ANKRD66 (ankyrin repeat domain 66) - Rat Genome Database

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Gene: ANKRD66 (ankyrin repeat domain 66) Homo sapiens
Analyze
Symbol: ANKRD66
Name: ankyrin repeat domain 66
RGD ID: 7204990
HGNC Page HGNC:44669
Description: Predicted to be located in nucleus; INTERACTS WITH 4,4'-sulfonyldiphenol; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin repeat domain-containing protein 66; hypothetical protein LOC100287718
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,746,933 - 46,759,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,746,933 - 46,759,506 (+)EnsemblGRCh38hg38GRCh38
GRCh37646,714,670 - 46,727,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera648,267,156 - 48,279,399 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef646,437,847 - 46,450,147 (+)NCBIHuRef
CHM1_1646,718,032 - 46,730,332 (+)NCBICHM1_1
T2T-CHM13v2.0646,584,578 - 46,597,154 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:14702039  


Genomics

Comparative Map Data
ANKRD66
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38646,746,933 - 46,759,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl646,746,933 - 46,759,506 (+)EnsemblGRCh38hg38GRCh38
GRCh37646,714,670 - 46,727,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera648,267,156 - 48,279,399 (+)NCBICelera
Cytogenetic Map6p12.3NCBI
HuRef646,437,847 - 46,450,147 (+)NCBIHuRef
CHM1_1646,718,032 - 46,730,332 (+)NCBICHM1_1
T2T-CHM13v2.0646,584,578 - 46,597,154 (+)NCBIT2T-CHM13v2.0
Ankrd66
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391743,845,064 - 43,862,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1743,845,079 - 43,854,530 (-)EnsemblGRCm39 Ensembl
GRCm381743,534,173 - 43,551,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1743,534,188 - 43,543,639 (-)EnsemblGRCm38mm10GRCm38
MGSCv371743,671,123 - 43,680,588 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361743,671,865 - 43,680,564 (-)NCBIMGSCv36mm8
Celera1746,956,886 - 46,966,446 (-)NCBICelera
Cytogenetic Map17B3NCBI
Ankrd66
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8924,918,206 - 24,938,481 (+)NCBIGRCr8
mRatBN7.2917,421,432 - 17,441,212 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl917,411,983 - 17,442,647 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0919,977,229 - 20,014,747 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl920,004,280 - 20,013,950 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0918,854,418 - 18,891,720 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4913,126,556 - 13,137,023 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera915,126,635 - 15,163,930 (+)NCBICelera
Cytogenetic Map9q13NCBI
Ankrd66
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543711,578,654 - 11,589,625 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543711,578,962 - 11,589,164 (+)NCBIChiLan1.0ChiLan1.0
ANKRD66
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2561,228,420 - 61,254,637 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1657,107,378 - 57,120,832 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0646,315,851 - 46,342,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1647,601,542 - 47,613,842 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl647,601,547 - 47,613,545 (+)Ensemblpanpan1.1panPan2
ANKRD66
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11214,919,258 - 14,933,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1214,937,679 - 14,964,857 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01215,406,287 - 15,433,566 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1215,419,492 - 15,433,402 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11214,921,757 - 14,948,839 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01215,010,484 - 15,037,960 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01215,156,998 - 15,184,215 (+)NCBIUU_Cfam_GSD_1.0
Ankrd66
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494650,362,485 - 50,374,136 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647613,586,805 - 13,610,694 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647613,586,570 - 13,611,981 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKRD66
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl741,543,392 - 41,559,558 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1741,542,801 - 41,558,939 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2748,204,111 - 48,220,133 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANKRD66
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11725,511,580 - 25,524,470 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604446,773,641 - 46,781,269 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ankrd66
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475413,883,280 - 13,889,576 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475413,882,530 - 13,896,741 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ANKRD66
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.1-12.3(chr6:44985760-47986838)x3 copy number gain See cases [RCV000135580] Chr6:44985760..47986838 [GRCh38]
Chr6:44953497..47954574 [GRCh37]
Chr6:45061475..48062533 [NCBI36]
Chr6:6p21.1-12.3		 likely pathogenic
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1		 pathogenic|uncertain significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p21.1-12.3(chr6:43636308-50947320)x1 copy number loss See cases [RCV000446897] Chr6:43636308..50947320 [GRCh37]
Chr6:6p21.1-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
GRCh37/hg19 6p12.3(chr6:46717940-46925746)x3 copy number gain not provided [RCV000682667] Chr6:46717940..46925746 [GRCh37]
Chr6:6p12.3		 likely benign
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_001162435.3(ANKRD66):c.-150C>T single nucleotide variant Inborn genetic diseases [RCV003292230] Chr6:46746937 [GRCh38]
Chr6:46714674 [GRCh37]
Chr6:6p12.3		 likely benign
GRCh37/hg19 6p21.1-12.3(chr6:43636308-50947320) copy number loss not specified [RCV002053568] Chr6:43636308..50947320 [GRCh37]
Chr6:6p21.1-12.3		 pathogenic
GRCh37/hg19 6p21.1-q12(chr6:43636308-64947206)x3 copy number gain not provided [RCV002221457] Chr6:43636308..64947206 [GRCh37]
Chr6:6p21.1-q12		 likely pathogenic
NM_001162435.3(ANKRD66):c.224G>A (p.Ser75Asn) single nucleotide variant Inborn genetic diseases [RCV002683653] Chr6:46753782 [GRCh38]
Chr6:46721519 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.-95G>T single nucleotide variant Inborn genetic diseases [RCV002865555] Chr6:46749897 [GRCh38]
Chr6:46717634 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.422G>A (p.Cys141Tyr) single nucleotide variant Inborn genetic diseases [RCV002883195] Chr6:46758752 [GRCh38]
Chr6:46726489 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.134G>A (p.Arg45Gln) single nucleotide variant Inborn genetic diseases [RCV002951288] Chr6:46752082 [GRCh38]
Chr6:46719819 [GRCh37]
Chr6:6p12.3		 likely benign
NM_001162435.3(ANKRD66):c.203C>G (p.Ala68Gly) single nucleotide variant Inborn genetic diseases [RCV002797536] Chr6:46753761 [GRCh38]
Chr6:46721498 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.181C>T (p.Arg61Trp) single nucleotide variant Inborn genetic diseases [RCV002763893] Chr6:46753739 [GRCh38]
Chr6:46721476 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.434A>G (p.Gln145Arg) single nucleotide variant Inborn genetic diseases [RCV002763618] Chr6:46758764 [GRCh38]
Chr6:46726501 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.551G>T (p.Gly184Val) single nucleotide variant Inborn genetic diseases [RCV002874232] Chr6:46758881 [GRCh38]
Chr6:46726618 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.-29C>A single nucleotide variant Inborn genetic diseases [RCV003197308] Chr6:46749963 [GRCh38]
Chr6:46717700 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.458G>A (p.Arg153His) single nucleotide variant Inborn genetic diseases [RCV003173987] Chr6:46758788 [GRCh38]
Chr6:46726525 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.274A>G (p.Ile92Val) single nucleotide variant Inborn genetic diseases [RCV003190614] Chr6:46753832 [GRCh38]
Chr6:46721569 [GRCh37]
Chr6:6p12.3		 likely benign
NM_001162435.3(ANKRD66):c.338C>T (p.Pro113Leu) single nucleotide variant Inborn genetic diseases [RCV003370883] Chr6:46753896 [GRCh38]
Chr6:46721633 [GRCh37]
Chr6:6p12.3		 uncertain significance
NM_001162435.3(ANKRD66):c.301G>A (p.Ala101Thr) single nucleotide variant Inborn genetic diseases [RCV003370879] Chr6:46753859 [GRCh38]
Chr6:46721596 [GRCh37]
Chr6:6p12.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1225
Count of miRNA genes:726
Interacting mature miRNAs:812
Transcripts:ENST00000445060, ENST00000536046, ENST00000565422
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 5 9 16
Low 2 5 2 226 1 46 252
Below cutoff 285 332 447 65 351 38 701 224 1892 26 690 481 27 238 395

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000445060   ⟹   ENSP00000457147
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl646,753,746 - 46,758,424 (+)Ensembl
RefSeq Acc Id: ENST00000565422   ⟹   ENSP00000454770
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl646,746,933 - 46,759,506 (+)Ensembl
RefSeq Acc Id: NM_001162435   ⟹   NP_001155907
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,746,933 - 46,759,506 (+)NCBI
GRCh37646,714,654 - 46,726,955 (+)NCBI
HuRef646,437,847 - 46,450,147 (+)NCBI
CHM1_1646,718,032 - 46,730,332 (+)NCBI
T2T-CHM13v2.0646,584,578 - 46,597,154 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017010148   ⟹   XP_016865637
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38646,746,933 - 46,758,714 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054353972   ⟹   XP_054209947
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0646,584,578 - 46,596,362 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001155907 (Get FASTA)   NCBI Sequence Viewer  
  XP_016865637 (Get FASTA)   NCBI Sequence Viewer  
  XP_054209947 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein B4E2M5 (Get FASTA)   NCBI Sequence Viewer  
  BAG65187 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000454770
  ENSP00000454770.2
  ENSP00000457147.1
Reference Protein Sequences
RefSeq Acc Id: NP_001155907   ⟸   NM_001162435
- UniProtKB: B4E2M5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016865637   ⟸   XM_017010148
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000457147   ⟸   ENST00000445060
RefSeq Acc Id: ENSP00000454770   ⟸   ENST00000565422
RefSeq Acc Id: XP_054209947   ⟸   XM_054353972
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B4E2M5-F1-model_v2 AlphaFold B4E2M5 1-196 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:44669 AgrOrtholog
COSMIC ANKRD66 COSMIC
Ensembl Genes ENSG00000230062 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000445060.1 UniProtKB/TrEMBL
  ENST00000565422 ENTREZGENE
  ENST00000565422.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000230062 GTEx
HGNC ID HGNC:44669 ENTREZGENE
Human Proteome Map ANKRD66 Human Proteome Map
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:100287718 UniProtKB/Swiss-Prot
NCBI Gene ANKRD66 ENTREZGENE
PANTHER ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ANK_REP_REGION DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot
  Ank_5 UniProtKB/TrEMBL
PharmGKB PA166049153 PharmGKB
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ANR66_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  H3BTF0_HUMAN UniProtKB/TrEMBL