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Gene: Mamdc4 (MAM domain containing 4) Rattus norvegicus

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Symbol:

Mamdc4

Name:

MAM domain containing 4

RGD ID:

708583

Description:

Predicted to be involved in nervous system development. Located in endosome. Orthologous to human MAMDC4 (MAM domain containing 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 3H-1,2-dithiole-3-thione.

Type:

protein-coding (Ensembl: pseudogene)

RefSeq Status:

VALIDATED

Previously known as:

Aegp; apical early endosomal glycoprotein; apical endosomal glycoprotein; LOC252882; MAM domain-containing protein 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MAMDC4 (MAM domain containing 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Mamdc4 (MAM domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mamdc4 (MAM domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MAMDC4 (MAM domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MAMDC4 (MAM domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mamdc4 (MAM domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MAMDC4 (MAM domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MAMDC4 (MAM domain containing 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mamdc4 (MAM domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-11o18.5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mamdc4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,780,523 - 28,789,139 (-)	NCBI		GRCr8
mRatBN7.2	3	8,382,387 - 8,391,003 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,382,387 - 8,391,003 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,487,568 - 11,496,183 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,073,794 - 20,082,409 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	18,263,637 - 18,272,252 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,786,523 - 2,795,109 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,786,523 - 2,795,109 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,767,911 - 2,776,632 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,733,164 - 3,743,019 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,733,163 - 3,743,019 (-)	NCBI
Celera	3	3,207,392 - 3,215,949 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 5 (ISO)

developmental and epileptic encephalopathy 14 (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

Leigh disease (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

tuberous sclerosis 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3H-1,2-dithiole-3-thione (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

allethrin (EXP)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

Cuprizon (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

endosulfan (EXP)

fenvalerate (EXP)

gentamycin (EXP)

iron dichloride (ISO)

methapyrilene (ISO)

methimazole (EXP)

ozone (ISO)

paracetamol (EXP)

pyrethrins (EXP)

resveratrol (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sulforaphane (ISO)

sunitinib (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein transport (IEA)

Cellular Component

endosome (IDA)

membrane (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells.	Speelman BA, etal., J Biol Chem 1995 Jan 27;270(4):1583-8.

Additional References at PubMed

PMID:20214753

Genomics

Comparative Map Data

Mamdc4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,780,523 - 28,789,139 (-)	NCBI		GRCr8
mRatBN7.2	3	8,382,387 - 8,391,003 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,382,387 - 8,391,003 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,487,568 - 11,496,183 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,073,794 - 20,082,409 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	18,263,637 - 18,272,252 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,786,523 - 2,795,109 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,786,523 - 2,795,109 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,767,911 - 2,776,632 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,733,164 - 3,743,019 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,733,163 - 3,743,019 (-)	NCBI
Celera	3	3,207,392 - 3,215,949 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

MAMDC4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	136,852,346 - 136,860,799 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	136,850,943 - 136,860,799 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	139,746,798 - 139,755,251 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	138,866,640 - 138,875,072 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	110,260,608 - 110,269,040 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,206,037 - 109,214,469 (+)	NCBI		HuRef
CHM1_1	9	139,895,552 - 139,903,984 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,086,528 - 149,094,981 (+)	NCBI		T2T-CHM13v2.0

Mamdc4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,453,124 - 25,461,328 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,453,127 - 25,464,857 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,563,115 - 25,571,316 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,563,115 - 25,574,845 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,418,635 - 25,426,836 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,385,124 - 25,393,325 (-)	NCBI		MGSCv36	mm8
Celera	2	25,290,882 - 25,299,083 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.41	NCBI

Mamdc4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	4,933,927 - 4,941,160 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	4,932,596 - 4,941,330 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAMDC4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,541,560 - 2,550,409 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,542,694 - 2,553,580 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	107,908,156 - 107,917,883 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	136,878,324 - 136,888,065 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	136,878,324 - 136,888,065 (+)	Ensembl	panpan1.1		panPan2

MAMDC4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,726,392 - 48,736,173 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,727,523 - 48,734,820 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,941,096 - 47,949,800 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,605,522 - 49,614,225 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	9	48,381,741 - 48,390,448 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,680,454 - 48,689,154 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,727,410 - 48,736,119 (-)	NCBI		UU_Cfam_GSD_1.0

Mamdc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,310,243 - 202,318,664 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	1,056,583 - 1,064,320 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	1,055,181 - 1,063,638 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAMDC4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,328,513 - 1,336,868 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,328,709 - 1,336,868 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	3,939,940 - 3,948,294 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Mamdc4
4 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	47
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000022390
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat

Markers in Region

RH139839

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	8,382,199 - 8,382,405 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	2,786,311 - 2,786,516	NCBI	Rnor6.0
Rnor_5.0	3	2,767,724 - 2,767,929	UniSTS	Rnor5.0
RGSC_v3.4	3	3,732,952 - 3,733,157	UniSTS	RGSC3.4
Celera	3	3,207,180 - 3,207,385	UniSTS
Cytogenetic Map	3	p13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	90	89	58	25	58	6	217	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_145768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L37380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022390 ⟹ ENSRNOP00000022390

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,382,387 - 8,391,003 (-)	Ensembl
Rnor_6.0 Ensembl	3	2,786,523 - 2,795,109 (-)	Ensembl

RefSeq Acc Id:

NM_145768 ⟹ NP_665711

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,780,523 - 28,789,139 (-)	NCBI
mRatBN7.2	3	8,382,387 - 8,391,003 (-)	NCBI
Rnor_6.0	3	2,786,523 - 2,795,109 (-)	NCBI
Rnor_5.0	3	2,767,911 - 2,776,632 (-)	NCBI
RGSC_v3.4	3	3,733,164 - 3,743,019 (-)	RGD
Celera	3	3,207,392 - 3,215,949 (-)	RGD

Sequence:

show sequence

CGAGAAGTCTCTAGACTGCACAGCTTCGCTTGCACTGGGACACCCTCTAGCCTGGCCATGTGCC
TGCCTAGCTGCCTCCTCTCAATCTGGGTCCTATTTATGGCTGCACAGTCTCTAGGCAAGACCTG
GGTCCCTGACCACTGCAGAAGCCCCACCGAAGCTACGTGCAACTTTGTGTGTGACTGTGGAGAC
TGTTCAGATGAGGCTCAGTGTGGTTTCCACGGTGCCTCAACTACCCCAAACACCCCCTTCACCT
GCAACTTTGAGCAGGATCCCTGTGGCTGGCAGGACATCAGCACCTCGGGCTATCGATGGCTTCG
AGACCGGGCAGGGGCAGGGCTGGATAGTTCTGGGCCCCATTCTGACCATACACGTGGCACTGAC
TTGGGCTGGTACATGGCTGTGGGAACCCATAGTGGGAAGGAGCCATCTACTCGGACTTTGCGCT
CTCCTGTCATGCGTGAGGCAGCCCCCACCTGTGAACTGAGGCTCTGGTACCACACTGACTCTAG
AGATGTCGCTGAGCTGCGGCTGGATCTGACCCATGGTATGGAGACACTGACTCTATGGCAGAGC
TCGGGACCTTGGGGTCCCTGGCCTGGCAGGGAACTAGCAGTGAACACTGGCCGAATCCAGGGTG
ACTTCAAAGTGACATTTTCTGCCACTCGAAATGCTACACACAGGGGCGCTGTGGCCTTGGATGA
CATGGAGTTCTGGGACTGTGGTCTGCCCATCCCTCAGGCCAGGTGTCCCCTGGGGCACCACCAC
TGCCAGAACAAAGCTTGTGTGGAGCCCCACCAGCTCTGTGACGGTGAAGACAACTGTGGAGACA
GTTCTGATGAAGACCCGCTCATCTGCAGCCACCACATGGCCACCGACTTTGAGACAGGCCTAGG
ACCATGGACCCAATTAGAGGGCTGGACACGGAACTTCAGTGCTGGCAGCATGGTGAGCCCTGCC
TGGCCCCACCGAGATCACAGCCGGAATAGTGCATATGGCTTCTTTCTCGTCTCTGTGGCCAAGC
CTGGCACCACTGCTGTCCTCTACAGCCCTGAGTTCCAAGGCTCAGTCTCCTACAACTGCTCGTT
CACCTTCTATTACTACCTGCATGGGTCTGAGGCCAACCAATTCCAGCTCTTTGTGCAGGCACAG
GGGCTCAACACCACCCAGCCTCCTGTCCTACTCCGAAGCCGCCATGGAGAGTTGGGGACAGCCT
GGGTCAGAGACCGGGTTAACATTCAAAGTGCCCATCCATTTCGGATCCTTCTTGCTGGGGAGAC
TGGTCCAGGAGGCTTCGTGGGCCTAGACGACCTTATCATGTCCAACCACTGCATACTTGTTCCA
GGTATGTCCACCCTGCAGTCATCACTTTCTGGACCTGTGCCATTGGCCCTCTATCCCCAGACAT
CCATCAAGCGAACCTGTGACGCAGGACATCTCTCCTGTGACGAGCTGTGTGTGCCCCCGGAGCA
GCTGTGTGATTTCCAGCAGCACTGTGCCGAAGGCGAGGATGAAGAGAAGTGTGGCACCACGGAC
TTTGAGTCTGCCTCTGCTGGGGGCTGGGAGGACATCAGTATAGGAAAGCTACAGTGGCAACGGG
CTGAAGCCCAGGAGAGCGGGAAGCCTGCCAGGGATACCAACCGGAATGCACCTGGGCACTTCCT
ATCTCTGCGGAAGGCCTGGGGGCAGCTACGATCTGAGGCCCGGGCTCTCACACCTACTCTGGGC
CCCTCTGGCCCTCACTGTGAACTCCACATGACTTACTATTTTCACAGTCATCCCCAAGGCTTCT
TGGCACTGGCTGTGGTGGAGAATGGCTTCCGGGAGCTGCTGTGGCAGGCTCCAAGCAGCAGCAG
TGGGGGCTGGACACTACAGAAGATTCTTCTTGGGGCACGGCGCTGGCCATTCCAGCTGGAGTTC
GTCAGTCTGGTGGACTTGGATGGCCCTGGCCAACAGGGGGCTGGGGTGGATAATGTGACCCTGA
GAGACTGCAACCCCATGGTGACCACTGAGAGTGACCAAGAGGTCTCCTGTAACTTTGAACGGGA
CTCCTGCAGCTGGCACACAGGCCACCTCACAGATGCCCACTGGCACCGTGTAAAAAGCCACGGC
TCTCAGTATGACCACACCACCGGCCAAGGTTTTTTCATGTTCCTGGATCCCATGGACCCACCTG
CTCGAGGCCAAGGTGCCCTGTTGCTCACAAGACCCCAGGTGCCAGTTGTCCCCAAGGAATGTCT
CAGCTTCTGGTACCATCTGCATGGGCCCCAGATTGGGACACTGTGCTTGGCCATGAGGAGGGAG
GGGGAGGAAGACACACTACTGTGGTCCCGGTCAGGCACCCACGGCAACCGCTGGCACCAGGCTT
GGGTCACTCTTCACCACCAGCTGCAGCCCAGCACCAAGTACCAGTTGCTGTTTGAAGGCCTCCG
GGATGGGTACCATGGCACAATGGGCCTGGATGACATGGCTGTGCGGCCTGGCCCCTGCTGGGCC
GCCAAGAGATGTTCCTTTGAAGACTCTGACTGTGGCTTCTCCCCAGGGGACTGGGGGCTGTGGA
CACGCCAGAATAATGCCTCAGGCCTTGGTCCTTGGGGTCCTTGGATAGACCATACCACAGGGAC
AGCCCAGGGGCACTACATGGTGGTGGACACCAGCCCAAATTTACTGCCCAAAGGTCATGTGGCC
TCTCTGACTTCAGAGGAGCACCCGCCCCTGTCCCGGCCTGCCTGCCTGTCCTTCTGGTACCACC
TGAGCTTCCACAATCCAGGCACCTTGAGGGTCTTCGTGGAAGAGAGCACAAGGCGCCAAGAGCT
CAGCATCAGTGGCCATGGTGGATTTGCGTGGCGCCTAGGCAGCGTGAATGTACAGGCTGAGCAG
GCCTGGAAGGTAGTGTTTGAGGCTATGGCTTCTGGCGTGGAACATTCCTACATGGCTCTGGATG
ACATTTCCCTCCAAGATGGGCCCTGTGCTCAGCCAGGGTCCTGTGACTTTGAATCTGGCCTGTG
TGGGTGGAGCCACCTGCCTTGGCCTGGTCTGGGTGGGTACAGCTGGGACTGGAGCAGTGGAGCC
ACTCCATCCCGGTACCCCCGGCCTTCAGTGGACCACACTGTGGGCACAGAAGCAGGCCACTTCG
CTTTCTTTGAAACCAGCGTGCTAGGTCCTGGGGGCCAGGCAGCCTGGCTCGGCAGTGAGCCACT
GCCAGCAACTGCAGTCTCCTGCCTCCACTTCTGGTACTACATGGGCTTTCCTGCGCATTTCTAC
AAGGGTGAGTTGAGAGTGCTCCTGAGCAGTACCCAAGGACAGCTAGCTGTGTGGCACCGGGGTG
GGCACTTGCGGGACCAGTGGCTACAAGTCCAGATTGAAGTGTCCAGCTCTGAGGAGTTCCAGAT
TGTTTTTGAAGCCACTCTGGGTGGCCAGCCGGCTCTAGGGCCCATTGCCCTTGATGATGTGGAG
TACTTGGCTGGACAACACTGCAAGCAACCTACACCTAGCCAGGGTAGAGTGGCAGCACCCGTGT
CTGTGCCGGTTGCAGTCGGAGGAGCCCTCCTCCTCTTCCTGTTGCTCCTGGGCCTTGGAGGTTG
GCACTGGCTGCAGAAGCAGCACCTCCCCTGCCAAAGTACAGATGCAGCAGCCTCTGGCTTTGAC
AATATCCTCTTCAATGCGGATCAAGTTACCCTCCCAGAATCAATCACCAGTAACCCATAGAGCA
CTCCAGACAAGGCCTGGCCTGACATGGCAACTCTCACAGCATTCAAACCTCACAGCACTGGCCT
GCCCACCTGCCTGTGGGCCTGGATGTAGGGACCGAGTCATGATTACCTCACCAGGTCTTCCTCT
ATCTGGTGTCTTTGCCCTCTGGTGTGATGGAGAAGGGTAGAGGAGTCTTTGTACTGTGAATAAA
TG

hide sequence

Protein Sequences


Protein RefSeqs	NP_665711	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA65200	(Get FASTA)	NCBI Sequence Viewer
	EDL93565	(Get FASTA)	NCBI Sequence Viewer
	Q63191	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_665711 ⟸ NM_145768
- Peptide Label:	precursor
- UniProtKB:	Q63191 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MCLPSCLLSIWVLFMAAQSLGKTWVPDHCRSPTEATCNFVCDCGDCSDEAQCGFHGASTTPNTP FTCNFEQDPCGWQDISTSGYRWLRDRAGAGLDSSGPHSDHTRGTDLGWYMAVGTHSGKEPSTRT LRSPVMREAAPTCELRLWYHTDSRDVAELRLDLTHGMETLTLWQSSGPWGPWPGRELAVNTGRI QGDFKVTFSATRNATHRGAVALDDMEFWDCGLPIPQARCPLGHHHCQNKACVEPHQLCDGEDNC GDSSDEDPLICSHHMATDFETGLGPWTQLEGWTRNFSAGSMVSPAWPHRDHSRNSAYGFFLVSV AKPGTTAVLYSPEFQGSVSYNCSFTFYYYLHGSEANQFQLFVQAQGLNTTQPPVLLRSRHGELG TAWVRDRVNIQSAHPFRILLAGETGPGGFVGLDDLIMSNHCILVPGMSTLQSSLSGPVPLALYP QTSIKRTCDAGHLSCDELCVPPEQLCDFQQHCAEGEDEEKCGTTDFESASAGGWEDISIGKLQW QRAEAQESGKPARDTNRNAPGHFLSLRKAWGQLRSEARALTPTLGPSGPHCELHMTYYFHSHPQ GFLALAVVENGFRELLWQAPSSSSGGWTLQKILLGARRWPFQLEFVSLVDLDGPGQQGAGVDNV TLRDCNPMVTTESDQEVSCNFERDSCSWHTGHLTDAHWHRVKSHGSQYDHTTGQGFFMFLDPMD PPARGQGALLLTRPQVPVVPKECLSFWYHLHGPQIGTLCLAMRREGEEDTLLWSRSGTHGNRWH QAWVTLHHQLQPSTKYQLLFEGLRDGYHGTMGLDDMAVRPGPCWAAKRCSFEDSDCGFSPGDWG LWTRQNNASGLGPWGPWIDHTTGTAQGHYMVVDTSPNLLPKGHVASLTSEEHPPLSRPACLSFW YHLSFHNPGTLRVFVEESTRRQELSISGHGGFAWRLGSVNVQAEQAWKVVFEAMASGVEHSYMA LDDISLQDGPCAQPGSCDFESGLCGWSHLPWPGLGGYSWDWSSGATPSRYPRPSVDHTVGTEAG HFAFFETSVLGPGGQAAWLGSEPLPATAVSCLHFWYYMGFPAHFYKGELRVLLSSTQGQLAVWH RGGHLRDQWLQVQIEVSSSEEFQIVFEATLGGQPALGPIALDDVEYLAGQHCKQPTPSQGRVAA PVSVPVAVGGALLLFLLLLGLGGWHWLQKQHLPCQSTDAAASGFDNILFNADQVTLPESITSNP hide sequence

Ensembl Acc Id:

ENSRNOP00000022390 ⟸ ENSRNOT00000022390

Protein Domains

LDL-receptor class A MAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63191-F1-model_v2	AlphaFold	Q63191	1-1216	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708583	AgrOrtholog
BioCyc Gene	G2FUF-50440	BioCyc
Ensembl Genes	ENSRNOG00000016584	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000022390	ENTREZGENE
Gene3D-CATH	2.60.120.200	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ConA-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAM_domain-containing	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:252882	UniProtKB/Swiss-Prot
NCBI Gene	252882	ENTREZGENE
PANTHER	APICAL ENDOSOMAL GLYCOPROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ldl_recept_a	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Mamdc4	PhenoGen
PRINTS	LDLRECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	LDLRA_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAM_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016584	RatGTEx
SMART	LDLa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Concanavalin A-like lectins/glucanases	UniProtKB/TrEMBL
	LDL receptor-like module	UniProtKB/TrEMBL
	SSF49899	UniProtKB/Swiss-Prot
	SSF57424	UniProtKB/Swiss-Prot
UniProt	A6JT82_RAT	UniProtKB/TrEMBL
	AEGP_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Mamdc4	MAM domain containing 4	Aegp	apical early endosomal glycoprotein	Symbol and Name updated	1299863	APPROVED
2005-07-08	Aegp	apical early endosomal glycoprotein	LOC252882		Symbol updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar