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Gene: PCLO (piccolo presynaptic cytomatrix protein) Homo sapiens
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Symbol: PCLO
Name: piccolo presynaptic cytomatrix protein
Description: Predicted to have calcium ion binding activity; calcium-dependent phospholipid binding activity; and profilin binding activity. Predicted to be involved in cytoskeleton organization. Localizes to extracellular exosome. Implicated in pontocerebellar hypoplasia type 3.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACZ; aczonin; cerebellar atrophy with progressive microcephaly; CLAM; DKFZp779G1236; PCH3; piccolo (presynaptic cytomatrix protein); presynaptic cytomatrix protein; protein piccolo
Orthologs:
Mus musculus (house mouse) : Pclo (piccolo (presynaptic cytomatrix protein))  MGI  Alliance
Rattus norvegicus (Norway rat) : Pclo (piccolo (presynaptic cytomatrix protein))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pclo (piccolo presynaptic cytomatrix protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PCLO (piccolo presynaptic cytomatrix protein)
Canis lupus familiaris (dog) : PCLO (piccolo presynaptic cytomatrix protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pclo (piccolo presynaptic cytomatrix protein)
Sus scrofa (pig) : PCLO (piccolo presynaptic cytomatrix protein)
Chlorocebus sabaeus (African green monkey) : PCLO (piccolo presynaptic cytomatrix protein)
Heterocephalus glaber (naked mole-rat) : Pclo (piccolo presynaptic cytomatrix protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl782,754,012 - 83,162,930 (-)EnsemblGRCh38hg38GRCh38
GRCh38782,754,012 - 83,164,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37782,383,321 - 82,792,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36782,225,378 - 82,630,133 (-)NCBINCBI36hg18NCBI36
Build 34782,188,346 - 82,224,200NCBI
Celera777,083,829 - 77,492,761 (-)NCBI
Cytogenetic Map7q21.11NCBI
HuRef776,984,730 - 77,393,999 (-)NCBIHuRef
CHM1_1782,313,403 - 82,722,210 (-)NCBICHM1_1
CRA_TCAGchr7v2781,715,437 - 82,124,409 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PCLO
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69449
Created: 2001-11-27
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.