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Gene: UBE2D2 (ubiquitin conjugating enzyme E2 D2) Homo sapiens
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Symbol: UBE2D2
Name: ubiquitin conjugating enzyme E2 D2
Description: Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: (E3-independent) E2 ubiquitin-conjugating enzyme D2; E2 ubiquitin-conjugating enzyme D2; E2(17)KB2; p53-regulated ubiquitin-conjugating enzyme 1; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B; ubiquitin carrier protein D2; ubiquitin conjugating enzyme E2D 2; ubiquitin-conjugating enzyme E2 D2; ubiquitin-conjugating enzyme E2(17)KB 2; ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); ubiquitin-protein ligase D2
Orthologs:
Mus musculus (house mouse) : Ube2d2a (ubiquitin-conjugating enzyme E2D 2A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ube2d2 (ubiquitin-conjugating enzyme E2D 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ube2d2 (ubiquitin conjugating enzyme E2 D2)
Pan paniscus (bonobo/pygmy chimpanzee) : UBE2D2 (ubiquitin conjugating enzyme E2 D2)
Canis lupus familiaris (dog) : UBE2D2 (ubiquitin conjugating enzyme E2 D2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ube2d2 (ubiquitin conjugating enzyme E2 D2)
Sus scrofa (pig) : UBE2D2 (ubiquitin conjugating enzyme E2 D2)
more info ...
Related Pseudogenes: UBE2DNL  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385139,561,166 - 139,628,434 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375138,940,751 - 139,008,019 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365138,920,935 - 138,988,203 (+)NCBINCBI36hg18NCBI36
Build 345138,920,934 - 138,988,200NCBI
Celera5135,015,760 - 135,083,018 (+)NCBI
Cytogenetic Map5q31.2NCBI
HuRef5134,083,642 - 134,151,382 (+)NCBIHuRef
CHM1_15138,373,349 - 138,440,624 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on UBE2D2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69475
Created: 2001-11-27
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.