Cdc5l (cell division cycle 5-like) - Rat Genome Database

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Gene: Cdc5l (cell division cycle 5-like) Rattus norvegicus
Analyze
Symbol: Cdc5l
Name: cell division cycle 5-like
RGD ID: 70892
Description: Enables enzyme binding activity; leucine zipper domain binding activity; and transcription corepressor binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to prolactin; and cellular response to wortmannin. Located in nuclear speck and perinuclear region of cytoplasm. Part of protein-DNA complex. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 3-chloropropane-1,2-diol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDC5 (cell division cycle 5 S. pombe homolog)-like; CDC5 (cell division cycle 5, S. pombe, homolog)-like; CDC5 cell division cycle 5-like; CDC5 cell division cycle 5-like (S. pombe); cdc5-like protein; cell division cycle 5-like (S. pombe); cell division cycle 5-like protein; cell division cycle 5-related protein; pombe Cdc5-related protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2915,564,949 - 15,603,453 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl915,564,767 - 15,603,450 (+)Ensembl
Rnor_6.0917,949,764 - 17,988,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,949,764 - 17,988,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,838,171 - 16,876,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,165,631 - 11,204,135 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1911,162,952 - 11,201,455 (+)NCBI
Celera913,308,462 - 13,346,957 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. Bonner AE, etal., Oncogene. 2004 Feb 5;23(5):1166-76.
2. NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. Boudrez A, etal., J Biol Chem. 2000 Aug 18;275(33):25411-7.
3. Splicing and beyond: the many faces of the Prp19 complex. Chanarat S and Strasser K, Biochim Biophys Acta. 2013 Oct;1833(10):2126-34. doi: 10.1016/j.bbamcr.2013.05.023. Epub 2013 Jun 3.
4. DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition. Engemann H, etal., Nucleic Acids Res 2002 Mar 15;30(6):1408-17.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. Hansel DE, etal., Am J Surg Pathol. 2005 Mar;29(3):390-9.
7. Prolactin, interleukin-2 and FGF-2 stimulate expression, nuclear distribution and DNA-binding of rat homolog of pombe Cdc5 in Nb2 T lymphoma cells. Johnson LM and Too CK, Mol Cell Endocrinol. 2001 Nov 26;184(1-2):151-61.
8. Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. Lu XY, etal., Mol Cancer Res. 2008 Jun;6(6):937-46. doi: 10.1158/1541-7786.MCR-07-2115.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Differential expression of elongation factor-2, alpha4 phosphoprotein and Cdc5-like protein in prolactin-dependent/independent rat lymphoid cells. Too CK Mol Cell Endocrinol 1997 Aug 8;131(2):221-32.
17. Involvement of the mouse Prp19 gene in neuronal/astroglial cell fate decisions. Urano Y, etal., J Biol Chem. 2006 Mar 17;281(11):7498-514. Epub 2005 Dec 13.
18. Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation. Urano-Tashiro Y, etal., J Neurosci Res. 2010 Oct;88(13):2787-97. doi: 10.1002/jnr.22455.
Additional References at PubMed
PMID:9038199   PMID:11082045   PMID:11991638   PMID:12477932   PMID:16332694   PMID:19946888   PMID:20176811   PMID:22681889   PMID:24332808   PMID:28076346  


Genomics

Comparative Map Data
Cdc5l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2915,564,949 - 15,603,453 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl915,564,767 - 15,603,450 (+)Ensembl
Rnor_6.0917,949,764 - 17,988,514 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,949,764 - 17,988,509 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0916,838,171 - 16,876,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4911,165,631 - 11,204,135 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1911,162,952 - 11,201,455 (+)NCBI
Celera913,308,462 - 13,346,957 (+)NCBICelera
Cytogenetic Map9q12NCBI
CDC5L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38644,387,706 - 44,450,425 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl644,387,706 - 44,450,425 (+)EnsemblGRCh38hg38GRCh38
GRCh37644,355,443 - 44,418,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36644,463,280 - 44,522,758 (+)NCBINCBI36hg18NCBI36
Build 34644,463,279 - 44,522,757NCBI
Celera645,908,480 - 45,967,835 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef644,077,869 - 44,140,670 (+)NCBIHuRef
CHM1_1644,358,890 - 44,421,686 (+)NCBICHM1_1
T2T-CHM13v2.0644,222,452 - 44,285,059 (+)NCBI
Cdc5l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391745,702,809 - 45,744,633 (-)NCBIGRCm39mm39
GRCm39 Ensembl1745,702,810 - 45,744,663 (-)Ensembl
GRCm381745,391,887 - 45,433,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1745,391,884 - 45,433,737 (-)EnsemblGRCm38mm10GRCm38
MGSCv371745,528,836 - 45,570,656 (-)NCBIGRCm37mm9NCBIm37
MGSCv361744,855,468 - 44,897,288 (-)NCBImm8
Celera1748,822,530 - 48,866,019 (-)NCBICelera
Cytogenetic Map17B3NCBI
Cdc5l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,990,613 - 10,032,034 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,990,613 - 10,032,034 (+)NCBIChiLan1.0ChiLan1.0
CDC5L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1645,265,845 - 45,326,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl645,265,845 - 45,326,383 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0643,983,840 - 44,043,029 (+)NCBIMhudiblu_PPA_v0panPan3
CDC5L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11212,779,936 - 12,822,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1212,780,010 - 12,822,801 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1212,807,973 - 12,851,031 (+)NCBI
ROS_Cfam_1.01213,266,108 - 13,309,161 (+)NCBI
ROS_Cfam_1.0 Ensembl1213,266,132 - 13,309,158 (+)Ensembl
UMICH_Zoey_3.11212,791,651 - 12,835,010 (+)NCBI
UNSW_CanFamBas_1.01212,879,429 - 12,922,495 (+)NCBI
UU_Cfam_GSD_1.01212,973,455 - 13,016,504 (+)NCBI
Cdc5l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494648,262,000 - 48,311,662 (+)NCBI
SpeTri2.0NW_00493647615,647,470 - 15,698,095 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC5L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl739,384,556 - 39,431,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1739,384,397 - 39,427,729 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2745,306,065 - 45,349,669 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC5L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11727,727,185 - 27,785,233 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1727,722,819 - 27,785,268 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604444,437,105 - 44,495,930 (+)NCBIVero_WHO_p1.0
Cdc5l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475415,477,193 - 15,517,636 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475415,477,188 - 15,517,656 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH125755  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,603,111 - 15,603,365 (+)MAPPERmRatBN7.2
Rnor_6.0917,988,173 - 17,988,426NCBIRnor6.0
Rnor_5.0916,876,580 - 16,876,833UniSTSRnor5.0
RGSC_v3.4911,203,794 - 11,204,047UniSTSRGSC3.4
Celera913,346,616 - 13,346,869UniSTS
Cytogenetic Map9q12UniSTS
RH131317  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2915,603,052 - 15,603,233 (+)MAPPERmRatBN7.2
Rnor_6.0917,988,114 - 17,988,294NCBIRnor6.0
Rnor_5.0916,876,521 - 16,876,701UniSTSRnor5.0
RGSC_v3.4911,203,735 - 11,203,915UniSTSRGSC3.4
Celera913,346,557 - 13,346,737UniSTS
RH 3.4 Map978.6UniSTS
Cytogenetic Map9q12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:45
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000027264
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027264   ⟹   ENSRNOP00000027264
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl915,564,767 - 15,603,450 (+)Ensembl
Rnor_6.0 Ensembl917,949,764 - 17,988,509 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112966   ⟹   ENSRNOP00000079717
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl915,564,767 - 15,591,798 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000120250   ⟹   ENSRNOP00000087958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl915,566,784 - 15,603,450 (+)Ensembl
RefSeq Acc Id: NM_053527   ⟹   NP_445979
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2915,564,949 - 15,603,453 (+)NCBI
Rnor_6.0917,949,764 - 17,988,514 (+)NCBI
Rnor_5.0916,838,171 - 16,876,921 (+)NCBI
RGSC_v3.4911,165,631 - 11,204,135 (+)RGD
Celera913,308,462 - 13,346,957 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445979 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD05365 (Get FASTA)   NCBI Sequence Viewer  
  AAI61839 (Get FASTA)   NCBI Sequence Viewer  
  EDM18727 (Get FASTA)   NCBI Sequence Viewer  
  O08837 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445979   ⟸   NM_053527
- UniProtKB: O08837 (UniProtKB/Swiss-Prot),   B1WBQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027264   ⟸   ENSRNOT00000027264
RefSeq Acc Id: ENSRNOP00000079717   ⟸   ENSRNOT00000112966
RefSeq Acc Id: ENSRNOP00000087958   ⟸   ENSRNOT00000120250
Protein Domains
HTH myb-type   Myb-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08837-F1-model_v2 AlphaFold O08837 1-802 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696548
Promoter ID:EPDNEW_R7072
Type:multiple initiation site
Name:Cdc5l_1
Description:cell division cycle 5-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,949,752 - 17,949,812EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
9 17975859 17975860 A C snv WKY/NHsd (RGD)
9 17975864 17975865 C A snv WKY/NHsd (RGD)
9 17975865 17975866 C T snv WKY/NHsd (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70892 AgrOrtholog
BioCyc Gene G2FUF-28161 BioCyc
Ensembl Genes ENSRNOG00000019975 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027264 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000079717.1 UniProtKB/TrEMBL
  ENSRNOP00000087958.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027264 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000112966.1 UniProtKB/TrEMBL
  ENSRNOT00000120250.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125496 IMAGE-MGC_LOAD
  IMAGE:9101355 IMAGE-MGC_LOAD
InterPro Cdc5p/Cef1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myb_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SANT/Myb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85434 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187349 IMAGE-MGC_LOAD
  MGC:93301 IMAGE-MGC_LOAD
NCBI Gene 85434 ENTREZGENE
Pfam Myb_Cef UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdc5l PhenoGen
PROSITE HTH_MYB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYB_LIKE UniProtKB/TrEMBL
SMART SANT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZNY5_RAT UniProtKB/TrEMBL
  A0A8I6A562_RAT UniProtKB/TrEMBL
  B1WBQ0 ENTREZGENE, UniProtKB/TrEMBL
  CDC5L_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-23 Cdc5l  cell division cycle 5-like  Cdc5l  CDC5 cell division cycle 5-like (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cdc5l  CDC5 cell division cycle 5-like (S. pombe)  Cdc5l  cell division cycle 5-like (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cdc5l  cell division cycle 5-like (S. pombe)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds the leucine zipper domain of DAP-like kinase (Dlk), binding occurs via the Cdc5l C-terminal region between residues 500 and 802 619664
gene_regulation differential display shows transcription upregulated by prolactin 61637