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Gene: Esrra (estrogen related receptor, alpha) Mus musculus
Symbol: Esrra
Name: estrogen related receptor, alpha
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Localizes to the nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human ESRRA (estrogen related receptor alpha); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 8-Br-cAMP.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ERR-alpha; Err1; ERRalpha; estrogen receptor related 1; estrogen receptor-like 1; estrogen-related receptor alpha; Estrra; Nr3b1; nuclear receptor subfamily 3 group B member 1; steroid hormone receptor ERR1; Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1)
Homo sapiens (human) : ESRRA (estrogen related receptor alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Esrra (estrogen related receptor, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Esrra (estrogen related receptor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : ESRRA (estrogen related receptor alpha)
Canis lupus familiaris (dog) : ESRRA (estrogen related receptor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Esrra (estrogen related receptor alpha)
Sus scrofa (pig) : ESRRA (estrogen related receptor alpha)
Chlorocebus sabaeus (green monkey) : ESRRA (estrogen related receptor alpha)
Heterocephalus glaber (naked mole-rat) : Esrra (estrogen related receptor alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl196,910,977 - 6,921,813 (-)Ensembl
GRCm38 Ensembl196,910,977 - 6,921,840 (-)Ensembl
GRCm38196,910,977 - 6,922,048 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37196,985,467 - 6,996,298 (-)NCBIGRCm37mm9NCBIm37
MGSCv36196,978,021 - 6,988,814 (-)NCBImm8
Celera196,687,756 - 6,698,743 (-)NCBICelera
Cytogenetic Map19 ANCBI
cM Map195.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Esrra
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730827
Created: 2003-12-10
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.