Ces2a (carboxylesterase 2A) - Rat Genome Database

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Gene: Ces2a (carboxylesterase 2A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ces2a
Name: carboxylesterase 2A
RGD ID: 708353
Description: Enables carboxylesterase activity and retinyl-palmitate esterase activity. Predicted to be involved in retinol metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: carboxylesterase 6; carboxylesterase isoenzyme; carboxylesterase isoenzyme gene; carboxylic ester hydrolase; Ces6; LOC246252; pyrethroid hydrolase Ces2a
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819135,885 - 142,935 (-)NCBIGRCr8
mRatBN7.219129,428 - 136,480 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19129,428 - 136,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19134,435 - 141,443 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.019868,131 - 875,141 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019143,363 - 150,371 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01959,110 - 64,378 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1959,197 - 64,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019506,180 - 507,580 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01954,661 - 64,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41937,686 - 44,736 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11937,685 - 44,736 (-)NCBI
Celera19125,426 - 132,478 (-)NCBICelera
Cytogenetic Map19p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.
Additional References at PubMed
PMID:19187434   PMID:34503976  


Genomics

Variants

.
Variants in Ces2a
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:8
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000015451
Prediction methods:Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 19 19 19
Low 2 15 14 14 12 2
Below cutoff 15 17 8 8 8 6 7 4 7 18 5 6

Sequence


RefSeq Acc Id: ENSRNOT00000015451   ⟹   ENSRNOP00000015451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl19129,428 - 136,480 (-)Ensembl
Rnor_6.0 Ensembl1959,197 - 64,303 (-)Ensembl
RefSeq Acc Id: NR_171898
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr819135,885 - 142,935 (-)NCBI
mRatBN7.219129,428 - 136,480 (-)NCBI
Protein Sequences
Protein RefSeqs NP_653344 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK61610 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071888.2
  ENSRNOP00055012416
  ENSRNOP00060018572
  ENSRNOP00065014882
GenBank Protein Q8K3R0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: ENSRNOP00000015451   ⟸   ENSRNOT00000015451
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3R0-F1-model_v2 AlphaFold Q8K3R0 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700902
Promoter ID:EPDNEW_R11426
Type:initiation region
Name:Ces2a_1
Description:carboxylesterase 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01964,334 - 64,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708353 AgrOrtholog
BioCyc Gene G2FUF-6675 BioCyc
Ensembl Genes ENSRNOG00000011330 Ensembl
  ENSRNOG00000012034 UniProtKB/TrEMBL
  ENSRNOG00055009154 UniProtKB/Swiss-Prot
  ENSRNOG00060013709 UniProtKB/Swiss-Prot
  ENSRNOG00065011965 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090543.2 UniProtKB/TrEMBL
  ENSRNOT00055015501 UniProtKB/Swiss-Prot
  ENSRNOT00060023415 UniProtKB/Swiss-Prot
  ENSRNOT00065019441 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246252 UniProtKB/Swiss-Prot
NCBI Gene 246252 ENTREZGENE
PANTHER CARBOXYLESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRETHROID HYDROLASE CES2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ces2a PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011330 RatGTEx
  ENSRNOG00000012034 RatGTEx
  ENSRNOG00055009154 RatGTEx
  ENSRNOG00060013709 RatGTEx
  ENSRNOG00065011965 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K1L3 ENTREZGENE, UniProtKB/TrEMBL
  EST2A_RAT UniProtKB/Swiss-Prot
  F7F3M3 ENTREZGENE
  Q8K3R0 ENTREZGENE
UniProt Secondary F7F3M3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-18 Ces2a  carboxylesterase 2A  Ces6  carboxylesterase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Ces6  carboxylesterase 6  LOC246252  carboxylesterase isoenzyme gene  Symbol and Name updated 1299863 APPROVED