FAM229A (family with sequence similarity 229 member A) - Rat Genome Database
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Gene: FAM229A (family with sequence similarity 229 member A) Homo sapiens
Analyze
Symbol: FAM229A
Name: family with sequence similarity 229 member A
RGD ID: 7204883
HGNC Page HGNC
Description: INTERACTS WITH cisplatin; clothianidin; leflunomide
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: family with sequence similarity 229, member A; uncharacterized protein LOC100128071
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl132,361,270 - 32,364,278 (-)EnsemblGRCh38hg38GRCh38
GRCh38132,361,270 - 32,362,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37132,826,871 - 32,827,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,597,776 - 32,600,431 (-)NCBINCBI36hg18NCBI36
Celera131,097,347 - 31,098,320 (-)NCBI
Cytogenetic Map1p35.1NCBI
HuRef130,942,251 - 30,943,224 (-)NCBIHuRef
CHM1_1132,942,319 - 32,943,292 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:14702039  


Genomics

Comparative Map Data
FAM229A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl132,361,270 - 32,364,278 (-)EnsemblGRCh38hg38GRCh38
GRCh38132,361,270 - 32,362,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37132,826,871 - 32,827,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36132,597,776 - 32,600,431 (-)NCBINCBI36hg18NCBI36
Celera131,097,347 - 31,098,320 (-)NCBI
Cytogenetic Map1p35.1NCBI
HuRef130,942,251 - 30,943,224 (-)NCBIHuRef
CHM1_1132,942,319 - 32,943,292 (-)NCBICHM1_1
Fam229a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394129,384,983 - 129,385,749 (+)NCBIGRCm39mm39
GRCm39 Ensembl4129,384,983 - 129,385,749 (+)Ensembl
GRCm384129,491,190 - 129,491,956 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4129,491,190 - 129,491,956 (+)EnsemblGRCm38mm10GRCm38
MGSCv374129,168,434 - 129,169,200 (+)NCBIGRCm37mm9NCBIm37
MGSCv364128,993,503 - 128,994,509 (+)NCBImm8
Celera4127,832,331 - 127,833,097 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
Fam229a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25141,829,716 - 141,830,705 (+)NCBI
Rnor_6.0 Ensembl5147,692,391 - 147,693,380 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05147,692,391 - 147,693,380 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05151,413,457 - 151,414,446 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,647,727 - 148,648,716 (+)NCBIRGSC3.4rn4RGSC3.4
Celera5140,305,249 - 140,306,238 (+)NCBICelera
Cytogenetic Map5q36NCBI
FAM229A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1132,652,878 - 32,653,593 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0131,646,769 - 31,648,924 (-)NCBIMhudiblu_PPA_v0panPan3
FAM229A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,876,345 - 68,877,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,874,679 - 68,877,498 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,456,119 - 65,458,552 (+)NCBI
ROS_Cfam_1.0269,441,836 - 69,444,270 (+)NCBI
UMICH_Zoey_3.1266,278,787 - 66,281,219 (+)NCBI
UNSW_CanFamBas_1.0267,275,135 - 67,276,743 (+)NCBI
UU_Cfam_GSD_1.0268,272,945 - 68,275,415 (+)NCBI
Fam229a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440505849,548,182 - 49,549,136 (-)NCBI
SpeTri2.0NW_00493647415,372,964 - 15,373,976 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM229A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1688,808,634 - 88,813,694 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2682,643,517 - 82,645,264 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM229A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120100,501,348 - 100,502,313 (+)NCBI
ChlSab1.1 Ensembl20100,501,500 - 100,502,153 (+)Ensembl
Fam229a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476415,571,768 - 15,572,782 (-)NCBI

Position Markers
RH102214  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37132,828,952 - 32,829,131UniSTSGRCh37
Build 36132,601,539 - 32,601,718RGDNCBI36
Celera131,099,428 - 31,099,607RGD
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map1p35-p34UniSTS
HuRef130,944,332 - 30,944,511UniSTS
GeneMap99-GB4 RH Map194.68UniSTS
GDB:315593  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37132,826,412 - 32,826,588UniSTSGRCh37
Build 36132,598,999 - 32,599,175RGDNCBI36
Celera131,096,876 - 31,097,064RGD
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map1p35.1UniSTS
HuRef130,941,788 - 30,941,968UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1310
Count of miRNA genes:622
Interacting mature miRNAs:690
Transcripts:ENST00000415596, ENST00000416512, ENST00000428500, ENST00000432622
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1006 697 1023 173 756 90 1906 463 1371 75 1071 1014 84 508 1192 2
Low 1426 2272 690 440 1138 365 2436 1712 2337 321 373 586 86 696 1589 1
Below cutoff 1 15 11 9 50 9 13 19 9 22 7 8 2 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000415596
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,361,729 - 32,364,278 (-)Ensembl
RefSeq Acc Id: ENST00000416512
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,361,271 - 32,364,223 (-)Ensembl
RefSeq Acc Id: ENST00000428500   ⟹   ENSP00000454338
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,361,298 - 32,361,824 (-)Ensembl
RefSeq Acc Id: ENST00000432622   ⟹   ENSP00000455971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl132,361,270 - 32,362,243 (-)Ensembl
RefSeq Acc Id: NM_001167676   ⟹   NP_001161148
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38132,361,270 - 32,362,243 (-)NCBI
GRCh37132,826,871 - 32,827,844 (-)NCBI
HuRef130,942,251 - 30,943,224 (-)NCBI
CHM1_1132,942,319 - 32,943,292 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001161148 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EAX07533 (Get FASTA)   NCBI Sequence Viewer  
  H3BQW9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001161148   ⟸   NM_001167676
- UniProtKB: H3BQW9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000454338   ⟸   ENST00000428500
RefSeq Acc Id: ENSP00000455971   ⟸   ENST00000432622


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p35.2-35.1(chr1:31122108-32402160)x3 copy number gain See cases [RCV000051802] Chr1:31122108..32402160 [GRCh38]
Chr1:31594955..32867761 [GRCh37]
Chr1:31367542..32640348 [NCBI36]
Chr1:1p35.2-35.1		 pathogenic
GRCh38/hg38 1p35.2-35.1(chr1:30766758-33359428)x1 copy number loss See cases [RCV000053802] Chr1:30766758..33359428 [GRCh38]
Chr1:31239605..33825029 [GRCh37]
Chr1:31012192..33597616 [NCBI36]
Chr1:1p35.2-35.1		 pathogenic
GRCh38/hg38 1p35.3-35.1(chr1:28424867-33122854)x1 copy number loss See cases [RCV000135447] Chr1:28424867..33122854 [GRCh38]
Chr1:28751378..33588455 [GRCh37]
Chr1:28623965..33361042 [NCBI36]
Chr1:1p35.3-35.1		 pathogenic
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p35.1(chr1:32608682-32953541)x3 copy number gain not provided [RCV000684559] Chr1:32608682..32953541 [GRCh37]
Chr1:1p35.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p35.2-34.3(chr1:31562164-37421958)x3 copy number gain not provided [RCV000748949] Chr1:31562164..37421958 [GRCh37]
Chr1:1p35.2-34.3		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
GRCh37/hg19 1p35.2-35.1(chr1:30819875-34380419)x3 copy number gain not provided [RCV001005079] Chr1:30819875..34380419 [GRCh37]
Chr1:1p35.2-35.1		 likely pathogenic
GRCh37/hg19 1p35.2-35.1(chr1:32139063-32940848)x4 copy number gain not provided [RCV000846712] Chr1:32139063..32940848 [GRCh37]
Chr1:1p35.2-35.1		 uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:44652 AgrOrtholog
COSMIC FAM229A COSMIC
Ensembl Genes ENSG00000225828 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000454338 UniProtKB/TrEMBL
  ENSP00000455971 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000428500 UniProtKB/TrEMBL
  ENST00000432622 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000225828 GTEx
HGNC ID HGNC:44652 ENTREZGENE
Human Proteome Map FAM229A Human Proteome Map
InterPro FAM229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:100128071 UniProtKB/Swiss-Prot
NCBI Gene FAM229A ENTREZGENE
PANTHER PTHR35355 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam UPF0731 UniProtKB/Swiss-Prot
PharmGKB PA166049148 PharmGKB
UniProt F229A_HUMAN UniProtKB/Swiss-Prot
  H3BMD6_HUMAN UniProtKB/TrEMBL
  H3BQW9 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 FAM229A  family with sequence similarity 229 member A    family with sequence similarity 229, member A  Symbol and/or name change 5135510 APPROVED