Dlc1 (deleted in liver cancer 1) - Rat Genome Database
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Gene: Dlc1 (deleted in liver cancer 1) Mus musculus
Analyze
Symbol: Dlc1
Name: deleted in liver cancer 1
RGD ID: 68617
MGI Page MGI
Description: Predicted to have several functions, including GTPase activator activity; SH2 domain binding activity; and phospholipase binding activity. Involved in several processes, including actin cytoskeleton organization; focal adhesion assembly; and nervous system development. Predicted to colocalize with actin filament and stress fiber. Is expressed in several structures, including central nervous system; liver; mandible; placenta; and trigeminal nerve. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A730069N07Rik; Arh; Arhgap7; dlc-1; FLJ21120; HP; hypothetical protein LOC244425; p122-R; p122-RhoGAP; rho GTPase-activating protein 7; rho-type GTPase-activating protein 7; RIKEN cDNA A730069N07 gene; STAR; stAR-related lipid transfer protein 12; STARD12; START domain-containing protein 12; uncharacterized protein LOC244425
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18297  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39837,034,893 - 37,420,343 (-)NCBIGRCm39mm39
GRCm38836,567,739 - 36,953,184 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl836,567,751 - 36,953,143 (-)EnsemblGRCm38mm10GRCm38
MGSCv37837,630,799 - 37,676,928 (-)NCBIGRCm37mm9NCBIm37
MGSCv36837,630,799 - 37,676,928 (-)NCBImm8
Celera839,196,115 - 39,243,125 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cumene  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
flutamide  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
glycidol  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
leflunomide  (ISO)
mercury dibromide  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10702663   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12034501   PMID:12040188   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583  
PMID:14610273   PMID:15710412   PMID:16141072   PMID:16141073   PMID:16919269   PMID:17967808   PMID:18519636   PMID:18799693   PMID:20199662   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:22792269   PMID:23010077   PMID:23375831   PMID:23511482   PMID:24590291   PMID:26427649   PMID:26496610   PMID:28193997   PMID:28358928   PMID:28408355   PMID:29202196   PMID:30028837  


Genomics

Comparative Map Data
Dlc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39837,034,893 - 37,420,343 (-)NCBIGRCm39mm39
GRCm38836,567,739 - 36,953,184 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl836,567,751 - 36,953,143 (-)EnsemblGRCm38mm10GRCm38
MGSCv37837,630,799 - 37,676,928 (-)NCBIGRCm37mm9NCBIm37
MGSCv36837,630,799 - 37,676,928 (-)NCBImm8
Celera839,196,115 - 39,243,125 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.05NCBI
DLC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl813,083,361 - 13,604,610 (-)EnsemblGRCh38hg38GRCh38
GRCh38813,083,361 - 13,604,620 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37812,940,870 - 13,462,129 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37812,940,870 - 13,373,167 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36812,985,243 - 13,416,766 (-)NCBINCBI36hg18NCBI36
Build 34812,985,242 - 13,416,766NCBI
Celera811,906,167 - 12,337,728 (-)NCBI
Cytogenetic Map8p22NCBI
HuRef811,483,338 - 11,914,734 (-)NCBIHuRef
CHM1_1813,142,556 - 13,574,157 (-)NCBICHM1_1
Dlc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21655,246,716 - 55,671,441 (+)NCBI
Rnor_6.0 Ensembl1659,077,574 - 59,247,754 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01658,776,489 - 59,247,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01658,638,567 - 58,928,425 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41659,312,930 - 59,355,129 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11659,313,004 - 59,355,204 (+)NCBI
Celera1653,351,212 - 53,453,368 (+)NCBICelera
Celera1653,685,682 - 53,727,187 (+)NCBICelera
Cytogenetic Map16q12.1-q12.2NCBI
Dlc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554633,598,985 - 3,990,849 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554633,599,415 - 3,981,187 (+)NCBIChiLan1.0ChiLan1.0
DLC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.189,037,742 - 9,087,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl89,037,742 - 9,460,233 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0812,282,190 - 12,809,770 (-)NCBIMhudiblu_PPA_v0panPan3
DLC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1636,531,754 - 36,943,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11636,531,754 - 36,943,033 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dlc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365732,493,051 - 2,658,396 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,170,195 - 1,637,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1171,169,709 - 1,637,171 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DLC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1811,211,230 - 11,632,278 (-)NCBI
Dlc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248393,495,580 - 3,899,009 (+)NCBI

Position Markers
AW742331  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38836,759,677 - 36,759,930UniSTSGRCm38
MGSCv37837,822,731 - 37,822,984UniSTSGRCm37
Celera839,391,539 - 39,391,792UniSTS
Cytogenetic Map8A4-B2UniSTS
Whitehead/MRC_RH8427.83UniSTS
AW743025  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38836,759,137 - 36,759,384UniSTSGRCm38
MGSCv37837,822,191 - 37,822,438UniSTSGRCm37
Celera839,395,521 - 39,395,768UniSTS
Celera839,390,995 - 39,391,245UniSTS
Cytogenetic Map8A4-B2UniSTS
Whitehead/MRC_RH8430.74UniSTS
BE199599  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38836,567,837 - 36,567,958UniSTSGRCm38
MGSCv37837,630,891 - 37,631,012UniSTSGRCm37
Celera839,196,207 - 39,196,328UniSTS
Cytogenetic Map8A4-B2UniSTS
Whitehead/MRC_RH8429.85UniSTS
D8Mit226  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38836,631,298 - 36,631,420UniSTSGRCm38
MGSCv37837,694,352 - 37,694,474UniSTSGRCm37
Celera839,260,377 - 39,260,491UniSTS
Cytogenetic Map8A4-B2UniSTS
cM Map822.0UniSTS
Whitehead Genetic823.0UniSTS
Whitehead_YAC8 UniSTS
D8Mit97  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38836,699,774 - 36,699,889UniSTSGRCm38
MGSCv37837,762,828 - 37,762,943UniSTSGRCm37
Cytogenetic Map8A4-B2UniSTS
cM Map820.0UniSTS
Whitehead Genetic820.8UniSTS
Whitehead_YAC8 UniSTS
Arhgap7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38836,578,925 - 36,579,124UniSTSGRCm38
MGSCv37837,641,979 - 37,642,178UniSTSGRCm37
Celera839,207,139 - 39,207,286UniSTS
Cytogenetic Map8A4-B2UniSTS
cM Map821.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8749417341494326Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8761318541613356Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8761318541613356Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8761318541613356Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81501654449016701Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81501654449016701Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81607934550079669Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81785394351854071Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81898786452987996Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81898786452987996Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82613028560130285Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83278698850837502Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83383736267837502Mouse
1301196Mnif1_mmacronutrient intake (mouse)Not determined83464277644852835Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83485394357344598Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83485394357344598Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83485394357344598Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83485394357344598Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2248
Count of miRNA genes:749
Interacting mature miRNAs:941
Transcripts:ENSMUST00000033923, ENSMUST00000036104, ENSMUST00000098826, ENSMUST00000145245, ENSMUST00000156312, ENSMUST00000163663, ENSMUST00000178717, ENSMUST00000179501, ENSMUST00000179652
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001194940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001194941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006509167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC103378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC138593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC168051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE199599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU169068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU169069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU169070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM008381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033923   ⟹   ENSMUSP00000033923
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,567,751 - 36,613,943 (-)Ensembl
RefSeq Acc Id: ENSMUST00000036104
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,849,126 - 36,952,357 (-)Ensembl
RefSeq Acc Id: ENSMUST00000098826   ⟹   ENSMUSP00000096425
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,567,751 - 36,733,054 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145245
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,593,231 - 36,613,874 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156312
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,572,145 - 36,577,269 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163663   ⟹   ENSMUSP00000132812
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,570,249 - 36,952,442 (-)Ensembl
RefSeq Acc Id: ENSMUST00000178717
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,857,711 - 36,952,422 (-)Ensembl
RefSeq Acc Id: ENSMUST00000179501   ⟹   ENSMUSP00000137498
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,938,555 - 36,953,143 (-)Ensembl
RefSeq Acc Id: ENSMUST00000179652
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl836,935,584 - 36,952,436 (-)Ensembl
RefSeq Acc Id: NM_001194940   ⟹   NP_001181869
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,034,893 - 37,419,596 (-)NCBI
GRCm38836,567,739 - 36,952,442 (-)NCBI
Celera839,196,109 - 39,592,727 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001194941   ⟹   NP_001181870
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,034,893 - 37,200,208 (-)NCBI
GRCm38836,567,739 - 36,733,054 (-)NCBI
Celera839,196,109 - 39,592,727 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_015802   ⟹   NP_056617
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,034,893 - 37,081,097 (-)NCBI
GRCm38836,567,739 - 36,613,943 (-)NCBI
MGSCv37837,630,799 - 37,676,928 (-)RGD
Celera839,196,109 - 39,592,727 (-)ENTREZGENE
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509166   ⟹   XP_006509229
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,034,897 - 37,420,343 (-)NCBI
GRCm38836,567,743 - 36,953,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006509167   ⟹   XP_006509230
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,245,726 - 37,419,810 (-)NCBI
GRCm38836,778,565 - 36,952,709 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242152   ⟹   XP_011240454
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,125,867 - 37,419,781 (-)NCBI
GRCm38836,658,713 - 36,952,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242153   ⟹   XP_011240455
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,255,310 - 37,419,779 (-)NCBI
GRCm38836,788,115 - 36,952,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312892   ⟹   XP_017168381
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,034,897 - 37,080,208 (-)NCBI
GRCm38836,567,743 - 36,612,811 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036154159   ⟹   XP_036010052
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39837,157,306 - 37,419,799 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_056617   ⟸   NM_015802
- Peptide Label: isoform 2
- UniProtKB: Q9R0Z9 (UniProtKB/Swiss-Prot),   E9QKB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001181869   ⟸   NM_001194940
- Peptide Label: isoform 1
- UniProtKB: D5M8I5 (UniProtKB/TrEMBL),   E9PXD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001181870   ⟸   NM_001194941
- Peptide Label: isoform 3
- UniProtKB: Q9R0Z9 (UniProtKB/Swiss-Prot),   A0A0R4J171 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509229   ⟸   XM_006509166
- Peptide Label: isoform X1
- UniProtKB: E9PXD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509230   ⟸   XM_006509167
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011240454   ⟸   XM_011242152
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011240455   ⟸   XM_011242153
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017168381   ⟸   XM_017312892
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000132812   ⟸   ENSMUST00000163663
RefSeq Acc Id: ENSMUSP00000096425   ⟸   ENSMUST00000098826
RefSeq Acc Id: ENSMUSP00000137498   ⟸   ENSMUST00000179501
RefSeq Acc Id: ENSMUSP00000033923   ⟸   ENSMUST00000033923
RefSeq Acc Id: XP_036010052   ⟸   XM_036154159
- Peptide Label: isoform X4
Protein Domains
Rho-GAP   SAM   START

Promoters
RGD ID:8666899
Promoter ID:EPDNEW_M11481
Type:initiation region
Name:Dlc1_1
Description:Mus musculus deleted in liver cancer 1 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11482  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38836,613,907 - 36,613,967EPDNEW
RGD ID:8666901
Promoter ID:EPDNEW_M11482
Type:multiple initiation site
Name:Dlc1_2
Description:Mus musculus deleted in liver cancer 1 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11481  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38836,732,974 - 36,733,034EPDNEW
RGD ID:6843032
Promoter ID:MM_KWN:54183
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000070716
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36837,637,966 - 37,641,282 (-)MPROMDB
RGD ID:6843034
Promoter ID:MM_KWN:54185
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000070714,   OTTMUST00000070715,   UC009LLS.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36837,676,556 - 37,677,167 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1354949 AgrOrtholog
Ensembl Genes ENSMUSG00000031523 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033923 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000096425 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000132812 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000137498 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033923 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000098826 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000163663 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000179501 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.530.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DLC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START_lipid-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:50768 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1354949 ENTREZGENE
NCBI Gene 50768 ENTREZGENE
PANTHER PTHR12659:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dlc1 PhenoGen
PROSITE RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  START UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J171 ENTREZGENE, UniProtKB/TrEMBL
  B9EKA3_MOUSE UniProtKB/TrEMBL
  D2JZZ5_MOUSE UniProtKB/TrEMBL
  D2JZZ6_MOUSE UniProtKB/TrEMBL
  D2JZZ7_MOUSE UniProtKB/TrEMBL
  D5M8I5 ENTREZGENE, UniProtKB/TrEMBL
  E9PXD2 ENTREZGENE, UniProtKB/TrEMBL
  E9QKB1 ENTREZGENE, UniProtKB/TrEMBL
  J3QPV2_MOUSE UniProtKB/TrEMBL
  Q8BR96_MOUSE UniProtKB/TrEMBL
  Q8C6U8_MOUSE UniProtKB/TrEMBL
  Q8C920_MOUSE UniProtKB/TrEMBL
  Q9R0Z9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TRX3 UniProtKB/Swiss-Prot
  Q3UH75 UniProtKB/Swiss-Prot
  Q8R541 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Dlc1  deleted in liver cancer 1  A730069N07Rik  RIKEN cDNA A730069N07 gene  Data Merged 737654 PROVISIONAL