Arpc1a (actin related protein 2/3 complex, subunit 1A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Arpc1a (actin related protein 2/3 complex, subunit 1A) Mus musculus
Analyze
Symbol: Arpc1a
Name: actin related protein 2/3 complex, subunit 1A
RGD ID: 731262
MGI Page MGI
Description: Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Located in muscle cell projection membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 0610010H08Rik; 1110030K07Rik; 41kDa; AA407347; actin-related protein 2/3 complex subunit 1A; Sid; sid 329; Sid32; Sid329; SOP2-like protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18937   Gm18961   Gm18962   Gm8843  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395145,020,679 - 145,045,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5145,020,640 - 145,045,571 (+)EnsemblGRCm39 Ensembl
GRCm385145,083,869 - 145,108,756 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5145,083,830 - 145,108,761 (+)EnsemblGRCm38mm10GRCm38
MGSCv375145,844,738 - 145,869,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365145,337,396 - 145,362,283 (+)NCBIMGSCv36mm8
Celera5142,075,658 - 142,100,687 (+)NCBICelera
Cytogenetic Map5G2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
2. Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer. Laurila E, etal., Genes Chromosomes Cancer. 2009 Apr;48(4):330-9.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Prabakaran S, etal., Mol Psychiatry. 2004 Jul;9(7):684-97, 643.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12473693   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17967808   PMID:18799693   PMID:20368287   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22553210   PMID:28706196  
PMID:29518331   PMID:30562941   PMID:32098917   PMID:32325033  


Genomics

Comparative Map Data
Arpc1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395145,020,679 - 145,045,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5145,020,640 - 145,045,571 (+)EnsemblGRCm39 Ensembl
GRCm385145,083,869 - 145,108,756 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5145,083,830 - 145,108,761 (+)EnsemblGRCm38mm10GRCm38
MGSCv375145,844,738 - 145,869,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365145,337,396 - 145,362,283 (+)NCBIMGSCv36mm8
Celera5142,075,658 - 142,100,687 (+)NCBICelera
Cytogenetic Map5G2NCBI
ARPC1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,325,898 - 99,366,262 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl799,325,898 - 99,366,262 (+)EnsemblGRCh38hg38GRCh38
GRCh37798,923,521 - 98,963,885 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36798,761,446 - 98,801,821 (+)NCBINCBI36Build 36hg18NCBI36
Build 34798,568,160 - 98,608,538NCBI
Celera793,657,670 - 93,698,057 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,559,314 - 93,599,623 (+)NCBIHuRef
CHM1_1798,853,571 - 98,893,965 (+)NCBICHM1_1
T2T-CHM13v2.07100,564,792 - 100,605,160 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,283,446 - 98,323,834 (+)NCBI
Arpc1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,502,496 - 9,525,304 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,502,501 - 9,525,330 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,307,262 - 10,330,326 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01210,930,465 - 10,953,529 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0129,953,893 - 9,976,958 (-)NCBIRnor_WKY
Rnor_6.01211,272,609 - 11,294,084 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,272,609 - 11,294,058 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,341,711 - 13,363,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1129,846,583 - 9,863,837 (-)NCBI
Celera1211,307,305 - 11,329,866 (-)NCBICelera
Cytogenetic Map12p11NCBI
Arpc1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546015,023,221 - 15,051,115 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546015,022,663 - 15,050,955 (+)NCBIChiLan1.0ChiLan1.0
ARPC1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17104,801,399 - 104,841,590 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7104,801,399 - 104,841,590 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0791,299,559 - 91,339,729 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ARPC1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1610,212,203 - 10,245,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl610,212,494 - 10,245,073 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha611,838,931 - 11,871,811 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0610,212,409 - 10,245,315 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl610,212,412 - 10,245,312 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1610,082,332 - 10,115,224 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0610,060,836 - 10,093,722 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0610,294,657 - 10,327,563 (-)NCBIUU_Cfam_GSD_1.0
Arpc1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344138,300,216 - 138,334,198 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367501,611,082 - 1,645,045 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARPC1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,197,760 - 6,324,524 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,296,257 - 6,324,526 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.236,434,509 - 6,462,700 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARPC1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,793,196 - 13,833,254 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,764,945 - 13,825,815 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660702,470,717 - 2,509,959 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arpc1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474032,771,885 - 32,805,516 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474032,771,870 - 32,801,047 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH124589  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385145,108,499 - 145,108,580UniSTSGRCm38
MGSCv375145,869,368 - 145,869,449UniSTSGRCm37
Celera5142,100,430 - 142,100,511UniSTS
Cytogenetic Map5G2UniSTS
RH125677  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385145,108,498 - 145,108,656UniSTSGRCm38
MGSCv375145,869,367 - 145,869,525UniSTSGRCm37
Celera5142,100,429 - 142,100,587UniSTS
Cytogenetic Map5G2UniSTS
UniSTS:235365  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385145,108,525 - 145,108,717UniSTSGRCm38
MGSCv375145,869,394 - 145,869,586UniSTSGRCm37
Celera5142,100,456 - 142,100,648UniSTS
Cytogenetic Map5G2UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13504735Ifvrq7_minfluenza virus resistance QTL 7 (mouse)5139509801151658149Mouse
13504737Ifvrq5_minfluenza virus resistance QTL 5 (mouse)5139509801151658149Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5139985755151658149Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1208
Count of miRNA genes:615
Interacting mature miRNAs:724
Transcripts:ENSMUST00000031625, ENSMUST00000124379, ENSMUST00000127694, ENSMUST00000134835, ENSMUST00000142276, ENSMUST00000147564
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000031625   ⟹   ENSMUSP00000031625
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,020,640 - 145,045,571 (+)Ensembl
GRCm38.p6 Ensembl5145,083,830 - 145,108,761 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124379   ⟹   ENSMUSP00000114421
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,020,910 - 145,034,038 (+)Ensembl
GRCm38.p6 Ensembl5145,084,100 - 145,097,228 (+)Ensembl
RefSeq Acc Id: ENSMUST00000127694   ⟹   ENSMUSP00000143026
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,020,716 - 145,045,566 (+)Ensembl
GRCm38.p6 Ensembl5145,083,906 - 145,108,756 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134835
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,020,694 - 145,032,993 (+)Ensembl
GRCm38.p6 Ensembl5145,083,884 - 145,096,183 (+)Ensembl
RefSeq Acc Id: ENSMUST00000142276
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,041,083 - 145,045,402 (+)Ensembl
GRCm38.p6 Ensembl5145,104,273 - 145,108,592 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147564
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,033,067 - 145,035,738 (+)Ensembl
GRCm38.p6 Ensembl5145,096,257 - 145,098,928 (+)Ensembl
RefSeq Acc Id: NM_019767   ⟹   NP_062741
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395145,020,679 - 145,045,566 (+)NCBI
GRCm385145,083,869 - 145,108,756 (+)ENTREZGENE
MGSCv375145,844,738 - 145,869,625 (+)RGD
Celera5142,075,658 - 142,100,687 (+)RGD
cM Map5 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062741   ⟸   NM_019767
- UniProtKB: Q3UL75 (UniProtKB/Swiss-Prot),   Q9R0Q6 (UniProtKB/Swiss-Prot),   A0A8C6ICP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000114421   ⟸   ENSMUST00000124379
RefSeq Acc Id: ENSMUSP00000031625   ⟸   ENSMUST00000031625
RefSeq Acc Id: ENSMUSP00000143026   ⟸   ENSMUST00000127694

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0Q6-F1-model_v2 AlphaFold Q9R0Q6 1-370 view protein structure

Promoters
RGD ID:6888732
Promoter ID:EPDNEW_M7817
Type:initiation region
Name:Arpc1a_1
Description:Mus musculus actin related protein 2/3 complex, subunit 1A ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385145,083,880 - 145,083,940EPDNEW
RGD ID:6837110
Promoter ID:MM_KWN:44819
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000055180,   OTTMUST00000055181,   OTTMUST00000055182,   OTTMUST00000055183
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365145,844,461 - 145,844,961 (+)MPROMDB
RGD ID:6837111
Promoter ID:MM_KWN:44822
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Brain
Transcripts:OTTMUST00000055185
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365145,864,791 - 145,865,472 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1928896 AgrOrtholog
Ensembl Genes ENSMUSG00000029621 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000031625 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114421.2 UniProtKB/TrEMBL
  ENSMUSP00000143026.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000031625 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000124379.3 UniProtKB/TrEMBL
  ENSMUST00000127694.8 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARC1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARPC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56443 UniProtKB/Swiss-Prot
MGD MGI:1928896 ENTREZGENE
NCBI Gene 56443 ENTREZGENE
PANTHER PTHR10709 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10709:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arpc1a PhenoGen
PIRSF ARP2/3_su1 UniProtKB/Swiss-Prot
PROSITE WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JF52_MOUSE UniProtKB/TrEMBL
  A0A8C6ICP4 ENTREZGENE
  ARC1A_MOUSE UniProtKB/Swiss-Prot
  D3YVI5_MOUSE UniProtKB/TrEMBL
  Q3UL75 ENTREZGENE
  Q9R0Q6 ENTREZGENE
UniProt Secondary Q3UL75 UniProtKB/Swiss-Prot