Clcn3 (chloride channel, voltage-sensitive 3) - Rat Genome Database
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Gene: Clcn3 (chloride channel, voltage-sensitive 3) Mus musculus
Analyze
Symbol: Clcn3
Name: chloride channel, voltage-sensitive 3
RGD ID: 730987
MGI Page MGI
Description: Exhibits antiporter activity. Involved in several processes, including chemical synaptic transmission; photoreceptor cell maintenance; and synaptic vesicle lumen acidification. Localizes to several cellular components, including endosome membrane; glutamatergic synapse; and synaptic vesicle. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and heart. Used to study neuronal ceroid lipofuscinosis 3. Orthologous to human CLCN3 (chloride voltage-gated channel 3); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: chloride channel 3; chloride channel protein 3; chloride transporter ClC-3; Clc; clC-3; Clc3; H(+)/Cl(-) exchange transporter 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,363,423 - 61,436,353 (-)NCBIGRCm39mm39
GRCm38860,910,389 - 60,983,317 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,910,389 - 60,983,300 (-)EnsemblGRCm38mm10GRCm38
MGSCv37863,389,186 - 63,462,108 (-)NCBIGRCm37mm9NCBIm37
MGSCv36863,802,531 - 63,875,442 (-)NCBImm8
Celera863,477,568 - 63,550,480 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (EXP,ISO)
acetazolamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (EXP)
benzo[a]pyrene  (EXP)
beta-carotene  (EXP)
bisphenol A  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (ISO)
D-mannitol  (ISO)
dextran sulfate  (EXP)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
flutamide  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
indinavir  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
lamivudine  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
nitrofen  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
saquinavir  (EXP)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal abdominal fat pad morphology  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal behavioral response to xenobiotic  (IAGP)
abnormal brain morphology  (IAGP)
abnormal entorhinal cortex morphology  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal excitatory postsynaptic potential  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eye physiology  (IAGP)
abnormal gait  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal ileum morphology  (IAGP)
abnormal liver physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal nervous system morphology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal posture  (IAGP)
abnormal renal protein reabsorption  (IAGP)
abnormal response to new environment  (IAGP)
abnormal retinal neuronal layer morphology  (IAGP)
abnormal synaptic vesicle morphology  (IAGP)
astrocytosis  (IAGP)
blindness  (IAGP)
congestive heart failure  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased cerebral cortex pyramidal cell number  (IAGP)
decreased circulating glucose level  (IAGP)
decreased hippocampus pyramidal cell number  (IAGP)
decreased retinal photoreceptor cell number  (IAGP)
decreased susceptibility to pharmacologically induced seizures  (IAGP)
decreased ventricle muscle contractility  (IAGP)
dilated cardiomyopathy  (IAGP)
disorganized photoreceptor outer segment  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
enlarged heart  (IAGP)
enlarged lateral ventricles  (IAGP)
gliosis  (IAGP)
hippocampal neuron degeneration  (IAGP)
hippocampus atrophy  (IAGP)
hyperactivity  (IAGP)
impaired coordination  (IAGP)
impaired neutrophil phagocytosis  (IAGP)
impaired synaptic plasticity  (IAGP)
increased heart weight  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
kyphoscoliosis  (IAGP)
kyphosis  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
loss of GABAergic neurons  (IAGP)
myocardium hypertrophy  (IAGP)
photoreceptor inner segment degeneration  (IAGP)
photoreceptor outer segment degeneration  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
reduced fertility  (IAGP)
reduced male fertility  (IAGP)
retinal degeneration  (IAGP)
seizures  (IAGP)
sepsis  (IAGP)
small hippocampus  (IAGP)
stereotypic behavior  (IAGP)
tonic-clonic seizures  (IAGP)
tremors  (IAGP)
References

Additional References at PubMed
PMID:7613034   PMID:7665160   PMID:8812471   PMID:8889548   PMID:9166581   PMID:9680377   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11182090   PMID:11217851  
PMID:11773602   PMID:12433961   PMID:12470859   PMID:12477932   PMID:12904583   PMID:14610273   PMID:14754994   PMID:15073168   PMID:15319524   PMID:15504734   PMID:15706348   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16222710   PMID:16522634   PMID:16985003   PMID:17046694   PMID:17110406   PMID:17442672   PMID:17673675   PMID:17699636   PMID:17908687   PMID:17967808  
PMID:18234851   PMID:18799693   PMID:18815226   PMID:18840613   PMID:18923035   PMID:19169251   PMID:19339555   PMID:19615374   PMID:19808023   PMID:19808024   PMID:19926787   PMID:20351103  
PMID:20506205   PMID:21071705   PMID:21267068   PMID:21378974   PMID:21732368   PMID:21873635   PMID:22179014   PMID:22534482   PMID:22847174   PMID:23006728   PMID:23115349   PMID:23165767  
PMID:23786998   PMID:24603049   PMID:24611720   PMID:24850147   PMID:25218423   PMID:25798587   PMID:25979088   PMID:26342074   PMID:26363227   PMID:26436462   PMID:26562480   PMID:26794461  
PMID:26925421   PMID:27363391   PMID:27460962   PMID:27760895   PMID:28437476   PMID:28468943   PMID:28972156   PMID:29158167   PMID:29949674   PMID:31679624   PMID:32118314   PMID:32290105  


Genomics

Comparative Map Data
Clcn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39861,363,423 - 61,436,353 (-)NCBIGRCm39mm39
GRCm38860,910,389 - 60,983,317 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,910,389 - 60,983,300 (-)EnsemblGRCm38mm10GRCm38
MGSCv37863,389,186 - 63,462,108 (-)NCBIGRCm37mm9NCBIm37
MGSCv36863,802,531 - 63,875,442 (-)NCBImm8
Celera863,477,568 - 63,550,480 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.9NCBI
CLCN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4169,612,633 - 169,723,673 (+)EnsemblGRCh38hg38GRCh38
GRCh384169,620,578 - 169,723,673 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374170,541,672 - 170,644,338 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364170,778,297 - 170,878,732 (+)NCBINCBI36hg18NCBI36
Build 344170,916,451 - 171,016,886NCBI
Celera4167,874,695 - 167,975,138 (+)NCBI
Cytogenetic Map4q33NCBI
HuRef4166,296,448 - 166,399,155 (+)NCBIHuRef
CHM1_14170,518,267 - 170,620,908 (+)NCBICHM1_1
Clcn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01632,448,821 - 32,520,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,449,116 - 32,519,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,283,743 - 32,355,489 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,447,259 - 32,518,533 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11632,447,333 - 32,517,457 (+)NCBI
Celera1629,122,247 - 29,193,279 (+)NCBICelera
Cytogenetic Map16p12NCBI
Clcn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540336,625,770 - 36,710,201 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540336,625,871 - 36,710,201 (-)NCBIChiLan1.0ChiLan1.0
CLCN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14173,909,980 - 174,014,786 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4173,925,474 - 174,011,681 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04161,838,061 - 161,943,072 (+)NCBIMhudiblu_PPA_v0panPan3
CLCN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2520,528,699 - 20,615,070 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12520,528,708 - 20,616,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Clcn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365161,678,610 - 1,760,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLCN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1420,026,929 - 20,127,155 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11420,037,628 - 20,127,160 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,332,126 - 21,421,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLCN3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17115,826,756 - 115,926,842 (+)NCBI
ChlSab1.1 Ensembl7115,826,778 - 115,928,609 (+)Ensembl
Clcn3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247691,156,522 - 1,246,531 (+)NCBI

Position Markers
RH129711  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38860,910,505 - 60,910,688UniSTSGRCm38
MGSCv37863,389,302 - 63,389,485UniSTSGRCm37
Celera863,477,684 - 63,477,867UniSTS
Cytogenetic Map8B3.1UniSTS
Clcn3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38860,982,927 - 60,983,122UniSTSGRCm38
MGSCv37863,461,724 - 63,461,919UniSTSGRCm37
Celera863,550,096 - 63,550,291UniSTS
Cytogenetic Map8B3.1UniSTS
cM Map832.2UniSTS
Clcn3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38860,982,927 - 60,983,081UniSTSGRCm38
MGSCv37863,461,724 - 63,461,878UniSTSGRCm37
Celera863,550,096 - 63,550,250UniSTS
Cytogenetic Map8B3.1UniSTS
cM Map832.2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2988
Count of miRNA genes:620
Interacting mature miRNAs:796
Transcripts:ENSMUST00000004430, ENSMUST00000056508, ENSMUST00000093490, ENSMUST00000110301, ENSMUST00000110302, ENSMUST00000129672, ENSMUST00000132234, ENSMUST00000145493, ENSMUST00000145741, ENSMUST00000147824
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001778397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF029347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI849432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB657631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB864905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB723319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF536658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX237945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000004430   ⟹   ENSMUSP00000004430
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,911,923 - 60,983,239 (-)Ensembl
RefSeq Acc Id: ENSMUST00000056508   ⟹   ENSMUSP00000058648
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,910,389 - 60,955,233 (-)Ensembl
RefSeq Acc Id: ENSMUST00000093490   ⟹   ENSMUSP00000091202
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,910,389 - 60,983,300 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110301   ⟹   ENSMUSP00000105930
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,911,923 - 60,983,239 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110302   ⟹   ENSMUSP00000105931
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,911,896 - 60,954,748 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129672
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,911,923 - 60,955,233 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132234
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,928,295 - 60,954,779 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145493
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,938,640 - 60,983,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145741
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,910,861 - 60,922,960 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147824
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl860,935,357 - 60,983,244 (-)Ensembl
RefSeq Acc Id: NM_007711   ⟹   NP_031737
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,423 - 61,436,345 (-)NCBI
GRCm38860,910,389 - 60,983,311 (-)ENTREZGENE
MGSCv37863,389,186 - 63,462,108 (-)RGD
Celera863,477,568 - 63,550,480 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_173873   ⟹   NP_776298
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,423 - 61,436,345 (-)NCBI
GRCm38860,910,389 - 60,983,311 (-)ENTREZGENE
MGSCv37863,389,186 - 63,462,108 (-)RGD
Celera863,477,568 - 63,550,480 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_173874   ⟹   NP_776299
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,423 - 61,436,345 (-)NCBI
GRCm38860,910,389 - 60,983,311 (-)ENTREZGENE
MGSCv37863,389,186 - 63,462,108 (-)RGD
Celera863,477,568 - 63,550,480 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_173876   ⟹   NP_776301
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,423 - 61,407,833 (-)NCBI
GRCm38860,910,389 - 60,954,799 (-)NCBI
MGSCv37863,389,186 - 63,462,108 (-)RGD
Celera863,477,568 - 63,550,480 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509259   ⟹   XP_006509322
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,892 - 61,408,535 (-)NCBI
GRCm38860,910,860 - 60,955,501 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509260   ⟹   XP_006509323
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,892 - 61,436,353 (-)NCBI
GRCm38860,910,860 - 60,983,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312552   ⟹   XP_017168041
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,892 - 61,399,447 (-)NCBI
GRCm38860,910,860 - 60,946,442 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312553   ⟹   XP_017168042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,376,229 - 61,436,347 (-)NCBI
GRCm38860,923,195 - 60,983,313 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153740   ⟹   XP_036009633
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,892 - 61,418,340 (-)NCBI
RefSeq Acc Id: XM_036153741   ⟹   XP_036009634
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,892 - 61,418,763 (-)NCBI
RefSeq Acc Id: XR_001778397
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,363,423 - 61,436,351 (-)NCBI
GRCm38860,910,389 - 60,983,317 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004934754
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39861,366,011 - 61,436,351 (-)NCBI
Protein Sequences
Protein RefSeqs NP_031737 (Get FASTA)   NCBI Sequence Viewer  
  NP_776298 (Get FASTA)   NCBI Sequence Viewer  
  NP_776299 (Get FASTA)   NCBI Sequence Viewer  
  NP_776301 (Get FASTA)   NCBI Sequence Viewer  
  XP_006509322 (Get FASTA)   NCBI Sequence Viewer  
  XP_006509323 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168041 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168042 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009633 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009634 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB95162 (Get FASTA)   NCBI Sequence Viewer  
  AAH57133 (Get FASTA)   NCBI Sequence Viewer  
  AAH57855 (Get FASTA)   NCBI Sequence Viewer  
  AAM89113 (Get FASTA)   NCBI Sequence Viewer  
  AAM89114 (Get FASTA)   NCBI Sequence Viewer  
  AAM89115 (Get FASTA)   NCBI Sequence Viewer  
  AAM89116 (Get FASTA)   NCBI Sequence Viewer  
  AAM89117 (Get FASTA)   NCBI Sequence Viewer  
  AAM89118 (Get FASTA)   NCBI Sequence Viewer  
  BAE24568 (Get FASTA)   NCBI Sequence Viewer  
  BAE28786 (Get FASTA)   NCBI Sequence Viewer  
  BAE29767 (Get FASTA)   NCBI Sequence Viewer  
  BAE35298 (Get FASTA)   NCBI Sequence Viewer  
  BAE36325 (Get FASTA)   NCBI Sequence Viewer  
  BAE37002 (Get FASTA)   NCBI Sequence Viewer  
  BAE41053 (Get FASTA)   NCBI Sequence Viewer  
  CAA55476 (Get FASTA)   NCBI Sequence Viewer  
  EDL28642 (Get FASTA)   NCBI Sequence Viewer  
  EDL28643 (Get FASTA)   NCBI Sequence Viewer  
  P51791 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_031737   ⟸   NM_007711
- Peptide Label: isoform a
- UniProtKB: P51791 (UniProtKB/Swiss-Prot),   Q790S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_776301   ⟸   NM_173876
- Peptide Label: isoform c
- UniProtKB: Q8K4W8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_776299   ⟸   NM_173874
- Peptide Label: isoform e
- UniProtKB: Q3TF45 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_776298   ⟸   NM_173873
- Peptide Label: isoform b
- UniProtKB: P51791 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006509323   ⟸   XM_006509260
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006509322   ⟸   XM_006509259
- Peptide Label: isoform X1
- UniProtKB: E9Q2I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168041   ⟸   XM_017312552
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017168042   ⟸   XM_017312553
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSMUSP00000105930   ⟸   ENSMUST00000110301
RefSeq Acc Id: ENSMUSP00000105931   ⟸   ENSMUST00000110302
RefSeq Acc Id: ENSMUSP00000091202   ⟸   ENSMUST00000093490
RefSeq Acc Id: ENSMUSP00000058648   ⟸   ENSMUST00000056508
RefSeq Acc Id: ENSMUSP00000004430   ⟸   ENSMUST00000004430
RefSeq Acc Id: XP_036009634   ⟸   XM_036153741
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036009633   ⟸   XM_036153740
- Peptide Label: isoform X2
Protein Domains
CBS

Promoters
RGD ID:8667141
Promoter ID:EPDNEW_M11601
Type:initiation region
Name:Clcn3_2
Description:Mus musculus chloride channel, voltage-sensitive 3 , transcriptvariant b, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11602  EPDNEW_M11603  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38860,954,770 - 60,954,830EPDNEW
RGD ID:8667143
Promoter ID:EPDNEW_M11602
Type:single initiation site
Name:Clcn3_3
Description:Mus musculus chloride channel, voltage-sensitive 3 , transcriptvariant b, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11601  EPDNEW_M11603  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38860,965,451 - 60,965,511EPDNEW
RGD ID:8667145
Promoter ID:EPDNEW_M11603
Type:initiation region
Name:Clcn3_1
Description:Mus musculus chloride channel, voltage-sensitive 3 , transcriptvariant b, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11601  EPDNEW_M11602  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38860,983,251 - 60,983,311EPDNEW
RGD ID:6842943
Promoter ID:MM_KWN:54489
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000053286
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,401,449 - 63,401,949 (-)MPROMDB
RGD ID:6842941
Promoter ID:MM_KWN:54490
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Brain,   ES_Cell,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000110302,   OTTMUST00000053284,   OTTMUST00000053290,   OTTMUST00000053291
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,433,189 - 63,433,689 (-)MPROMDB
RGD ID:6842821
Promoter ID:MM_KWN:54492
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK050074_B230317F23RIK,   NM_007711,   NM_173873,   NM_173874,   UC009LTP.1,   UC009LTQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36863,461,916 - 63,462,416 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103555 AgrOrtholog
Ensembl Genes ENSMUSG00000004319 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000004430 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000058648 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000091202 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000105930 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000105931 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000004430 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000056508 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000093490 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000110301 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000110302 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl_channel-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12725 UniProtKB/Swiss-Prot
MGD MGI:103555 ENTREZGENE
NCBI Gene 12725 ENTREZGENE
Pfam CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage_CLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clcn3 PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLCHANNEL3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.25263 ENTREZGENE
  Mm.259751 ENTREZGENE
UniProt A0A6Q6Q7B9_MOUSE UniProtKB/TrEMBL
  CLCN3_MOUSE UniProtKB/Swiss-Prot
  E9Q2I1 ENTREZGENE, UniProtKB/TrEMBL
  P51791 ENTREZGENE
  Q3TF45 ENTREZGENE
  Q3TTK0_MOUSE UniProtKB/TrEMBL
  Q3UEX5_MOUSE UniProtKB/TrEMBL
  Q6PEV2_MOUSE UniProtKB/TrEMBL
  Q6PGA5_MOUSE UniProtKB/TrEMBL
  Q790S0 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4W7_MOUSE UniProtKB/TrEMBL
  Q8K4W8 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4W9_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TF45 UniProtKB/Swiss-Prot
  Q8K4X0 UniProtKB/Swiss-Prot
  Q8K4X1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-20 Clcn3  chloride channel, voltage-sensitive 3    chloride channel 3  Symbol and/or name change 5135510 APPROVED