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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | RGD:736714 | 6480464 | 1, 2-Dimethylhydrazine results in increased expression of PNCK mRNA | CTD | PMID:22206623 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:736714 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:736714 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1605290 | 6480464 | PNCK mRNA affects the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] | CTD | PMID:21479225 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:736714 | 6480464 | Fenretinide results in increased expression of PNCK mRNA | CTD | PMID:28973697 | 5-aza-2'-deoxycytidine | affects expression | ISO | RGD:1605290 | 6480464 | Decitabine affects the expression of PNCK mRNA | CTD | PMID:23300844 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PNCK mRNA | CTD | PMID:24780913 | acrylamide | decreases expression | ISO | RGD:1605290 | 6480464 | Acrylamide results in decreased expression of PNCK mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | ISO | RGD:1605290 | 6480464 | Aflatoxin B1 results in increased methylation of PNCK exon | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:1605290 | 6480464 | aflatoxin B2 results in increased methylation of PNCK exon | CTD | PMID:30157460 | arsenite(3-) | increases expression | ISO | RGD:736714 | 6480464 | arsenite results in increased expression of PNCK mRNA | CTD | PMID:33053406 | benzo[a]pyrene | multiple interactions | ISO | RGD:736714 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to PNCK promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases methylation | ISO | RGD:1605290 | 6480464 | Benzo(a)pyrene results in decreased methylation of PNCK 3' UTR, Benzo(a)pyrene results in decreased methylation of PNCK promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | RGD:1605290 | 6480464 | Benzo(a)pyrene results in increased methylation of PNCK exon | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | RGD:736714 | 6480464 | Benzo(a)pyrene results in increased expression of PNCK mRNA | CTD | PMID:22228805 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1605290 | 6480464 | Diethylhexyl Phthalate results in decreased expression of PNCK mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PNCK mRNA | CTD | PMID:25181051, PMID:34947998 | bisphenol A | affects expression | ISO | RGD:1605290 | 6480464 | bisphenol A affects the expression of PNCK mRNA | CTD | PMID:30903817 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PNCK gene | CTD | PMID:28505145 | carbon nanotube | decreases expression | ISO | RGD:736714 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | choline | multiple interactions | ISO | RGD:736714 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PNCK mRNA | CTD | PMID:20938992 | chrysene | increases expression | ISO | RGD:736714 | 6480464 | chrysene results in increased expression of PNCK mRNA | CTD | PMID:26377693 | cisplatin | affects expression | ISO | RGD:1605290 | 6480464 | Cisplatin affects the expression of PNCK mRNA | CTD | PMID:23300844 | dioxygen | increases expression | ISO | RGD:1605290 | 6480464 | Oxygen deficiency results in increased expression of PNCK mRNA | CTD | PMID:26516004 | dorsomorphin | multiple interactions | ISO | RGD:1605290 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | ethanol | multiple interactions | EXP | | 6480464 | [Fish Oils co-treated with Ethanol] results in increased expression of PNCK mRNA | CTD | PMID:17347304 | ethanol | increases expression | ISO | RGD:736714 | 6480464 | Ethanol results in increased expression of PNCK mRNA | CTD | PMID:30319688 | ethanol | multiple interactions | ISO | RGD:736714 | 6480464 | Ethanol affects the expression of and affects the splicing of PNCK mRNA | CTD | PMID:30319688 | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of PNCK mRNA | CTD | PMID:34044035 | folic acid | multiple interactions | ISO | RGD:736714 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PNCK mRNA | CTD | PMID:20938992 | L-methionine | multiple interactions | ISO | RGD:736714 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PNCK mRNA | CTD | PMID:20938992 | lead(0) | affects expression | ISO | RGD:1605290 | 6480464 | Lead affects the expression of PNCK mRNA | CTD | PMID:28903495 | lead(2+) | affects expression | ISO | RGD:1605290 | 6480464 | Lead affects the expression of PNCK mRNA | CTD | PMID:28903495 | Licochalcone B | increases expression | ISO | RGD:1605290 | 6480464 | licochalcone B results in increased expression of PNCK mRNA | CTD | PMID:33647349 | lipopolysaccharide | multiple interactions | ISO | RGD:1605290 | 6480464 | [S-(1, 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of PNCK mRNA | CTD | PMID:35811015 | methylmercury chloride | decreases expression | ISO | RGD:1605290 | 6480464 | methylmercuric chloride results in decreased expression of PNCK mRNA | CTD | PMID:28001369 | PCB138 | multiple interactions | ISO | RGD:736714 | 6480464 | [2 more ... | CTD | PMID:25510870 | phenylmercury acetate | decreases expression | ISO | RGD:1605290 | 6480464 | Phenylmercuric Acetate results in decreased expression of PNCK mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1605290 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PNCK mRNA | CTD | PMID:27188386 | rotenone | decreases expression | ISO | RGD:736714 | 6480464 | Rotenone results in decreased expression of PNCK mRNA | CTD | PMID:23186747 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | RGD:1605290 | 6480464 | [S-(1, 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of PNCK mRNA | CTD | PMID:35811015 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | RGD:1605290 | 6480464 | S-(1, 2-dichlorovinyl)cysteine results in decreased expression of PNCK mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | RGD:1605290 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of PNCK mRNA | CTD | PMID:19281266 | sulforaphane | increases expression | ISO | RGD:1605290 | 6480464 | sulforaphane results in increased expression of PNCK mRNA | CTD | PMID:31838189 | testosterone | increases expression | ISO | RGD:1605290 | 6480464 | Testosterone results in increased expression of PNCK mRNA | CTD | PMID:33359661 | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of PNCK gene | CTD | PMID:27618143 | trichostatin A | decreases expression | ISO | RGD:1605290 | 6480464 | trichostatin A results in decreased expression of PNCK mRNA | CTD | PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:1605290 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PNCK mRNA | CTD | PMID:27188386 | trimellitic anhydride | decreases expression | ISO | RGD:736714 | 6480464 | trimellitic anhydride results in decreased expression of PNCK mRNA | CTD | PMID:19042947 | triptonide | increases expression | ISO | RGD:736714 | 6480464 | triptonide results in increased expression of PNCK mRNA | CTD | PMID:33045310 | valproic acid | increases methylation | ISO | RGD:1605290 | 6480464 | Valproic Acid results in increased methylation of PNCK gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | RGD:1605290 | 6480464 | Valproic Acid results in decreased expression of PNCK mRNA | CTD | PMID:26272509 | valproic acid | multiple interactions | ISO | RGD:1605290 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PNCK mRNA | CTD | PMID:27188386 | |