Opn5 (opsin 5) - Rat Genome Database

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Gene: Opn5 (opsin 5) Rattus norvegicus
Analyze
Symbol: Opn5
Name: opsin 5
RGD ID: 727869
Description: Predicted to enable 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Predicted to be involved in several processes, including cellular response to UV; entrainment of circadian clock by photoperiod; and hyaloid vascular plexus regression. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human OPN5 (opsin 5); INTERACTS WITH bisphenol A; cadmium dichloride; arsane (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: G protein-coupled receptor 136; Gpr136; opsin-5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2918,368,393 - 18,416,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,368,416 - 18,415,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx926,956,058 - 27,004,844 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0932,030,602 - 32,079,396 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0930,316,445 - 30,365,243 (+)NCBIRnor_WKY
Rnor_6.0921,045,457 - 21,092,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl921,045,457 - 21,093,172 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,906,290 - 19,953,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4914,124,601 - 14,171,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1914,121,922 - 14,169,169 (+)NCBI
Celera916,070,854 - 16,117,985 (+)NCBICelera
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, etal., FEBS Lett 2003 Nov 20;554(3):381-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22022612   PMID:22043319   PMID:24403072  


Genomics

Comparative Map Data
Opn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2918,368,393 - 18,416,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl918,368,416 - 18,415,476 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx926,956,058 - 27,004,844 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0932,030,602 - 32,079,396 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0930,316,445 - 30,365,243 (+)NCBIRnor_WKY
Rnor_6.0921,045,457 - 21,092,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl921,045,457 - 21,093,172 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0919,906,290 - 19,953,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4914,124,601 - 14,171,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1914,121,922 - 14,169,169 (+)NCBI
Celera916,070,854 - 16,117,985 (+)NCBICelera
Cytogenetic Map9q13NCBI
OPN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38647,782,032 - 47,826,381 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl647,781,982 - 47,832,780 (+)EnsemblGRCh38hg38GRCh38
GRCh37647,749,768 - 47,794,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36647,857,757 - 47,902,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 34647,857,756 - 47,900,394NCBI
Celera649,306,026 - 49,350,372 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef647,477,682 - 47,522,032 (+)NCBIHuRef
CHM1_1647,752,716 - 47,797,055 (+)NCBICHM1_1
T2T-CHM13v2.0647,623,816 - 47,668,165 (+)NCBIT2T-CHM13v2.0
Opn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391742,867,670 - 42,922,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1742,867,674 - 42,922,286 (-)EnsemblGRCm39 Ensembl
GRCm381742,556,779 - 42,611,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1742,556,783 - 42,611,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv371742,693,732 - 42,748,262 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361742,020,267 - 42,074,797 (-)NCBIMGSCv36mm8
Celera1745,969,490 - 46,026,568 (-)NCBICelera
Cytogenetic Map17B3NCBI
Opn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543712,171,544 - 12,213,264 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543712,171,544 - 12,197,409 (+)NCBIChiLan1.0ChiLan1.0
OPN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1658,143,792 - 58,186,587 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0647,364,955 - 47,409,199 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1648,628,456 - 48,672,673 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl648,628,478 - 48,658,119 (+)Ensemblpanpan1.1panPan2
OPN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11215,831,311 - 15,858,121 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1215,831,311 - 15,877,721 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1215,797,418 - 15,824,184 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01216,333,888 - 16,360,664 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1216,333,888 - 16,380,319 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11215,843,016 - 15,869,767 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,935,312 - 15,964,118 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01216,083,053 - 16,111,818 (+)NCBIUU_Cfam_GSD_1.0
Opn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494651,193,882 - 51,223,130 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647612,722,563 - 12,766,512 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493647612,740,038 - 12,766,310 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl742,476,125 - 42,527,121 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1742,476,125 - 42,507,181 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
OPN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11724,478,464 - 24,509,720 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1724,478,672 - 24,508,814 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604447,794,660 - 47,840,617 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Opn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,307,738 - 13,332,287 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475413,307,738 - 13,332,287 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Opn5
348 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:33
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000031759
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat

Markers in Region
AU048761  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2918,384,254 - 18,384,424 (+)MAPPERmRatBN7.2
Rnor_6.0921,061,297 - 21,061,466NCBIRnor6.0
Rnor_5.0919,922,312 - 19,922,481UniSTSRnor5.0
RGSC_v3.4914,140,627 - 14,140,796UniSTSRGSC3.4
Celera916,086,765 - 16,086,934UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system appendage
High
Medium
Low
Below cutoff 1 1 1 1 1 1 1 12 19 5 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031759   ⟹   ENSRNOP00000030570
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl918,368,416 - 18,415,476 (+)Ensembl
Rnor_6.0 Ensembl921,045,457 - 21,093,172 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106707   ⟹   ENSRNOP00000080812
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl918,368,416 - 18,415,418 (+)Ensembl
RefSeq Acc Id: NM_001389270   ⟹   NP_001376199
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2918,368,393 - 18,416,098 (+)NCBI
RefSeq Acc Id: XM_039083542   ⟹   XP_038939470
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2918,368,416 - 18,415,493 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001376199 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939470 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP72140 (Get FASTA)   NCBI Sequence Viewer  
  EDM18681 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000030570   ⟸   ENSRNOT00000031759
RefSeq Acc Id: NP_001376199   ⟸   NM_001389270
- UniProtKB: A0A8I5ZTV0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038939470   ⟸   XM_039083542
- Peptide Label: isoform X1
- UniProtKB: A0A8J8YD44 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080812   ⟸   ENSRNOT00000106707
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQN6-F1-model_v2 AlphaFold Q7TQN6 1-534 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727869 AgrOrtholog
BioCyc Gene G2FUF-28093 BioCyc
Ensembl Genes ENSRNOG00000012689 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000030570 ENTREZGENE
  ENSRNOP00000030570.6 UniProtKB/TrEMBL
  ENSRNOP00000080812 ENTREZGENE
  ENSRNOP00000080812.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031759 ENTREZGENE
  ENSRNOT00000031759.6 UniProtKB/TrEMBL
  ENSRNOT00000106707 ENTREZGENE
  ENSRNOT00000106707.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Peropsin UniProtKB/TrEMBL
  Retinal_BS UniProtKB/TrEMBL
NCBI Gene 316259 ENTREZGENE
PANTHER OPSIN UniProtKB/TrEMBL
  OPSIN-5 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Opn5 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PEROPSIN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
  OPSIN UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I5ZTV0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8YD44 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQN6_RAT UniProtKB/TrEMBL
UniProt Secondary E9PTI9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Opn5  opsin 5  Gpr136  G protein-coupled receptor 136  Symbol and Name updated 1299863 APPROVED