Acsm2 (acyl-CoA synthetase medium-chain family member 2) - Rat Genome Database

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Gene: Acsm2 (acyl-CoA synthetase medium-chain family member 2) Rattus norvegicus
Analyze
Symbol: Acsm2
Name: acyl-CoA synthetase medium-chain family member 2
RGD ID: 708383
Description: Predicted to enable acid-thiol ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in fatty acid biosynthetic process and medium-chain fatty-acyl-CoA metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to several human genes including ACSM2A (acyl-CoA synthetase medium chain family member 2A); PARTICIPATES IN fatty acid beta degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acsm2a; acyl-CoA synthetase medium-chain family member 2A; acyl-coenzyme A synthetase ACSM2, mitochondrial; benzoate--CoA ligase; butyrate--CoA ligase 2; butyryl coenzyme A synthetase 2; butyryl-coenzyme A synthetase 2; kidney-specific protein (KS); kidney-specific protein KS; KS; LOC246263; middle-chain acyl-CoA synthetase 2; xenobiotic/medium-chain fatty acid:CoA ligase
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,347,705 - 183,386,453 (+)NCBIGRCr8
mRatBN7.21173,916,368 - 173,955,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,916,368 - 173,955,116 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,231,825 - 182,270,521 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01189,417,932 - 189,456,631 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,153,148 - 182,193,165 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,289,957 - 189,329,007 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,289,957 - 189,395,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,227,765 - 196,266,992 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41177,830,613 - 177,869,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11177,969,858 - 178,008,307 (+)NCBI
Celera1171,667,471 - 171,705,910 (+)NCBICelera
Cytogenetic Map1q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butralin  (EXP)
CGP 52608  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
fentin chloride  (EXP)
flutamide  (EXP)
glafenine  (EXP)
glucose  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
leflunomide  (EXP)
melatonin  (EXP,ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
O-methyleugenol  (ISO)
oxycodone  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
pyrazinecarboxamide  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tetracycline  (ISO)
thioacetamide  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney. Hilgers KF, etal., Kidney Int 1998 Nov;54(5):1444-54.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:18614015   PMID:19345228  


Genomics

Comparative Map Data
Acsm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81183,347,705 - 183,386,453 (+)NCBIGRCr8
mRatBN7.21173,916,368 - 173,955,116 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,916,368 - 173,955,116 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1182,231,825 - 182,270,521 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01189,417,932 - 189,456,631 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,153,148 - 182,193,165 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01189,289,957 - 189,329,007 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,289,957 - 189,395,276 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01196,227,765 - 196,266,992 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41177,830,613 - 177,869,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11177,969,858 - 178,008,307 (+)NCBI
Celera1171,667,471 - 171,705,910 (+)NCBICelera
Cytogenetic Map1q35NCBI
ACSM2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381620,451,521 - 20,487,669 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1620,451,461 - 20,487,669 (+)EnsemblGRCh38hg38GRCh38
GRCh371620,462,843 - 20,498,991 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361620,370,360 - 20,406,492 (+)NCBINCBI36Build 36hg18NCBI36
Celera1619,617,914 - 19,631,073 (+)NCBICelera
Celera1619,790,180 - 19,797,288 (-)NCBICelera
Cytogenetic Map16p12.3NCBI
HuRef1618,999,519 - 19,035,632 (+)NCBIHuRef
CHM1_11620,551,160 - 20,587,291 (+)NCBICHM1_1
T2T-CHM13v2.01620,382,562 - 20,418,674 (+)NCBIT2T-CHM13v2.0
Acsm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397119,153,563 - 119,199,917 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7119,153,563 - 119,199,913 (+)EnsemblGRCm39 Ensembl
GRCm387119,554,340 - 119,600,694 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7119,554,340 - 119,600,690 (+)EnsemblGRCm38mm10GRCm38
MGSCv377126,697,854 - 126,744,208 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367119,352,881 - 119,387,329 (+)NCBIMGSCv36mm8
Celera7119,472,012 - 119,518,406 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map763.97NCBI
LOC479822
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1624,864,952 - 24,893,830 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,180,062 - 39,208,987 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0625,021,437 - 25,050,364 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1624,822,297 - 24,851,221 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0624,717,429 - 24,746,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0625,105,579 - 25,134,524 (-)NCBIUU_Cfam_GSD_1.0
ACSM2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1325,357,943 - 25,387,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2326,138,057 - 26,166,416 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Acsm2
306 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat

Markers in Region
RH134354  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21173,954,863 - 173,955,063 (+)MAPPERmRatBN7.2
Rnor_6.01189,328,755 - 189,328,954NCBIRnor6.0
Rnor_5.01196,266,740 - 196,266,939UniSTSRnor5.0
RGSC_v3.41177,868,809 - 177,869,008UniSTSRGSC3.4
Celera1171,705,658 - 171,705,857UniSTS
Cytogenetic Map1q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 35 35 29
Low 6 2 2 2 3 3 2 5 11 3
Below cutoff 1 16 16 4 14 4 5 5 27 27 5

Sequence


RefSeq Acc Id: ENSRNOT00000020587   ⟹   ENSRNOP00000020587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1173,916,368 - 173,955,116 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106466   ⟹   ENSRNOP00000092168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1173,916,368 - 173,955,116 (+)Ensembl
RefSeq Acc Id: NM_144748   ⟹   NP_653349
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81183,347,705 - 183,386,453 (+)NCBI
mRatBN7.21173,916,368 - 173,955,116 (+)NCBI
Rnor_6.01189,289,957 - 189,329,007 (+)NCBI
Rnor_5.01196,227,765 - 196,266,992 (+)NCBI
RGSC_v3.41177,830,613 - 177,869,061 (+)RGD
Celera1171,667,471 - 171,705,910 (+)RGD
Sequence:
RefSeq Acc Id: NP_653349   ⟸   NM_144748
- UniProtKB: Q6AZ63 (UniProtKB/Swiss-Prot),   O70490 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020587   ⟸   ENSRNOT00000020587
RefSeq Acc Id: ENSRNOP00000092168   ⟸   ENSRNOT00000106466
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70490-F1-model_v2 AlphaFold O70490 1-572 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690351
Promoter ID:EPDNEW_R876
Type:multiple initiation site
Name:Acsm2_2
Description:acyl-CoA synthetase medium-chain family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R878  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01189,289,961 - 189,290,021EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708383 AgrOrtholog
BioCyc Gene G2FUF-57651 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
BioCyc Pathway Image FAO-PWY BioCyc
  PWY-5143 BioCyc
  PWY-5972 BioCyc
  PWY-6000 BioCyc
  PWY-7049 BioCyc
  PWY-8181 BioCyc
  PWY3DJ-11470 BioCyc
  PWY66-387 BioCyc
  PWY66-388 BioCyc
  PWY66-389 BioCyc
  PWY66-391 BioCyc
Ensembl Genes ENSRNOG00000042084 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000064951 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020587 ENTREZGENE
  ENSRNOT00000020587.4 UniProtKB/TrEMBL
  ENSRNOT00000055083.5 UniProtKB/TrEMBL
  ENSRNOT00000080338.2 UniProtKB/TrEMBL
  ENSRNOT00000106466.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.12780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110246 IMAGE-MGC_LOAD
InterPro AMP-bd_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-bd_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246263 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93153 IMAGE-MGC_LOAD
NCBI Gene 246263 ENTREZGENE
PANTHER ACYL-COENZYME A SYNTHETASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYL-COENZYME A SYNTHETASE ACSM1, MITOCHONDRIAL UniProtKB/TrEMBL
  ACYL-COENZYME A SYNTHETASE ACSM2B, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-binding_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acsm2 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042084 RatGTEx
  ENSRNOG00000064951 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSN9_RAT UniProtKB/TrEMBL
  A0A0G2K125_RAT UniProtKB/TrEMBL
  A0A8I6AF03_RAT UniProtKB/TrEMBL
  ACSM2_RAT UniProtKB/Swiss-Prot
  F1M1W1_RAT UniProtKB/TrEMBL
  O70490 ENTREZGENE
  Q6AZ63 ENTREZGENE
UniProt Secondary Q6AZ63 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-17 Acsm2  acyl-CoA synthetase medium-chain family member 2  Acsm2a  acyl-CoA synthetase medium-chain family member 2A  Name and Symbol changed 629549 APPROVED
2012-01-09 Acsm2a  acyl-CoA synthetase medium-chain family member 2A  Acsm2  acyl-CoA synthetase medium-chain family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-27 Acsm2  acyl-CoA synthetase medium-chain family member 2  Acsm2a  acyl-CoA synthetase medium-chain family member 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Acsm2a  acyl-CoA synthetase medium-chain family member 2A  Acsm2a  acyl-CoA synthetase medium-chain family member 2a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Acsm2a  acyl-CoA synthetase medium-chain family member 2a  LOC246263  kidney-specific protein (KS)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 LOC246263        Symbol and Name status set to provisional 70820 PROVISIONAL