Zfp354c (zinc finger protein 354C) - Rat Genome Database

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Gene: Zfp354c (zinc finger protein 354C) Mus musculus
Analyze
Symbol: Zfp354c
Name: zinc finger protein 354C
RGD ID: 69448
MGI Page MGI
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of sprouting angiogenesis and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; lung; and spleen. Orthologous to human ZNF354C (zinc finger protein 354C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5330421P20Rik; AJ1; AJ18; AW743325; KIAA4218; Kid; Kid3; kidney, ischemia, and developmentally-regulated protein 3; mKIAA4218; Tcf17l2; transcription factor 17-like 2; Znf354c
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,701,912 - 50,718,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,701,913 - 50,718,551 (-)EnsemblGRCm39 Ensembl
GRCm381150,811,085 - 50,827,731 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,811,086 - 50,827,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,624,587 - 50,641,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,654,789 - 50,671,154 (-)NCBIMGSCv36mm8
Celera1155,373,192 - 55,389,837 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nuclear membrane  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10786630   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12070276   PMID:12477932   PMID:12801648   PMID:14610273   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:18287559   PMID:18799693   PMID:20059953   PMID:20412781   PMID:21677750   PMID:21873635   PMID:34321999  


Genomics

Comparative Map Data
Zfp354c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,701,912 - 50,718,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,701,913 - 50,718,551 (-)EnsemblGRCm39 Ensembl
GRCm381150,811,085 - 50,827,731 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,811,086 - 50,827,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,624,587 - 50,641,233 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,654,789 - 50,671,154 (-)NCBIMGSCv36mm8
Celera1155,373,192 - 55,389,837 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.93NCBI
ZNF354C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,060,373 - 179,083,977 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,060,373 - 179,083,977 (+)EnsemblGRCh38hg38GRCh38
GRCh375178,487,374 - 178,510,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365178,420,213 - 178,440,301 (+)NCBINCBI36Build 36hg18NCBI36
Build 345178,420,212 - 178,440,295NCBI
Celera5174,114,833 - 174,134,921 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,215,131 - 173,235,219 (+)NCBIHuRef
CHM1_15177,920,809 - 177,940,927 (+)NCBICHM1_1
T2T-CHM13v2.05179,613,560 - 179,637,167 (+)NCBIT2T-CHM13v2.0
Zfp354c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,630,738 - 35,647,176 (-)NCBIGRCr8
mRatBN7.21035,129,720 - 35,145,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,132,959 - 35,145,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,815,883 - 39,826,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0108,355,135 - 8,366,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,809,549 - 34,820,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,311,343 - 36,322,356 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,307,670 - 36,323,055 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,078,674 - 36,094,684 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41036,387,210 - 36,398,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11036,388,258 - 36,399,272 (-)NCBI
Celera1034,492,608 - 34,503,621 (-)NCBICelera
Cytogenetic Map10q22NCBI
Znf354c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554172,853,263 - 2,854,930 (+)NCBIChiLan1.0ChiLan1.0
ZNF354C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,003,937 - 174,030,148 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,143,498 - 172,169,688 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,221,135 - 174,247,281 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,512,177 - 181,535,139 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,512,177 - 181,535,130 (+)Ensemblpanpan1.1panPan2
ZNF354C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12380,811,135 - 80,832,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2380,810,931 - 80,828,920 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,166,403 - 12,190,812 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf354c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473342,018,395 - 42,056,783 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp354c
530 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1619
Count of miRNA genes:734
Interacting mature miRNAs:942
Transcripts:ENSMUST00000000632, ENSMUST00000109135, ENSMUST00000136333, ENSMUST00000139465
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse

Markers in Region
AW743325  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381150,811,138 - 50,811,412UniSTSGRCm38
MGSCv371150,624,640 - 50,624,914UniSTSGRCm37
Celera1155,373,245 - 55,373,519UniSTS
Cytogenetic Map11B1.3UniSTS
Whitehead/MRC_RH11653.86UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000000632   ⟹   ENSMUSP00000000632
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,705,391 - 50,717,285 (-)Ensembl
GRCm38.p6 Ensembl1150,814,564 - 50,826,458 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109135   ⟹   ENSMUSP00000104763
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,701,913 - 50,718,517 (-)Ensembl
GRCm38.p6 Ensembl1150,811,086 - 50,827,690 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,717,103 - 50,718,551 (-)Ensembl
GRCm38.p6 Ensembl1150,826,276 - 50,827,724 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139465
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,708,020 - 50,718,513 (-)Ensembl
GRCm38.p6 Ensembl1150,817,193 - 50,827,686 (-)Ensembl
RefSeq Acc Id: NM_013922   ⟹   NP_038950
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391150,701,912 - 50,718,558 (-)NCBI
GRCm381150,811,085 - 50,827,731 (-)NCBI
MGSCv371150,624,587 - 50,641,233 (-)RGD
Celera1155,373,192 - 55,389,837 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_038950   ⟸   NM_013922
- UniProtKB: Q8C365 (UniProtKB/Swiss-Prot),   Q3UKS9 (UniProtKB/Swiss-Prot),   Q9JLD3 (UniProtKB/Swiss-Prot),   Q571J5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000000632   ⟸   ENSMUST00000000632
RefSeq Acc Id: ENSMUSP00000104763   ⟸   ENSMUST00000109135
Protein Domains
KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q571J5-F1-model_v2 AlphaFold Q571J5 1-560 view protein structure

Promoters
RGD ID:6822497
Promoter ID:MM_KWN:7262
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:ENSMUST00000000632
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,640,436 - 50,640,936 (-)MPROMDB
RGD ID:6822496
Promoter ID:MM_KWN:7263
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   Brain,   ES_Cell,   Liver,   MEF_B4,   MEF_B6
Transcripts:NM_013922,   OTTMUST00000017933,   OTTMUST00000017934
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,640,974 - 50,641,474 (-)MPROMDB
RGD ID:8674520
Promoter ID:EPDNEW_M15291
Type:initiation region
Name:Zfp354c_1
Description:Mus musculus zinc finger protein 354C , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381150,827,724 - 50,827,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353621 AgrOrtholog
Ensembl Genes ENSMUSG00000044807 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000632.7 UniProtKB/Swiss-Prot
  ENSMUST00000109135 ENTREZGENE
  ENSMUST00000109135.9 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.140 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro KRAB UniProtKB/Swiss-Prot
  KRAB_dom_sf UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:30944 UniProtKB/Swiss-Prot
MGD MGI:1353621 ENTREZGENE
NCBI Gene 30944 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN 691 UniProtKB/Swiss-Prot
Pfam KRAB UniProtKB/Swiss-Prot
  zf-C2H2 UniProtKB/Swiss-Prot
  zf-H2C2_2 UniProtKB/Swiss-Prot
PhenoGen Zfp354c PhenoGen
PROSITE KRAB UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART KRAB UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF109640 UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot
UniProt Q3UKS9 ENTREZGENE
  Q571J5 ENTREZGENE
  Q8C365 ENTREZGENE
  Q9JLD3 ENTREZGENE
  Z354C_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3UKS9 UniProtKB/Swiss-Prot
  Q8C365 UniProtKB/Swiss-Prot
  Q9JLD3 UniProtKB/Swiss-Prot