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Gene: Isca1 (iron-sulfur cluster assembly 1) Rattus norvegicus
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Symbol: Isca1
Name: iron-sulfur cluster assembly 1
Description: Predicted to have 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; ammonium chloride; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Hbld2; HESB like domain containing 2; HesB protein; HESB-like domain-containing protein 2; hIscA; iron sulfur assembly protein IscA; iron-sulfur assembly protein IscA; iron-sulfur cluster assembly 1 homolog (S. cerevisiae); iron-sulfur cluster assembly 1 homolog, mitochondrial; LOC290985
Orthologs:
Homo sapiens (human) : ISCA1 (iron-sulfur cluster assembly 1)  HGNC  Alliance
Mus musculus (house mouse) : Isca1 (iron-sulfur cluster assembly 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isca1 (iron-sulfur cluster assembly 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ISCA1 (iron-sulfur cluster assembly 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isca1 (iron-sulfur cluster assembly 1)
more info ...
Related Pseudogenes: Isca1-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0175,281,727 - 5,294,386 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl175,281,727 - 5,294,384 (+)Ensembl
Rnor_5.0177,507,069 - 7,519,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41710,808,966 - 10,821,681 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11710,808,965 - 10,821,679 (+)NCBI
Celera175,026,823 - 5,039,495 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Isca1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 727792
Created: 2003-11-05
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.