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Gene: Pde4c (phosphodiesterase 4C) Rattus norvegicus
Symbol: Pde4c
Name: phosphodiesterase 4C
RGD ID: 727918
Description: Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to localize to several cellular components, including cilium; cytosol; and perinuclear region of cytoplasm. Orthologous to human PDE4C (phosphodiesterase 4C); PARTICIPATES IN protein kinase A (PKA) signaling pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cAMP-specific 3',5'-cyclic phosphodiesterase 4C; cAMP-specific 3,5-cyclic phosphodiesterase 4C; cAMP-specific 35-cyclic phosphodiesterase 4C; Dpde1; MGC188426; phosphodiesterase 4C, cAMP specific; phosphodiesterase 4C, cAMP-specific; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
Homo sapiens (human) : PDE4C (phosphodiesterase 4C)  HGNC  Alliance
Mus musculus (house mouse) : Pde4c (phosphodiesterase 4C, cAMP specific)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pde4c (phosphodiesterase 4C)
Pan paniscus (bonobo/pygmy chimpanzee) : PDE4C (phosphodiesterase 4C)
Canis lupus familiaris (dog) : PDE4C (phosphodiesterase 4C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pde4c (phosphodiesterase 4C)
Sus scrofa (pig) : PDE4C (phosphodiesterase 4C)
Chlorocebus sabaeus (African green monkey) : PDE4C (phosphodiesterase 4C)
Heterocephalus glaber (naked mole-rat) : Pde4c (phosphodiesterase 4C)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01620,442,305 - 20,466,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,442,609 - 20,460,959 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,462,609 - 20,466,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,298,910 - 20,318,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,197,277 - 19,215,627 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,197,497 - 19,200,188 (-)NCBI
Celera1618,903,793 - 18,907,574 (-)NCBICelera
Celera1618,883,915 - 18,902,144 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Pde4c
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727918
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.