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Gene: PDK2 (pyruvate dehydrogenase kinase 2) Homo sapiens
Symbol: PDK2
Name: pyruvate dehydrogenase kinase 2
RGD ID: 69481
Description: Exhibits ATP binding activity; protein homodimerization activity; and pyruvate dehydrogenase (acetyl-transferring) kinase activity. Involved in cellular response to reactive oxygen species and intrinsic apoptotic signaling pathway by p53 class mediator. Localizes to cytosol; mitochondrion; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; PDH kinase 2; PDHK2; PDKII; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase kinase, isozyme 2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial
Mus musculus (house mouse) : Pdk2 (pyruvate dehydrogenase kinase, isoenzyme 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdk2 (pyruvate dehydrogenase kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdk2 (pyruvate dehydrogenase kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PDK2 (pyruvate dehydrogenase kinase 2)
Canis lupus familiaris (dog) : PDK2 (pyruvate dehydrogenase kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdk2 (pyruvate dehydrogenase kinase 2)
Sus scrofa (pig) : PDK2 (pyruvate dehydrogenase kinase 2)
Chlorocebus sabaeus (African green monkey) : PDK2 (pyruvate dehydrogenase kinase 2)
Heterocephalus glaber (naked mole-rat) : Pdk2 (pyruvate dehydrogenase kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1750,094,737 - 50,112,152 (+)EnsemblGRCh38hg38GRCh38
GRCh381750,094,737 - 50,112,152 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371748,172,101 - 48,188,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,527,695 - 45,543,422 (+)NCBINCBI36hg18NCBI36
Build 341745,527,694 - 45,543,421NCBI
Celera1744,632,807 - 44,648,538 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1743,539,977 - 43,556,609 (+)NCBIHuRef
CHM1_11748,236,413 - 48,253,044 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDK2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69481
Created: 2001-11-27
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.