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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pde4c | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Pde4c (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PDE4C mRNA | CTD | PMID:36331819 | Pde4c | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Pde4c (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PDE4C mRNA | CTD | PMID:22206623 | Pde4c | Rat | 17beta-estradiol | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PDE4C mRNA | CTD | PMID:15849065 | Pde4c | Rat | 17beta-estradiol | multiple interactions | ISO | PDE4C (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of PDE4C mRNA and [Estradiol co-treated with TGFB1 protein] results in increased expression of PDE4C mRNA | CTD | PMID:20404318 and PMID:30165855 | Pde4c | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pde4c (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PDE4C mRNA | CTD | PMID:21570461 and PMID:26377647 | Pde4c | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PDE4C mRNA | CTD | PMID:30096437 | Pde4c | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pde4c (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PDE4C mRNA | CTD | PMID:27913140 | Pde4c | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PDE4C mRNA | CTD | PMID:27913140 | Pde4c | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | bisphenol S results in decreased expression of PDE4C mRNA | CTD | PMID:27685785 | Pde4c | Rat | actinomycin D | multiple interactions | ISO | PDE4C (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of PDE4C mRNA | CTD | PMID:38460933 | Pde4c | Rat | aflatoxin B1 | affects expression | ISO | PDE4C (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of PDE4C protein | CTD | PMID:20106945 | Pde4c | Rat | aflatoxin B1 | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of PDE4C mRNA | CTD | PMID:21632981 more ... | Pde4c | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PDE4C mRNA | CTD | PMID:16483693 | Pde4c | Rat | arsane | affects expression | ISO | PDE4C (Homo sapiens) | 6480464 | Arsenic affects the expression of PDE4C mRNA | CTD | PMID:18414638 | Pde4c | Rat | arsenic atom | affects expression | ISO | PDE4C (Homo sapiens) | 6480464 | Arsenic affects the expression of PDE4C mRNA | CTD | PMID:18414638 | Pde4c | Rat | arsenite(3-) | increases methylation | ISO | PDE4C (Homo sapiens) | 6480464 | arsenite results in increased methylation of PDE4C promoter | CTD | PMID:23974009 | Pde4c | Rat | benzo[a]pyrene | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PDE4C mRNA | CTD | PMID:20106945 more ... | Pde4c | Rat | benzo[a]pyrene | affects methylation | ISO | PDE4C (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PDE4C 3' UTR more ... | CTD | PMID:27901495 | Pde4c | Rat | benzo[a]pyrene | decreases methylation | ISO | PDE4C (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PDE4C exon | CTD | PMID:27901495 | Pde4c | Rat | benzo[e]pyrene | decreases methylation | ISO | PDE4C (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of PDE4C intron | CTD | PMID:30157460 | Pde4c | Rat | bisphenol A | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PDE4C mRNA | CTD | PMID:15223131 | Pde4c | Rat | bisphenol A | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PDE4C mRNA | CTD | PMID:31715268 | Pde4c | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PDE4C mRNA | CTD | PMID:25181051 more ... | Pde4c | Rat | bisphenol F | decreases expression | EXP | | 6480464 | 4 and 4'-bisphenol F results in decreased expression of PDE4C mRNA | CTD | PMID:26186136 | Pde4c | Rat | bisphenol F | decreases expression | ISO | Pde4c (Mus musculus) | 6480464 | bisphenol F results in decreased expression of PDE4C mRNA | CTD | PMID:38685157 | Pde4c | Rat | butan-1-ol | multiple interactions | ISO | PDE4C (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PDE4C mRNA | CTD | PMID:29432896 | Pde4c | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of PDE4C mRNA | CTD | PMID:19167457 | Pde4c | Rat | carbon nanotube | decreases expression | ISO | Pde4c (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Pde4c | Rat | CGP 52608 | multiple interactions | ISO | PDE4C (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PDE4C gene] | CTD | PMID:28238834 | Pde4c | Rat | chloropicrin | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | chloropicrin results in increased expression of PDE4C mRNA | CTD | PMID:26352163 and PMID:28476498 | Pde4c | Rat | cisplatin | multiple interactions | ISO | PDE4C (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of PDE4C mRNA and [Cisplatin co-treated with panobinostat] affects the expression of PDE4C mRNA | CTD | PMID:21791302 and PMID:27392435 | Pde4c | Rat | cisplatin | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Cisplatin results in increased expression of PDE4C mRNA | CTD | PMID:27392435 | Pde4c | Rat | copper(II) sulfate | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PDE4C mRNA | CTD | PMID:19549813 | Pde4c | Rat | dioxygen | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of PDE4C mRNA | CTD | PMID:26516004 | Pde4c | Rat | folic acid | decreases expression | ISO | Pde4c (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PDE4C mRNA | CTD | PMID:25629700 | Pde4c | Rat | formaldehyde | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PDE4C mRNA | CTD | PMID:23649840 | Pde4c | Rat | formaldehyde | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PDE4C mRNA | CTD | PMID:28937961 | Pde4c | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PDE4C mRNA | CTD | PMID:22061828 | Pde4c | Rat | inulin | multiple interactions | ISO | Pde4c (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of PDE4C mRNA | CTD | PMID:36331819 | Pde4c | Rat | methapyrilene | decreases methylation | ISO | PDE4C (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of PDE4C intron | CTD | PMID:30157460 | Pde4c | Rat | methotrexate | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Methotrexate results in increased expression of PDE4C mRNA | CTD | PMID:24449571 | Pde4c | Rat | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | Pde4c (Mus musculus) | 6480464 | Ethylnitrosourea results in increased mutagenesis of PDE4C mRNA | CTD | PMID:27776689 | Pde4c | Rat | Nutlin-3 | multiple interactions | ISO | PDE4C (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of PDE4C mRNA | CTD | PMID:38460933 | Pde4c | Rat | ozone | multiple interactions | ISO | Pde4c (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PDE4C mRNA | CTD | PMID:34911549 | Pde4c | Rat | panobinostat | multiple interactions | ISO | PDE4C (Homo sapiens) | 6480464 | [Cisplatin co-treated with panobinostat] affects the expression of PDE4C mRNA | CTD | PMID:21791302 | Pde4c | Rat | paracetamol | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PDE4C mRNA | CTD | PMID:22230336 and PMID:26690555 | Pde4c | Rat | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of PDE4C mRNA | CTD | PMID:18198484 | Pde4c | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Pde4c (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PDE4C mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of PDE4C mRNA | CTD | PMID:36331819 | Pde4c | Rat | picoxystrobin | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of PDE4C mRNA | CTD | PMID:33512557 | Pde4c | Rat | pyrimidifen | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | pyrimidifen results in decreased expression of PDE4C mRNA | CTD | PMID:33512557 | Pde4c | Rat | quercetin | increases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Quercetin results in increased expression of PDE4C mRNA | CTD | PMID:21632981 | Pde4c | Rat | roflumilast | decreases activity | ISO | PDE4C (Homo sapiens) | 6480464 | Roflumilast results in decreased activity of PDE4C protein | CTD | PMID:15901792 | Pde4c | Rat | silicon dioxide | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of PDE4C mRNA | CTD | PMID:23806026 | Pde4c | Rat | sodium arsenite | affects methylation | ISO | PDE4C (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of PDE4C gene | CTD | PMID:28589171 | Pde4c | Rat | sodium arsenite | increases expression | ISO | Pde4c (Mus musculus) | 6480464 | sodium arsenite results in increased expression of PDE4C mRNA | CTD | PMID:37682722 | Pde4c | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PDE4C mRNA | CTD | PMID:31150632 | Pde4c | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PDE4C mRNA | CTD | PMID:34492290 | Pde4c | Rat | titanium dioxide | decreases methylation | ISO | Pde4c (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of PDE4C gene | CTD | PMID:35295148 | Pde4c | Rat | triclosan | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Triclosan results in decreased expression of PDE4C mRNA | CTD | PMID:30510588 | Pde4c | Rat | triptonide | increases expression | ISO | Pde4c (Mus musculus) | 6480464 | triptonide results in increased expression of PDE4C mRNA | CTD | PMID:33045310 | Pde4c | Rat | valproic acid | increases methylation | ISO | PDE4C (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of PDE4C gene | CTD | PMID:29154799 | Pde4c | Rat | valproic acid | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PDE4C mRNA | CTD | PMID:23527032 | Pde4c | Rat | vorinostat | decreases expression | ISO | PDE4C (Homo sapiens) | 6480464 | vorinostat results in decreased expression of PDE4C mRNA | CTD | PMID:27188386 | |