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Gene: GLRA1 (glycine receptor alpha 1) Homo sapiens
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Symbol: GLRA1
Name: glycine receptor alpha 1
Description: Exhibits several functions, including cation binding activity; extracellularly glycine-gated chloride channel activity; and taurine binding activity. Predicted to contribute to chloride channel activity. Involved in several processes, including cellular response to ethanol; cellular response to zinc ion; and negative regulation of transmission of nerve impulse. Localizes to integral component of plasma membrane and intracellular membrane-bounded organelle. Implicated in hyperekplexia 1.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-1; glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome); HKPX1; MGC138878; MGC138879; STHE
Orthologs:
Mus musculus (house mouse) : Glra1 (glycine receptor, alpha 1 subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Glra1 (glycine receptor, alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glra1 (glycine receptor alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GLRA1 (glycine receptor alpha 1)
Canis lupus familiaris (dog) : GLRA1 (glycine receptor alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glra1 (glycine receptor alpha 1)
Sus scrofa (pig) : GLRA1 (glycine receptor alpha 1)
Chlorocebus sabaeus (African green monkey) : GLRA1 (glycine receptor alpha 1)
Heterocephalus glaber (naked mole-rat) : Glra1 (glycine receptor alpha 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl5151,822,513 - 151,924,842 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl5151,822,513 - 151,924,851 (-)EnsemblGRCh38hg38GRCh38
GRCh385151,822,513 - 151,924,851 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375151,202,074 - 151,304,397 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,182,361 - 151,284,596 (-)NCBINCBI36hg18NCBI36
Build 345151,182,360 - 151,284,596NCBI
Celera5147,283,467 - 147,385,844 (-)NCBI
Cytogenetic Map5q33.1NCBI
HuRef5146,347,483 - 146,449,349 (-)NCBIHuRef
CHM1_15150,634,496 - 150,736,836 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GLRA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730939
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.