Prlhr (prolactin releasing hormone receptor) - Rat Genome Database

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Gene: Prlhr (prolactin releasing hormone receptor) Rattus norvegicus
Analyze
Symbol: Prlhr
Name: prolactin releasing hormone receptor
RGD ID: 71037
Description: Enables G protein-coupled receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway and feeding behavior. Predicted to be located in membrane. Predicted to be active in cilium; neuron projection; and plasma membrane. Used to study obesity. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human PRLHR (prolactin releasing hormone receptor); PARTICIPATES IN obesity pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor 10; G-protein coupled receptor 10; Gpr10; prolactin-releasing peptide receptor; prRP receptor; prRPR; Uhr-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   BN.OLETF-(D1Rat169-D1Rat90)/Got  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,592,735 - 269,594,422 (-)NCBIGRCr8
mRatBN7.21259,606,704 - 259,608,391 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,606,704 - 259,608,391 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1267,812,258 - 267,813,943 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,518,288 - 274,519,973 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,171,127 - 267,172,814 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01281,754,472 - 281,756,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1281,754,724 - 281,756,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,097,316 - 289,099,003 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,068,380 - 267,070,067 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,279,424 - 267,281,112 (-)NCBI
Celera1255,251,200 - 255,252,887 (-)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
hypertension  (ISO)
obesity  (IAGP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (IEA,ISO)
membrane  (IEA)
neuron projection  (IBA)
plasma membrane  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Association between physical activity and blood pressure is modified by variants in the G-protein coupled receptor 10. Franks PW, etal., Hypertension. 2004 Feb;43(2):224-8. Epub 2003 Dec 22.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28.
5. Gene Data Set MGD Curation, June 12, 2002
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Expression of neuropeptide FF, prolactin-releasing peptide, and the receptor UHR1/GPR10 genes during embryogenesis in the rat. Nieminen ML, etal., Dev Dyn 2003 Mar;226(3):561-9.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Mutated G-protein-coupled receptor GPR10 is responsible for the hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat. Watanabe TK, etal., Clin Exp Pharmacol Physiol. 2005 May-Jun;32(5-6):355-66.
13. Sequence and tissue distribution of a candidate G-coupled receptor cloned from rat hypothalamus. Welch SK, etal., Biochem Biophys Res Commun 1995 Apr 17;209(2):606-13.
Additional References at PubMed
PMID:10498338   PMID:14742914   PMID:15752583   PMID:19540425   PMID:28154160  


Genomics

Comparative Map Data
Prlhr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81269,592,735 - 269,594,422 (-)NCBIGRCr8
mRatBN7.21259,606,704 - 259,608,391 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1259,606,704 - 259,608,391 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1267,812,258 - 267,813,943 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,518,288 - 274,519,973 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,171,127 - 267,172,814 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01281,754,472 - 281,756,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1281,754,724 - 281,756,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01289,097,316 - 289,099,003 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,068,380 - 267,070,067 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11267,279,424 - 267,281,112 (-)NCBI
Celera1255,251,200 - 255,252,887 (-)NCBICelera
Cytogenetic Map1q55NCBI
PRLHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810118,589,997 - 118,595,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10118,589,997 - 118,595,648 (-)EnsemblGRCh38hg38GRCh38
GRCh3710120,349,509 - 120,355,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,342,906 - 120,345,150 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410120,343,633 - 120,344,746NCBI
Celera10114,083,566 - 114,085,810 (-)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10113,981,999 - 113,984,243 (-)NCBIHuRef
CHM1_110120,637,272 - 120,639,516 (-)NCBICHM1_1
T2T-CHM13v2.010119,485,136 - 119,490,787 (-)NCBIT2T-CHM13v2.0
Prlhr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,454,079 - 60,457,907 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,455,170 - 60,456,742 (-)EnsemblGRCm39 Ensembl
GRCm381960,465,641 - 60,468,933 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,466,732 - 60,468,304 (-)EnsemblGRCm38mm10GRCm38
MGSCv371960,542,636 - 60,544,207 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361960,521,404 - 60,522,967 (-)NCBIMGSCv36mm8
Celera1962,669,595 - 62,671,166 (-)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
Prlhr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543123,192,018 - 23,193,130 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543123,192,018 - 23,193,130 (-)NCBIChiLan1.0ChiLan1.0
PRLHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28130,445,186 - 130,456,588 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110130,450,787 - 130,461,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010114,922,829 - 115,168,506 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110118,589,819 - 118,592,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10118,590,543 - 118,591,655 (-)Ensemblpanpan1.1panPan2
PRLHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12828,950,300 - 28,956,140 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2828,954,469 - 28,955,581 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2829,097,625 - 29,099,209 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02829,484,495 - 29,486,071 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,484,543 - 29,485,655 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,042,666 - 29,044,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,056,498 - 29,061,577 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,255,022 - 29,256,598 (-)NCBIUU_Cfam_GSD_1.0
Prlhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721317,378,820 - 17,384,205 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,180,436 - 8,181,548 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,177,111 - 8,181,663 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRLHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14128,614,131 - 128,619,457 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114128,617,352 - 128,619,419 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,132,093 - 140,134,255 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRLHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,399,821 - 111,402,946 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604872,660,323 - 72,667,180 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prlhr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473728,094,507 - 28,095,941 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473728,093,837 - 28,099,377 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prlhr
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:126
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000013170
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
737975Bw122Body weight QTL 1229.110.005body mass (VT:0001259)body weight (CMO:0000012)1258843780260122809Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat

Markers in Region
D1Bda66  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21259,606,801 - 259,606,940 (+)MAPPERmRatBN7.2
Rnor_6.01281,754,570 - 281,754,708NCBIRnor6.0
Rnor_5.01289,097,414 - 289,097,552UniSTSRnor5.0
RGSC_v3.41267,068,478 - 267,068,616UniSTSRGSC3.4
Celera1255,251,298 - 255,251,436UniSTS
Cytogenetic Map1q55UniSTS


Related Rat Strains
The following Strains have been annotated to Prlhr
BN.OLETF-(D1Rat169-D1Rat90)/Got    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 2 111 39 30 19 13 19 4 50 29 93 30 11

Sequence


Ensembl Acc Id: ENSRNOT00000013170   ⟹   ENSRNOP00000013170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1259,606,704 - 259,608,391 (-)Ensembl
Rnor_6.0 Ensembl1281,754,724 - 281,756,159 (-)Ensembl
RefSeq Acc Id: NM_139193   ⟹   NP_631932
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81269,592,735 - 269,594,422 (-)NCBI
mRatBN7.21259,606,704 - 259,608,391 (-)NCBI
Rnor_6.01281,754,472 - 281,756,159 (-)NCBI
Rnor_5.01289,097,316 - 289,099,003 (-)NCBI
RGSC_v3.41267,068,380 - 267,070,067 (-)RGD
Celera1255,251,200 - 255,252,887 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_631932 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB34129 (Get FASTA)   NCBI Sequence Viewer  
  EDL94576 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013170.3
GenBank Protein Q64121 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_631932   ⟸   NM_139193
- UniProtKB: Q64121 (UniProtKB/Swiss-Prot),   G3V791 (UniProtKB/TrEMBL),   A6JIA2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013170   ⟸   ENSRNOT00000013170
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64121-F1-model_v2 AlphaFold Q64121 1-370 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71037 AgrOrtholog
BioCyc Gene G2FUF-55231 BioCyc
Ensembl Genes ENSRNOG00000009922 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013170.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prolrel_pep_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246075 UniProtKB/Swiss-Prot
NCBI Gene 246075 ENTREZGENE
PANTHER NEUROPEPTIDE Y RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24235:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prlhr PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRPRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009922 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JIA2 ENTREZGENE, UniProtKB/TrEMBL
  G3V791 ENTREZGENE, UniProtKB/TrEMBL
  PRLHR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Prlhr  prolactin releasing hormone receptor  Gpr10  G protein-coupled receptor 10  Symbol and Name updated 1299863 APPROVED
2002-07-09 Gpr10  G protein-coupled receptor 10      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in pituitary, cerebellum, and hypothalamus 70750