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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cocaine-Related Disorders | | ISO | RGD:1349743 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:18438686 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cocaine-Related Disorders | | ISO | RGD:1349743 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:18438686 | |
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# | Reference Title | Reference Citation |
1. | Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. | Apperson ML, etal., J Neurosci 1996 Nov 1;16(21):6839-52. |
2. | CaMKII regulation in information processing and storage. | Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19. |
3. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
4. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
5. | Developmentally regulated alternative splicing of densin modulates protein-protein interaction and subcellular localization. | Jiao Y, etal., J Neurochem. 2008 Jun;105(5):1746-60. Epub 2008 Feb 4. |
6. | Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole. | Kinnunen AK, etal., J Neurochem. 2003 Aug;86(3):736-48. |
7. | Toluene disrupts synaptogenesis in cultured hippocampal neurons. | Lin HM, etal., Toxicol Lett. 2009 Jan 30;184(2):90-6. Epub 2008 Nov 7. |
8. | Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1. | Ohtakara K, etal., Genes Cells. 2002 Nov;7(11):1149-60. |
9. | Postsynaptic shank antagonizes dendrite branching induced by the leucine-rich repeat protein Densin-180. | Quitsch A, etal., J Neurosci. 2005 Jan 12;25(2):479-87. |
10. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
11. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
12. | Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. | Robison AJ, etal., J Biol Chem. 2005 Oct 21;280(42):35329-36. Epub 2005 Aug 24. |
13. | Association of calcium/calmodulin-dependent kinase II with developmentally regulated splice variants of the postsynaptic density protein densin-180. | Strack S, etal., J Biol Chem 2000 Aug 18;275(33):25061-4. |
14. | Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. | Yang L, etal., J Cell Biol. 1997 Jun 16;137(6):1199-210. |
PMID:11160423 | PMID:20124353 | PMID:21610080 | PMID:22871113 | PMID:23516094 | PMID:25931508 | PMID:30325965 |
Lrrc7 (Rattus norvegicus - Norway rat) |
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LRRC7 (Homo sapiens - human) |
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Lrrc7 (Mus musculus - house mouse) |
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Lrrc7 (Chinchilla lanigera - long-tailed chinchilla) |
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LRRC7 (Pan paniscus - bonobo/pygmy chimpanzee) |
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LRRC7 (Canis lupus familiaris - dog) |
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Lrrc7 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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LRRC7 (Sus scrofa - pig) |
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LRRC7 (Chlorocebus sabaeus - green monkey) |
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Lrrc7 (Heterocephalus glaber - naked mole-rat) |
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Variants in Lrrc7
1977 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | reproductive system | respiratory system | appendage | |
High | ||||||||||||
Medium | 38 | |||||||||||
Low | 36 | 3 | 2 | 1 | 2 | 30 | 13 | 1 | ||||
Below cutoff | 1 | 7 | 19 | 11 | 12 | 11 | 6 | 6 | 4 | 26 | 10 | 6 |
RefSeq Transcripts | NM_001393674 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_057142 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AC117096 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AF266164 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473952 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348625 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348626 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348627 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348628 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348629 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348630 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348631 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348632 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348633 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348634 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348635 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348636 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348637 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348638 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348639 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348640 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348641 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348642 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348643 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
EU348644 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000080 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
U66707 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000016073 ⟹ ENSRNOP00000016073 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000033502 ⟹ ENSRNOP00000034455 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000066024 ⟹ ENSRNOP00000059517 | ||||||||||||
RefSeq Status: | |||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000099468 ⟹ ENSRNOP00000082144 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000115389 ⟹ ENSRNOP00000082626 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000116114 ⟹ ENSRNOP00000093706 | ||||||||
RefSeq Status: | |||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_057142 ⟹ NP_476483 | ||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_001380603 | (Get FASTA) | NCBI Sequence Viewer |
NP_476483 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAC52881 | (Get FASTA) | NCBI Sequence Viewer |
AAF76466 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52040 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52041 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52042 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52043 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52044 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52045 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52046 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52047 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52048 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52049 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52050 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52051 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52052 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52053 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52054 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52055 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52056 | (Get FASTA) | NCBI Sequence Viewer | |
ACA52057 | (Get FASTA) | NCBI Sequence Viewer | |
EDL82579 | (Get FASTA) | NCBI Sequence Viewer | |
P70587 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_476483 ⟸ NM_057142 |
- UniProtKB: | P70587 (UniProtKB/Swiss-Prot), F1M4K6 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000016073 ⟸ ENSRNOT00000016073 |
RefSeq Acc Id: | ENSRNOP00000034455 ⟸ ENSRNOT00000033502 |
RefSeq Acc Id: | ENSRNOP00000059517 ⟸ ENSRNOT00000066024 |
RefSeq Acc Id: | ENSRNOP00000093706 ⟸ ENSRNOT00000116114 |
RefSeq Acc Id: | ENSRNOP00000082144 ⟸ ENSRNOT00000099468 |
RefSeq Acc Id: | ENSRNOP00000082626 ⟸ ENSRNOT00000115389 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P70587-F1-model_v2 | AlphaFold | P70587 | 1-1490 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:708527 | AgrOrtholog |
BioCyc Gene | G2FUF-50703 | BioCyc |
Ensembl Genes | ENSRNOG00000011980 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Protein | ENSRNOP00000016073.5 | UniProtKB/TrEMBL |
ENSRNOP00000034455.5 | UniProtKB/TrEMBL | |
ENSRNOP00000059517 | ENTREZGENE | |
ENSRNOP00000059517.4 | UniProtKB/TrEMBL | |
ENSRNOP00000082144.1 | UniProtKB/TrEMBL | |
ENSRNOP00000082626.1 | UniProtKB/TrEMBL | |
ENSRNOP00000093706.1 | UniProtKB/Swiss-Prot | |
Ensembl Transcript | ENSRNOT00000016073.8 | UniProtKB/TrEMBL |
ENSRNOT00000033502.6 | UniProtKB/TrEMBL | |
ENSRNOT00000066024 | ENTREZGENE | |
ENSRNOT00000066024.5 | UniProtKB/TrEMBL | |
ENSRNOT00000099468.1 | UniProtKB/TrEMBL | |
ENSRNOT00000115389.1 | UniProtKB/TrEMBL | |
ENSRNOT00000116114.1 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 2.30.42.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
3.80.10.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | Leu-rich_rpt | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Leu-rich_rpt_typical-subtyp | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRR_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PDZ_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:117284 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
NCBI Gene | 117284 | ENTREZGENE |
PANTHER | DISCS LARGE | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
LEUCINE-RICH REPEAT-CONTAINING PROTEIN 7 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | LRR_8 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Lrrc7 | PhenoGen |
PROSITE | LRR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SMART | LRR_BAC | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
LRR_SD22 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
LRR_TYP | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | L domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Outer arm dynein light chain 1 | UniProtKB/TrEMBL | |
RNI-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF50156 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A0A0MXW8_RAT | UniProtKB/TrEMBL |
A0A8I5ZTY2_RAT | UniProtKB/TrEMBL | |
A0A8I6G9P9_RAT | UniProtKB/TrEMBL | |
F1LMG7_RAT | UniProtKB/TrEMBL | |
F1M4K6 | ENTREZGENE, UniProtKB/TrEMBL | |
LRRC7_RAT | UniProtKB/Swiss-Prot, ENTREZGENE | |
UniProt Secondary | Q9JI42 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2005-07-08 | Lrrc7 | leucine rich repeat containing 7 | LOC117284 | densin-180 | Symbol and Name updated | 1299863 | APPROVED |
Note Type | Note | Reference |
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