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Gene: TIMP4 (TIMP metallopeptidase inhibitor 4) Homo sapiens
Symbol: TIMP4
Name: TIMP metallopeptidase inhibitor 4
Description: Predicted to have metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of proteolysis; response to cytokine; and response to hormone. Predicted to localize to the extracellular matrix and extracellular space. Implicated in nephroblastoma. Biomarker of ductal carcinoma in situ; female reproductive organ cancer (multiple); prostate carcinoma in situ; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: metalloproteinase inhibitor 4; TIMP-4; tissue inhibitor of metalloproteinase 4; tissue inhibitor of metalloproteinases 4
Mus musculus (house mouse) : Timp4 (tissue inhibitor of metalloproteinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Timp4 (TIMP metallopeptidase inhibitor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp4 (TIMP metallopeptidase inhibitor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP4 (TIMP metallopeptidase inhibitor 4)
Canis lupus familiaris (dog) : TIMP4 (TIMP metallopeptidase inhibitor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp4 (TIMP metallopeptidase inhibitor 4)
Sus scrofa (pig) : TIMP4 (TIMP metallopeptidase inhibitor 4)
Chlorocebus sabaeus (green monkey) : TIMP4 (TIMP metallopeptidase inhibitor 4)
Heterocephalus glaber (naked mole-rat) : Timp4 (TIMP metallopeptidase inhibitor 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl312,153,068 - 12,158,912 (-)Ensembl
GRCh38312,153,068 - 12,158,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37312,194,568 - 12,200,851 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,169,568 - 12,175,647 (-)NCBINCBI36hg18NCBI36
Build 34312,169,569 - 12,175,647NCBI
Celera312,132,043 - 12,138,067 (-)NCBI
Cytogenetic Map3p25.2NCBI
HuRef312,128,374 - 12,134,601 (-)NCBIHuRef
CHM1_1312,144,898 - 12,151,125 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TIMP4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69155
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2020-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.