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Gene: DGAT1 (diacylglycerol O-acyltransferase 1) Homo sapiens
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Symbol: DGAT1
Name: diacylglycerol O-acyltransferase 1
RGD ID: 731052
Description: Exhibits diacylglycerol O-acyltransferase activity. Involved in monoacylglycerol biosynthetic process; triglyceride biosynthetic process; and very-low-density lipoprotein particle assembly. Predicted to localize to endoplasmic reticulum membrane; integral component of membrane; and intracellular membrane-bounded organelle. Implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACAT related gene product 1; ACAT-related gene product 1; acyl coenzyme A:cholesterol acyltransferase related gene 1; acyl-CoA retinol O-fatty-acyltransferase; acyl-CoA:diacylglycerol acyltransferase; ARAT; ARGP1; DGAT; diacylglycerol O-acyltransferase (mouse) homolog; diacylglycerol O-acyltransferase homolog; diacylglycerol O-acyltransferase homolog 1; DIAR7; diglyceride acyltransferase; retinol O-fatty-acyltransferase
Orthologs:
Mus musculus (house mouse) : Dgat1 (diacylglycerol O-acyltransferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dgat1 (diacylglycerol O-acyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dgat1 (diacylglycerol O-acyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DGAT1 (diacylglycerol O-acyltransferase 1)
Canis lupus familiaris (dog) : DGAT1 (diacylglycerol O-acyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dgat1 (diacylglycerol O-acyltransferase 1)
Sus scrofa (pig) : DGAT1 (diacylglycerol O-acyltransferase 1)
Chlorocebus sabaeus (African green monkey) : DGAT1 (diacylglycerol O-acyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Dgat1 (diacylglycerol O-acyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8144,314,584 - 144,326,910 (-)EnsemblGRCh38hg38GRCh38
GRCh388144,314,584 - 144,326,852 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,538,246 - 145,550,582 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,510,762 - 145,521,375 (-)NCBINCBI36hg18NCBI36
Build 348145,510,762 - 145,521,350NCBI
Celera8141,713,015 - 141,725,223 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,652,765 - 140,665,081 (-)NCBIHuRef
CHM1_18145,576,522 - 145,588,858 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DGAT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731052
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.