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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | CAKUT | | ISO | RGD:731949 | 8554872 | ClinVar Annotator: match by term: Congenital anomalies of kidney and urinary tract | ClinVar | PMID:27657687 | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | CAKUT | | ISO | RGD:731949 | 8554872 | ClinVar Annotator: match by term: Congenital anomalies of kidney and urinary tract | ClinVar | PMID:27657687 | |
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# | Reference Title | Reference Citation |
1. | Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. | Bonner AE, etal., Oncogene. 2004 Feb 5;23(5):1166-76. |
2. | NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. | Boudrez A, etal., J Biol Chem. 2000 Aug 18;275(33):25411-7. |
3. | Splicing and beyond: the many faces of the Prp19 complex. | Chanarat S and Strasser K, Biochim Biophys Acta. 2013 Oct;1833(10):2126-34. doi: 10.1016/j.bbamcr.2013.05.023. Epub 2013 Jun 3. |
4. | DAP-like kinase interacts with the rat homolog of Schizosaccharomyces pombe CDC5 protein, a factor involved in pre-mRNA splicing and required for G2/M phase transition. | Engemann H, etal., Nucleic Acids Res 2002 Mar 15;30(6):1408-17. |
5. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
6. | CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. | Hansel DE, etal., Am J Surg Pathol. 2005 Mar;29(3):390-9. |
7. | Prolactin, interleukin-2 and FGF-2 stimulate expression, nuclear distribution and DNA-binding of rat homolog of pombe Cdc5 in Nb2 T lymphoma cells. | Johnson LM and Too CK, Mol Cell Endocrinol. 2001 Nov 26;184(1-2):151-61. |
8. | Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. | Lu XY, etal., Mol Cancer Res. 2008 Jun;6(6):937-46. doi: 10.1158/1541-7786.MCR-07-2115. |
9. | Gene Data Set | MGD Curation, June 12, 2002 |
10. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
11. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
12. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
13. | GOA pipeline | RGD automated data pipeline |
14. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
15. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
16. | Differential expression of elongation factor-2, alpha4 phosphoprotein and Cdc5-like protein in prolactin-dependent/independent rat lymphoid cells. | Too CK Mol Cell Endocrinol 1997 Aug 8;131(2):221-32. |
17. | Involvement of the mouse Prp19 gene in neuronal/astroglial cell fate decisions. | Urano Y, etal., J Biol Chem. 2006 Mar 17;281(11):7498-514. Epub 2005 Dec 13. |
18. | Implication of Akt-dependent Prp19 alpha/14-3-3beta/Cdc5L complex formation in neuronal differentiation. | Urano-Tashiro Y, etal., J Neurosci Res. 2010 Oct;88(13):2787-97. doi: 10.1002/jnr.22455. |
PMID:9038199 | PMID:11082045 | PMID:11991638 | PMID:12477932 | PMID:16332694 | PMID:19946888 | PMID:20176811 | PMID:22681889 | PMID:24332808 | PMID:28076346 |
Cdc5l (Rattus norvegicus - Norway rat) |
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CDC5L (Homo sapiens - human) |
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Cdc5l (Mus musculus - house mouse) |
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Cdc5l (Chinchilla lanigera - long-tailed chinchilla) |
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CDC5L (Pan paniscus - bonobo/pygmy chimpanzee) |
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CDC5L (Canis lupus familiaris - dog) |
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Cdc5l (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CDC5L (Sus scrofa - pig) |
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CDC5L (Chlorocebus sabaeus - green monkey) |
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Cdc5l (Heterocephalus glaber - naked mole-rat) |
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RH125755 |
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RH131317 |
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The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 43 | 57 | 41 | 19 | 41 | 8 | 11 | 74 | 35 | 41 | 11 | 8 |
Low | |||||||||||||
Below cutoff |
RefSeq Transcripts | NM_053527 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
GenBank Nucleotide | AF000578 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC087007 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC111403 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC161839 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473987 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000213 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000027264 ⟹ ENSRNOP00000027264 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000112966 ⟹ ENSRNOP00000079717 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000120250 ⟹ ENSRNOP00000087958 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_053527 ⟹ NP_445979 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_445979 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAD05365 | (Get FASTA) | NCBI Sequence Viewer |
AAI61839 | (Get FASTA) | NCBI Sequence Viewer | |
EDM18727 | (Get FASTA) | NCBI Sequence Viewer | |
O08837 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_445979 ⟸ NM_053527 |
- UniProtKB: | O08837 (UniProtKB/Swiss-Prot), B1WBQ0 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000027264 ⟸ ENSRNOT00000027264 |
RefSeq Acc Id: | ENSRNOP00000079717 ⟸ ENSRNOT00000112966 |
RefSeq Acc Id: | ENSRNOP00000087958 ⟸ ENSRNOT00000120250 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-O08837-F1-model_v2 | AlphaFold | O08837 | 1-802 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13696548 | ||||||||
Promoter ID: | EPDNEW_R7072 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Cdc5l_1 | ||||||||
Description: | cell division cycle 5-like | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Chromosome | Start Pos | End Pos | Reference Nucleotide | Variant Nucleotide | Variant Type | Strain |
9 | 17975859 | 17975860 | A | C | snv | WKY/NHsd (RGD) |
9 | 17975864 | 17975865 | C | A | snv | WKY/NHsd (RGD) |
9 | 17975865 | 17975866 | C | T | snv | WKY/NHsd (RGD) |
Database | Acc Id | Source(s) |
AGR Gene | RGD:70892 | AgrOrtholog |
BioCyc Gene | G2FUF-28161 | BioCyc |
Ensembl Genes | ENSRNOG00000019975 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000027264 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOP00000079717.1 | UniProtKB/TrEMBL | |
ENSRNOP00000087958.1 | UniProtKB/TrEMBL | |
Ensembl Transcript | ENSRNOT00000027264 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOT00000112966.1 | UniProtKB/TrEMBL | |
ENSRNOT00000120250.1 | UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:7125496 | IMAGE-MGC_LOAD |
IMAGE:9101355 | IMAGE-MGC_LOAD | |
InterPro | Cdc5p/Cef1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Homeobox-like_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Myb_dom | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SANT/Myb | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:85434 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MGC_CLONE | MGC:187349 | IMAGE-MGC_LOAD |
MGC:93301 | IMAGE-MGC_LOAD | |
NCBI Gene | 85434 | ENTREZGENE |
Pfam | Myb_Cef | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | Cdc5l | PhenoGen |
PROSITE | HTH_MYB | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
MYB_LIKE | UniProtKB/TrEMBL | |
SMART | SANT | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF46689 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A8I5ZNY5_RAT | UniProtKB/TrEMBL |
A0A8I6A562_RAT | UniProtKB/TrEMBL | |
B1WBQ0 | ENTREZGENE, UniProtKB/TrEMBL | |
CDC5L_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2013-01-23 | Cdc5l | cell division cycle 5-like | Cdc5l | CDC5 cell division cycle 5-like (S. pombe) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2008-09-26 | Cdc5l | CDC5 cell division cycle 5-like (S. pombe) | Cdc5l | cell division cycle 5-like (S. pombe) | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-07-09 | Cdc5l | cell division cycle 5-like (S. pombe) | Symbol and Name updated to reflect Human and Mouse nomenclature | 70877 | APPROVED |
Note Type | Note | Reference |
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gene_physical_interaction | binds the leucine zipper domain of DAP-like kinase (Dlk), binding occurs via the Cdc5l C-terminal region between residues 500 and 802 | 619664 |
gene_regulation | differential display shows transcription upregulated by prolactin | 61637 |