Pdgfc (platelet-derived growth factor, C polypeptide) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pdgfc (platelet-derived growth factor, C polypeptide) Mus musculus
Analyze
Symbol: Pdgfc
Name: platelet-derived growth factor, C polypeptide
RGD ID: 68606
MGI Page MGI
Description: Enables platelet-derived growth factor receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; and regulation of protein phosphorylation. Located in extracellular region. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human PDGFC (platelet derived growth factor C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110064L01Rik; AI647969; fallotein; PDGF-; PDGF-C; platelet-derived growth factor C; SCDGF; spinal cord-derived growth factor; VEGF-E
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39380,943,723 - 81,121,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl380,943,723 - 81,121,347 (+)EnsemblGRCm39 Ensembl
GRCm38381,036,416 - 81,214,040 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,036,416 - 81,214,040 (+)EnsemblGRCm38mm10GRCm38
MGSCv37380,840,338 - 81,017,953 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36381,122,343 - 81,299,958 (+)NCBIMGSCv36mm8
Celera381,066,860 - 81,242,401 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map335.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)
Mesothelioma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dibenz[a,h]anthracene  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
etoposide  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
quercetin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
sulforaphane  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
cytosol  (IEA,ISO)
extracellular region  (IDA)
extracellular space  (IBA,IEA,ISO)
nucleus  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney morphology  (IEA)
abnormal lean body mass  (IEA)
abnormal liver morphology  (IEA)
abnormal myotome development  (IAGP)
abnormal nasal septum morphology  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palate bone morphology  (IAGP)
abnormal retina pigmentation  (IEA)
abnormal scapula morphology  (IAGP)
abnormal seminal vesicle morphology  (IEA)
abnormal small intestine morphology  (IAGP)
abnormal somite development  (IAGP)
blistering  (IAGP)
cleft secondary palate  (IAGP)
common atrium  (IAGP)
decreased body size  (IAGP)
decreased embryo size  (IAGP)
decreased heart rate  (IEA)
decreased small intestinal villus number  (IAGP)
edema  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
enlarged spleen  (IEA)
failure of palatal shelf elevation  (IAGP)
hydrops fetalis  (IAGP)
increased CD4-negative, CD25-positive NK T cell number  (IEA)
increased circulating creatinine level  (IEA)
increased granulocyte number  (IEA)
increased monocyte cell number  (IEA)
increased red blood cell distribution width  (IEA)
kyphosis  (IAGP)
midline facial cleft  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
palatal shelf hypoplasia  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
pericardial effusion  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
rib bifurcation  (IAGP)
rib fusion  (IAGP)
short nasal septum  (IAGP)
short sternum  (IAGP)
spina bifida  (IAGP)
spina bifida occulta  (IAGP)
wavy neural tube  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10806482   PMID:10922068   PMID:10960785   PMID:11042159   PMID:11076861   PMID:11297552   PMID:11744381   PMID:11857815   PMID:11940581   PMID:12032822  
PMID:12477932   PMID:12651897   PMID:12875986   PMID:12972405   PMID:14610273   PMID:15061151   PMID:15234987   PMID:15361870   PMID:15372073   PMID:15728360   PMID:16141072   PMID:16141073  
PMID:16443219   PMID:16830225   PMID:16897342   PMID:17066417   PMID:17344076   PMID:17904120   PMID:17941048   PMID:18184860   PMID:18194151   PMID:18287559   PMID:18367558   PMID:18460333  
PMID:19111878   PMID:19217431   PMID:20231377   PMID:20489153   PMID:20548288   PMID:20562862   PMID:20566880   PMID:20643125   PMID:20981831   PMID:21267068   PMID:21440680   PMID:21731673  
PMID:21873635   PMID:22230248   PMID:22362252   PMID:22369999   PMID:22696295   PMID:23141925   PMID:23529017   PMID:23714575   PMID:23856609   PMID:23929039   PMID:23938297   PMID:24046351  
PMID:24086166   PMID:24269585   PMID:24371228   PMID:24709779   PMID:24952961   PMID:25267616   PMID:26216283   PMID:26988758   PMID:27033449   PMID:27492130   PMID:28725968   PMID:28947535  
PMID:29079201   PMID:29345101   PMID:29529015   PMID:29688375   PMID:29750781   PMID:30021009   PMID:30228991   PMID:30827511   PMID:31112136   PMID:31712577   PMID:32913205   PMID:33361796  
PMID:34184034   PMID:34847773   PMID:35691459   PMID:35876806   PMID:36914817   PMID:37497597   PMID:37591247   PMID:37615370   PMID:38110169   PMID:38355793  


Genomics

Comparative Map Data
Pdgfc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39380,943,723 - 81,121,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl380,943,723 - 81,121,347 (+)EnsemblGRCm39 Ensembl
GRCm38381,036,416 - 81,214,040 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,036,416 - 81,214,040 (+)EnsemblGRCm38mm10GRCm38
MGSCv37380,840,338 - 81,017,953 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36381,122,343 - 81,299,958 (+)NCBIMGSCv36mm8
Celera381,066,860 - 81,242,401 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map335.73NCBI
PDGFC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384156,760,454 - 156,971,799 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4156,760,454 - 156,971,799 (-)EnsemblGRCh38hg38GRCh38
GRCh374157,681,606 - 157,892,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364157,902,214 - 158,111,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 344158,040,368 - 158,250,151NCBI
Celera4155,025,774 - 155,235,563 (-)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4153,433,623 - 153,643,623 (-)NCBIHuRef
CHM1_14157,660,122 - 157,869,922 (-)NCBICHM1_1
T2T-CHM13v2.04160,106,105 - 160,317,463 (-)NCBIT2T-CHM13v2.0
Pdgfc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82168,613,409 - 168,791,575 (+)NCBIGRCr8
mRatBN7.22166,316,870 - 166,493,449 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2166,316,803 - 166,493,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2173,505,985 - 173,680,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02171,520,356 - 171,702,464 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02166,129,200 - 166,311,291 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02179,952,227 - 180,126,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2179,952,227 - 180,128,283 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02199,362,291 - 199,537,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42172,635,732 - 172,811,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12172,585,837 - 172,761,110 (+)NCBI
Celera2160,357,528 - 160,531,962 (+)NCBICelera
Cytogenetic Map2q33-q34NCBI
Pdgfc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547110,418,455 - 10,500,668 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547110,318,683 - 10,500,624 (+)NCBIChiLan1.0ChiLan1.0
PDGFC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23154,652,310 - 154,863,474 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14155,007,121 - 155,219,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04149,105,330 - 149,317,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14160,921,353 - 161,132,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,922,827 - 161,131,960 (-)Ensemblpanpan1.1panPan2
PDGFC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11554,143,637 - 54,239,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1554,145,381 - 54,345,830 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1554,484,878 - 54,682,918 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01554,865,056 - 55,063,272 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1554,865,080 - 55,064,935 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11554,105,044 - 54,303,114 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01554,213,698 - 54,411,745 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01554,528,725 - 54,726,824 (-)NCBIUU_Cfam_GSD_1.0
Pdgfc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530135,991,126 - 36,189,515 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365763,357,424 - 3,554,890 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365763,357,399 - 3,555,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl845,578,002 - 45,808,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1845,579,065 - 45,808,789 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2847,676,639 - 47,817,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17103,345,122 - 103,562,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7103,344,895 - 103,562,962 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603783,027,150 - 83,244,526 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdgfc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248481,484,947 - 1,674,641 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248481,484,904 - 1,674,410 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pdgfc
11123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1910
Count of miRNA genes:639
Interacting mature miRNAs:819
Transcripts:ENSMUST00000029652, ENSMUST00000129285, ENSMUST00000143721
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse

Markers in Region
AW549711  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,213,657 - 81,213,756UniSTSGRCm38
MGSCv37381,017,579 - 81,017,678UniSTSGRCm37
Celera381,242,027 - 81,242,126UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3772.94UniSTS
AI647969  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,213,657 - 81,213,756UniSTSGRCm38
MGSCv37381,017,579 - 81,017,678UniSTSGRCm37
Celera381,242,027 - 81,242,126UniSTS
Cytogenetic Map3E3UniSTS
Whitehead/MRC_RH3772.94UniSTS
D3Mit245  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,086,398 - 81,086,547UniSTSGRCm38
MGSCv37380,890,320 - 80,890,469UniSTSGRCm37
Celera381,110,807 - 81,110,954UniSTS
Cytogenetic Map3E3UniSTS
cM Map338.3UniSTS
Whitehead Genetic328.4UniSTS
Whitehead/MRC_RH3772.94UniSTS
Whitehead_YAC3 UniSTS
D3Dcr10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,168,399 - 81,168,497UniSTSGRCm38
MGSCv37380,972,321 - 80,972,419UniSTSGRCm37
Celera381,196,902 - 81,197,002UniSTS
Cytogenetic Map3E3UniSTS
cM Map3 UniSTS
D3Dcr9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,150,097 - 81,150,193UniSTSGRCm38
MGSCv37380,954,019 - 80,954,115UniSTSGRCm37
Celera381,178,589 - 81,178,685UniSTS
Cytogenetic Map3E3UniSTS
cM Map3 UniSTS
UniSTS:234712  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,062,602 - 81,062,803UniSTSGRCm38
MGSCv37380,866,524 - 80,866,725UniSTSGRCm37
Celera381,092,821 - 81,093,022UniSTS
Cytogenetic Map3E3UniSTS
D3Mit358  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38381,150,108 - 81,150,222UniSTSGRCm38
MGSCv37380,954,030 - 80,954,144UniSTSGRCm37
Celera381,178,600 - 81,178,714UniSTS
Cytogenetic Map3E3UniSTS
cM Map334.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF117608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF266467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF286725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK042767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK081347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD741441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS019503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM867549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000029652   ⟹   ENSMUSP00000029652
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl380,943,723 - 81,121,347 (+)Ensembl
GRCm38.p6 Ensembl381,036,416 - 81,214,040 (+)Ensembl
Ensembl Acc Id: ENSMUST00000129285   ⟹   ENSMUSP00000118970
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl380,944,479 - 81,121,341 (+)Ensembl
GRCm38.p6 Ensembl381,037,172 - 81,214,034 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143721   ⟹   ENSMUSP00000122047
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl380,944,731 - 81,118,077 (+)Ensembl
GRCm38.p6 Ensembl381,037,424 - 81,210,770 (+)Ensembl
RefSeq Acc Id: NM_001357746   ⟹   NP_001344675
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39380,943,723 - 81,121,347 (+)NCBI
GRCm38381,036,416 - 81,214,040 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019971   ⟹   NP_064355
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39380,943,723 - 81,121,347 (+)NCBI
GRCm38381,036,416 - 81,214,040 (+)NCBI
MGSCv37380,840,338 - 81,017,953 (+)RGD
Celera381,066,860 - 81,242,401 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_064355   ⟸   NM_019971
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9QY71 (UniProtKB/Swiss-Prot),   Q9JHV8 (UniProtKB/Swiss-Prot),   Q99JM4 (UniProtKB/Swiss-Prot),   Q8CI19 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001344675   ⟸   NM_001357746
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000122047   ⟸   ENSMUST00000143721
Ensembl Acc Id: ENSMUSP00000029652   ⟸   ENSMUST00000029652
Ensembl Acc Id: ENSMUSP00000118970   ⟸   ENSMUST00000129285
Protein Domains
CUB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CI19-F1-model_v2 AlphaFold Q8CI19 1-345 view protein structure

Promoters
RGD ID:6834213
Promoter ID:MM_KWN:34661
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day4,   BoneMarrow_2Hour,   ES_Cell,   Kidney,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000071532,   UC008POI.1,   UC008POK.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36380,839,846 - 80,841,457 (+)MPROMDB
RGD ID:6880946
Promoter ID:EPDNEW_M3924
Type:initiation region
Name:Pdgfc_2
Description:Mus musculus platelet-derived growth factor, C polypeptide ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3925  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38381,036,455 - 81,036,515EPDNEW
RGD ID:6880948
Promoter ID:EPDNEW_M3925
Type:multiple initiation site
Name:Pdgfc_1
Description:Mus musculus platelet-derived growth factor, C polypeptide ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3924  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38381,039,286 - 81,039,346EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859631 AgrOrtholog
Ensembl Genes ENSMUSG00000028019 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029652 ENTREZGENE
  ENSMUST00000029652.4 UniProtKB/Swiss-Prot
  ENSMUST00000129285.8 UniProtKB/TrEMBL
  ENSMUST00000143721.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.290 UniProtKB/Swiss-Prot
InterPro CUB_dom UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  PDGF/VEGF_dom UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:54635 UniProtKB/Swiss-Prot
MGD MGI:1859631 ENTREZGENE
NCBI Gene Pdgfc ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR UniProtKB/Swiss-Prot
  PTHR11633:SF5 UniProtKB/Swiss-Prot
Pfam CUB UniProtKB/Swiss-Prot
  PDGF UniProtKB/Swiss-Prot
PhenoGen Pdgfc PhenoGen
PROSITE CUB UniProtKB/Swiss-Prot
  PDGF_2 UniProtKB/Swiss-Prot
SMART CUB UniProtKB/Swiss-Prot
  PDGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot
  SSF57501 UniProtKB/Swiss-Prot
UniProt D6RGS6_MOUSE UniProtKB/TrEMBL
  PDGFC_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q99JM4 ENTREZGENE
  Q9JHV8 ENTREZGENE
  Q9QY71 ENTREZGENE
UniProt Secondary Q99JM4 UniProtKB/Swiss-Prot
  Q9JHV8 UniProtKB/Swiss-Prot
  Q9QY71 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Pdgfc  platelet-derived growth factor, C polypeptide  1110064L01Rik  RIKEN cDNA 1110064L01 gene  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 1110064L01Rik  RIKEN cDNA 1110064L01 gene  Pdgfc  platelet-derived growth factor, C polypeptide  Symbol and/or name change 5135510 APPROVED