Mepe (matrix extracellular phosphoglycoprotein) - Rat Genome Database
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Gene: Mepe (matrix extracellular phosphoglycoprotein) Rattus norvegicus
Analyze
Symbol: Mepe
Name: matrix extracellular phosphoglycoprotein
RGD ID: 71036
Description: Predicted to have extracellular matrix protein binding activity. Involved in regulation of bone remodeling. Predicted to localize to extracellular matrix. Orthologous to human MEPE (matrix extracellular phosphoglycoprotein); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: matrix extracellular phosphoglycoprotein with ASARM motif; matrix extracellular phosphoglycoprotein with ASARM motif (bone); OF45; osteoblast/osteocyte factor 45; osteoregulin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0146,782,011 - 6,793,561 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,782,012 - 6,793,558 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,770,080 - 6,781,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,529,356 - 6,540,902 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1146,529,355 - 6,540,902 (-)NCBI
Celera145,559,406 - 5,571,012 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12421822   PMID:15843468   PMID:19005008   PMID:19617624   PMID:22766095   PMID:24255709   PMID:27039006  


Genomics

Comparative Map Data
Mepe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0146,782,011 - 6,793,561 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,782,012 - 6,793,558 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,770,080 - 6,781,630 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,529,356 - 6,540,902 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1146,529,355 - 6,540,902 (-)NCBI
Celera145,559,406 - 5,571,012 (-)NCBICelera
Cytogenetic Map14p22NCBI
MEPE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl487,821,411 - 87,846,817 (+)EnsemblGRCh38hg38GRCh38
GRCh38487,821,398 - 87,846,817 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37488,742,563 - 88,767,969 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,973,164 - 88,986,968 (+)NCBINCBI36hg18NCBI36
Build 34489,111,317 - 89,125,121NCBI
Celera486,030,825 - 86,056,232 (+)NCBI
Cytogenetic Map4q22.1NCBI
HuRef484,488,173 - 84,513,583 (+)NCBIHuRef
CHM1_1488,719,339 - 88,744,756 (+)NCBICHM1_1
Mepe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,473,195 - 104,486,477 (+)NCBIGRCm39mm39
GRCm385104,325,329 - 104,338,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,325,329 - 104,338,611 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,754,348 - 104,767,630 (+)NCBIGRCm37mm9NCBIm37
MGSCv365104,565,678 - 104,578,858 (+)NCBImm8
MGSCv365101,920,930 - 101,938,649 (+)NCBImm8
Cytogenetic Map5E5NCBI
Mepe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554742,048,883 - 2,064,515 (-)NCBIChiLan1.0ChiLan1.0
MEPE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1490,838,938 - 90,864,338 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,838,938 - 90,864,332 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0480,125,612 - 80,139,539 (+)NCBIMhudiblu_PPA_v0panPan3
MEPE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3211,212,531 - 11,222,805 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13211,212,531 - 11,222,805 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mepe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936905284,849 - 297,297 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEPE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,186,888 - 131,198,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,186,563 - 131,198,418 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,416,700 - 140,430,560 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MEPE
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,201,916 - 36,216,446 (+)NCBI
Mepe
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248724,345,045 - 4,358,456 (+)NCBI

Position Markers
BE097139  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0146,791,857 - 6,792,051NCBIRnor6.0
Rnor_5.0146,779,926 - 6,780,120UniSTSRnor5.0
RGSC_v3.4146,539,198 - 6,539,392UniSTSRGSC3.4
Celera145,569,308 - 5,569,502UniSTS
Cytogenetic Map14p22UniSTS
RH 3.4 Map14114.9UniSTS
BE107579  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0146,782,057 - 6,782,232NCBIRnor6.0
Rnor_5.0146,770,126 - 6,770,301UniSTSRnor5.0
RGSC_v3.4146,529,398 - 6,529,573UniSTSRGSC3.4
Celera145,559,448 - 5,559,623UniSTS
Cytogenetic Map14p22UniSTS
RH 3.4 Map1488.2UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14127597761Rat
619619Rf4Renal disease susceptibility QTL 44.10.002total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14134403399Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14141333960Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14141333960Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14142766285Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14222782512680613Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14222782519230541Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14483323310729268Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14483323319909932Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14483323319909932Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14483323323004027Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14483323326466248Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14483323333040042Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:127
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000002927
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium
Low 1 23
Below cutoff 6 13 8 2 5 21 17 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002927   ⟹   ENSRNOP00000002927
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl146,782,012 - 6,793,558 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091558   ⟹   ENSRNOP00000074247
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl146,782,012 - 6,786,144 (-)Ensembl
RefSeq Acc Id: NM_024142   ⟹   NP_077056
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,782,015 - 6,793,561 (-)NCBI
Rnor_5.0146,770,080 - 6,781,630 (-)NCBI
RGSC_v3.4146,529,356 - 6,540,902 (-)RGD
Celera145,559,406 - 5,571,012 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250634   ⟹   XP_006250696
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,782,011 - 6,791,930 (-)NCBI
Rnor_5.0146,770,080 - 6,781,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006250635   ⟹   XP_006250697
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,782,011 - 6,787,954 (-)NCBI
Rnor_5.0146,770,080 - 6,781,630 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_077056   ⟸   NM_024142
- Peptide Label: precursor
- UniProtKB: Q9ES02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250696   ⟸   XM_006250634
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006250697   ⟸   XM_006250635
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K7K7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002927   ⟸   ENSRNOT00000002927
RefSeq Acc Id: ENSRNOP00000074247   ⟸   ENSRNOT00000091558

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699172
Promoter ID:EPDNEW_R9697
Type:single initiation site
Name:Mepe_1
Description:matrix extracellular phosphoglycoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,793,557 - 6,793,617EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 6770471 6770472 G C snv COP/CrCrl (MCW & UW), MR/N (KNAW), WAG/Rij (KNAW), DA/BklArbNsi (KNAW), F344/NSlc (KyushuU), IS-Tlk/Kyo (KyushuU), SBH/Ygl (MCW), ACI/N (KNAW), F344/NCrl (KNAW), FHL/EurMcwi (KNAW), LEC/Tj (KyushuU), ACI/EurMcwi (MCW), IS/Kyo (KyushuU), LE/Stm (Illumina) (KNAW), LEW/NCrl (KNAW), WN/N (KNAW), SDLEF7/Barth (UDEL), ACI/EurMcwi (KNAW), SBH/Ygl (KNAW), F344/NRrrc (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), LEW/Crl (KNAW), LE/Stm (KyushuU), F344/Stm (KyushuU), GH/OmrMcwi (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (KNAW), F344/Jcl (KyushuU), FHH/EurMcwi (MCW), F344/NRrrc (SOLiD) (KNAW), F344/NHsd (KNAW), F344/DuCrlCrlj (KyushuU), BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), MHS/Gib (KNAW), M520/N (KNAW), LE/OrlBarth (UDEL), Crl:SD (UDEL), HTX/Kyo (KyushuU), HWY/Slc (KyushuU)
14 6770899 6770900 T C snv FHH/EurMcwi (KNAW), FHH/EurMcwi (MCW), FHL/EurMcwi (KNAW), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), FHL/EurMcwi (MCW)
14 6771041 6771042 C G snv DOB/Oda (KyushuU), BUF/MNa (KyushuU), RCS/Kyo (KyushuU)
14 6771082 6771083 T C snv LE/Stm (SOLiD) (KNAW), LE/Stm (KyushuU), FHH/EurMcwi (KNAW), LE/Stm (Illumina) (KNAW), FHH/EurMcwi (MCW), LEC/Tj (KyushuU), FHL/EurMcwi (KNAW), FHL/EurMcwi (MCW)
14 6771353 6771354 C T snv DA/BklArbNsi (KNAW), Crl:SD (UDEL), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), IS/Kyo (KyushuU), F344/Stm (KyushuU), SBH/Ygl (MCW), F344/NCrl (KNAW), MHS/Gib (KNAW), SBH/Ygl (KNAW), M520/N (KNAW), WN/N (KNAW), BDIX.Cg-Tal/NemOda (KyushuU), COP/CrCrl (MCW & UW), MR/N (KNAW), F344/NRrrc (Illumina) (KNAW), F344/Jcl (KyushuU), GH/OmrMcwi (MCW), WAG/Rij (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NHsd (KNAW), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), IS-Tlk/Kyo (KyushuU), ACI/EurMcwi (MCW), HTX/Kyo (KyushuU), HWY/Slc (KyushuU), BDIX/NemOda (KyushuU), ACI/N (KNAW), ACI/EurMcwi (KNAW), LEW/NCrl (KNAW), LEW/Crl (KNAW)
14 6771502 6771503 G A snv F344/Jcl (KyushuU), F344/DuCrlCrlj (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), F344/Stm (KyushuU), F344/NRrrc (Illumina) (KNAW), LE/OrlBarth (UDEL), ACI/EurMcwi (KNAW), Crl:SD (UDEL), SDLEF7/Barth (UDEL), LEW/Crl (KNAW), ACI/N (KNAW), COP/CrCrl (MCW & UW), WN/N (KNAW), F344/NCrl (KNAW), F344/NSlc (KyushuU), HWY/Slc (KyushuU), IS/Kyo (KyushuU), LEW/NCrl (KNAW), DA/BklArbNsi (KNAW), SBH/Ygl (MCW), IS-Tlk/Kyo (KyushuU), SBH/Ygl (KNAW), MR/N (KNAW), F344/NHsd (KNAW), GH/OmrMcwi (MCW), HTX/Kyo (KyushuU), WAG/Rij (KNAW), F344/NRrrc (SOLiD) (KNAW), ACI/EurMcwi (MCW), M520/N (KNAW), BDIX/NemOda (KyushuU), MHS/Gib (KNAW)
14 6771550 6771551 G A snv HTX/Kyo (KyushuU), SBH/Ygl (KNAW), ACI/EurMcwi (KNAW), COP/CrCrl (MCW & UW), ACI/EurMcwi (MCW), HWY/Slc (KyushuU), IS/Kyo (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), F344/Jcl (KyushuU), F344/NSlc (KyushuU), IS-Tlk/Kyo (KyushuU), LE/OrlBarth (UDEL), F344/NHsd (KNAW), F344/NRrrc (SOLiD) (KNAW), MR/N (KNAW), MHS/Gib (KNAW), SBH/Ygl (MCW), DA/BklArbNsi (KNAW), F344/NRrrc (Illumina) (KNAW), F344/DuCrlCrlj (KyushuU), SDLEF7/Barth (UDEL), F344/NCrl (KNAW), WAG/Rij (KNAW), F344/Stm (KyushuU), Crl:SD (UDEL), WN/N (KNAW), M520/N (KNAW), LEW/Crl (KNAW), ACI/N (KNAW), GH/OmrMcwi (MCW), LEW/NCrl (KNAW)


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 6782402 6782403 G C snv CDR, LEW/Crl (RGD), CDS, ACI/EurMcwi (RGD), MR/N (MCW), SBH/Ygl (RGD), MHS/Gib (RGD), FHL/EurMcwi (RGD), WN/N (MCW), SBH/Ygl (MCW), FHL/EurMcwi (MCW), LE/Stm (RGD), F344/NCrl (RGD), LEW/NCrlBR (RGD), F344/NRrrc (MCW), ACI/N (MCW), WAG/Rij (RGD), ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), FHH/EurMcwi (MCW), FHH/EurMcwi (RGD)
14 6782830 6782831 T C snv FHH/EurMcwi (RGD), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), FHL/EurMcwi (RGD), LE/Stm (RGD)
14 6783013 6783014 T C snv FHL/EurMcwi (RGD), FHL/EurMcwi (MCW), LE/Stm (RGD), FHH/EurMcwi (MCW), FHH/EurMcwi (RGD)
14 6783284 6783285 C T snv ACI/N (MCW), MR/N (MCW), ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), LEW/Crl (RGD), F344/NRrrc (MCW), LEW/NCrlBR (RGD), SBH/Ygl (RGD), GH/OmrMcwi (MCW), MHS/Gib (RGD), CDR, CDS, WN/N (MCW), M520/N (MCW), F344/NCrl (RGD), SBH/Ygl (MCW), ACI/EurMcwi (RGD), WAG/Rij (RGD)
14 6783433 6783434 G A snv CDS, MHS/Gib (RGD), ACI/N (MCW), LEW/NCrlBR (RGD), WN/N (MCW), SBH/Ygl (MCW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), ACI/EurMcwi (MCW), M520/N (MCW), CDR, LEW/Crl (RGD), F344/NRrrc (MCW), ACI/EurMcwi (RGD), SBH/Ygl (RGD), F344/NCrl (RGD), MR/N (MCW), WAG/Rij (RGD)
14 6783481 6783482 G A snv GH/OmrMcwi (MCW), MR/N (MCW), ACI/EurMcwi (MCW), COP/CrCrl (MCW & UW), F344/NCrl (RGD), M520/N (MCW), ACI/N (MCW), CDS, CDR, WAG/Rij (RGD), ACI/EurMcwi (RGD), WN/N (MCW), SBH/Ygl (RGD), MHS/Gib (RGD), SBH/Ygl (MCW), F344/NRrrc (MCW), LEW/Crl (RGD), LEW/NCrlBR (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71036 AgrOrtholog
Ensembl Genes ENSRNOG00000002154 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000002927 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000074247 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002927 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000091558 ENTREZGENE, UniProtKB/TrEMBL
InterPro Osteoregulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79110 UniProtKB/Swiss-Prot
NCBI Gene 79110 ENTREZGENE
PANTHER PTHR16510 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Osteoregulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mepe PhenoGen
UniProt A0A0G2K7K7 ENTREZGENE
  A0A4X0UXX8_RAT UniProtKB/TrEMBL
  A0A4X0WLY2_RAT UniProtKB/TrEMBL
  MEPE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2K7K7 UniProtKB/Swiss-Prot
  D6C6P2 UniProtKB/Swiss-Prot
  Q8K3V0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-06 Mepe  matrix extracellular phosphoglycoprotein  Mepe  matrix extracellular phosphoglycoprotein with ASARM motif (bone)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Mepe  matrix extracellular phosphoglycoprotein with ASARM motif (bone)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a serine/glycine-rich secreted peptide containing numerous potential phosphorylation sites and one RGD sequence motif 70633
gene_expression expressed only in bone 70633