RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2) - Rat Genome Database

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Gene: RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2) Homo sapiens
Analyze
Symbol: RASGRF2
Name: Ras protein specific guanine nucleotide releasing factor 2
RGD ID: 69460
HGNC Page HGNC:9876
Description: Enables guanyl-nucleotide exchange factor activity. Involved in response to endoplasmic reticulum stress. Located in endoplasmic reticulum.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp781H1715; GRF2; guanine nucleotide-releasing factor 2; ras guanine nucleotide exchange factor 2; Ras protein-specific guanine nucleotide-releasing factor 2; RAS-GRF2; ras-specific guanine nucleotide-releasing factor 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,960,363 - 81,230,162 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,960,363 - 81,230,162 (+)EnsemblGRCh38hg38GRCh38
GRCh37580,256,182 - 80,525,981 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36580,292,314 - 80,557,709 (+)NCBINCBI36Build 36hg18NCBI36
Build 34580,292,313 - 80,557,709NCBI
Celera576,160,831 - 76,426,223 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,465,367 - 75,734,900 (+)NCBIHuRef
CHM1_1579,689,169 - 79,958,778 (+)NCBICHM1_1
T2T-CHM13v2.0581,444,995 - 81,714,744 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9027497   PMID:9032266   PMID:9707409   PMID:10373510   PMID:11238945   PMID:11756498   PMID:11856323   PMID:12376548   PMID:12477932   PMID:12787561   PMID:14622581   PMID:14702039  
PMID:14749369   PMID:16344560   PMID:16596198   PMID:17353931   PMID:17923690   PMID:18029348   PMID:19692568   PMID:20011522   PMID:20379614   PMID:21130132   PMID:21685891   PMID:21873635  
PMID:22419666   PMID:23223532   PMID:23414517   PMID:23568457   PMID:23827383   PMID:24692549   PMID:25335168   PMID:27856453   PMID:27992614   PMID:30249655   PMID:30359168   PMID:32203420  
PMID:32298357   PMID:36774506   PMID:37029817  


Genomics

Comparative Map Data
RASGRF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,960,363 - 81,230,162 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,960,363 - 81,230,162 (+)EnsemblGRCh38hg38GRCh38
GRCh37580,256,182 - 80,525,981 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36580,292,314 - 80,557,709 (+)NCBINCBI36Build 36hg18NCBI36
Build 34580,292,313 - 80,557,709NCBI
Celera576,160,831 - 76,426,223 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,465,367 - 75,734,900 (+)NCBIHuRef
CHM1_1579,689,169 - 79,958,778 (+)NCBICHM1_1
T2T-CHM13v2.0581,444,995 - 81,714,744 (+)NCBIT2T-CHM13v2.0
Rasgrf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,028,526 - 92,268,584 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,028,519 - 92,268,164 (-)EnsemblGRCm39 Ensembl
GRCm381391,880,407 - 92,131,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1391,880,400 - 92,131,656 (-)EnsemblGRCm38mm10GRCm38
MGSCv371392,020,012 - 92,127,647 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv371392,792,695 - 92,901,449 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361392,358,671 - 92,462,280 (-)NCBIMGSCv36mm8
Celera1395,507,627 - 95,744,228 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.43NCBI
Rasgrf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8224,848,699 - 25,096,773 (-)NCBIGRCr8
mRatBN7.2223,113,613 - 23,361,537 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,117,004 - 23,361,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,154,119 - 30,396,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,254,458 - 28,496,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,080,067 - 23,323,713 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0221,460,041 - 21,698,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0240,664,646 - 40,904,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,113,649 - 22,360,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1222,034,017 - 22,281,339 (-)NCBI
Celera219,216,953 - 19,453,016 (-)NCBICelera
Cytogenetic Map2q12NCBI
Rasgrf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541828,930,616 - 29,065,110 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541828,930,666 - 29,126,495 (-)NCBIChiLan1.0ChiLan1.0
RASGRF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2434,071,454 - 34,349,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,225,079 - 32,503,237 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0534,048,832 - 34,326,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1534,359,896 - 34,635,488 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,359,896 - 34,635,488 (-)Ensemblpanpan1.1panPan2
RASGRF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,047,304 - 26,286,919 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,050,260 - 26,286,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,282,954 - 27,522,340 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0325,961,452 - 26,200,939 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl325,964,823 - 26,201,470 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1325,917,048 - 26,141,554 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0325,882,708 - 26,122,066 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,162,682 - 26,402,121 (-)NCBIUU_Cfam_GSD_1.0
Rasgrf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,051,996 - 182,288,402 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936469337,130 - 573,776 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936469337,340 - 573,763 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASGRF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl289,528,111 - 89,790,719 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1289,525,948 - 89,794,103 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,513,920 - 91,699,524 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RASGRF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1475,114,512 - 75,378,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl475,115,109 - 75,373,851 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,980,283 - 24,251,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasgrf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247431,604,915 - 1,790,473 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RASGRF2
53 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_006909.2(RASGRF2):c.1839-302T>A single nucleotide variant Lung cancer [RCV000096195] Chr5:81112308 [GRCh38]
Chr5:80408127 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh38/hg38 5q13.3-22.1(chr5:74163186-110809453)x3 copy number gain See cases [RCV000051839] Chr5:74163186..110809453 [GRCh38]
Chr5:73459011..110145153 [GRCh37]
Chr5:73494767..110173052 [NCBI36]
Chr5:5q13.3-22.1		 pathogenic
GRCh38/hg38 5q14.1(chr5:79665668-81197686)x1 copy number loss See cases [RCV000052576] Chr5:79665668..81197686 [GRCh38]
Chr5:78961491..80493505 [GRCh37]
Chr5:78997247..80529261 [NCBI36]
Chr5:5q14.1		 uncertain significance
NM_006909.2(RASGRF2):c.316G>A (p.Glu106Lys) single nucleotide variant Malignant melanoma [RCV000067019] Chr5:81042904 [GRCh38]
Chr5:80338723 [GRCh37]
Chr5:80374479 [NCBI36]
Chr5:5q14.1		 not provided
NM_006909.2(RASGRF2):c.2070C>T (p.Phe690=) single nucleotide variant Malignant melanoma [RCV000067020] Chr5:81112841 [GRCh38]
Chr5:80408660 [GRCh37]
Chr5:80444416 [NCBI36]
Chr5:5q14.1		 not provided
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q14.1(chr5:79678575-80868550)x3 copy number gain See cases [RCV000448914] Chr5:79678575..80868550 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NM_006909.3(RASGRF2):c.2050G>A (p.Asp684Asn) single nucleotide variant Inborn genetic diseases [RCV003293825] Chr5:81112821 [GRCh38]
Chr5:80408640 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh37/hg19 5q14.1(chr5:79625636-80884586)x3 copy number gain not provided [RCV000682570] Chr5:79625636..80884586 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh37/hg19 5q14.1(chr5:80080727-80490942)x3 copy number gain not provided [RCV000682572] Chr5:80080727..80490942 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh37/hg19 5q14.1(chr5:79992417-80346470)x3 copy number gain not provided [RCV000682571] Chr5:79992417..80346470 [GRCh37]
Chr5:5q14.1		 likely benign
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q14.1(chr5:79990131-80337995)x3 copy number gain not provided [RCV000744891] Chr5:79990131..80337995 [GRCh37]
Chr5:5q14.1		 benign
GRCh37/hg19 5q14.1(chr5:80255984-80256784)x1 copy number loss not provided [RCV000744892] Chr5:80255984..80256784 [GRCh37]
Chr5:5q14.1		 benign
GRCh37/hg19 5q14.1(chr5:80255984-80256909)x1 copy number loss not provided [RCV000744893] Chr5:80255984..80256909 [GRCh37]
Chr5:5q14.1		 benign
GRCh37/hg19 5q14.1(chr5:80503528-80594346)x3 copy number gain not provided [RCV000744894] Chr5:80503528..80594346 [GRCh37]
Chr5:5q14.1		 benign
NM_006909.3(RASGRF2):c.2596+4A>G single nucleotide variant not provided [RCV000961624] Chr5:81123771 [GRCh38]
Chr5:80419590 [GRCh37]
Chr5:5q14.1		 benign
NM_006909.3(RASGRF2):c.888-4A>G single nucleotide variant not provided [RCV000969199] Chr5:81080117 [GRCh38]
Chr5:80375936 [GRCh37]
Chr5:5q14.1		 benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
GRCh37/hg19 5q14.1(chr5:80501001-80600333)x3 copy number gain not provided [RCV000848377] Chr5:80501001..80600333 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.1225A>G (p.Arg409Gly) single nucleotide variant Inborn genetic diseases [RCV003245051] Chr5:81085865 [GRCh38]
Chr5:80381684 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh37/hg19 5q14.1(chr5:80423020-80485467)x1 copy number loss not provided [RCV001005695] Chr5:80423020..80485467 [GRCh37]
Chr5:5q14.1		 likely benign
GRCh37/hg19 5q14.1(chr5:79985830-80348469)x3 copy number gain not provided [RCV000847960] Chr5:79985830..80348469 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh37/hg19 5q14.1(chr5:79664621-80767791)x3 copy number gain not provided [RCV000845611] Chr5:79664621..80767791 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh37/hg19 5q14.1(chr5:80323403-80577511)x3 copy number gain not provided [RCV001005694] Chr5:80323403..80577511 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3208C>T (p.Arg1070Cys) single nucleotide variant Inborn genetic diseases [RCV003274751] Chr5:81212417 [GRCh38]
Chr5:80508236 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3130A>T (p.Met1044Leu) single nucleotide variant Inborn genetic diseases [RCV003239830] Chr5:81208412 [GRCh38]
Chr5:80504231 [GRCh37]
Chr5:5q14.1		 uncertain significance
GRCh37/hg19 5q13.2-15(chr5:72790061-97478870)x3 copy number gain not provided [RCV001005683] Chr5:72790061..97478870 [GRCh37]
Chr5:5q13.2-15		 pathogenic
GRCh37/hg19 5q14.1(chr5:79528733-80545287)x3 copy number gain not provided [RCV001005691] Chr5:79528733..80545287 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.1850G>A (p.Arg617His) single nucleotide variant Inborn genetic diseases [RCV003253880] Chr5:81112621 [GRCh38]
Chr5:80408440 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2776G>A (p.Val926Ile) single nucleotide variant Inborn genetic diseases [RCV002901985] Chr5:81180264 [GRCh38]
Chr5:80476083 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3188A>G (p.Asn1063Ser) single nucleotide variant Inborn genetic diseases [RCV002733665] Chr5:81212397 [GRCh38]
Chr5:80508216 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2065C>A (p.Pro689Thr) single nucleotide variant Inborn genetic diseases [RCV002752602] Chr5:81112836 [GRCh38]
Chr5:80408655 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3346T>C (p.Ser1116Pro) single nucleotide variant Inborn genetic diseases [RCV002728485] Chr5:81212555 [GRCh38]
Chr5:80508374 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.544A>G (p.Ile182Val) single nucleotide variant Inborn genetic diseases [RCV002689217] Chr5:81070492 [GRCh38]
Chr5:80366311 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.812G>A (p.Arg271Gln) single nucleotide variant Inborn genetic diseases [RCV002708216] Chr5:81073377 [GRCh38]
Chr5:80369196 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.33C>G (p.His11Gln) single nucleotide variant Inborn genetic diseases [RCV002844115] Chr5:80960771 [GRCh38]
Chr5:80256590 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3112G>A (p.Glu1038Lys) single nucleotide variant Inborn genetic diseases [RCV002759345] Chr5:81208394 [GRCh38]
Chr5:80504213 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2701G>A (p.Glu901Lys) single nucleotide variant Inborn genetic diseases [RCV002799196] Chr5:81180189 [GRCh38]
Chr5:80476008 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2516C>A (p.Ser839Tyr) single nucleotide variant Inborn genetic diseases [RCV002789173] Chr5:81123687 [GRCh38]
Chr5:80419506 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3625G>A (p.Ala1209Thr) single nucleotide variant Inborn genetic diseases [RCV002826265] Chr5:81225681 [GRCh38]
Chr5:80521500 [GRCh37]
Chr5:5q14.1		 likely benign
NM_006909.3(RASGRF2):c.1211A>G (p.His404Arg) single nucleotide variant Inborn genetic diseases [RCV002878192] Chr5:81085851 [GRCh38]
Chr5:80381670 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3520G>A (p.Glu1174Lys) single nucleotide variant Inborn genetic diseases [RCV002960462] Chr5:81217441 [GRCh38]
Chr5:80513260 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3434A>G (p.Asn1145Ser) single nucleotide variant Inborn genetic diseases [RCV002939585] Chr5:81215955 [GRCh38]
Chr5:80511774 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2633C>T (p.Pro878Leu) single nucleotide variant Inborn genetic diseases [RCV003011001] Chr5:81127110 [GRCh38]
Chr5:80422929 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2731C>T (p.Arg911Trp) single nucleotide variant Inborn genetic diseases [RCV002679661] Chr5:81180219 [GRCh38]
Chr5:80476038 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.1385G>T (p.Arg462Leu) single nucleotide variant Inborn genetic diseases [RCV003207599] Chr5:81086948 [GRCh38]
Chr5:80382767 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2866C>G (p.Leu956Val) single nucleotide variant Inborn genetic diseases [RCV003207461] Chr5:81201402 [GRCh38]
Chr5:80497221 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2492C>T (p.Ala831Val) single nucleotide variant Inborn genetic diseases [RCV003190838] Chr5:81123663 [GRCh38]
Chr5:80419482 [GRCh37]
Chr5:5q14.1		 likely benign
NM_006909.3(RASGRF2):c.2141T>C (p.Val714Ala) single nucleotide variant Inborn genetic diseases [RCV003186178] Chr5:81113591 [GRCh38]
Chr5:80409410 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.2522C>T (p.Ala841Val) single nucleotide variant Inborn genetic diseases [RCV003283326] Chr5:81123693 [GRCh38]
Chr5:80419512 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.3070G>A (p.Glu1024Lys) single nucleotide variant Inborn genetic diseases [RCV003379075] Chr5:81207348 [GRCh38]
Chr5:80503167 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.679A>T (p.Thr227Ser) single nucleotide variant Inborn genetic diseases [RCV003345147] Chr5:81073244 [GRCh38]
Chr5:80369063 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.1634A>G (p.Gln545Arg) single nucleotide variant Inborn genetic diseases [RCV003372507] Chr5:81094871 [GRCh38]
Chr5:80390690 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.550G>A (p.Ala184Thr) single nucleotide variant Inborn genetic diseases [RCV003385357] Chr5:81070498 [GRCh38]
Chr5:80366317 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.1721A>G (p.Gln574Arg) single nucleotide variant Inborn genetic diseases [RCV003385538] Chr5:81094958 [GRCh38]
Chr5:80390777 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.1829A>G (p.His610Arg) single nucleotide variant Inborn genetic diseases [RCV003373801] Chr5:81109069 [GRCh38]
Chr5:80404888 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.1267T>C (p.Ser423Pro) single nucleotide variant Inborn genetic diseases [RCV003365133] Chr5:81085907 [GRCh38]
Chr5:80381726 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.1063C>G (p.Gln355Glu) single nucleotide variant Inborn genetic diseases [RCV003385913] Chr5:81080691 [GRCh38]
Chr5:80376510 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.13G>C (p.Val5Leu) single nucleotide variant Inborn genetic diseases [RCV003368789] Chr5:80960751 [GRCh38]
Chr5:80256570 [GRCh37]
Chr5:5q14.1		 uncertain significance
NM_006909.3(RASGRF2):c.721A>C (p.Met241Leu) single nucleotide variant Inborn genetic diseases [RCV003386568] Chr5:81073286 [GRCh38]
Chr5:80369105 [GRCh37]
Chr5:5q14.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2138
Count of miRNA genes:1063
Interacting mature miRNAs:1316
Transcripts:ENST00000265080, ENST00000502677, ENST00000503795, ENST00000512186, ENST00000514946
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D17S1288  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,456,448 - 80,456,562UniSTSGRCh37
Build 36580,492,204 - 80,492,318RGDNCBI36
Celera576,360,732 - 76,360,846RGD
Cytogenetic Map5q13UniSTS
HuRef575,665,396 - 75,665,510UniSTS
Marshfield Genetic Map1745.93UniSTS
Marshfield Genetic Map1745.93RGD
G29263  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,524,800 - 80,524,932UniSTSGRCh37
Build 36580,560,556 - 80,560,688RGDNCBI36
Celera576,429,070 - 76,429,202RGD
Cytogenetic Map5q13UniSTS
HuRef575,733,719 - 75,733,851UniSTS
RH119541  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,283,322 - 80,283,642UniSTSGRCh37
Build 36580,319,078 - 80,319,398RGDNCBI36
Celera576,187,594 - 76,187,914RGD
Cytogenetic Map5q13UniSTS
HuRef575,492,133 - 75,492,453UniSTS
TNG Radiation Hybrid Map562909.0UniSTS
G59864  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,396,779 - 80,396,882UniSTSGRCh37
Build 36580,432,535 - 80,432,638RGDNCBI36
Celera576,301,064 - 76,301,167RGD
Cytogenetic Map5q13UniSTS
HuRef575,605,722 - 75,605,825UniSTS
TNG Radiation Hybrid Map562953.0UniSTS
SHGC-142860  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,483,578 - 80,483,870UniSTSGRCh37
Build 36580,519,334 - 80,519,626RGDNCBI36
Celera576,387,849 - 76,388,141RGD
Cytogenetic Map5q13UniSTS
HuRef575,692,509 - 75,692,801UniSTS
TNG Radiation Hybrid Map563010.0UniSTS
SHGC-84312  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,403,438 - 80,403,721UniSTSGRCh37
Build 36580,439,194 - 80,439,477RGDNCBI36
Celera576,307,723 - 76,308,006RGD
Cytogenetic Map5q13UniSTS
HuRef575,612,381 - 75,612,664UniSTS
TNG Radiation Hybrid Map562950.0UniSTS
A009B02  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,523,616 - 80,523,824UniSTSGRCh37
Build 36580,559,372 - 80,559,580RGDNCBI36
Celera576,427,886 - 76,428,094RGD
Cytogenetic Map5q13UniSTS
HuRef575,732,535 - 75,732,743UniSTS
GeneMap99-GB4 RH Map5387.88UniSTS
G20891  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,305,109 - 80,305,316UniSTSGRCh37
Build 36580,340,865 - 80,341,072RGDNCBI36
Celera576,209,403 - 76,209,610RGD
Cytogenetic Map5q13UniSTS
HuRef575,514,243 - 75,514,450UniSTS
D5S2632  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,525,791 - 80,525,930UniSTSGRCh37
Build 36580,561,547 - 80,561,686RGDNCBI36
Celera576,430,061 - 76,430,200RGD
Cytogenetic Map5q13UniSTS
HuRef575,734,710 - 75,734,849UniSTS
GeneMap99-G3 RH Map52945.0UniSTS
D5S2322  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,524,791 - 80,524,930UniSTSGRCh37
Build 36580,560,547 - 80,560,686RGDNCBI36
Celera576,429,061 - 76,429,200RGD
Cytogenetic Map5q13UniSTS
HuRef575,733,710 - 75,733,849UniSTS
GeneMap99-GB4 RH Map5387.58UniSTS
Whitehead-RH Map5283.9UniSTS
Whitehead-YAC Contig Map5 UniSTS
NCBI RH Map5422.3UniSTS
G20459  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,524,699 - 80,524,856UniSTSGRCh37
Build 36580,560,455 - 80,560,612RGDNCBI36
Celera576,428,969 - 76,429,126RGD
Cytogenetic Map5q13UniSTS
HuRef575,733,618 - 75,733,775UniSTS
A005S20  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,524,699 - 80,524,856UniSTSGRCh37
Build 36580,560,455 - 80,560,612RGDNCBI36
Celera576,428,969 - 76,429,126RGD
Cytogenetic Map5q13UniSTS
HuRef575,733,618 - 75,733,775UniSTS
GeneMap99-GB4 RH Map5387.38UniSTS
G20896  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,277,736 - 80,277,861UniSTSGRCh37
Build 36580,313,492 - 80,313,617RGDNCBI36
Celera576,182,005 - 76,182,130RGD
Cytogenetic Map5q13UniSTS
HuRef575,486,550 - 75,486,675UniSTS
D5S1437  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,436,073 - 80,436,302UniSTSGRCh37
Build 36580,471,829 - 80,472,058RGDNCBI36
Celera576,340,358 - 76,340,587RGD
Cytogenetic Map5q13UniSTS
HuRef575,645,021 - 75,645,250UniSTS
RASGRF2__5650  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,521,514 - 80,522,139UniSTSGRCh37
Build 36580,557,270 - 80,557,895RGDNCBI36
Celera576,425,784 - 76,426,409RGD
HuRef575,730,433 - 75,731,058UniSTS
G32371  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37580,523,616 - 80,523,824UniSTSGRCh37
Celera576,427,886 - 76,428,094UniSTS
Cytogenetic Map5q13UniSTS
HuRef575,732,535 - 75,732,743UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 32 16 85 5 10 6 787 10 1277 38 187 125 514 507 2
Low 2335 2583 1330 350 1081 188 3432 2145 2400 328 1167 1359 168 1 690 2228 3 1
Below cutoff 55 389 309 267 813 269 122 28 50 40 91 116 5 53

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_030334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024446142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002956166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC020901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC026427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF023130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF181250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF186017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL598102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC041953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC126112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU430075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX502901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ834808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA219722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA230428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LS482416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000265080   ⟹   ENSP00000265080
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl580,960,363 - 81,230,162 (+)Ensembl
RefSeq Acc Id: ENST00000502677
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl581,070,024 - 81,088,564 (+)Ensembl
RefSeq Acc Id: ENST00000503795   ⟹   ENSP00000421771
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl580,960,689 - 81,225,812 (+)Ensembl
RefSeq Acc Id: ENST00000512186
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl581,092,916 - 81,096,506 (+)Ensembl
RefSeq Acc Id: ENST00000514946
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl581,019,407 - 81,073,222 (+)Ensembl
RefSeq Acc Id: ENST00000638442   ⟹   ENSP00000491428
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl580,960,739 - 81,088,579 (+)Ensembl
RefSeq Acc Id: NM_006909   ⟹   NP_008840
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,960,363 - 81,230,162 (+)NCBI
GRCh37580,256,491 - 80,525,981 (+)NCBI
Build 36580,292,314 - 80,557,709 (+)NCBI Archive
HuRef575,465,367 - 75,734,900 (+)NCBI
CHM1_1579,689,169 - 79,958,778 (+)NCBI
T2T-CHM13v2.0581,444,995 - 81,714,744 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005248565   ⟹   XP_005248622
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,960,363 - 81,183,314 (+)NCBI
GRCh37580,256,491 - 80,525,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017009683   ⟹   XP_016865172
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,960,363 - 81,138,545 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047417463   ⟹   XP_047273419
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,985,308 - 81,230,162 (+)NCBI
RefSeq Acc Id: XM_047417464   ⟹   XP_047273420
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,976,119 - 81,230,162 (+)NCBI
RefSeq Acc Id: XM_047417465   ⟹   XP_047273421
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38581,065,622 - 81,230,162 (+)NCBI
RefSeq Acc Id: XM_047417466   ⟹   XP_047273422
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38581,065,351 - 81,230,162 (+)NCBI
RefSeq Acc Id: XM_054353036   ⟹   XP_054209011
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0581,469,958 - 81,714,744 (+)NCBI
RefSeq Acc Id: XM_054353037   ⟹   XP_054209012
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0581,460,754 - 81,714,744 (+)NCBI
RefSeq Acc Id: XM_054353038   ⟹   XP_054209013
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0581,550,285 - 81,714,744 (+)NCBI
RefSeq Acc Id: XM_054353039   ⟹   XP_054209014
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0581,550,013 - 81,714,744 (+)NCBI
RefSeq Acc Id: XM_054353040   ⟹   XP_054209015
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0581,444,995 - 81,667,921 (+)NCBI
RefSeq Acc Id: XM_054353041   ⟹   XP_054209016
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0581,444,995 - 81,623,174 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_008840   ⟸   NM_006909
- UniProtKB: B9EG89 (UniProtKB/Swiss-Prot),   Q9UK56 (UniProtKB/Swiss-Prot),   O14827 (UniProtKB/Swiss-Prot),   A0A2X0SFL3 (UniProtKB/TrEMBL),   D6RAS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005248622   ⟸   XM_005248565
- Peptide Label: isoform X3
- UniProtKB: D6RAS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016865172   ⟸   XM_017009683
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000421771   ⟸   ENST00000503795
RefSeq Acc Id: ENSP00000491428   ⟸   ENST00000638442
RefSeq Acc Id: ENSP00000265080   ⟸   ENST00000265080
RefSeq Acc Id: XP_047273420   ⟸   XM_047417464
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047273419   ⟸   XM_047417463
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047273422   ⟸   XM_047417466
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047273421   ⟸   XM_047417465
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054209015   ⟸   XM_054353040
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054209016   ⟸   XM_054353041
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054209012   ⟸   XM_054353037
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054209011   ⟸   XM_054353036
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054209014   ⟸   XM_054353039
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054209013   ⟸   XM_054353038
- Peptide Label: isoform X2
Protein Domains
DH   IQ   N-terminal Ras-GEF   PH   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O14827-F1-model_v2 AlphaFold O14827 1-1237 view protein structure

Promoters
RGD ID:6803496
Promoter ID:HG_KWN:50577
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour
Transcripts:OTTHUMT00000239215
Position:
Human AssemblyChrPosition (strand)Source
Build 36580,291,536 - 80,292,637 (+)MPROMDB
RGD ID:6870008
Promoter ID:EPDNEW_H8169
Type:initiation region
Name:RASGRF2_1
Description:Ras protein specific guanine nucleotide releasing factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38580,960,672 - 80,960,732EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9876 AgrOrtholog
COSMIC RASGRF2 COSMIC
Ensembl Genes ENSG00000113319 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000265080 ENTREZGENE
  ENST00000265080.9 UniProtKB/Swiss-Prot
  ENST00000503795.1 UniProtKB/TrEMBL
  ENST00000638442.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000113319 GTEx
HGNC ID HGNC:9876 ENTREZGENE
Human Proteome Map RASGRF2 Human Proteome Map
InterPro DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5924 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5924 ENTREZGENE
OMIM 606614 OMIM
PANTHER FACIOGENITAL DYSPLASIA PROTEIN UniProtKB/TrEMBL
  LD03170P UniProtKB/TrEMBL
  PTHR23113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23113:SF187 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34239 PharmGKB
PROSITE DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEFN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2PP99_HUMAN UniProtKB/TrEMBL
  A0A2X0SFL3 ENTREZGENE, UniProtKB/TrEMBL
  B9EG89 ENTREZGENE
  D6RAS9 ENTREZGENE, UniProtKB/TrEMBL
  O14827 ENTREZGENE
  Q68DX5_HUMAN UniProtKB/TrEMBL
  Q9UK56 ENTREZGENE
  RGRF2_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary B9EG89 UniProtKB/Swiss-Prot
  Q9UK56 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 RASGRF2  Ras protein specific guanine nucleotide releasing factor 2    Ras protein-specific guanine nucleotide-releasing factor 2  Symbol and/or name change 5135510 APPROVED