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Gene: DLC1 (DLC1 Rho GTPase activating protein) Homo sapiens
Symbol: DLC1
Name: DLC1 Rho GTPase activating protein
Description: Exhibits GTPase activator activity and SH2 domain binding activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of cellular component organization; and positive regulation of apoptotic process. Localizes to several cellular components, including caveola; focal adhesion; and ruffle membrane. Implicated in colorectal cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARHGAP7; deleted in liver cancer 1 protein; deleted in liver cancer 1 variant 2; deleted in liver cancer variant 4; FLJ21120; HP; p122-RhoGAP; rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; rho-type GTPase-activating protein 7; StAR-related lipid transfer (START) domain containing 12; STARD12; START domain-containing protein 12
Mus musculus (house mouse) : Dlc1 (deleted in liver cancer 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dlc1 (DLC1 Rho GTPase activating protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlc1 (DLC1 Rho GTPase activating protein)
Pan paniscus (bonobo/pygmy chimpanzee) : DLC1 (DLC1 Rho GTPase activating protein)
Canis lupus familiaris (dog) : DLC1 (DLC1 Rho GTPase activating protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlc1 (DLC1 Rho GTPase activating protein)
Sus scrofa (pig) : DLC1 (DLC1 Rho GTPase activating protein)
Chlorocebus sabaeus (African green monkey) : DLC1 (DLC1 Rho GTPase activating protein)
Heterocephalus glaber (naked mole-rat) : Dlc1 (DLC1 Rho GTPase activating protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: DLC1 (Gene ID: 10395) and DYNLL1 (Gene ID: 8655) share the DLC1 symbol/alias in common. DLC1 is sometimes used as an alternative name for dynein light chain LC8-type 1 (DYNLL1), which can be confused with the official symbol for DLC1 Rho GTPase activating protein (DLC1). [05 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl813,083,361 - 13,604,610 (-)EnsemblGRCh38hg38GRCh38
GRCh38813,083,361 - 13,604,620 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37812,940,870 - 13,373,167 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36812,985,243 - 13,416,766 (-)NCBINCBI36hg18NCBI36
Build 34812,985,242 - 13,416,766NCBI
Celera811,906,167 - 12,337,728 (-)NCBI
Cytogenetic Map8p22NCBI
HuRef811,483,338 - 11,914,734 (-)NCBIHuRef
CHM1_1813,142,556 - 13,574,157 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DLC1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68616
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.