Hnmt (histamine N-methyltransferase) - Rat Genome Database

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Gene: Hnmt (histamine N-methyltransferase) Rattus norvegicus
Analyze
Symbol: Hnmt
Name: histamine N-methyltransferase
RGD ID: 71049
Description: Enables histamine N-methyltransferase activity. Involved in several processes, including histamine metabolic process; response to cocaine; and response to interleukin-1. Predicted to be located in centrosome; cytoplasm; and nucleoplasm. Predicted to be active in cytosol. Used to study brain infarction. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive intellectual developmental disorder 51; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; homocysteine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HMT; MGC105411
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.236,591,804 - 6,623,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,591,463 - 6,624,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx39,674,061 - 9,706,077 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,260,252 - 18,292,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,450,071 - 16,482,087 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03905,111 - 937,038 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3904,765 - 937,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03896,736 - 928,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,057,938 - 2,089,955 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,057,591 - 2,090,146 (-)NCBI
Celera31,418,360 - 1,450,377 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
caspofungin  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
GW 4064  (ISO)
Heliotrine  (ISO)
histamine  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
maneb  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methylmercury chloride  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (ISO)
nicardipine  (EXP)
nickel atom  (ISO)
nifedipine  (EXP)
O-methyleugenol  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (ISO)
cytoplasm  (ISO,ISS)
cytosol  (ISO,TAS)
nucleoplasm  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reduction of the infarct size by simultaneous administration of L-histidine and diphenhydramine in ischaemic rat brains. Adachi N, etal., Resuscitation. 2011 Feb;82(2):219-21. Epub 2010 Dec 4.
2. Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson's disease. Agundez JA, etal., Neuromolecular Med. 2008;10(1):10-6. Epub 2007 Nov 6.
3. Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives. Apelt J, etal., Pharmazie. 2005 Feb;60(2):97-106.
4. Rat histamine N-methyltransferase. Quantification, tissue distribution, purification, and immunologic properties. Bowsher RR, etal., J Biol Chem. 1983 Oct 25;258(20):12215-20.
5. No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. Deindl P, etal., Pediatr Allergy Immunol. 2005 Feb;16(1):40-2.
6. Inhibition of rat kidney histamine-N-methyltransferase by biogenic amines. Fuhr N and Kownatzki E, Pharmacology. 1986;32(2):114-20.
7. Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis. Garcia-Martin E, etal., Clin Exp Allergy. 2007 Aug;37(8):1175-82.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Variability of the L-Histidine decarboxylase gene in allergic rhinitis. Gervasini G, etal., Allergy. 2010 Dec;65(12):1576-84. doi: 10.1111/j.1398-9995.2010.02425.x.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Horton JR, etal., Structure (Camb) 2001 Sep;9(9):837-49.
12. Effect of cocaine on the histaminergic neuron system in the rat brain. Ito C, etal., J Neurochem. 1997 Aug;69(2):875-8.
13. Effects of the acute and chronic restraint stresses on the central histaminergic neuron system of Fischer rat. Ito C, etal., Neurosci Lett. 1999 Mar 5;262(2):143-5.
14. Hypothalamic neuronal histamine modulates physiological responses induced by interleukin-1 beta. Kang M, etal., Am J Physiol. 1995 Dec;269(6 Pt 2):R1308-13.
15. Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor. Keeling BH, etal., Parkinsonism Relat Disord. 2010 Feb;16(2):112-4. Epub 2009 Sep 20.
16. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
17. Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children. Kennedy MJ, etal., Pharmacotherapy. 2008 Dec;28(12):1495-501.
18. Causal relationship between a tumour growth and the changes in histamine metabolism in tissues of sarcoma-bearing rat. Kierska D, etal., Agents Actions. 1987 Apr;20(3-4):314-6.
19. Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease. Kim SH, etal., Neurosci Lett. 2002 Mar 22;321(3):169-72.
20. Genomic structure of the rat and mouse histamine N-methyltransferase gene. Kitanaka N, etal., Jpn J Pharmacol 2002 Jan;88(1):85-92.
21. Developmental characteristics of histamine methyltransferase and phenylethanolamine-N-methyl-transferase of rat brain. Kouvelas ED, etal., Experientia. 1976 Sep 15;32(9):1136-8.
22. The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor. Ledesma MC, etal., Neuromolecular Med. 2008;10(4):356-61. Epub 2008 Jun 10.
23. No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease. Marasovic-Susnjara I, etal., Neurosci Lett. 2011 Feb 4;489(2):119-21. Epub 2010 Dec 5.
24. Gene Data Set MGD Curation, June 12, 2002
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Reduction in brain infarction by augmentation of central histaminergic activity in rats. Motoki A, etal., Brain Res. 2005 Dec 20;1066(1-2):172-8. Epub 2005 Dec 5.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD. Schulze HA, etal., Genes Immun. 2008 Apr;9(3):240-8. Epub 2008 Mar 13.
35. Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. Sharma S, etal., J Hum Genet. 2005;50(12):611-7. Epub 2005 Oct 5.
36. Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study. Szczepankiewicz A, etal., Clin Mol Allergy. 2010 Nov 1;8:14.
37. Histamine N-methyltransferase from rat kidney. Cloning, nucleotide sequence, and expression in Escherichia coli cells. Takemura M, etal., J Biol Chem 1992 Aug 5;267(22):15687-91.
38. Structural analysis of histamine N-methyltransferase gene. Takemura M, etal., Methods Find Exp Clin Pharmacol 1995 Nov;17 Suppl C:1-4.
39. Functional increase of brain histaminergic signaling in Huntington's disease. van Wamelen DJ, etal., Brain Pathol. 2011 Jul;21(4):419-27. doi: 10.1111/j.1750-3639.2010.00465.x. Epub 2010 Dec 27.
40. The effect of hypertonic saline administration or stalk transection on histamine and histamine N-methyltransferase in the rat posterior pituitary. Verburg KM, etal., Agents Actions. 1986 Aug;18(5-6):494-8.
41. Effect of in vivo glucocorticoid administration on histamine metabolism in rat brain synaptosomes. Walajtys-Rode E, etal., Neurosci Lett. 1989 Feb 27;97(3):340-4.
42. Histamine N-methyltransferase functional polymorphism: lack of association with schizophrenia. Yan L, etal., Am J Med Genet. 2000 Jun 12;96(3):404-6.
43. Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. Yan L, etal., Pharmacogenetics. 2000 Apr;10(3):261-6.
Additional References at PubMed
PMID:11475331   PMID:12477932   PMID:15489334   PMID:19056867   PMID:24270810   PMID:26206890  


Genomics

Comparative Map Data
Hnmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.236,591,804 - 6,623,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,591,463 - 6,624,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx39,674,061 - 9,706,077 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,260,252 - 18,292,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0316,450,071 - 16,482,087 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03905,111 - 937,038 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3904,765 - 937,102 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03896,736 - 928,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,057,938 - 2,089,955 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,057,591 - 2,090,146 (-)NCBI
Celera31,418,360 - 1,450,377 (-)NCBICelera
Cytogenetic Map3p13NCBI
HNMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,964,473 - 138,016,364 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2137,964,020 - 138,016,364 (+)EnsemblGRCh38hg38GRCh38
GRCh372138,722,043 - 138,773,934 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362138,438,278 - 138,490,404 (+)NCBINCBI36Build 36hg18NCBI36
Build 342138,555,539 - 138,605,968NCBI
Celera2132,435,248 - 132,487,397 (+)NCBICelera
Cytogenetic Map2q22.1NCBI
HuRef2130,713,418 - 130,765,454 (+)NCBIHuRef
CHM1_12138,726,296 - 138,778,405 (+)NCBICHM1_1
T2T-CHM13v2.02138,410,245 - 138,462,150 (+)NCBIT2T-CHM13v2.0
Hnmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,892,923 - 23,939,756 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,892,922 - 23,939,406 (-)EnsemblGRCm39 Ensembl
GRCm38224,002,911 - 24,049,758 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,002,910 - 24,049,394 (-)EnsemblGRCm38mm10GRCm38
MGSCv37223,858,431 - 23,904,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36223,824,929 - 23,871,385 (-)NCBIMGSCv36mm8
Celera223,732,675 - 23,779,256 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.06NCBI
Hnmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554405,084,081 - 5,139,348 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554405,084,198 - 5,137,577 (+)NCBIChiLan1.0ChiLan1.0
HNMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B36,926,108 - 36,976,706 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B21,840,342 - 21,892,744 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B142,036,321 - 142,088,315 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B142,036,321 - 142,088,315 (+)Ensemblpanpan1.1panPan2
HNMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11940,656,266 - 40,702,498 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1940,655,161 - 40,702,218 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1940,904,101 - 40,950,749 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01942,091,906 - 42,138,299 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1942,089,996 - 42,139,886 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11940,762,610 - 40,807,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01940,903,954 - 40,950,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01942,141,523 - 42,187,878 (+)NCBIUU_Cfam_GSD_1.0
Hnmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303103,451,547 - 103,494,746 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646938,122,454 - 38,166,398 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493646938,125,877 - 38,166,429 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1513,732,680 - 13,768,199 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11513,733,412 - 13,768,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21516,061,749 - 16,096,444 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11022,188,151 - 22,238,665 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1022,188,110 - 22,238,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040176,049,336 - 176,100,718 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hnmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473237,620,925 - 37,691,708 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473237,621,014 - 37,689,873 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hnmt
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:74
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000007471
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat

Markers in Region
RH130243  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.236,591,519 - 6,591,736 (+)MAPPERmRatBN7.2
Rnor_6.03904,827 - 905,043NCBIRnor6.0
Rnor_5.03896,452 - 896,668UniSTSRnor5.0
RGSC_v3.432,057,654 - 2,057,870UniSTSRGSC3.4
Celera31,418,076 - 1,418,292UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 25 17
Low 37 2 4
Below cutoff 2 14 6 9 6 3 3 6 2 27 7 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007471   ⟹   ENSRNOP00000007471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl36,591,463 - 6,624,012 (-)Ensembl
Rnor_6.0 Ensembl3904,765 - 937,102 (-)Ensembl
RefSeq Acc Id: NM_031044   ⟹   NP_112306
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.236,591,804 - 6,623,821 (-)NCBI
Rnor_6.03905,111 - 937,038 (-)NCBI
Rnor_5.03896,736 - 928,663 (-)NCBI
RGSC_v3.432,057,938 - 2,089,955 (-)RGD
Celera31,418,360 - 1,450,377 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_112306   ⟸   NM_031044
- UniProtKB: Q59JM9 (UniProtKB/Swiss-Prot),   Q01984 (UniProtKB/Swiss-Prot),   A6JSX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007471   ⟸   ENSRNOT00000007471

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01984-F1-model_v2 AlphaFold Q01984 1-295 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71049 AgrOrtholog
BioCyc Gene G2FUF-50525 BioCyc
BioCyc Pathway PWY-6181 [histamine degradation] BioCyc
Ensembl Genes ENSRNOG00000005223 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007471 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007471 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7319794 IMAGE-MGC_LOAD
InterPro HHMT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81676 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105411 IMAGE-MGC_LOAD
NCBI Gene 81676 ENTREZGENE
Pfam Methyltransf_23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HNMT RGD
PhenoGen Hnmt PhenoGen
PIRSF HHMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SAM_HNMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP S-adenosyl-L-methionine-dependent methyltransferases UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JSX2 ENTREZGENE, UniProtKB/TrEMBL
  A6JSX3_RAT UniProtKB/TrEMBL
  HNMT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q59JM9 ENTREZGENE
UniProt Secondary Q59JM9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Hnmt  histamine N-methyltransferase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference