NFIC (nuclear factor I C) - Rat Genome Database
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Gene: NFIC (nuclear factor I C) Homo sapiens
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Symbol: NFIC
Name: nuclear factor I C
RGD ID: 69148
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Localizes to fibrillar center and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCAAT-binding transcription factor; CCAAT-box-binding transcription factor; CTF; CTF5; MGC20153; NF-I; NF-I/C; NF1-C; NFI; NFI-C; nuclear factor 1 C-type; nuclear factor 1/C; nuclear factor i/c; nuclear factor I/C (CCAAT-binding transcription factor); TGGCA-binding protein
Orthologs:
Mus musculus (house mouse) : Nfic (nuclear factor I/C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfic (nuclear factor I/C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfic (nuclear factor I C)
Pan paniscus (bonobo/pygmy chimpanzee) : NFIC (nuclear factor I C)
Canis lupus familiaris (dog) : NFIC (nuclear factor I C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfic (nuclear factor I C)
Sus scrofa (pig) : NFIC (nuclear factor I C)
Chlorocebus sabaeus (African green monkey) : NFIC (nuclear factor I C)
Heterocephalus glaber (naked mole-rat) : Nfic (nuclear factor I C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl193,314,403 - 3,469,217 (+)EnsemblGRCh38hg38GRCh38
GRCh38193,359,630 - 3,469,217 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37193,359,561 - 3,469,215 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,310,616 - 3,414,603 (+)NCBINCBI36hg18NCBI36
Build 34193,317,572 - 3,414,603NCBI
Celera193,296,412 - 3,400,416 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef193,125,600 - 3,235,130 (+)NCBIHuRef
CHM1_1193,359,193 - 3,468,863 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[e]pyrene  (EXP)
bisphenol A  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
crotonaldehyde  (EXP)
cyclosporin A  (EXP)
dicrotophos  (EXP)
dimethylarsinic acid  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
entinostat  (EXP)
ethanol  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
gentamycin  (ISO)
glycidol  (ISO)
isoprenaline  (ISO)
methapyrilene  (EXP)
methoxychlor  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
naphthalene  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
SB 431542  (EXP)
selenium atom  (EXP)
sodium arsenite  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
toluene  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
zebularine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)


Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1524678   PMID:3398920   PMID:7590749   PMID:7961993   PMID:8628270   PMID:8710515   PMID:8889548   PMID:9099724   PMID:9417094   PMID:10085123   PMID:10327073   PMID:10737800  
PMID:12221105   PMID:12477932   PMID:12624117   PMID:14684846   PMID:15057824   PMID:15302935   PMID:15342556   PMID:15489334   PMID:15851553   PMID:15999204   PMID:16189514   PMID:16847321  
PMID:17081983   PMID:17186943   PMID:17936922   PMID:18421093   PMID:18765927   PMID:18775869   PMID:18809517   PMID:19274049   PMID:19322201   PMID:19505873   PMID:19706729   PMID:19752192  
PMID:19755487   PMID:20145151   PMID:20379614   PMID:20881960   PMID:21873635   PMID:22195013   PMID:22242598   PMID:22420942   PMID:22939624   PMID:23208493   PMID:23839947   PMID:24324551  
PMID:24801901   PMID:25220407   PMID:25609649   PMID:25668322   PMID:25879941   PMID:26496610   PMID:27503909   PMID:28076901   PMID:28183528   PMID:28192407   PMID:28205554   PMID:28473536  
PMID:28514442   PMID:28515276   PMID:28611215   PMID:28794006   PMID:28986522   PMID:29117863   PMID:29490077   PMID:29507755   PMID:29509190   PMID:29568061   PMID:29656893   PMID:30021884  
PMID:30804502   PMID:32296183  


Genomics

Comparative Map Data
NFIC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl193,314,403 - 3,469,217 (+)EnsemblGRCh38hg38GRCh38
GRCh38193,359,630 - 3,469,217 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37193,359,561 - 3,469,215 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,310,616 - 3,414,603 (+)NCBINCBI36hg18NCBI36
Build 34193,317,572 - 3,414,603NCBI
Celera193,296,412 - 3,400,416 (+)NCBI
Cytogenetic Map19p13.3NCBI
HuRef193,125,600 - 3,235,130 (+)NCBIHuRef
CHM1_1193,359,193 - 3,468,863 (+)NCBICHM1_1
Nfic
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,232,025 - 81,267,753 (-)NCBI
GRCm381081,396,191 - 81,431,919 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,396,186 - 81,455,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,858,936 - 80,889,918 (-)NCBIGRCm37mm9NCBIm37
MGSCv361080,799,320 - 80,830,302 (-)NCBImm8
Celera1082,417,224 - 82,449,357 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Nfic
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0711,151,941 - 11,179,544 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,152,038 - 11,177,664 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,315,473 - 11,346,698 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,768,135 - 9,793,584 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.179,788,771 - 9,793,584 (+)NCBI
Celera76,478,006 - 6,497,550 (+)NCBICelera
Cytogenetic Map7q11NCBI
Nfic
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,095,450 - 5,139,442 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,095,219 - 5,139,561 (-)NCBIChiLan1.0ChiLan1.0
NFIC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1193,340,343 - 3,446,810 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,294,319 - 3,440,417 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0192,387,226 - 2,495,475 (+)NCBI
NFIC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2055,914,855 - 56,014,907 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12055,920,614 - 55,980,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nfic
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365881,928,661 - 1,963,525 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFIC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,193,304 - 75,297,380 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,193,113 - 75,262,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,687,011 - 75,711,260 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NFIC
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl63,135,480 - 3,227,601 (+)Ensembl
ChlSab1.163,128,553 - 3,232,485 (+)NCBI
Nfic
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
RH67057  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,467,731 - 3,467,867UniSTSGRCh37
Build 36193,418,731 - 3,418,867RGDNCBI36
Celera193,404,546 - 3,404,686RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,233,629 - 3,233,787UniSTS
SHGC-147406  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,402,703 - 3,403,034UniSTSGRCh37
Build 36193,353,703 - 3,354,034RGDNCBI36
Celera193,339,511 - 3,339,842RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,168,992 - 3,169,323UniSTS
TNG Radiation Hybrid Map1978.0UniSTS
A008X33  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,466,986 - 3,467,146UniSTSGRCh37
Build 36193,417,986 - 3,418,146RGDNCBI36
Celera193,403,801 - 3,403,961RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,232,884 - 3,233,044UniSTS
GeneMap99-GB4 RH Map1931.4UniSTS
WI-12079  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,468,965 - 3,469,092UniSTSGRCh37
Build 36193,419,965 - 3,420,092RGDNCBI36
Celera193,405,784 - 3,405,911RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,234,885 - 3,235,012UniSTS
GeneMap99-GB4 RH Map1932.22UniSTS
Whitehead-RH Map1917.1UniSTS
RH70943  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,462,757 - 3,462,882UniSTSGRCh37
Build 36193,413,757 - 3,413,882RGDNCBI36
Celera193,399,570 - 3,399,695RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,228,652 - 3,228,777UniSTS
GeneMap99-GB4 RH Map1931.92UniSTS
RH47688  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,464,988 - 3,465,119UniSTSGRCh37
Build 36193,415,988 - 3,416,119RGDNCBI36
Celera193,401,801 - 3,401,932RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,230,883 - 3,231,014UniSTS
GeneMap99-GB4 RH Map1932.22UniSTS
RH36034  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,468,980 - 3,469,096UniSTSGRCh37
Build 36193,419,980 - 3,420,096RGDNCBI36
Celera193,405,799 - 3,405,915RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,234,900 - 3,235,016UniSTS
GeneMap99-GB4 RH Map1931.92UniSTS
A009K36  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,364,675 - 3,364,833UniSTSGRCh37
Build 36193,315,675 - 3,315,833RGDNCBI36
Celera193,301,483 - 3,301,641RGD
Cytogenetic Map19p13.3UniSTS
HuRef193,130,177 - 3,130,335UniSTS
GeneMap99-GB4 RH Map1931.92UniSTS
G32369  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,467,731 - 3,467,867UniSTSGRCh37
Celera193,404,546 - 3,404,686UniSTS
Cytogenetic Map19p13.3UniSTS
HuRef193,233,629 - 3,233,787UniSTS
G32622  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37193,364,675 - 3,364,833UniSTSGRCh37
Celera193,301,483 - 3,301,641UniSTS
Cytogenetic Map19p13.3UniSTS
HuRef193,130,177 - 3,130,335UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR124-2hsa-miR-124-3pMirtarbaseexternal_infoProteomicsFunctional MTI (Weak)18668037

Predicted Target Of
Summary Value
Count of predictions:7657
Count of miRNA genes:1303
Interacting mature miRNAs:1707
Transcripts:ENST00000341919, ENST00000346156, ENST00000395111, ENST00000443272, ENST00000586919, ENST00000588839, ENST00000589123, ENST00000589164, ENST00000589537, ENST00000589969, ENST00000590282
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2365 2218 1687 590 911 431 4174 2124 3361 367 1443 1596 175 1 1204 2787 3 2
Low 71 769 39 34 1030 34 183 73 373 52 17 16 1 3
Below cutoff 3 4 10 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_030333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001245002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001245004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001245005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_205843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005259564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006722759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC005514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC007792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC093077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL042511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE887429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF763988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI253961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP279194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ894051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU727954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB053896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK431049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X92857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000341919   ⟹   ENSP00000342194
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,366,549 - 3,462,967 (+)Ensembl
RefSeq Acc Id: ENST00000395111   ⟹   ENSP00000378543
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,359,647 - 3,463,142 (+)Ensembl
RefSeq Acc Id: ENST00000443272   ⟹   ENSP00000396843
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,366,583 - 3,469,217 (+)Ensembl
RefSeq Acc Id: ENST00000586919   ⟹   ENSP00000465177
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,359,683 - 3,456,600 (+)Ensembl
RefSeq Acc Id: ENST00000588839
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,410,596 - 3,425,147 (+)Ensembl
RefSeq Acc Id: ENST00000589123   ⟹   ENSP00000465655
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,359,563 - 3,469,217 (+)Ensembl
RefSeq Acc Id: ENST00000589164
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,452,579 - 3,457,989 (+)Ensembl
RefSeq Acc Id: ENST00000589537
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,435,046 - 3,463,255 (+)Ensembl
RefSeq Acc Id: ENST00000589969
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,452,641 - 3,454,350 (+)Ensembl
RefSeq Acc Id: ENST00000590282   ⟹   ENSP00000466647
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,366,583 - 3,462,900 (+)Ensembl
RefSeq Acc Id: ENST00000641145   ⟹   ENSP00000492983
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl193,314,403 - 3,469,217 (+)Ensembl
RefSeq Acc Id: NM_001245002   ⟹   NP_001231931
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,366,583 - 3,469,217 (+)NCBI
GRCh37193,359,561 - 3,469,215 (+)NCBI
HuRef193,125,600 - 3,235,130 (+)NCBI
CHM1_1193,366,184 - 3,468,863 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001245004   ⟹   NP_001231933
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,366,583 - 3,469,217 (+)NCBI
GRCh37193,359,561 - 3,469,215 (+)NCBI
HuRef193,125,600 - 3,235,130 (+)NCBI
CHM1_1193,366,184 - 3,468,863 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001245005   ⟹   NP_001231934
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,359,630 - 3,469,217 (+)NCBI
HuRef193,125,600 - 3,235,130 (+)NCBI
CHM1_1193,359,193 - 3,468,863 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005597   ⟹   NP_005588
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,366,583 - 3,469,217 (+)NCBI
GRCh37193,359,561 - 3,469,215 (+)NCBI
Build 36193,317,573 - 3,414,603 (+)NCBI Archive
HuRef193,125,600 - 3,235,130 (+)NCBI
CHM1_1193,366,184 - 3,468,863 (+)NCBI
Sequence:
RefSeq Acc Id: NM_205843   ⟹   NP_995315
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,359,630 - 3,469,217 (+)NCBI
GRCh37193,359,561 - 3,469,215 (+)NCBI
Build 36193,310,616 - 3,414,603 (+)NCBI Archive
HuRef193,125,600 - 3,235,130 (+)NCBI
CHM1_1193,359,193 - 3,468,863 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005259564   ⟹   XP_005259621
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,366,583 - 3,469,217 (+)NCBI
GRCh37193,359,561 - 3,469,215 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006722759   ⟹   XP_006722822
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,359,650 - 3,458,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017026834   ⟹   XP_016882323
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,366,583 - 3,458,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017026835   ⟹   XP_016882324
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,366,583 - 3,457,901 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017026836   ⟹   XP_016882325
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,359,650 - 3,469,216 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231931 (Get FASTA)   NCBI Sequence Viewer  
  NP_001231933 (Get FASTA)   NCBI Sequence Viewer  
  NP_001231934 (Get FASTA)   NCBI Sequence Viewer  
  NP_005588 (Get FASTA)   NCBI Sequence Viewer  
  NP_995315 (Get FASTA)   NCBI Sequence Viewer  
  XP_005259621 (Get FASTA)   NCBI Sequence Viewer  
  XP_006722822 (Get FASTA)   NCBI Sequence Viewer  
  XP_016882323 (Get FASTA)   NCBI Sequence Viewer  
  XP_016882324 (Get FASTA)   NCBI Sequence Viewer  
  XP_016882325 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC32593 (Get FASTA)   NCBI Sequence Viewer  
  AAC32594 (Get FASTA)   NCBI Sequence Viewer  
  AAC33190 (Get FASTA)   NCBI Sequence Viewer  
  AAC33191 (Get FASTA)   NCBI Sequence Viewer  
  AAC33192 (Get FASTA)   NCBI Sequence Viewer  
  AAC62842 (Get FASTA)   NCBI Sequence Viewer  
  AAH12120 (Get FASTA)   NCBI Sequence Viewer  
  BAC85258 (Get FASTA)   NCBI Sequence Viewer  
  BAF82574 (Get FASTA)   NCBI Sequence Viewer  
  BAH12672 (Get FASTA)   NCBI Sequence Viewer  
  BAH12681 (Get FASTA)   NCBI Sequence Viewer  
  BAH14259 (Get FASTA)   NCBI Sequence Viewer  
  CAA31012 (Get FASTA)   NCBI Sequence Viewer  
  CAA63440 (Get FASTA)   NCBI Sequence Viewer  
  CAG38745 (Get FASTA)   NCBI Sequence Viewer  
  EAW69323 (Get FASTA)   NCBI Sequence Viewer  
  EAW69324 (Get FASTA)   NCBI Sequence Viewer  
  EAW69325 (Get FASTA)   NCBI Sequence Viewer  
  EAW69326 (Get FASTA)   NCBI Sequence Viewer  
  P08651 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_995315   ⟸   NM_205843
- Peptide Label: isoform 2
- UniProtKB: P08651 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_005588   ⟸   NM_005597
- Peptide Label: isoform 5
- UniProtKB: P08651 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001231934   ⟸   NM_001245005
- Peptide Label: isoform 4
- UniProtKB: P08651 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001231931   ⟸   NM_001245002
- Peptide Label: isoform 1
- UniProtKB: P08651 (UniProtKB/Swiss-Prot),   B7Z4T6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231933   ⟸   NM_001245004
- Peptide Label: isoform 3
- UniProtKB: P08651 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005259621   ⟸   XM_005259564
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006722822   ⟸   XM_006722759
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016882325   ⟸   XM_017026836
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016882323   ⟸   XM_017026834
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016882324   ⟸   XM_017026835
- Peptide Label: isoform X4
- UniProtKB: P08651 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000465177   ⟸   ENST00000586919
RefSeq Acc Id: ENSP00000465655   ⟸   ENST00000589123
RefSeq Acc Id: ENSP00000396843   ⟸   ENST00000443272
RefSeq Acc Id: ENSP00000492983   ⟸   ENST00000641145
RefSeq Acc Id: ENSP00000466647   ⟸   ENST00000590282
RefSeq Acc Id: ENSP00000378543   ⟸   ENST00000395111
RefSeq Acc Id: ENSP00000342194   ⟸   ENST00000341919
Protein Domains
CTF/NF-I

Promoters
RGD ID:6795447
Promoter ID:HG_KWN:28512
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000346156,   ENST00000395111,   NM_205843
Position:
Human AssemblyChrPosition (strand)Source
Build 36193,310,101 - 3,310,742 (+)MPROMDB
RGD ID:6795449
Promoter ID:HG_KWN:28513
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000269778,   ENST00000343825,   NM_005597
Position:
Human AssemblyChrPosition (strand)Source
Build 36193,316,876 - 3,317,752 (+)MPROMDB
RGD ID:6851450
Promoter ID:EP73526
Type:multiple initiation site
Name:HS_NFIC
Description:Nuclear factor I/C (CCAAT-binding transcription factor).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36193,317,581 - 3,317,641EPD
RGD ID:7238003
Promoter ID:EPDNEW_H24747
Type:initiation region
Name:NFIC_2
Description:nuclear factor I C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24749  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,359,630 - 3,359,690EPDNEW
RGD ID:7238007
Promoter ID:EPDNEW_H24749
Type:initiation region
Name:NFIC_1
Description:nuclear factor I C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H24747  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38193,366,584 - 3,366,644EPDNEW
RGD ID:6811693
Promoter ID:HG_ACW:39247
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NFIC.FAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 36193,385,874 - 3,386,374 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_205843.2(NFIC):c.535+249A>G single nucleotide variant Lung cancer [RCV000101232] Chr19:3382492 [GRCh38]
Chr19:3382490 [GRCh37]
Chr19:19p13.3
uncertain significance
GRCh38/hg38 19p13.3(chr19:1565575-4108128)x3 copy number gain See cases [RCV000052878] Chr19:1565575..4108128 [GRCh38]
Chr19:1565574..4108126 [GRCh37]
Chr19:1516574..4059126 [NCBI36]
Chr19:19p13.3
pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:1972245-9648879)x3 copy number gain See cases [RCV000052879] Chr19:1972245..9648879 [GRCh38]
Chr19:1972244..9759555 [GRCh37]
Chr19:1923244..9620555 [NCBI36]
Chr19:19p13.3-13.2
pathogenic
GRCh38/hg38 19p13.3-13.2(chr19:265917-8564134)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052876]|See cases [RCV000052876] Chr19:265917..8564134 [GRCh38]
Chr19:265917..8629018 [GRCh37]
Chr19:216917..8535018 [NCBI36]
Chr19:19p13.3-13.2
pathogenic
GRCh38/hg38 19p13.3(chr19:233565-4699472)x3 copy number gain See cases [RCV000052575] Chr19:233565..4699472 [GRCh38]
Chr19:233565..4699484 [GRCh37]
Chr19:184565..4650484 [NCBI36]
Chr19:19p13.3
pathogenic
GRCh38/hg38 19p13.3(chr19:3080621-3730716)x3 copy number gain See cases [RCV000054107] Chr19:3080621..3730716 [GRCh38]
Chr19:3080619..3730714 [GRCh37]
Chr19:3031619..3681714 [NCBI36]
Chr19:19p13.3
uncertain significance
GRCh38/hg38 19p13.3(chr19:2926238-4051635)x1 copy number loss See cases [RCV000053942] Chr19:2926238..4051635 [GRCh38]
Chr19:2926236..4051633 [GRCh37]
Chr19:2877236..4002633 [NCBI36]
Chr19:19p13.3
pathogenic
NM_205843.2(NFIC):c.1062C>T (p.Ile354=) single nucleotide variant Malignant melanoma [RCV000072056] Chr19:3452486 [GRCh38]
Chr19:3452484 [GRCh37]
Chr19:3403484 [NCBI36]
Chr19:19p13.3
not provided
GRCh38/hg38 19p13.3(chr19:3338024-4833139)x1 copy number loss See cases [RCV000134482] Chr19:3338024..4833139 [GRCh38]
Chr19:3338022..4833151 [GRCh37]
Chr19:3289022..4784151 [NCBI36]
Chr19:19p13.3
pathogenic
GRCh38/hg38 19p13.3(chr19:1549144-4288720)x1 copy number loss See cases [RCV000134795] Chr19:1549144..4288720 [GRCh38]
Chr19:1549143..4288717 [GRCh37]
Chr19:1500143..4239717 [NCBI36]
Chr19:19p13.3
pathogenic
GRCh38/hg38 19p13.3(chr19:3437996-4039217)x1 copy number loss See cases [RCV000135779] Chr19:3437996..4039217 [GRCh38]
Chr19:3437994..4039215 [GRCh37]
Chr19:3388994..3990215 [NCBI36]
Chr19:19p13.3
pathogenic
GRCh38/hg38 19p13.3(chr19:3080621-4912622)x3 copy number gain See cases [RCV000137713] Chr19:3080621..4912622 [GRCh38]
Chr19:3080619..4912634 [GRCh37]
Chr19:3031619..4863634 [NCBI36]
Chr19:19p13.3
likely pathogenic
GRCh38/hg38 19p13.3(chr19:3020573-3482611)x3 copy number gain See cases [RCV000139774] Chr19:3020573..3482611 [GRCh38]
Chr19:3020571..3482609 [GRCh37]
Chr19:2971571..3433609 [NCBI36]
Chr19:19p13.3
uncertain significance
GRCh38/hg38 19p13.3(chr19:2884401-3451078)x3 copy number gain See cases [RCV000143086] Chr19:2884401..3451078 [GRCh38]
Chr19:2884399..3451076 [GRCh37]
Chr19:2835399..3402076 [NCBI36]
Chr19:19p13.3
uncertain significance
GRCh38/hg38 19p13.3(chr19:259395-6795611)x3 copy number gain See cases [RCV000142627] Chr19:259395..6795611 [GRCh38]
Chr19:259395..6795622 [GRCh37]
Chr19:210395..6746622 [NCBI36]
Chr19:19p13.3
pathogenic
GRCh37/hg19 19p13.3(chr19:2652901-4342179)x3 copy number gain See cases [RCV000448078] Chr19:2652901..4342179 [GRCh37]
Chr19:19p13.3
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.3-13.2(chr19:3120160-9732820)x3 copy number gain not provided [RCV000684096] Chr19:3120160..9732820 [GRCh37]
Chr19:19p13.3-13.2
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3(chr19:3015481-3543109)x3 copy number gain not provided [RCV000740000] Chr19:3015481..3543109 [GRCh37]
Chr19:19p13.3
benign
Single allele deletion Internal malformations [RCV000787421] Chr19:2229488..4004142 [GRCh37]
Chr19:19p13.3
uncertain significance
GRCh37/hg19 19p13.3(chr19:3076808-4796782) copy number loss not provided [RCV000767742] Chr19:3076808..4796782 [GRCh37]
Chr19:19p13.3
pathogenic
NC_000019.9:g.1406030_3597207dup duplication Neurodevelopmental disorder [RCV000787423] Chr19:1406030..3597207 [GRCh37]
Chr19:19p13.3
uncertain significance
GRCh37/hg19 19p13.3(chr19:260912-4384674)x3 copy number gain See cases [RCV001007443] Chr19:260912..4384674 [GRCh37]
Chr19:19p13.3
pathogenic
GRCh37/hg19 19p13.3(chr19:3132909-3907470)x3 copy number gain not provided [RCV000847631] Chr19:3132909..3907470 [GRCh37]
Chr19:19p13.3
uncertain significance
GRCh37/hg19 19p13.3(chr19:3134686-3501127)x3 copy number gain not provided [RCV000847642] Chr19:3134686..3501127 [GRCh37]
Chr19:19p13.3
uncertain significance
GRCh37/hg19 19p13.3(chr19:260911-4788357)x3 copy number gain not provided [RCV000846988] Chr19:260911..4788357 [GRCh37]
Chr19:19p13.3
pathogenic
GRCh37/hg19 19p13.3(chr19:260911-3501271)x3 copy number gain not provided [RCV001007025] Chr19:260911..3501271 [GRCh37]
Chr19:19p13.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7786 AgrOrtholog
COSMIC NFIC COSMIC
Ensembl Genes ENSG00000141905 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000342194 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000378543 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000396843 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465177 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000465655 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000466647 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000492983 UniProtKB/TrEMBL
Ensembl Transcript ENST00000341919 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000395111 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000443272 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000586919 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000589123 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000590282 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000641145 UniProtKB/TrEMBL
GTEx ENSG00000141905 GTEx
HGNC ID HGNC:7786 ENTREZGENE
Human Proteome Map NFIC Human Proteome Map
InterPro CTF/NFI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTF/NFI_DNA-bd-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTF/NFI_DNA-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTF/NFI_DNA-bd_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4782 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4782 ENTREZGENE
OMIM 600729 OMIM
PANTHER PTHR11492 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CTF_NFI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NfI_DNAbd_pre-N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31592 PharmGKB
PROSITE CTF_NFI_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTF_NFI_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.170131 ENTREZGENE
UniProt A0A286YEX4_HUMAN UniProtKB/TrEMBL
  B7Z4T6 ENTREZGENE, UniProtKB/TrEMBL
  NFIC_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6FI30_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K1H0 UniProtKB/Swiss-Prot
  B7Z4U5 UniProtKB/Swiss-Prot
  B7Z9C3 UniProtKB/Swiss-Prot
  K7EMU1 UniProtKB/Swiss-Prot
  P08652 UniProtKB/Swiss-Prot
  Q14932 UniProtKB/Swiss-Prot
  Q9UPJ3 UniProtKB/Swiss-Prot
  Q9UPJ9 UniProtKB/Swiss-Prot
  Q9UPK0 UniProtKB/Swiss-Prot
  Q9UPK1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 NFIC  nuclear factor I C  NFIC  nuclear factor I/C (CCAAT-binding transcription factor)  Symbol and/or name change 5135510 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.