENTREZGENE
NCBI Gene 67310 ENTREZGENE
PANTHER PROLACTIN-8A9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prl8a9 PhenoGen
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0M6L0N6 ENTREZGENE, UniProtKB/TrEMBL
  PR8A9_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE