Zp3r (zona pellucida 3 receptor) - Rat Genome Database

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Gene: Zp3r (zona pellucida 3 receptor) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zp3r
Name: zona pellucida 3 receptor
RGD ID: 727846
Description: Involved in binding activity of sperm to zona pellucida. Located in acrosomal matrix.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100911214; MGC94417; sp56; sperm fertilization protein 56; zona pellucida sperm-binding protein 3 receptor; zona pellucida sperm-binding protein 3 receptor-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,572,283 - 44,617,101 (-)NCBIGRCr8
mRatBN7.21342,019,998 - 42,064,836 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,020,018 - 42,064,812 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1344,623,937 - 44,671,831 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01345,912,065 - 45,959,976 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,159,396 - 43,204,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,286,375 - 47,331,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,286,393 - 47,331,187 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,375,709 - 52,420,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,497,114 - 43,542,044 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,511,156 - 43,556,087 (-)NCBI
Celera1342,371,213 - 42,416,046 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning of rat sp56, the homologue of mouse sperm ZP3 receptor-sp56. He XB, etal., Cell Res 2003 Apr;13(2):121-9.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Zp3r
272 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:131
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000035577, ENSRNOT00000049915
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 7
Low 1
Below cutoff 1 1 2 2 3 2 1

Sequence


RefSeq Acc Id: ENSRNOT00000035577   ⟹   ENSRNOP00000031964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,020,018 - 42,064,812 (-)Ensembl
Rnor_6.0 Ensembl1347,286,393 - 47,331,187 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000049915   ⟹   ENSRNOP00000048027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,020,018 - 42,064,812 (-)Ensembl
Rnor_6.0 Ensembl1347,286,393 - 47,331,187 (-)Ensembl
RefSeq Acc Id: NM_001270844   ⟹   NP_001257773
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,572,283 - 44,617,077 (-)NCBI
mRatBN7.21342,020,018 - 42,064,812 (-)NCBI
Rnor_6.01347,286,393 - 47,331,187 (-)NCBI
Rnor_5.01352,375,709 - 52,420,503 (-)NCBI
Celera1342,371,213 - 42,416,046 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270845   ⟹   NP_001257774
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,572,283 - 44,617,077 (-)NCBI
mRatBN7.21342,020,018 - 42,064,812 (-)NCBI
Rnor_6.01347,286,393 - 47,331,187 (-)NCBI
Rnor_5.01352,375,709 - 52,420,503 (-)NCBI
Celera1342,371,213 - 42,416,046 (-)NCBI
Sequence:
RefSeq Acc Id: NM_182815   ⟹   NP_877967
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,572,283 - 44,617,077 (-)NCBI
mRatBN7.21342,020,018 - 42,064,812 (-)NCBI
Rnor_6.01347,286,393 - 47,331,187 (-)NCBI
Rnor_5.01352,375,709 - 52,420,503 (-)NCBI
RGSC_v3.41343,497,114 - 43,542,044 (-)RGD
Celera1342,371,213 - 42,416,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249713   ⟹   XP_006249775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,572,283 - 44,617,101 (-)NCBI
mRatBN7.21342,019,998 - 42,064,836 (-)NCBI
Rnor_6.01347,286,375 - 47,331,213 (-)NCBI
Rnor_5.01352,375,709 - 52,420,503 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598691   ⟹   XP_017454180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,572,283 - 44,617,101 (-)NCBI
mRatBN7.21342,019,998 - 42,064,836 (-)NCBI
Rnor_6.01347,286,375 - 47,321,111 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272064   ⟹   XP_063128134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,572,283 - 44,617,099 (-)NCBI
RefSeq Acc Id: XM_063272065   ⟹   XP_063128135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,572,283 - 44,617,099 (-)NCBI
RefSeq Acc Id: NP_877967   ⟸   NM_182815
- Peptide Label: isoform 1 precursor
- UniProtKB: Q7TSY4 (UniProtKB/Swiss-Prot),   Q7TSY3 (UniProtKB/Swiss-Prot),   G3V902 (UniProtKB/TrEMBL),   A6IBY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257774   ⟸   NM_001270845
- Peptide Label: isoform 3 precursor
- UniProtKB: Q7TSY4 (UniProtKB/Swiss-Prot),   Q7TSY3 (UniProtKB/Swiss-Prot),   Q6AXW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257773   ⟸   NM_001270844
- Peptide Label: isoform 2
- UniProtKB: Q7TSY4 (UniProtKB/Swiss-Prot),   Q7TSY3 (UniProtKB/Swiss-Prot),   F7EUY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249775   ⟸   XM_006249713
- Peptide Label: isoform X1
- UniProtKB: Q7TSY4 (UniProtKB/Swiss-Prot),   Q7TSY3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454180   ⟸   XM_017598691
- Peptide Label: isoform X2
- UniProtKB: Q7TSY4 (UniProtKB/Swiss-Prot),   Q7TSY3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031964   ⟸   ENSRNOT00000035577
RefSeq Acc Id: ENSRNOP00000048027   ⟸   ENSRNOT00000049915
RefSeq Acc Id: XP_063128135   ⟸   XM_063272065
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128134   ⟸   XM_063272064
- Peptide Label: isoform X3
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSY4-F1-model_v2 AlphaFold Q7TSY4 1-577 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727846 AgrOrtholog
BioCyc Gene G2FUF-18373 BioCyc
Ensembl Genes ENSRNOG00000025862 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035577 ENTREZGENE
  ENSRNOT00000035577.7 UniProtKB/TrEMBL
  ENSRNOT00000049915 ENTREZGENE
  ENSRNOT00000049915.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.3730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.28.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134311 IMAGE-MGC_LOAD
InterPro C4bp_oligo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:289010 UniProtKB/TrEMBL
MGC_CLONE MGC:94417 IMAGE-MGC_LOAD
NCBI Gene 289010 ENTREZGENE
PANTHER COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZONA PELLUCIDA SPERM-BINDING PROTEIN 3 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C4bp_oligo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zp3r PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025862 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Complement_control_module UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IBY6 ENTREZGENE, UniProtKB/TrEMBL
  F7EUY5 ENTREZGENE, UniProtKB/TrEMBL
  G3V902 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXW5 ENTREZGENE, UniProtKB/TrEMBL
  Q7TSY3 ENTREZGENE
  Q7TSY4 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q7TSY3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Zp3r  zona pellucida 3 receptor  LOC100911214  zona pellucida sperm-binding protein 3 receptor-like  Data merged from RGD:6494291 737654 PROVISIONAL
2012-07-05 LOC100911214  zona pellucida sperm-binding protein 3 receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Zp3r  zona pellucida 3 receptor  sp56    Symbol updated 1299863 APPROVED