Lrrc7 (leucine rich repeat containing 7) - Rat Genome Database

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Gene: Lrrc7 (leucine rich repeat containing 7) Rattus norvegicus
Analyze
Symbol: Lrrc7
Name: leucine rich repeat containing 7
RGD ID: 708527
Description: Enables protein kinase binding activity. Involved in positive regulation of neuron projection development and response to organic cyclic compound. Located in several cellular components, including axon initial segment; dendritic spine; and filopodium. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human LRRC7 (leucine rich repeat containing 7); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: densin; densin 13T-16; densin 13T-17; densin 13T-23; densin 13T-29; densin 13T-41; densin 13T-43; densin 13T-57; densin 13T-57C; densin 13T-72; densin 13T-89; densin-180; leucine-rich repeat-containing protein 7; LOC117284
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lrrc7Tn(sb-T2/Bart3)2.253Mcwi  
Genetic Models: F344-Lrrc7Tn(sb-T2/Bart3)2.253Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82249,792,441 - 250,294,267 (-)NCBIGRCr8
mRatBN7.22247,146,616 - 247,634,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2247,147,752 - 247,634,547 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,879,113 - 255,357,086 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,772,486 - 253,250,577 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,741,203 - 248,227,243 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02264,910,594 - 265,300,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2264,910,594 - 265,300,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02283,549,882 - 283,934,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42256,228,792 - 256,644,029 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12256,243,398 - 256,458,663 (-)NCBI
Celera2238,947,973 - 239,318,491 (-)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. Apperson ML, etal., J Neurosci 1996 Nov 1;16(21):6839-52.
2. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization. Jiao Y, etal., J Neurochem. 2008 Jun;105(5):1746-60. Epub 2008 Feb 4.
6. Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole. Kinnunen AK, etal., J Neurochem. 2003 Aug;86(3):736-48.
7. Toluene disrupts synaptogenesis in cultured hippocampal neurons. Lin HM, etal., Toxicol Lett. 2009 Jan 30;184(2):90-6. Epub 2008 Nov 7.
8. Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1. Ohtakara K, etal., Genes Cells. 2002 Nov;7(11):1149-60.
9. Postsynaptic shank antagonizes dendrite branching induced by the leucine-rich repeat protein Densin-180. Quitsch A, etal., J Neurosci. 2005 Jan 12;25(2):479-87.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. Robison AJ, etal., J Biol Chem. 2005 Oct 21;280(42):35329-36. Epub 2005 Aug 24.
13. Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180. Strack S, etal., J Biol Chem 2000 Aug 18;275(33):25061-4.
14. Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. Yang L, etal., J Cell Biol. 1997 Jun 16;137(6):1199-210.
15. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, etal., Hum Genet. 2008 Jun;123(5):495-506. doi: 10.1007/s00439-008-0501-0. Epub 2008 Apr 26.
Additional References at PubMed
PMID:11160423   PMID:20124353   PMID:21610080   PMID:22871113   PMID:23516094   PMID:25931508   PMID:30325965  


Genomics

Comparative Map Data
Lrrc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82249,792,441 - 250,294,267 (-)NCBIGRCr8
mRatBN7.22247,146,616 - 247,634,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2247,147,752 - 247,634,547 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,879,113 - 255,357,086 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,772,486 - 253,250,577 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,741,203 - 248,227,243 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02264,910,594 - 265,300,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2264,910,594 - 265,300,868 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02283,549,882 - 283,934,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42256,228,792 - 256,644,029 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12256,243,398 - 256,458,663 (-)NCBI
Celera2238,947,973 - 239,318,491 (-)NCBICelera
Cytogenetic Map2q45NCBI
LRRC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38169,567,922 - 70,144,364 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl169,567,922 - 70,151,945 (+)EnsemblGRCh38hg38GRCh38
GRCh37170,033,605 - 70,610,047 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36169,998,446 - 70,361,759 (+)NCBINCBI36Build 36hg18NCBI36
Build 34169,937,878 - 70,299,947NCBI
Celera168,515,739 - 68,879,117 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef168,336,211 - 68,700,364 (+)NCBIHuRef
CHM1_1170,341,207 - 70,704,575 (+)NCBICHM1_1
T2T-CHM13v2.0169,444,558 - 70,022,853 (+)NCBIT2T-CHM13v2.0
Lrrc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393157,772,823 - 158,268,254 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3157,788,528 - 158,267,858 (-)EnsemblGRCm39 Ensembl
GRCm39 Ensembl3157,772,823 - 157,781,749 (-)EnsemblGRCm39 Ensembl
GRCm383158,067,186 - 158,561,983 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3158,082,891 - 158,562,221 (-)EnsemblGRCm38mm10GRCm38
MGSCv373157,747,403 - 158,225,185 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363158,018,188 - 158,497,514 (-)NCBIMGSCv36mm8
Celera3164,551,795 - 165,021,656 (-)NCBICelera
Cytogenetic Map3H4NCBI
cM Map381.68NCBI
Lrrc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542321,769,366 - 22,269,781 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542321,764,046 - 22,269,590 (-)NCBIChiLan1.0ChiLan1.0
LRRC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21156,729,554 - 157,306,887 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11155,889,299 - 156,466,539 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0168,802,557 - 69,359,159 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1170,792,893 - 71,345,038 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl170,794,254 - 71,343,917 (+)Ensemblpanpan1.1panPan2
LRRC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1675,578,651 - 75,964,171 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl675,580,515 - 75,964,156 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha678,192,058 - 78,683,655 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0676,172,143 - 76,670,419 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl676,170,136 - 76,671,316 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1675,723,968 - 76,216,099 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0675,619,437 - 76,117,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0676,120,686 - 76,612,920 (-)NCBIUU_Cfam_GSD_1.0
Lrrc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505882,071,931 - 82,603,512 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365911,900,334 - 2,416,912 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365911,905,434 - 2,417,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6142,735,890 - 143,274,231 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16142,735,676 - 143,273,992 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26132,308,495 - 132,436,571 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12063,016,441 - 63,567,809 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2063,018,105 - 63,565,817 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603354,048,609 - 54,605,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474225,863,434 - 26,243,376 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474225,849,355 - 26,384,417 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrc7
2666 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:461
Count of miRNA genes:100
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000016073, ENSRNOT00000016453, ENSRNOT00000033502, ENSRNOT00000052190, ENSRNOT00000066024
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat


Genetic Models
This gene Lrrc7 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 38
Low 36 3 2 1 2 30 13 1
Below cutoff 1 7 19 11 12 11 6 6 4 26 10 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_057142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF266164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU348644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000016073   ⟹   ENSRNOP00000016073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2247,211,159 - 247,533,340 (-)Ensembl
Rnor_6.0 Ensembl2264,973,457 - 265,300,868 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000033502   ⟹   ENSRNOP00000034455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2247,208,691 - 247,533,340 (-)Ensembl
Rnor_6.0 Ensembl2264,973,457 - 265,300,868 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000066024   ⟹   ENSRNOP00000059517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2247,147,752 - 247,533,340 (-)Ensembl
Rnor_6.0 Ensembl2264,910,594 - 265,300,868 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099468   ⟹   ENSRNOP00000082144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2247,147,752 - 247,634,547 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115389   ⟹   ENSRNOP00000082626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2247,147,752 - 247,634,547 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116114   ⟹   ENSRNOP00000093706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2247,147,752 - 247,533,340 (-)Ensembl
RefSeq Acc Id: NM_001393674   ⟹   NP_001380603
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,805,448 - 250,293,718 (-)NCBI
mRatBN7.22247,146,616 - 247,634,945 (-)NCBI
RefSeq Acc Id: NM_057142   ⟹   NP_476483
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,805,448 - 250,293,718 (-)NCBI
mRatBN7.22247,146,616 - 247,634,945 (-)NCBI
Rnor_6.02264,910,594 - 265,300,860 (-)NCBI
Rnor_5.02283,549,882 - 283,934,360 (-)NCBI
RGSC_v3.42256,228,792 - 256,644,029 (-)RGD
Celera2238,947,973 - 239,318,491 (-)RGD
Sequence:
RefSeq Acc Id: XM_063281181   ⟹   XP_063137251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,261 (-)NCBI
RefSeq Acc Id: XM_063281182   ⟹   XP_063137252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,263 (-)NCBI
RefSeq Acc Id: XM_063281183   ⟹   XP_063137253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,257 (-)NCBI
RefSeq Acc Id: XM_063281184   ⟹   XP_063137254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,806,995 - 250,294,263 (-)NCBI
RefSeq Acc Id: XM_063281185   ⟹   XP_063137255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,261 (-)NCBI
RefSeq Acc Id: XM_063281186   ⟹   XP_063137256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,260 (-)NCBI
RefSeq Acc Id: XM_063281187   ⟹   XP_063137257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,258 (-)NCBI
RefSeq Acc Id: XM_063281188   ⟹   XP_063137258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,264 (-)NCBI
RefSeq Acc Id: XM_063281189   ⟹   XP_063137259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,260 (-)NCBI
RefSeq Acc Id: XM_063281190   ⟹   XP_063137260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 250,294,259 (-)NCBI
RefSeq Acc Id: XM_063281191   ⟹   XP_063137261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,792,441 - 249,972,996 (-)NCBI
RefSeq Acc Id: XM_063281192   ⟹   XP_063137262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82249,972,888 - 250,294,267 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001380603 (Get FASTA)   NCBI Sequence Viewer  
  NP_476483 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137251 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137252 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137253 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137254 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137255 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137256 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137257 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137258 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137259 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137260 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137261 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137262 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52881 (Get FASTA)   NCBI Sequence Viewer  
  AAF76466 (Get FASTA)   NCBI Sequence Viewer  
  ACA52040 (Get FASTA)   NCBI Sequence Viewer  
  ACA52041 (Get FASTA)   NCBI Sequence Viewer  
  ACA52042 (Get FASTA)   NCBI Sequence Viewer  
  ACA52043 (Get FASTA)   NCBI Sequence Viewer  
  ACA52044 (Get FASTA)   NCBI Sequence Viewer  
  ACA52045 (Get FASTA)   NCBI Sequence Viewer  
  ACA52046 (Get FASTA)   NCBI Sequence Viewer  
  ACA52047 (Get FASTA)   NCBI Sequence Viewer  
  ACA52048 (Get FASTA)   NCBI Sequence Viewer  
  ACA52049 (Get FASTA)   NCBI Sequence Viewer  
  ACA52050 (Get FASTA)   NCBI Sequence Viewer  
  ACA52051 (Get FASTA)   NCBI Sequence Viewer  
  ACA52052 (Get FASTA)   NCBI Sequence Viewer  
  ACA52053 (Get FASTA)   NCBI Sequence Viewer  
  ACA52054 (Get FASTA)   NCBI Sequence Viewer  
  ACA52055 (Get FASTA)   NCBI Sequence Viewer  
  ACA52056 (Get FASTA)   NCBI Sequence Viewer  
  ACA52057 (Get FASTA)   NCBI Sequence Viewer  
  EDL82579 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016073.5
  ENSRNOP00000034455.5
  ENSRNOP00000059517
  ENSRNOP00000059517.4
  ENSRNOP00000082144.1
  ENSRNOP00000082626
  ENSRNOP00000082626.1
  ENSRNOP00000093706.1
GenBank Protein P70587 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476483   ⟸   NM_057142
- Peptide Label: isoform 2
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot),   A6HWU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016073   ⟸   ENSRNOT00000016073
RefSeq Acc Id: ENSRNOP00000034455   ⟸   ENSRNOT00000033502
RefSeq Acc Id: ENSRNOP00000059517   ⟸   ENSRNOT00000066024
RefSeq Acc Id: ENSRNOP00000093706   ⟸   ENSRNOT00000116114
RefSeq Acc Id: ENSRNOP00000082144   ⟸   ENSRNOT00000099468
RefSeq Acc Id: ENSRNOP00000082626   ⟸   ENSRNOT00000115389
RefSeq Acc Id: NP_001380603   ⟸   NM_001393674
- Peptide Label: isoform 1
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot),   F1M4K6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137258   ⟸   XM_063281188
- Peptide Label: isoform X8
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137252   ⟸   XM_063281182
- Peptide Label: isoform X2
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137255   ⟸   XM_063281185
- Peptide Label: isoform X5
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137251   ⟸   XM_063281181
- Peptide Label: isoform X1
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137256   ⟸   XM_063281186
- Peptide Label: isoform X6
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137259   ⟸   XM_063281189
- Peptide Label: isoform X9
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137260   ⟸   XM_063281190
- Peptide Label: isoform X10
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137257   ⟸   XM_063281187
- Peptide Label: isoform X7
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot),   A0A8I5ZTY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137253   ⟸   XM_063281183
- Peptide Label: isoform X3
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot),   A0A8I6G9P9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137261   ⟸   XM_063281191
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063137254   ⟸   XM_063281184
- Peptide Label: isoform X4
- UniProtKB: Q9JI42 (UniProtKB/Swiss-Prot),   P70587 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063137262   ⟸   XM_063281192
- Peptide Label: isoform X12
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70587-F1-model_v2 AlphaFold P70587 1-1490 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708527 AgrOrtholog
BioCyc Gene G2FUF-50703 BioCyc
Ensembl Genes ENSRNOG00000011980 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016073.8 UniProtKB/TrEMBL
  ENSRNOT00000033502.6 UniProtKB/TrEMBL
  ENSRNOT00000066024 ENTREZGENE
  ENSRNOT00000066024.5 UniProtKB/TrEMBL
  ENSRNOT00000099468.1 UniProtKB/TrEMBL
  ENSRNOT00000115389 ENTREZGENE
  ENSRNOT00000115389.1 UniProtKB/TrEMBL
  ENSRNOT00000116114.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117284 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117284 ENTREZGENE
PANTHER DISCS LARGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT-CONTAINING PROTEIN 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrrc7 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011980 RatGTEx
SMART LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Outer arm dynein light chain 1 UniProtKB/TrEMBL
  RNI-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A0MXW8_RAT UniProtKB/TrEMBL
  A0A8I5ZTY2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G9P9 ENTREZGENE, UniProtKB/TrEMBL
  A6HWU2 ENTREZGENE, UniProtKB/TrEMBL
  F1LMG7_RAT UniProtKB/TrEMBL
  F1M4K6 ENTREZGENE, UniProtKB/TrEMBL
  LRRC7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9JI42 ENTREZGENE
UniProt Secondary Q9JI42 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Lrrc7  leucine rich repeat containing 7  LOC117284  densin-180  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference