Timp4 (tissue inhibitor of metalloproteinase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Timp4 (tissue inhibitor of metalloproteinase 4) Mus musculus
Analyze
Symbol: Timp4
Name: tissue inhibitor of metalloproteinase 4
RGD ID: 69156
MGI Page MGI
Description: Predicted to enable metalloendopeptidase inhibitor activity and zinc ion binding activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in sarcomere. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain ventricular layer; genitourinary system; hemolymphoid system gland; musculature; and ventral grey horn. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: metalloproteinase inhibitor 4; TIMP; TIMP-4; tissue inhibitor of metalloproteinases 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,221,405 - 115,229,166 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,218,853 - 115,229,166 (-)EnsemblGRCm39 Ensembl
GRCm386115,244,444 - 115,252,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,241,892 - 115,252,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv376115,195,634 - 115,201,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,211,438 - 115,217,467 (-)NCBIMGSCv36mm8
Celera6117,084,697 - 117,090,930 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
alpha-Zearalanol  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cantharidin  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (EXP)
fonofos  (ISO)
indometacin  (ISO)
isoprenaline  (EXP,ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (ISO)
methamphetamine  (EXP)
monodansylcadaverine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctanoic acid  (ISO)
ramipril  (ISO)
resveratrol  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (EXP,ISO)
temozolomide  (ISO)
terbufos  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp TM, etal., J Hypertens 2003 Sep;21(9):1719-27.
2. Inhibition of adjuvant-induced arthritis by systemic tissue inhibitor of metalloproteinases 4 gene delivery. Celiker MY, etal., Arthritis Rheum. 2002 Dec;46(12):3361-8.
3. Inhibition of Wilms' tumor growth by intramuscular administration of tissue inhibitor of metalloproteinases-4 plasmid DNA. Celiker MY, etal., Oncogene. 2001 Jul 19;20(32):4337-43.
4. Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats. Chan CY, etal., J Vasc Surg. 2007 Apr;45(4):804-11.
5. TIMP-4 is regulated by vascular injury in rats. Dollery CM, etal., Circ Res. 1999 Mar 19;84(5):498-504.
6. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
7. mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas. Hagemann T, etal., Eur J Cancer. 2001 Oct;37(15):1839-46.
8. Zhonghua wai ke za zhi [Chinese journal of surgery] Jiang X, etal., Zhonghua Wai Ke Za Zhi. 2000 Apr;38(4):291-3, 19.
9. Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. Kaschina E, etal., Physiol Genomics 2004 Sep 16;19(1):41-9. Epub 2004 Jul 06.
10. Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor. Lee S, etal., Cell Res. 2006 Sep;16(9):750-8.
11. MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. Li H, etal., Cardiovasc Res. 2000 May;46(2):298-306.
12. Tissue inhibitor of metalloproteinases-4 is expressed in cervical cancer patients. Lizarraga F, etal., Anticancer Res. 2005 Jan-Feb;25(1B):623-7.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure. Mujumdar VS and Tyagi SC, J Hypertens. 1999 Feb;17(2):261-70.
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26. Pilka R, etal., Mol Hum Reprod. 2004 Sep;10(9):641-50. Epub 2004 Jul 23.
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinase-3 and -4 in normal ovary and ovarian carcinoma. Ripley D, etal., Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1794-800.
21. Imbalance between tissue inhibitor of metalloproteinase-4 and matrix metalloproteinases during acute myocardial ischemia-reperfusion injury. Schulze CJ, etal., Circulation. 2003 May 20;107(19):2487-92. Epub 2003 Apr 21.
22. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
23. Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer. Tunuguntla R, etal., Gynecol Oncol. 2003 Jun;89(3):453-9.
24. Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4. Wang M, etal., Oncogene. 1997 Jun 12;14(23):2767-74.
25. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. Zhao YG, etal., Cancer Res. 2004 Jan 15;64(2):590-8.
Additional References at PubMed
PMID:8889548   PMID:8939999   PMID:9013889   PMID:9693046   PMID:10225966   PMID:10349636   PMID:10621841   PMID:10922068   PMID:10952938   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:11359935   PMID:11988080   PMID:12151094   PMID:12477932   PMID:12606590   PMID:15063736   PMID:15117845   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16469749   PMID:19339693  
PMID:20516072   PMID:21141538   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23117660   PMID:23375831   PMID:23524300   PMID:24358288   PMID:24373743   PMID:24842912   PMID:24993046  
PMID:25150980   PMID:25745981   PMID:25805621   PMID:25807548   PMID:25999146   PMID:26597823   PMID:27396717   PMID:27879248   PMID:28489004   PMID:28740132   PMID:30783098   PMID:31371388  
PMID:31677819   PMID:33763067   PMID:33792349   PMID:36459450   PMID:38355793  


Genomics

Comparative Map Data
Timp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,221,405 - 115,229,166 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,218,853 - 115,229,166 (-)EnsemblGRCm39 Ensembl
GRCm386115,244,444 - 115,252,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,241,892 - 115,252,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv376115,195,634 - 115,201,867 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,211,438 - 115,217,467 (-)NCBIMGSCv36mm8
Celera6117,084,697 - 117,090,930 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.29NCBI
TIMP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,153,068 - 12,158,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,153,068 - 12,158,912 (-)EnsemblGRCh38hg38GRCh38
GRCh37312,194,568 - 12,200,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,169,568 - 12,175,647 (-)NCBINCBI36Build 36hg18NCBI36
Build 34312,169,569 - 12,175,647NCBI
Celera312,132,043 - 12,138,067 (-)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef312,128,374 - 12,134,601 (-)NCBIHuRef
CHM1_1312,144,898 - 12,151,125 (-)NCBICHM1_1
T2T-CHM13v2.0312,151,357 - 12,157,146 (-)NCBIT2T-CHM13v2.0
Timp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,978,667 - 149,985,350 (-)NCBIGRCr8
mRatBN7.24148,306,021 - 148,312,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,304,490 - 148,312,558 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,531,322 - 154,537,832 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,314,411 - 150,320,921 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,938,223 - 148,944,733 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,156,948 - 147,163,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,156,948 - 147,163,467 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,445,694 - 210,452,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,375,072 - 151,381,591 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4137,199,851 - 137,206,370 (-)NCBICelera
Cytogenetic Map4q42NCBI
Timp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,685,031 - 14,693,211 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542914,689,016 - 14,693,211 (-)NCBIChiLan1.0ChiLan1.0
TIMP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2212,141,127 - 12,149,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,144,168 - 12,154,025 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0312,079,195 - 12,087,485 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,425,429 - 12,433,192 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,425,429 - 12,433,192 (-)Ensemblpanpan1.1panPan2
TIMP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,399,522 - 6,405,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,399,522 - 6,405,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha206,435,643 - 6,441,210 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0206,428,241 - 6,462,722 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,428,701 - 6,439,507 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,146,856 - 6,152,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0206,497,799 - 6,503,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,473,392 - 6,478,960 (+)NCBIUU_Cfam_GSD_1.0
Timp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,413,957 - 17,420,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,489,545 - 1,495,478 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,488,993 - 1,496,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,179,806 - 68,190,942 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,179,803 - 68,191,199 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,371,793 - 75,377,933 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TIMP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,134,133 - 48,140,870 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,134,637 - 48,140,600 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041118,360,254 - 118,370,994 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624956330,327 - 337,299 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624956331,275 - 341,561 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:344
Count of miRNA genes:240
Interacting mature miRNAs:278
Transcripts:ENSMUST00000032462
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
8552704Cia43_mcollagen induced arthritis QTL 43 (mouse)Not determined6114159241119737532Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043891Tilss4_mTNF-induced lethal shock susceptibility 3 (mouse)Not determined6112246918125333748Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
10412207Cypr5_mcytokine production 5 (mouse)Not determined6110815180144815323Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
13463481Mcvq14_mmean corpuscular volume QTL 14 (mouse)6111142448145142541Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined105982366120894102Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse

Markers in Region
RH118303  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386115,245,437 - 115,245,597UniSTSGRCm38
MGSCv376115,195,455 - 115,195,615UniSTSGRCm37
Celera6117,084,518 - 117,084,678UniSTS
Cytogenetic Map6E3UniSTS
Cytogenetic Map6FUniSTS
cM Map646.0UniSTS
cM Map650.3UniSTS
Whitehead/MRC_RH61185.32UniSTS
Whitehead_YAC6 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000032462   ⟹   ENSMUSP00000032462
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6115,218,853 - 115,229,166 (-)Ensembl
GRCm38.p6 Ensembl6115,241,892 - 115,252,205 (-)Ensembl
Ensembl Acc Id: ENSMUST00000205131   ⟹   ENSMUSP00000144785
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6115,223,793 - 115,228,809 (-)Ensembl
GRCm38.p6 Ensembl6115,246,832 - 115,251,848 (-)Ensembl
RefSeq Acc Id: NM_001356406   ⟹   NP_001343335
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396115,221,405 - 115,229,166 (-)NCBI
GRCm386115,244,444 - 115,252,205 (-)NCBI
Sequence:
RefSeq Acc Id: NM_080639   ⟹   NP_542370
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396115,221,405 - 115,229,166 (-)NCBI
GRCm386115,244,444 - 115,252,205 (-)NCBI
MGSCv376115,195,634 - 115,201,867 (-)RGD
Celera6117,084,697 - 117,090,930 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_151459
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396115,221,405 - 115,229,166 (-)NCBI
GRCm386115,244,444 - 115,252,205 (-)NCBI
Sequence:
RefSeq Acc Id: NP_542370   ⟸   NM_080639
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9JHB3 (UniProtKB/Swiss-Prot),   Q924B7 (UniProtKB/Swiss-Prot),   Q3USH7 (UniProtKB/TrEMBL),   Q8C577 (UniProtKB/TrEMBL),   Q8CAG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001343335   ⟸   NM_001356406
- Peptide Label: isoform 2
- UniProtKB: A0A0N4SUR1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000032462   ⟸   ENSMUST00000032462
Ensembl Acc Id: ENSMUSP00000144785   ⟸   ENSMUST00000205131
Protein Domains
NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHB3-F1-model_v2 AlphaFold Q9JHB3 1-224 view protein structure

Promoters
RGD ID:6848846
Promoter ID:MM_TRO:8470
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6
Transcripts:MTR002753.6.2084.1,   MTR002753.6.2084.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366115,199,876 - 115,200,376 (-)MPROMDB
RGD ID:6840072
Promoter ID:MM_KWN:47241
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   Brain
Transcripts:NM_080639,   UC009DIQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366115,201,496 - 115,202,802 (-)MPROMDB
RGD ID:6890710
Promoter ID:EPDNEW_M8806
Type:multiple initiation site
Name:Timp4_1
Description:Mus musculus tissue inhibitor of metalloproteinase 4 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386115,251,849 - 115,251,909EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109125 AgrOrtholog
Ensembl Genes ENSMUSG00000030317 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032462 ENTREZGENE
  ENSMUST00000032462.9 UniProtKB/Swiss-Prot
  ENSMUST00000205131.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110595 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109125 ENTREZGENE
NCBI Gene Timp4 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11844:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Timp4 PhenoGen
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SUR1 ENTREZGENE, UniProtKB/TrEMBL
  Q3USH7 ENTREZGENE, UniProtKB/TrEMBL
  Q6GXA6_MOUSE UniProtKB/TrEMBL
  Q8C577 ENTREZGENE, UniProtKB/TrEMBL
  Q8CAG3 ENTREZGENE, UniProtKB/TrEMBL
  Q8VH23_MOUSE UniProtKB/TrEMBL
  Q924B7 ENTREZGENE
  Q9JHB3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q924B7 UniProtKB/Swiss-Prot