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Gene: SOAT1 (sterol O-acyltransferase 1) Homo sapiens
Symbol: SOAT1
Name: sterol O-acyltransferase 1
Description: Exhibits cholesterol O-acyltransferase activity; cholesterol binding activity; and fatty-acyl-CoA binding activity. Involved in several processes, including cholesterol efflux; cholesterol esterification; and macrophage derived foam cell differentiation. Localizes to the endoplasmic reticulum and endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACACT; ACAT; ACAT-1; ACAT1; acyl-Coenzyme A: cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase 1; cholesterol acyltransferase 1; RP11-215I23.2; SOAT; STAT; sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
Mus musculus (house mouse) : Soat1 (sterol O-acyltransferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Soat1 (sterol O-acyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Soat1 (sterol O-acyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SOAT1 (sterol O-acyltransferase 1)
Canis lupus familiaris (dog) : SOAT1 (sterol O-acyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Soat1 (sterol O-acyltransferase 1)
Sus scrofa (pig) : SOAT1 (sterol O-acyltransferase 1)
Chlorocebus sabaeus (green monkey) : SOAT1 (sterol O-acyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Soat1 (sterol O-acyltransferase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: ACAT1 (Gene ID: 38) and SOAT1 (Gene ID: 6646) share the ACAT1 symbol/alias in common. ACAT1 is a widely used alternative name for sterol O-acyltransferase 1 (SOAT1), which can be confused with the official symbol for ACAT1 (acetyl-CoA acetyltransferase 1, GeneID 38). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1179,293,714 - 179,358,680 (+)Ensembl
GRCh381179,293,714 - 179,358,680 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371179,262,849 - 179,327,815 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,529,640 - 177,591,076 (+)NCBINCBI36hg18NCBI36
Build 341175,994,673 - 176,056,109NCBI
Celera1152,371,279 - 152,432,730 (+)NCBI
Cytogenetic Map1q25.2NCBI
HuRef1150,490,026 - 150,555,022 (+)NCBIHuRef
CHM1_11180,686,373 - 180,751,320 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SOAT1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731038
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.